Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0237 | 0.2246 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0237 | 0.2246 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.0237 | 0.2246 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.0299 | 0.4136 | 0.8334 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0334 | 0.5216 | 0.5 |
Onchocerca volvulus | Matrilysin homolog | 0.0299 | 0.4136 | 1 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0299 | 0.4136 | 1 |
Brugia malayi | thymidylate synthase | 0.0237 | 0.2246 | 0.4525 |
Onchocerca volvulus | 0.0237 | 0.2246 | 0.4288 | |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0334 | 0.5216 | 0.5 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0237 | 0.2246 | 1 |
Brugia malayi | Hemopexin family protein | 0.0191 | 0.0827 | 0.1666 |
Brugia malayi | Matrixin family protein | 0.0326 | 0.4963 | 1 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.049 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0334 | 0.5216 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.0326 | 0.4963 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0334 | 0.5216 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0334 | 0.5216 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.0237 | 0.2246 | 0.4525 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0334 | 0.5216 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Variation (functional) | = 0 % | Effect on the frequency rate of spontaneously beating atria from Reserpine-treated guinea pigs as percentage variation from the control at concentration of 10E-6 M | ChEMBL. | 8809156 |
Variation (functional) | = 3.33 % | Compound was evaluated for its effect on the frequency rate of spontaneously beating atria from Reserpine-treated guinea pigs as percentage variation from the control at concentration of 3 x 10E-6 M | ChEMBL. | 8809156 |
Variation (functional) | = 3.33 % | Compound was evaluated for its effect on the frequency rate of spontaneously beating atria from Reserpine-treated guinea pigs as percentage variation from the control at different concentration of 10E-5 M | ChEMBL. | 8809156 |
Variation (functional) | = 3.33 % | Compound was evaluated for its effect on the frequency rate of spontaneously beating atria from Reserpine-treated guinea pigs as percentage variation from the control at different concentration of 3 x 10E-5 M | ChEMBL. | 8809156 |
Variation (functional) | = 3.51 % | Effect on the contractile force of spontaneously beating atria from Reserpine-treated guinea pigs as percentage variation from the control at concentration of 10E-6 M | ChEMBL. | 8809156 |
Variation (functional) | = 3.71 % | Compound was evaluated for its effect on the frequency rate of spontaneously beating atria from Reserpine-treated guinea pigs as percentage variation from the control at different concentration of 10E-4 M | ChEMBL. | 8809156 |
Variation (functional) | = 7.42 % | Compound was evaluated for its effect on the frequency rate of spontaneously beating atria from Reserpine-treated guinea pigs as percentage variation from the control at different concentration of 3 x 10E-4 M | ChEMBL. | 8809156 |
Variation (functional) | = 7.58 % | Effect on the contractile force of spontaneously beating atria from Reserpine-treated guinea pigs as percentage variation from the control at concentration of 3 x 10E-6 M | ChEMBL. | 8809156 |
Variation (functional) | = 9.67 % | Effect on the contractile force of spontaneously beating atria from Reserpine-treated guinea pigs as percentage variation from the control at concentration of 10E-5 M | ChEMBL. | 8809156 |
Variation (functional) | = 11.11 % | Compound was evaluated for its effect on the frequency rate of spontaneously beating atria from Reserpine-treated guinea pigs as percentage variation from the control at different concentration of 10E-3 M | ChEMBL. | 8809156 |
Variation (functional) | = 12.51 % | Effect on the contractile force of spontaneously beating atria from Reserpine-treated guinea pigs as percentage variation from the control at concentration of 3 x 10E-5 M | ChEMBL. | 8809156 |
Variation (functional) | = 13.23 % | Effect on the contractile force of spontaneously beating atria from Reserpine treated guinea pigs as percentage variation from the control at concentration of 10E-4 M | ChEMBL. | 8809156 |
Variation (functional) | = 14.21 % | Effect on the contractile force of spontaneously beating atria from Reserpine-treated guinea pigs as percentage variation from the control at concentration of 3 x 10E-4 M | ChEMBL. | 8809156 |
Variation (functional) | = 18.64 % | Effect on the contractile force of spontaneously beating atria from Reserpine-treated guinea pigs as percentage variation from the control at concentration of 10E-3 M | ChEMBL. | 8809156 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.