TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 260.219 | Formula: C10H13FN2O5
H donors: 3 H acceptors: 4 LogP: -0.58 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: OCC1OC(C(C1O)C)n1cc(F)c(=O)[nH]c1=O
InChi: 1S/C10H13FN2O5/c1-4-7(15)6(3-14)18-9(4)13-2-5(11)8(16)12-10(13)17/h2,4,6-7,9,14-15H,3H2,1H3,(H,12,16,17)
InChiKey: VEIPDPYFJUUBOQ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0037	0.5608	1
Brugia malayi	GnHR receptor homolog	0.0037	0.5608	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0037	0.5608	1
Echinococcus granulosus	7TM GPCR rhodopsin	0.0037	0.5608	1
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0037	0.5608	1
Brugia malayi	larval opioid receptor	0.0037	0.5608	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.0037	0.5608	0.5559
Onchocerca volvulus		0.0037	0.5608	1
Echinococcus granulosus	neuropeptides capa receptor	0.0037	0.5608	1
Brugia malayi	G-protein coupled receptor	0.0037	0.5608	1
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0037	0.5608	0.5559
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0037	0.5608	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0037	0.5608	1
Echinococcus multilocularis	lamin	0.0028	0.4088	0.6945
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0037	0.5608	1
Brugia malayi	sulfakinin receptor protein	0.0037	0.5608	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.5608	1
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0037	0.5608	1
Onchocerca volvulus		0.0037	0.5608	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.5608	1
Echinococcus multilocularis	g protein coupled receptor	0.0037	0.5608	1
Onchocerca volvulus		0.0037	0.5608	1
Brugia malayi	G protein-coupled receptor	0.0037	0.5608	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0037	0.5608	1
Brugia malayi	Serotonin receptor	0.0037	0.5608	1
Onchocerca volvulus		0.0037	0.5608	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0037	0.5608	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.5608	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0525	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0037	0.5608	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.5608	1
Onchocerca volvulus		0.0037	0.5608	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.5608	1
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0037	0.5608	1
Onchocerca volvulus		0.0029	0.4393	0.2007
Echinococcus multilocularis	lamin dm0	0.0028	0.4088	0.6945
Echinococcus granulosus	hypothetical protein	0.0037	0.5608	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0525	1
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0037	0.5608	1
Onchocerca volvulus		0.0037	0.5608	1
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0037	0.5608	1
Brugia malayi	Dopamine receptor protein 2	0.0037	0.5608	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0037	0.5608	1
Schistosoma mansoni	biogenic amine receptor	0.0037	0.5608	0.5559
Loa Loa (eye worm)	hypothetical protein	0.0037	0.5608	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0037	0.5608	1
Schistosoma mansoni	opsin-like receptor	0.0037	0.5608	0.5559
Brugia malayi	Dopamine receptor protein 1	0.0037	0.5608	1
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0013	0.1658	0.2059
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0037	0.5608	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.5608	1
Schistosoma mansoni	hypothetical protein	0.0037	0.5608	0.5559
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0037	0.5608	0.5559
Brugia malayi	neuropeptide F receptor	0.0037	0.5608	1
Echinococcus granulosus	lamin	0.0028	0.4088	0.6945
Schistosoma mansoni	biogenic amine receptor	0.0037	0.5608	0.5559
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0037	0.5608	1
Echinococcus multilocularis	fmrfamide receptor	0.0037	0.5608	1
Schistosoma mansoni	amine GPCR	0.0037	0.5608	0.5559
Loa Loa (eye worm)	hypothetical protein	0.0013	0.1572	0.1356
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0037	0.5608	0.5559
Loa Loa (eye worm)	hypothetical protein	0.0037	0.5608	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0037	0.5608	0.5559
Loa Loa (eye worm)	hypothetical protein	0.0037	0.5608	1
Brugia malayi	G-protein coupled receptor	0.0037	0.5608	1
Brugia malayi	hypothetical protein	0.0037	0.5608	1
Onchocerca volvulus		0.0037	0.5608	1
Echinococcus granulosus	neuropeptide s receptor	0.0037	0.5608	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0037	0.5608	0.5559
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0037	0.5608	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.5608	1
Echinococcus multilocularis	neuropeptide s receptor	0.0037	0.5608	1
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0037	0.5608	1
Schistosoma mansoni	amine GPCR	0.0037	0.5608	0.5559
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0037	0.5608	1
Schistosoma mansoni	biogenic amine receptor	0.0037	0.5608	0.5559
Echinococcus multilocularis	cpg binding protein	0.0031	0.4678	0.8131
Schistosoma mansoni	neuropeptide receptor	0.0037	0.5608	0.5559
Echinococcus multilocularis	neuropeptide receptor	0.0037	0.5608	1
Brugia malayi	hypothetical protein	0.0037	0.5608	1
Echinococcus multilocularis	sex peptide receptor	0.0037	0.5608	1
Schistosoma mansoni	neuropeptide f receptor 76f	0.0037	0.5608	0.5559
Loa Loa (eye worm)	hypothetical protein	0.0037	0.5608	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0037	0.5608	1
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0037	0.5608	0.5559
Loa Loa (eye worm)	hypothetical protein	0.0037	0.5608	1
Echinococcus granulosus	neuropeptide receptor	0.0037	0.5608	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.5608	1
Echinococcus granulosus	G protein coupled receptor 139	0.0037	0.5608	1
Echinococcus multilocularis	g protein coupled receptor	0.0037	0.5608	1
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0037	0.5608	0.5559
Echinococcus multilocularis	neuropeptide receptor	0.0037	0.5608	1
Echinococcus multilocularis	g protein coupled receptor	0.0037	0.5608	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.5608	1
Onchocerca volvulus		0.0037	0.5608	1
Echinococcus granulosus	g-protein coupled receptor	0.0037	0.5608	1
Echinococcus granulosus	sex peptide receptor	0.0037	0.5608	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0037	0.5608	1
Echinococcus granulosus	neuropeptide Y receptor	0.0037	0.5608	1
Onchocerca volvulus		0.0037	0.5608	1
Schistosoma mansoni	neuropeptide receptor	0.0037	0.5608	0.5559
Schistosoma mansoni	amine GPCR	0.0037	0.5608	0.5559
Echinococcus granulosus	neuropeptide receptor A26	0.0037	0.5608	1
Brugia malayi	hypothetical protein	0.0037	0.5608	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0037	0.5608	1
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0037	0.5608	1
Echinococcus multilocularis	serotonin receptor	0.0037	0.5608	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.5608	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0037	0.5608	1
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0037	0.5608	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0037	0.5608	1
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0037	0.5608	1
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0037	0.5608	1
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0037	0.5608	1
Echinococcus granulosus	g protein coupled receptor	0.0037	0.5608	1
Schistosoma mansoni	amine GPCR	0.0037	0.5608	0.5559
Brugia malayi	Intermediate filament tail domain containing protein	0.0028	0.4088	0.6759
Brugia malayi	CXXC zinc finger family protein	0.0029	0.4393	0.741
Brugia malayi	AKH receptor	0.0037	0.5608	1
Schistosoma mansoni	hypothetical protein	0.0037	0.5608	0.5559
Schistosoma mansoni	lamin	0.0028	0.4088	0.4023
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0007	0.0634	0.0531
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0525	1
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0037	0.5608	1
Trichomonas vaginalis	helicase, putative	0.0007	0.0525	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.5608	1
Echinococcus granulosus	orexin receptor type 2	0.0037	0.5608	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0037	0.5608	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0037	0.5608	0.5559
Brugia malayi	hypothetical protein	0.0037	0.5608	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0037	0.5608	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0037	0.5608	0.5559
Loa Loa (eye worm)	neuropeptide F receptor	0.0037	0.5608	1
Brugia malayi	hypothetical protein	0.0037	0.5608	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.5608	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.4088	0.6745
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0037	0.5608	0.5559
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0037	0.5608	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.5608	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0037	0.5608	0.5559
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0037	0.5608	1
Brugia malayi	Serotonin receptor	0.0037	0.5608	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.5608	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0037	0.5608	0.5559
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0037	0.5608	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.5608	1
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0525	1
Schistosoma mansoni	opsin-like receptor	0.0037	0.5608	0.5559
Echinococcus granulosus	rhodopsin orphan GPCR	0.0037	0.5608	1
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0037	0.5608	1
Brugia malayi	Dopamine receptor	0.0037	0.5608	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0037	0.5608	1
Echinococcus granulosus	serotonin receptor	0.0037	0.5608	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.5608	1
Echinococcus granulosus	g protein coupled receptor	0.0037	0.5608	1
Schistosoma mansoni	hypothetical protein	0.0037	0.5608	0.5559
Brugia malayi	hypothetical protein	0.0037	0.5608	1
Echinococcus granulosus	neuropeptide FF receptor 2	0.0037	0.5608	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0037	0.5608	0.5559
Loa Loa (eye worm)	hypothetical protein	0.0037	0.5608	1
Echinococcus multilocularis	dro:myosuppressin receptor	0.0037	0.5608	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0037	0.5608	0.5559
Onchocerca volvulus		0.0037	0.5608	1
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0028	0.4088	0.6745
Loa Loa (eye worm)	melatonin receptor type 1A	0.0037	0.5608	1
Brugia malayi	putative neuropeptide receptor NPR1	0.0037	0.5608	1
Schistosoma mansoni	histamine h1 receptor	0.0037	0.5608	0.5559
Loa Loa (eye worm)	hypothetical protein	0.0037	0.5608	1
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0007	0.0525	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0037	0.5608	1
Schistosoma mansoni	myosin xvIII	0.0037	0.5608	0.5559
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0007	0.0525	1
Schistosoma mansoni	intermediate filament proteins	0.0028	0.4088	0.4023
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0056	0.8867	0.5
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0525	1
Echinococcus granulosus	cpg binding protein	0.0031	0.4678	0.8131
Echinococcus multilocularis	neuropeptides capa receptor	0.0037	0.5608	1
Echinococcus granulosus	dro:myosuppressin receptor	0.0037	0.5608	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.5608	1
Brugia malayi	Melatonin receptor type 1A	0.0037	0.5608	1
Echinococcus multilocularis	G protein coupled receptor 139	0.0037	0.5608	1
Brugia malayi	hypothetical protein	0.0037	0.5608	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0525	1
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0037	0.5608	0.5559
Schistosoma mansoni	adenoreceptor	0.0037	0.5608	0.5559
Brugia malayi	hypothetical protein	0.0037	0.5608	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0037	0.5608	1
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0037	0.5608	0.5559
Onchocerca volvulus		0.0037	0.5608	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.5608	1
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0015	0.1908	0.2075
Loa Loa (eye worm)	hypothetical protein	0.0013	0.1658	0.154
Echinococcus granulosus	rhodopsin orphan GPCR	0.0037	0.5608	1
Echinococcus multilocularis	serotonin receptor	0.0037	0.5608	1
Echinococcus multilocularis	fmrfamide receptor	0.0037	0.5608	1
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0037	0.5608	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.5608	1
Schistosoma mansoni	hypothetical protein	0.0037	0.5608	0.5559
Echinococcus granulosus	biogenic amine 5HT receptor	0.0037	0.5608	1
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0525	1
Schistosoma mansoni	opsin-like receptor	0.0037	0.5608	0.5559
Echinococcus granulosus	fmrfamide receptor	0.0037	0.5608	1
Brugia malayi	RE15519p	0.0037	0.5608	1
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0525	1
Schistosoma mansoni	neuropeptide receptor	0.0037	0.5608	0.5559
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0037	0.5608	0.5559
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0037	0.5608	1
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0525	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.5608	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.5608	1
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0525	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0037	0.5608	1
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0037	0.5608	1
Echinococcus granulosus	lamin dm0	0.0028	0.4088	0.6945
Brugia malayi	hypothetical protein	0.0037	0.5608	1
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0525	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0037	0.5608	1
Echinococcus multilocularis	orexin receptor type 2	0.0037	0.5608	1
Brugia malayi	putative neuropeptide receptor	0.0037	0.5608	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.5608	1
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0525	1
Echinococcus granulosus	allatostatin A receptor	0.0037	0.5608	1
Echinococcus multilocularis	musashi	0.0028	0.4088	0.6945
Echinococcus granulosus	tm gpcr rhodopsin	0.0037	0.5608	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0037	0.5608	1
Onchocerca volvulus		0.0037	0.5608	1
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0037	0.5608	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.5608	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.5608	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.5608	1
Brugia malayi	G protein-coupled receptor F59B2.13	0.0037	0.5608	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.5608	1
Schistosoma mansoni	lamin	0.0028	0.4088	0.4023
Echinococcus granulosus	somatostatin receptor	0.0037	0.5608	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0525	1
Brugia malayi	cytoplasmic intermediate filament protein	0.0015	0.1908	0.2108
Schistosoma mansoni	neuropeptide F-like receptor	0.0037	0.5608	0.5559
Echinococcus multilocularis	g-protein coupled receptor	0.0037	0.5608	1
Echinococcus granulosus	neuropeptides capa receptor	0.0037	0.5608	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.5608	1
Echinococcus multilocularis	somatostatin receptor	0.0037	0.5608	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0037	0.5608	0.5559
Onchocerca volvulus		0.0037	0.5608	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.5608	1
Echinococcus granulosus	neuropeptide receptor	0.0037	0.5608	1
Loa Loa (eye worm)	TYRA-2 protein	0.0037	0.5608	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0037	0.5608	0.5559
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0037	0.5608	0.5559
Echinococcus granulosus	rhodopsin orphan GPCR	0.0037	0.5608	1
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0939	0.0613
Echinococcus granulosus	intermediate filament protein	0.0028	0.4088	0.6945
Echinococcus granulosus	g protein coupled receptor	0.0037	0.5608	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0037	0.5608	0.5559
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0037	0.5608	0.5559
Schistosoma mansoni	cpg binding protein	0.0031	0.4678	0.4619
Loa Loa (eye worm)	hypothetical protein	0.0037	0.5608	1
Brugia malayi	neuropeptide F receptor	0.0037	0.5608	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0037	0.5608	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0037	0.5608	1
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0939	0.0613
Echinococcus granulosus	neuropeptide Y receptor	0.0037	0.5608	1
Onchocerca volvulus		0.0037	0.5608	1
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0037	0.5608	0.5559
Loa Loa (eye worm)	hypothetical protein	0.0037	0.5608	1
Brugia malayi	follicle stimulating hormone receptor	0.0037	0.5608	1
Onchocerca volvulus		0.0037	0.5608	1
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0037	0.5608	1
Loa Loa (eye worm)	intermediate filament protein	0.0028	0.4088	0.6745
Schistosoma mansoni	cpg binding protein	0.0031	0.4678	0.4619
Echinococcus multilocularis	neuropeptides capa receptor	0.0037	0.5608	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.5608	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0037	0.5608	1
Schistosoma mansoni	cpg binding protein	0.0029	0.4393	0.4331
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0037	0.5608	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0037	0.5608	0.5559
Loa Loa (eye worm)	hypothetical protein	0.0013	0.1572	0.1356
Onchocerca volvulus		0.0037	0.5608	1
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0037	0.5608	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0037	0.5608	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.5608	1
Brugia malayi	intermediate filament protein	0.0028	0.4088	0.6759
Echinococcus granulosus	7tm_1 domain containing protein	0.0037	0.5608	1
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0525	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0037	0.5608	0.5559
Echinococcus multilocularis	allatostatin A receptor	0.0037	0.5608	1
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.4393	0.7399
Loa Loa (eye worm)	hypothetical protein	0.0037	0.5608	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.5608	1
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0037	0.5608	1
Schistosoma mansoni	amine GPCR	0.0037	0.5608	0.5559
Loa Loa (eye worm)	hypothetical protein	0.0037	0.5608	1
Echinococcus multilocularis	neuropeptide receptor A26	0.0037	0.5608	1
Brugia malayi	hypothetical protein	0.0037	0.5608	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0037	0.5608	0.5559
Brugia malayi	ORL1-like opioid receptor	0.0037	0.5608	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.5608	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0037	0.5608	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.4002	0.6561
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0037	0.5608	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0037	0.5608	1
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0525	1
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0037	0.5608	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.5608	1
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0013	0.1658	0.2059
Onchocerca volvulus		0.0037	0.5608	1
Schistosoma mansoni	neuropeptide receptor	0.0037	0.5608	0.5559

Activities

Activity type	Activity value	Assay description	Source	Reference
CC50 (functional)	> 100 ug ml-1	Cytotoxic concentration required to inhibit NC-37 cells by 50%	ChEMBL.	No reference
EC50 (functional)	> 100 ug ml-1	Concentration required to reduce HSV-1 (KOS strain) induced cytopathogenicity in NC-37 cells	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 302195

Bibliographic References

No literature references available for this target.

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Detailed information for compound 212968