Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Anandamide amidohydrolase | References | |
Homo sapiens | acetylcholinesterase (Yt blood group) | References | |
Homo sapiens | butyrylcholinesterase | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | acetylcholinesterase (Yt blood group) | 614 aa | 510 aa | 26.5 % |
Echinococcus granulosus | fatty acid amide hydrolase 1 | Anandamide amidohydrolase | 579 aa | 470 aa | 28.7 % |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | Anandamide amidohydrolase | 579 aa | 470 aa | 28.3 % |
Schistosoma japonicum | Fatty-acid amide hydrolase 1, putative | Anandamide amidohydrolase | 579 aa | 499 aa | 24.6 % |
Brugia malayi | Carboxylesterase family protein | butyrylcholinesterase | 602 aa | 546 aa | 30.2 % |
Onchocerca volvulus | Anandamide amidohydrolase | 579 aa | 539 aa | 34.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | 0.0164 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0164 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0164 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0164 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0164 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0164 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2.06 nM | Inhibition of human serum BuChE using butyrylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's method | ChEMBL. | 27309570 |
IC50 (binding) | = 125 nM | Inhibition of recombinant human AChE expressed in HEK293 cells using acetylthiocholine iodide as substrate preincubated for 120 mins followed by substrate addition by Ellman's method | ChEMBL. | 27309570 |
IC50 (binding) | = 249.5 nM | Inhibition of FAAH in rat brain membrane using N-arachidonoyl-[14C]-ethanolamine as substrate preincubated for 20 mins followed by substrate addition measured after 30 mins by scintillation counting method | ChEMBL. | 27309570 |
IC50 (binding) | = 1847.9 nM | Inhibition of FAAH in rat brain membrane using N-arachidonoyl-[14C]-ethanolamine as substrate incubated for 30 mins by scintillation counting method | ChEMBL. | 27309570 |
Inhibition (binding) | Inhibition of recombinant human AChE expressed in HEK293 cells assessed as enzyme carbamoylation using acetylthiocholine iodide as substrate preincubated with enzyme followed by substrate addition by Ellman's method | ChEMBL. | 27309570 | |
Inhibition (binding) | Inhibition of human serum BuChE assessed as enzyme carbamoylation using butyrylthiocholine iodide as substrate preincubated with enzyme followed by substrate addition by Ellman's method | ChEMBL. | 27309570 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.