Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | metacaspase 5, putative | 0.0045 | 0.2236 | 0.3935 |
Plasmodium vivax | hypothetical protein, conserved | 0.0045 | 0.2236 | 1 |
Trypanosoma brucei | metacaspase MCA2 | 0.0045 | 0.2236 | 0.565 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0045 | 0.2236 | 0.3051 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0045 | 0.2236 | 0.3051 |
Leishmania major | metacaspase, putative | 0.0045 | 0.2236 | 0.447 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0045 | 0.2236 | 0.3051 |
Echinococcus granulosus | caspase 8 | 0.0045 | 0.2236 | 0.1964 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0031 | 0.0704 | 0.178 |
Echinococcus multilocularis | caspase 3, apoptosis cysteine peptidase | 0.012 | 1 | 1 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0045 | 0.2236 | 0.3051 |
Entamoeba histolytica | arginine N-methyltransferase protein, putative | 0.0049 | 0.2604 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1471 | 0.0639 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0063 | 0.405 | 1 |
Echinococcus granulosus | protein arginine N methyltransferase 8 | 0.0031 | 0.077 | 0.0446 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0038 | 0.1471 | 0.3718 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 0.3996 | 0.4122 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0077 | 0.5576 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0062 | 0.3958 | 1 |
Giardia lamblia | NADPH oxidoreductase, putative | 0.0077 | 0.5576 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0062 | 0.3958 | 1 |
Plasmodium falciparum | metacaspase-like protein | 0.0045 | 0.2236 | 1 |
Plasmodium falciparum | metacaspase 1 | 0.0045 | 0.2236 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0062 | 0.3958 | 1 |
Echinococcus multilocularis | protein arginine methyltransferase | 0.0031 | 0.077 | 0.0446 |
Echinococcus granulosus | dna polymerase kappa | 0.0062 | 0.3958 | 0.3746 |
Echinococcus multilocularis | caspase 3 | 0.0075 | 0.5277 | 0.5112 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0045 | 0.2236 | 0.3051 |
Trypanosoma brucei | Metacaspase-4 | 0.0045 | 0.2236 | 0.565 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0035 | 0.1119 | 0.2827 |
Echinococcus granulosus | dna polymerase eta | 0.0035 | 0.1119 | 0.0808 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.0045 | 0.2236 | 0.4545 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0041 | 0.1823 | 0.3211 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.6634 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0045 | 0.2236 | 0.3051 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0062 | 0.3958 | 1 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0063 | 0.405 | 1 |
Leishmania major | DNA polymerase kappa, putative | 0.0041 | 0.1823 | 0.3211 |
Trichomonas vaginalis | NAD(P)H dehydrogenase, putative | 0.0077 | 0.5576 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0031 | 0.0704 | 0.178 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0062 | 0.3958 | 1 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0063 | 0.405 | 0.3554 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0031 | 0.0704 | 0.178 |
Echinococcus granulosus | caspase 3 | 0.0075 | 0.5277 | 0.5112 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0035 | 0.1119 | 0.0808 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0077 | 0.5576 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0062 | 0.3958 | 1 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0035 | 0.1119 | 0.0378 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0035 | 0.1119 | 0.0378 |
Trypanosoma cruzi | metacaspase, putative | 0.0045 | 0.2236 | 0.3935 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0038 | 0.1471 | 0.3718 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.2236 | 0.2025 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0062 | 0.3958 | 0.6633 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0063 | 0.405 | 0.5315 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0062 | 0.3958 | 1 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0045 | 0.2236 | 0.3051 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.1912 | 0.1437 |
Trichomonas vaginalis | NAD(P)H dehydrogenase, putative | 0.0077 | 0.5576 | 1 |
Trypanosoma cruzi | metacaspase 5, putative | 0.0045 | 0.2236 | 0.3935 |
Plasmodium vivax | metacaspase 1, putative | 0.0045 | 0.2236 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0062 | 0.3996 | 0.3495 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0062 | 0.3996 | 0.3785 |
Trypanosoma cruzi | arginine N-methyltransferase, putative | 0.0049 | 0.2604 | 0.5231 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0077 | 0.5576 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0049 | 0.2604 | 1 |
Echinococcus multilocularis | dna polymerase eta | 0.0035 | 0.1119 | 0.0808 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0062 | 0.3958 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 0.3996 | 0.4122 |
Brugia malayi | mucosa associated lymphoid tissue lymphoma translocation protein 1 | 0.0045 | 0.2236 | 0.2025 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0041 | 0.1823 | 0.2403 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.0045 | 0.2236 | 0.4545 |
Echinococcus multilocularis | caspase | 0.012 | 1 | 1 |
Echinococcus multilocularis | caspase 8 | 0.0045 | 0.2236 | 0.1964 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0062 | 0.3958 | 1 |
Schistosoma mansoni | subfamily C14A unassigned peptidase (C14 family) | 0.0045 | 0.2236 | 0.1588 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0045 | 0.2236 | 0.3051 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.0045 | 0.2236 | 0.4545 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0062 | 0.3958 | 1 |
Trichomonas vaginalis | NAD(P)H dehydrogenase, putative | 0.0077 | 0.5576 | 1 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0035 | 0.1119 | 0.0808 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0077 | 0.5576 | 1 |
Echinococcus granulosus | apoptotic protease activating factor 1 | 0.0042 | 0.1912 | 0.1628 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0063 | 0.405 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0077 | 0.5576 | 1 |
Brugia malayi | hypothetical protein | 0.0042 | 0.1912 | 0.1437 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0077 | 0.5576 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0062 | 0.3958 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0045 | 0.2236 | 0.3051 |
Leishmania major | DNA polymerase eta, putative | 0.0035 | 0.1119 | 0.1064 |
Trypanosoma brucei | Protein arginine N-methyltransferase 1 catalytic subunit | 0.0049 | 0.2604 | 0.658 |
Trypanosoma brucei | unspecified product | 0.0055 | 0.3254 | 0.822 |
Trypanosoma cruzi | metacaspase, putative | 0.0045 | 0.2236 | 0.3935 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0062 | 0.3958 | 1 |
Echinococcus multilocularis | caspase 2 | 0.0088 | 0.6634 | 0.6516 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0045 | 0.2236 | 0.3051 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2604 | 0.2693 |
Echinococcus granulosus | caspase 2 | 0.0088 | 0.6634 | 0.6516 |
Schistosoma mansoni | caspase-3 (C14 family) | 0.012 | 1 | 1 |
Onchocerca volvulus | Cell death protein 3 homolog | 0.0088 | 0.6634 | 1 |
Brugia malayi | Cell death protein 3 precursor | 0.0088 | 0.6634 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0045 | 0.2236 | 0.3051 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0055 | 0.3254 | 0.822 |
Trypanosoma brucei | metacaspase | 0.0045 | 0.2236 | 0.565 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.1823 | 0.4607 |
Schistosoma mansoni | DNA polymerase eta | 0.0035 | 0.1119 | 0.0378 |
Giardia lamblia | NADPH oxidoreductase, putative | 0.0077 | 0.5576 | 1 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0045 | 0.2236 | 0.3051 |
Echinococcus multilocularis | dna polymerase kappa | 0.0062 | 0.3958 | 0.3746 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0062 | 0.3958 | 0.6633 |
Echinococcus multilocularis | protein arginine N methyltransferase 8 | 0.0031 | 0.077 | 0.0446 |
Trypanosoma brucei | metacaspase MCA3 | 0.0045 | 0.2236 | 0.565 |
Trypanosoma cruzi | arginine N-methyltransferase, putative | 0.0049 | 0.2604 | 0.5231 |
Brugia malayi | polk-prov protein | 0.0038 | 0.1471 | 0.0639 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0077 | 0.5576 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0062 | 0.3996 | 1 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0063 | 0.405 | 0.3842 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0077 | 0.5576 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0077 | 0.5576 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0062 | 0.3958 | 1 |
Brugia malayi | hypothetical protein | 0.0049 | 0.2604 | 0.2693 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0045 | 0.2236 | 0.3051 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0077 | 0.5576 | 1 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0045 | 0.2236 | 0.3051 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0058 | 0.3562 | 0.5809 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0055 | 0.3226 | 0.3819 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 0.3996 | 0.4122 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.012 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0077 | 0.5576 | 1 |
Trypanosoma brucei | metacaspase 5, putative | 0.0045 | 0.2236 | 0.565 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0088 | 0.6634 | 0.6354 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0063 | 0.405 | 0.3842 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0062 | 0.3958 | 1 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0045 | 0.2236 | 0.3051 |
Echinococcus granulosus | protein arginine methyltransferase | 0.0031 | 0.077 | 0.0446 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0077 | 0.5576 | 1 |
Echinococcus multilocularis | apoptotic protease activating factor 1 | 0.0042 | 0.1912 | 0.1628 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0062 | 0.3996 | 0.9835 |
Giardia lamblia | NADPH oxidoreductase, putative | 0.0077 | 0.5576 | 1 |
Trypanosoma cruzi | metacaspase, putative | 0.0045 | 0.2236 | 0.3935 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.1912 | 0.1237 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0077 | 0.5576 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0062 | 0.3958 | 1 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0063 | 0.405 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0062 | 0.3996 | 0.9815 |
Echinococcus granulosus | caspase | 0.012 | 1 | 1 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0062 | 0.3996 | 0.3785 |
Trypanosoma cruzi | metacaspase, putative | 0.0045 | 0.2236 | 0.3935 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0062 | 0.3996 | 0.3495 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Activity against P. berghei in mice. | ChEMBL. | 6991691 | |
Activity (binding) | Ability to inhibit hypoxanthine-guanine phosphoribosyltransferase in crude extracts of H.Ep.-2 cells. | ChEMBL. | 6991691 | |
Activity (functional) | Not significant 0 | Activity against P. berghei in mice. | ChEMBL. | 6991691 |
Activity (binding) | NI 0 | Ability to inhibit hypoxanthine-guanine phosphoribosyltransferase in crude extracts of H.Ep.-2 cells. | ChEMBL. | 6991691 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.