TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 383.175 | Formula: C23H21N5O
H donors: 1 H acceptors: 3 LogP: 3.09 Rotable bonds: 4
Rule of 5 violations (Lipinski): 0
SMILES: O1CCN(CC1)c1ccc(cc1)Nc1cncc2c1nc(cn2)c1ccccc1
InChi: InChI=1S/C23H21N5O/c1-2-4-17(5-3-1)20-16-25-21-14-24-15-22(23(21)27-20)26-18-6-8-19(9-7-18)28-10-12-29-13-11-28/h1-9,14-16,26H,10-13H2
InChiKey: UMKXZBLGOSKWKR-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Bibliographic reference
Homo sapiens	neurotrophic tyrosine kinase, receptor, type 1	No references
Homo sapiens	YES proto-oncogene 1, Src family tyrosine kinase	No references
Homo sapiens	mitogen-activated protein kinase 1	No references
Homo sapiens	Pim-1 proto-oncogene, serine/threonine kinase	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	tyrosine protein kinase Blk	Get druggable targets OG5_127750	All targets in OG5_127750
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Cryptosporidium hominis	MAPK	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus granulosus	mitogen activated protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Candida albicans	MAP kinase-like orf	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	Get druggable targets OG5_127750	All targets in OG5_127750
Brugia malayi	SRC-1	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	CAMK/PIM protein kinase	Get druggable targets OG5_134863	All targets in OG5_134863
Leishmania donovani	mitogen-activated protein kinase 4	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma brucei gambiense	protein kinase, putative,tyrosine protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania braziliensis	mitogen activated protein kinase, putative,map kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma japonicum	Mitogen-activated protein kinase 3, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Candida albicans	Serine/threonine protein kinase of MAP kinase family	Get druggable targets OG5_126781	All targets in OG5_126781
Giardia lamblia	Kinase, CMGC MAPK	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma japonicum	ko:K08892 fyn-related kinase, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Lyn	Get druggable targets OG5_127750	All targets in OG5_127750
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	Get druggable targets OG5_127750	All targets in OG5_127750
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Brugia malayi	Serine/threonine-protein kinase Pim-3	Get druggable targets OG5_134863	All targets in OG5_134863
Echinococcus granulosus	tyrosine protein kinase HCK	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	proto oncogene serine:threonine protein kinase	Get druggable targets OG5_134863	All targets in OG5_134863
Echinococcus multilocularis	mitogen activated protein kinase 3	Get druggable targets OG5_126781	All targets in OG5_126781
Cryptosporidium parvum	MAPK, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus multilocularis	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Src64B	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	mitogen activated protein kinase 3	Get druggable targets OG5_126781	All targets in OG5_126781
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Loa Loa (eye worm)	SRC-1	Get druggable targets OG5_127750	All targets in OG5_127750
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania infantum	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	Get druggable targets OG5_126781	All targets in OG5_126781
Loa Loa (eye worm)	TK protein kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	mitogen activated protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	ko:K04371 extracellular signal-regulated kinase 1/2, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania mexicana	mitogen-activated protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus multilocularis	tyrosine protein kinase Src64B	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma japonicum	ko:K05703 proto-oncogene tyrosine-protein kinase Fyn, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FGR, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Brugia malayi	MAP kinase sur-1	Get druggable targets OG5_126781	All targets in OG5_126781
Candida albicans	MAP kinase-like orf	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FYN, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Mitogen-activated protein kinase 3, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma japonicum	ko:K04702 proto-oncogene serine/threonine-protein kinase Pim-1, putative	Get druggable targets OG5_134863	All targets in OG5_134863
Echinococcus multilocularis	tyrosine protein kinase Blk	Get druggable targets OG5_127750	All targets in OG5_127750
Trypanosoma congolense	tyrosine protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma brucei	mitogen activated protein kinase 4, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_134863	All targets in OG5_134863
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase Yrk, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Candida albicans	Serine/threonine protein kinase of MAP kinase family	Get druggable targets OG5_126781	All targets in OG5_126781
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_134863	All targets in OG5_134863
Echinococcus multilocularis	tyrosine protein kinase Srms	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Candida albicans	MAP kinase implicated in PKC1-controlled signalling pathway	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania donovani	mitogen activated protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Loa Loa (eye worm)	TK protein kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FYN, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Onchocerca volvulus	Serine\/threonine protein kinase homolog	Get druggable targets OG5_134863	All targets in OG5_134863
Echinococcus multilocularis	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	Get druggable targets OG5_127750	All targets in OG5_127750
Trypanosoma brucei gambiense	mitogen-activated protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Loa Loa (eye worm)	CAMK/PIM protein kinase	Get druggable targets OG5_134863	All targets in OG5_134863
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Leishmania braziliensis	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus multilocularis	tyrosine protein kinase Fgr	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Trypanosoma brucei	protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Brugia malayi	protein-tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Leishmania mexicana	mitogen activated protein kinase, putative,map kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus multilocularis	tyrosine protein kinase HCK	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	proto oncogene serine:threonine protein kinase	Get druggable targets OG5_134863	All targets in OG5_134863
Leishmania infantum	mitogen activated protein kinase, putative,map kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	mitogen-activated protein kinase 5	mitogen-activated protein kinase 1	360 aa	361 aa	33.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	TK/FER protein kinase	0.0007	0.0135	0.0135
Onchocerca volvulus	Serine\/threonine protein kinase homolog	0.0193	1	1
Giardia lamblia	Kinase, CMGC MAPK	0.0062	0.3053	0.5
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0047	0.2239	0.2239
Loa Loa (eye worm)	TK/FER protein kinase	0.0007	0.0135	0.0135
Brugia malayi	SRC-1	0.0047	0.2239	0.2239
Schistosoma mansoni	serine/threonine protein kinase	0.0062	0.3053	0.3053
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0047	0.2239	0.2239
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0009	0.0235	0.0235
Echinococcus granulosus	tyrosine protein kinase HCK	0.0038	0.1762	0.1762
Echinococcus multilocularis	NCK adaptor protein	0.0009	0.0235	0.0235
Schistosoma mansoni	growth factor receptor-bound protein	0.0009	0.0235	0.0235
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0006	0.0059	0.0335
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.004	0.1868	0.1868
Entamoeba histolytica	protein kinase, putative	0.0006	0.0059	0.0335
Onchocerca volvulus		0.0006	0.0053	0.0053
Loa Loa (eye worm)	TK/FER protein kinase	0.0007	0.0135	0.0135
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0048	0.2298	0.2298
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0047	0.2239	0.2239
Trichomonas vaginalis	CMGC family protein kinase	0.0062	0.3053	0.5
Brugia malayi	SH2 domain containing protein	0.0007	0.0135	0.0135
Onchocerca volvulus		0.0007	0.0135	0.0135
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0042	0.2004	0.2004
Echinococcus granulosus	c src tyrosine kinase	0.0012	0.0371	0.0371
Echinococcus multilocularis	proto oncogene serine:threonine protein kinase	0.0193	1	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0012	0.0371	0.0371
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0062	0.3053	0.5
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0062	0.3053	0.5
Echinococcus multilocularis	mitogen activated protein kinase	0.0062	0.3053	0.3053
Trichomonas vaginalis	CMGC family protein kinase	0.0062	0.3053	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0007	0.0129	0.0129
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0009	0.0235	0.0235
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0062	0.3053	0.3053
Echinococcus granulosus	tyrosine protein kinase Blk	0.0042	0.2004	0.2004
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0042	0.2004	0.2004
Echinococcus granulosus	proto oncogene serine:threonine protein kinase	0.0193	1	1
Brugia malayi	Variant SH3 domain containing protein	0.0009	0.0235	0.0235
Brugia malayi	Sex muscle abnormal protein 5	0.0009	0.0235	0.0235
Brugia malayi	Protein kinase domain containing protein	0.0007	0.0135	0.0135
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0007	0.0135	0.0768
Onchocerca volvulus		0.0007	0.0135	0.0135
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0047	0.2239	0.2239
Loa Loa (eye worm)	SRC-1	0.0047	0.2239	0.2239
Schistosoma mansoni	tyrosine kinase	0.0047	0.2239	0.2239
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0007	0.0135	0.0135
Loa Loa (eye worm)	TK/FER protein kinase	0.0007	0.0135	0.0135
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0062	0.3053	0.5
Schistosoma mansoni	tyrosine kinase	0.0007	0.0135	0.0135
Echinococcus granulosus	tyrosine protein kinase shark	0.0007	0.0135	0.0135
Schistosoma mansoni	tyrosine kinase	0.0047	0.2239	0.2239
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0007	0.0135	0.0135
Loa Loa (eye worm)	TK/FER protein kinase	0.0007	0.0135	0.0135
Brugia malayi	Serine/threonine-protein kinase Pim-3	0.0193	1	1
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0135	0.0135
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0047	0.2239	0.2239
Brugia malayi	MAP kinase sur-1	0.0062	0.3053	0.3053
Brugia malayi	Tyrosine-protein kinase abl-1	0.0012	0.0371	0.0371
Brugia malayi	Protein kinase domain containing protein	0.0007	0.0135	0.0135
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0062	0.3053	0.5
Echinococcus multilocularis	tyrosine protein kinase shark	0.0007	0.0135	0.0135
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0007	0.0135	0.0135
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0047	0.2239	0.2239
Loa Loa (eye worm)	TK/FER protein kinase	0.0007	0.0135	0.0135
Echinococcus granulosus	tyrosine protein kinase Srms	0.0007	0.0135	0.0135
Loa Loa (eye worm)	TK protein kinase	0.0038	0.1762	0.1762
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0012	0.0371	0.0371
Echinococcus multilocularis	c src tyrosine kinase	0.0012	0.0371	0.0371
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0062	0.3053	0.5
Trypanosoma brucei	protein kinase, putative	0.0062	0.3053	0.5
Brugia malayi	protein-tyrosine kinase	0.0042	0.2004	0.2004
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0047	0.2239	0.2239
Loa Loa (eye worm)	TK/FER protein kinase	0.0007	0.0135	0.0135
Loa Loa (eye worm)	TK/FER protein kinase	0.0007	0.0135	0.0135
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0062	0.3053	0.5
Echinococcus granulosus	NCK adaptor protein	0.0009	0.0235	0.0235
Loa Loa (eye worm)	TK/FER protein kinase	0.0007	0.0135	0.0135
Trichomonas vaginalis	CMGC family protein kinase	0.0062	0.3053	0.5
Schistosoma mansoni	tyrosine kinase	0.0012	0.0371	0.0371
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0047	0.2239	0.2239
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0038	0.1762	0.1762
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0009	0.0235	0.0235
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0062	0.3053	0.3053
Loa Loa (eye worm)	TK protein kinase	0.0042	0.2004	0.2004
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0062	0.3053	0.5
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.0193	1	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.004	0.1868	0.1868
Schistosoma mansoni	serine/threonine protein kinase	0.0193	1	1
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0007	0.0135	0.0135
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0047	0.2239	0.2239
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0047	0.2239	0.2239
Schistosoma mansoni	tyrosine kinase	0.0012	0.0371	0.0371
Trichomonas vaginalis	CMGC family protein kinase	0.0062	0.3053	0.5
Onchocerca volvulus		0.0007	0.0135	0.0135
Echinococcus granulosus	mitogen activated protein kinase	0.0062	0.3053	0.3053
Schistosoma mansoni	growth factor receptor-bound protein	0.0009	0.0235	0.0235
Brugia malayi	Protein kinase domain containing protein	0.0007	0.0135	0.0135
Brugia malayi	hypothetical protein	0.0007	0.0135	0.0135
Loa Loa (eye worm)	TK/ABL protein kinase	0.0007	0.0135	0.0135
Schistosoma mansoni	adapter molecule crk	0.0009	0.0235	0.0235
Brugia malayi	SH2 domain containing protein	0.0007	0.0135	0.0135
Echinococcus granulosus	tyrosine kinase	0.0007	0.0135	0.0135
Echinococcus granulosus	growth factor receptor bound protein 2	0.0009	0.0235	0.0235
Entamoeba histolytica	protein kinase, putative	0.0038	0.1762	1
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0235	0.0235
Schistosoma mansoni	tyrosine kinase	0.0007	0.0135	0.0135
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0047	0.2239	0.2239
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0047	0.2239	0.2239
Onchocerca volvulus		0.0007	0.0135	0.0135
Brugia malayi	Protein kinase domain containing protein	0.0007	0.0135	0.0135
Brugia malayi	Variant SH3 domain containing protein	0.0009	0.0235	0.0235
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0042	0.2004	0.2004
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0042	0.2004	0.2004
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0012	0.0371	0.0371
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0047	0.2239	0.2239
Brugia malayi	Protein kinase domain containing protein	0.0007	0.0135	0.0135
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0009	0.0235	0.0235
Schistosoma mansoni	nck2/grb4	0.0009	0.0235	0.0235
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0047	0.2239	0.2239
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0012	0.0371	0.0371
Onchocerca volvulus		0.0007	0.0135	0.0135
Onchocerca volvulus		0.0007	0.0135	0.0135
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0062	0.3053	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0047	0.2239	0.2239
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.0193	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0007	0.0135	0.0135
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0047	0.2239	0.2239
Echinococcus multilocularis	tyrosine kinase	0.0007	0.0135	0.0135
Echinococcus granulosus	mitogen activated protein kinase 3	0.0062	0.3053	0.3053
Echinococcus granulosus	tyrosine kinase	0.0042	0.2004	0.2004

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 5.11 uM	Inhibition of N-terminal His6-tagged human recombinant Yes expressed in baculovirus infected insect Sf21 cells after 1 hr by Alphascreen assay	ChEMBL.	No reference
IC50 (binding)	= 5.32 uM	Inhibition of N-terminal His6-tagged human recombinant TrkA (440 to end residues) expressed in baculovirus infected insect Sf21 cells after 1 hr by Alphascreen assay	ChEMBL.	No reference
IC50 (binding)	= 8.3 uM	Inhibition of N-terminal GST-tagged recombinant human full length Pim-1 expressed in Escherichia coli after 1 hr by Alphascreen assay	ChEMBL.	No reference
IC50 (binding)	= 8.43 uM	Inhibition of recombinant ERK2 (unknown origin) after 1 hr by Alphascreen assay	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3780632

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 2134759