Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | Starlite/ChEMBL | References |
Rattus norvegicus | Dihydrofolate reductase | Starlite/ChEMBL | References |
Pneumocystis carinii | Dihydrofolate reductase | Starlite/ChEMBL | References |
Mycobacterium avium | Dihydrofolate reductase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Conserved protein | 0.0242 | 0.0738 | 0.2051 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0676 | 0.3598 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0676 | 0.3598 | 1 |
Mycobacterium ulcerans | glyoxalase GloA | 0.0242 | 0.0738 | 0.2051 |
Loa Loa (eye worm) | hypothetical protein | 0.0242 | 0.0738 | 0.0738 |
Onchocerca volvulus | Putative protein | 0.1647 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0421 | 0.1918 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0242 | 0.0738 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0421 | 0.1918 | 1 |
Mycobacterium ulcerans | glyoxalase GloA | 0.0242 | 0.0738 | 0.2051 |
Brugia malayi | lactoylglutathione lyase | 0.0242 | 0.0738 | 0.0738 |
Mycobacterium ulcerans | biphenyl-2,3-diol 1,2-dioxygenase | 0.0242 | 0.0738 | 0.2051 |
Mycobacterium ulcerans | hypothetical protein | 0.0242 | 0.0738 | 0.2051 |
Mycobacterium ulcerans | hypothetical protein | 0.0242 | 0.0738 | 0.2051 |
Mycobacterium ulcerans | hypothetical protein | 0.0242 | 0.0738 | 0.2051 |
Schistosoma mansoni | 4-hydroxyphenylpyruvate dioxygenase | 0.0242 | 0.0738 | 0.2051 |
Mycobacterium tuberculosis | Conserved protein | 0.0242 | 0.0738 | 0.2051 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0242 | 0.0738 | 0.2051 |
Echinococcus granulosus | dihydrofolate reductase | 0.0676 | 0.3598 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0421 | 0.1918 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0676 | 0.3598 | 1 |
Mycobacterium tuberculosis | Conserved protein TB27.3 | 0.0242 | 0.0738 | 0.2051 |
Schistosoma mansoni | gynecophoral canal protein | 0.0242 | 0.0738 | 0.2051 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0421 | 0.1918 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0421 | 0.1918 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0242 | 0.0738 | 0.2051 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0676 | 0.3598 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0242 | 0.0738 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.0676 | 0.3598 | 0.3598 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0676 | 0.3598 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.0676 | 0.3598 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0421 | 0.1918 | 0.5 |
Loa Loa (eye worm) | 4-hydroxyphenylpyruvate dioxygenase | 0.1647 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0242 | 0.0738 | 0.2051 |
Brugia malayi | dihydrofolate reductase family protein | 0.0676 | 0.3598 | 0.3598 |
Mycobacterium tuberculosis | Cadmium inducible protein CadI | 0.0242 | 0.0738 | 0.2051 |
Mycobacterium ulcerans | hypothetical protein | 0.0242 | 0.0738 | 0.2051 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0676 | 0.3598 | 0.3598 |
Mycobacterium ulcerans | hypothetical protein | 0.0242 | 0.0738 | 0.2051 |
Onchocerca volvulus | Lactoylglutathione lyase homolog | 0.0242 | 0.0738 | 0.0738 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5.11 | Inhibition of rat liver DHFR by spectrophotometric assay | ChEMBL. | 20117005 |
IC50 (binding) | = 45.9 | Selectivity ratio of IC50 for rat liver DHFR to IC50 for Toxoplasma gondii DHFR | ChEMBL. | 17552508 |
IC50 (binding) | = 0.1 mM | Inhibition of Mycobacterium avium DHFR | ChEMBL. | 17552508 |
IC50 (binding) | = 0.1 mM | Inhibition of Mycobacterium avium DHFR | ChEMBL. | 17552508 |
IC50 (binding) | = 0.17 mM | Inhibition of Toxoplasma gondii DHFR | ChEMBL. | 17552508 |
IC50 (binding) | = 0.17 mM | Inhibition of Toxoplasma gondii DHFR | ChEMBL. | 17552508 |
IC50 (binding) | = 7.8 mM | Inhibition of rat liver DHFR | ChEMBL. | 17552508 |
IC50 (binding) | = 7.8 mM | Inhibition of rat liver DHFR | ChEMBL. | 17552508 |
IC50 (binding) | = 14.6 mM | Inhibition of Pneumocystis carinii DHFR | ChEMBL. | 17552508 |
IC50 (binding) | = 14.6 mM | Inhibition of Pneumocystis carinii DHFR | ChEMBL. | 17552508 |
IC50 (binding) | = 0.1 uM | Inhibitory concentration against Dihydrofolate reductase from Mycobacterium avium (M. avium) | ChEMBL. | 15214795 |
IC50 (binding) | = 0.1 uM | Inhibitory concentration against Dihydrofolate reductase from Mycobacterium avium (M. avium) | ChEMBL. | 15214795 |
IC50 (binding) | = 0.17 uM | Inhibitory concentration against Dihydrofolate reductase from Toxoplasma gondii (T. gondii) | ChEMBL. | 15214795 |
IC50 (binding) | = 0.17 uM | Inhibitory concentration against Dihydrofolate reductase from Toxoplasma gondii (T. gondii) | ChEMBL. | 15214795 |
IC50 (binding) | = 0.17 uM | Inhibition of Toxoplasma gondii DHFR by spectrophotometric assay | ChEMBL. | 20117005 |
IC50 (binding) | = 7.8 uM | Inhibitory concentration against Dihydrofolate reductase from rat liver | ChEMBL. | 15214795 |
IC50 (binding) | = 7.8 uM | Inhibitory concentration against Dihydrofolate reductase from rat liver | ChEMBL. | 15214795 |
IC50 (binding) | = 7.8 uM | Inhibition of rat liver DHFR using dihydrofolic acid substrate and NADPH cofactor | ChEMBL. | 18605720 |
IC50 (binding) | = 7.8 uM | Inhibition of rat liver DHFR by spectrophotometric assay | ChEMBL. | 20117005 |
IC50 (binding) | = 14.6 uM | Inhibition of Dihydrofolate reductase from Pneumocystis carinii (P. carinii) | ChEMBL. | 15214795 |
IC50 (binding) | = 14.6 uM | Inhibition of Dihydrofolate reductase from Pneumocystis carinii (P. carinii) | ChEMBL. | 15214795 |
IC50 (binding) | = 14.6 uM | Inhibition of Pneumocystis carinii DHFR using dihydrofolic acid substrate and NADPH cofactor | ChEMBL. | 18605720 |
Ratio IC50 (binding) | = 0.5 | Selectivity ratio of IC50 for rat liver DHFR to IC50 for Pneumocystis carinii DHFR | ChEMBL. | 17552508 |
Ratio IC50 (binding) | = 78 | Selectivity ratio of IC50 for rat liver DHFR to IC50 for Mycobacterium avium DHFR | ChEMBL. | 17552508 |
Selectivity ratio (binding) | = 0.5 | Selectivity ratio [(IC50 rlDHFR)/(IC50 pcDHFR) | ChEMBL. | 15214795 |
Selectivity ratio (binding) | = 45.9 | Selectivity ratio (IC50rlDHFR)/(IC50 tgDHFR) | ChEMBL. | 15214795 |
Selectivity ratio (binding) | = 78 | Selectivity ratio (IC50 rlDHFR)/(IC50 maDHFR) | ChEMBL. | 15214795 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.