Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | HMG-CoA reductase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.1201 | 0.1874 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0125 | 0.4622 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0024 | 0.0134 | 0.0134 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0112 | 0.4067 | 0.8342 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0123 | 0.4532 | 0.4532 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.1201 | 0.1874 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.2103 | 0.2103 |
Schistosoma mansoni | hypothetical protein | 0.005 | 0.1316 | 0.2053 |
Mycobacterium tuberculosis | Probable reductase | 0.0112 | 0.4067 | 0.8342 |
Schistosoma mansoni | patched 1 | 0.0068 | 0.2103 | 0.3282 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0246 | 1 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0112 | 0.4067 | 0.8342 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0078 | 0.2523 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0024 | 0.0134 | 0.0134 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0068 | 0.2103 | 0.2103 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0123 | 0.4532 | 0.4532 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0049 | 0.1272 | 0.1272 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0165 | 0.6408 | 1 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0165 | 0.6408 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0165 | 0.6408 | 1 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.0165 | 0.6408 | 1 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.0165 | 0.6408 | 0.6408 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0068 | 0.2103 | 0.2103 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.1201 | 0.1201 |
Brugia malayi | Thioredoxin reductase | 0.0049 | 0.1272 | 0.1272 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.0165 | 0.6408 | 0.6408 |
Schistosoma mansoni | survival motor neuron protein | 0.005 | 0.1316 | 0.2053 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0112 | 0.4067 | 0.8342 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0049 | 0.1272 | 0.1272 |
Plasmodium falciparum | glutathione reductase | 0.0049 | 0.1272 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0123 | 0.4532 | 0.7072 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0068 | 0.2103 | 0.2103 |
Loa Loa (eye worm) | glutathione reductase | 0.0049 | 0.1272 | 0.1272 |
Plasmodium falciparum | thioredoxin reductase | 0.0049 | 0.1272 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0078 | 0.2523 | 1 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0068 | 0.2103 | 0.3282 |
Schistosoma mansoni | lipoxygenase | 0.0086 | 0.2894 | 0.4517 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0048 | 0.1201 | 0.1201 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0048 | 0.1201 | 0.1201 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0125 | 0.4622 | 1 |
Echinococcus multilocularis | protein patched | 0.0068 | 0.2103 | 0.2103 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.6408 | 0.6408 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0078 | 0.2523 | 1 |
Echinococcus multilocularis | protein dispatched 1 | 0.0068 | 0.2103 | 0.2103 |
Plasmodium vivax | glutathione reductase, putative | 0.0049 | 0.1272 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0112 | 0.4067 | 0.8342 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0049 | 0.1272 | 0.1272 |
Brugia malayi | CHE-14 protein | 0.0068 | 0.2103 | 0.2103 |
Toxoplasma gondii | thioredoxin reductase | 0.0049 | 0.1272 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.1201 | 0.1874 |
Brugia malayi | Hydroxymethylglutaryl-coenzyme A reductase family protein | 0.0165 | 0.6408 | 0.6408 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.1201 | 0.1201 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.005 | 0.1316 | 0.1316 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0049 | 0.1272 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0246 | 1 | 1 |
Brugia malayi | glutathione reductase | 0.0049 | 0.1272 | 0.1272 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0068 | 0.2103 | 0.2103 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0125 | 0.4622 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0112 | 0.4067 | 0.8342 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0165 | 0.6408 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0125 | 0.4622 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.1201 | 0.1201 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0068 | 0.2103 | 0.2103 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.1201 | 0.1201 |
Onchocerca volvulus | 0.005 | 0.1316 | 1 | |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0068 | 0.2103 | 0.2103 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 1 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0078 | 0.2523 | 1 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.0165 | 0.6408 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.