TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 476.086 | Formula: C21H22BrFN4O3
H donors: 1 H acceptors: 2 LogP: 3.88 Rotable bonds: 6
Rule of 5 violations (Lipinski): 0
SMILES: COc1cc2c(ncnc2cc1OCC1OCCN(C1)C)Nc1ccc(cc1F)Br
InChi: InChI=1S/C21H22BrFN4O3/c1-27-5-6-29-14(10-27)11-30-20-9-18-15(8-19(20)28-2)21(25-12-24-18)26-17-4-3-13(22)7-16(17)23/h3-4,7-9,12,14H,5-6,10-11H2,1-2H3,(H,24,25,26)
InChiKey: ZPNITDGPLQDXIJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	EPH receptor B4		No references
Homo sapiens	EPH receptor A2		No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	ephrin receptor 1 precursor	Get druggable targets OG5_126715	All targets in OG5_126715
Schistosoma japonicum	ko:K05109 Eph receptor A8, putative	Get druggable targets OG5_126715	All targets in OG5_126715
Schistosoma mansoni	ephrin receptor	Get druggable targets OG5_126715	All targets in OG5_126715
Onchocerca volvulus		Get druggable targets OG5_126715	All targets in OG5_126715
Echinococcus granulosus	ephrin type A receptor 4 A	Get druggable targets OG5_126715	All targets in OG5_126715
Loa Loa (eye worm)	TK/EPH protein kinase	Get druggable targets OG5_126715	All targets in OG5_126715
Echinococcus multilocularis	ephrin type A receptor 4 A	Get druggable targets OG5_126715	All targets in OG5_126715
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126715	All targets in OG5_126715
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126715	All targets in OG5_126715

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	cyclin family protein	0.0188	0.0745	0.4494
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0738	0.0737
Loa Loa (eye worm)	cyclin domain-containing protein	0.0188	0.0745	0.0743
Echinococcus granulosus	Furin 1	0.0474	0.2277	0.2238
Loa Loa (eye worm)	hypothetical protein	0.0073	0.013	0.0128
Mycobacterium ulcerans	zinc metalloprotease	0.0194	0.078	1
Echinococcus granulosus	cyclin B	0.0326	0.1482	0.144
Giardia lamblia	Furin precursor putative serine protease	0.0389	0.1818	0.5066
Schistosoma mansoni	Lysine-specific histone demethylase 1	0.0482	0.2316	0.2316
Trichomonas vaginalis	cyclins, putative	0.0188	0.0745	0.1162
Trichomonas vaginalis	cyclins, putative	0.0183	0.072	0.1122
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0098	0.0264	0.2474
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0187	0.0738	0.0738
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0075	0.0143	0.0178
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0187	0.0738	0.093
Trichomonas vaginalis	conserved hypothetical protein	0.0389	0.1818	0.2955
Plasmodium falciparum	lysine-specific histone demethylase 1, putative	0.0098	0.0264	0.2474
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0187	0.0738	0.0693
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0163	0.0612	1
Echinococcus granulosus	neuropeptide receptor	0.0187	0.0738	0.0693
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0738	0.0737
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0187	0.0738	0.0738
Schistosoma mansoni	neuropeptide receptor	0.0187	0.0738	0.0738
Schistosoma mansoni	opsin-like receptor	0.0187	0.0738	0.0738
Trichomonas vaginalis	cyclin B, putative	0.0326	0.1482	0.2394
Schistosoma mansoni	Nep2 peptidase (M13 family)	0.0098	0.0265	0.0265
Echinococcus granulosus	sortilin	0.0068	0.0107	0.0058
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0187	0.0738	0.0693
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0187	0.0738	0.0738
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0086	0.02	0.0252
Onchocerca volvulus		0.0187	0.0738	0.249
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0098	0.0264	0.1775
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0738	0.0737
Loa Loa (eye worm)	hypothetical protein	0.014	0.0489	0.0487
Onchocerca volvulus		0.0187	0.0738	0.249
Brugia malayi	G-protein coupled receptor	0.0187	0.0738	0.0693
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0187	0.0738	0.093
Echinococcus multilocularis		0.0098	0.0264	0.0332
Brugia malayi	Myb-like DNA-binding domain containing protein	0.0179	0.0698	0.0652
Echinococcus multilocularis	allatostatin A receptor	0.0187	0.0738	0.093
Mycobacterium ulcerans	monoamine oxidase	0.0098	0.0264	0.1906
Brugia malayi	Melatonin receptor type 1A	0.0187	0.0738	0.0693
Schistosoma mansoni	hypothetical protein	0.0051	0.0012	0.0012
Mycobacterium ulcerans	hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase	0.014	0.0489	0.5434
Loa Loa (eye worm)	peptidase family M13 containing protein	0.0144	0.0509	0.0507
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0738	0.0737
Brugia malayi	GnHR receptor homolog	0.0187	0.0738	0.0693
Loa Loa (eye worm)	neuropeptide F receptor	0.0187	0.0738	0.0737
Echinococcus multilocularis	ephrin type A receptor 4 A	0.016	0.0597	0.0751
Trichomonas vaginalis	conserved hypothetical protein	0.0188	0.0745	0.1162
Schistosoma mansoni	amine GPCR	0.0187	0.0738	0.0738
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0075	0.0143	0.0178
Onchocerca volvulus		0.0187	0.0738	0.249
Schistosoma mansoni	patched 1	0.0058	0.0049	0.0049
Brugia malayi	putative neuropeptide receptor NPR1	0.0187	0.0738	0.0693
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.0066	0.0092	0.0072
Onchocerca volvulus		0.0523	0.2534	1
Brugia malayi	Hydroxymethylglutaryl-coenzyme A reductase family protein	0.014	0.0489	0.0442
Echinococcus multilocularis	g protein coupled receptor	0.0187	0.0738	0.093
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0187	0.0738	0.093
Plasmodium falciparum	protoporphyrinogen oxidase	0.0098	0.0264	0.2474
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0187	0.0738	0.0738
Echinococcus multilocularis	protein dispatched 1	0.0058	0.0049	0.006
Onchocerca volvulus		0.0143	0.0504	0.1511
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0738	0.0737
Brugia malayi	ORL1-like opioid receptor	0.0187	0.0738	0.0693
Echinococcus multilocularis	fmrfamide receptor	0.0187	0.0738	0.093
Trypanosoma brucei	3-hydroxy-3-methylglutaryl-CoA reductase, putative	0.014	0.0489	0.2585
Loa Loa (eye worm)	peptidase family M1 containing protein	0.0207	0.0846	0.0844
Echinococcus granulosus	biogenic amine 5HT receptor	0.0187	0.0738	0.0693
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0187	0.0738	0.0693
Echinococcus granulosus	somatostatin receptor	0.0187	0.0738	0.0693
Brugia malayi	hypothetical protein	0.0187	0.0738	0.0693
Echinococcus granulosus	g protein coupled receptor	0.0187	0.0738	0.0693
Toxoplasma gondii	subtilisin SUB6	0.0086	0.02	0.1388
Schistosoma mansoni	amine GPCR	0.0187	0.0738	0.0738
Echinococcus multilocularis	g-protein coupled receptor	0.0187	0.0738	0.093
Trypanosoma brucei	RNA helicase, putative	0.0102	0.0289	0.1089
Echinococcus multilocularis	neuropeptide s receptor	0.0187	0.0738	0.093
Schistosoma mansoni	hypothetical protein	0.0051	0.0012	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0523	0.2534	0.2532
Echinococcus multilocularis	neuropeptide receptor	0.0187	0.0738	0.093
Echinococcus multilocularis	aminopeptidase N	0.0255	0.1106	0.1394
Brugia malayi	larval opioid receptor	0.0187	0.0738	0.0693
Schistosoma mansoni	hydroxymethylglutaryl-CoA reductase (NADPH)	0.014	0.0489	0.0489
Echinococcus granulosus	cyclins	0.0188	0.0745	0.0699
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0527	0.0525
Brugia malayi	G protein-coupled receptor	0.0187	0.0738	0.0693
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0738	0.0737
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0187	0.0738	0.0738
Echinococcus granulosus	biogenic amine 5HT receptor	0.0187	0.0738	0.0693
Echinococcus multilocularis	sortilin	0.0068	0.0107	0.0132
Trypanosoma cruzi	3-hydroxy-3-methylglutaryl-CoA reductase	0.014	0.0489	0.3293
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0086	0.02	0.0252
Echinococcus granulosus	ephrin type A receptor 4 A	0.016	0.0597	0.055
Toxoplasma gondii	subtilisin SUB4	0.0086	0.02	0.1388
Echinococcus multilocularis	neuroendocrine convertase 2	0.1217	0.6243	0.7878
Brugia malayi	Serotonin receptor	0.0187	0.0738	0.0693
Brugia malayi	Dopamine receptor	0.0187	0.0738	0.0693
Trichomonas vaginalis	cyclin D, putative	0.0188	0.0745	0.1162
Echinococcus multilocularis	epidermal growth factor receptor	0.0139	0.0483	0.0608
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0098	0.0264	0.1906
Schistosoma mansoni	hypothetical protein	0.0187	0.0738	0.0738
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0187	0.0738	0.093
Schistosoma mansoni	cytosol alanyl aminopeptidase (M01 family)	0.0075	0.0143	0.0143
Echinococcus multilocularis	endothelin converting enzyme 1	0.0194	0.078	0.0982
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0738	0.0737
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0086	0.02	0.0252
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0075	0.0143	0.0178
Echinococcus multilocularis	cyclins	0.0188	0.0745	0.0938
Schistosoma mansoni	family M13 non-peptidase homologue (M13 family)	0.0098	0.0265	0.0265
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0187	0.0738	0.0737
Echinococcus multilocularis	serotonin receptor	0.0187	0.0738	0.093
Schistosoma mansoni	hypothetical protein	0.0051	0.0012	0.0012
Schistosoma mansoni	furin-1 (S08 family)	0.0828	0.4166	0.4166
Brugia malayi	neuropeptide F receptor	0.0187	0.0738	0.0693
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0474	0.2277	0.3722
Toxoplasma gondii	subtilisin SUB9	0.0086	0.02	0.1388
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0187	0.0738	0.0738
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0738	0.0737
Schistosoma mansoni	neuropeptide F-like receptor	0.0187	0.0738	0.0738
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0187	0.0738	0.093
Onchocerca volvulus		0.0187	0.0738	0.249
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0187	0.0738	0.0738
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0187	0.0738	0.0693
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0187	0.0738	0.093
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0187	0.0738	0.093
Trypanosoma cruzi	subtilisin-like serine peptidase, putative	0.0086	0.02	0.134
Trichomonas vaginalis	cyclin B, putative	0.0326	0.1482	0.2394
Mycobacterium ulcerans	dehydrogenase	0.0098	0.0264	0.1906
Schistosoma mansoni	neuropeptide receptor	0.0341	0.1566	0.1566
Mycobacterium leprae	PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO)	0.0098	0.0264	0.111
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0075	0.0143	0.0094
Plasmodium falciparum	cyclin	0.0188	0.0745	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0187	0.0738	0.0738
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0187	0.0738	0.0737
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0639	0.3154	0.312
Loa Loa (eye worm)	hypothetical protein	0.018	0.0705	0.0703
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0098	0.0264	0.1906
Mycobacterium ulcerans	proline rich membrane-anchored mycosin MycP5	0.0086	0.02	0.0894
Echinococcus multilocularis	cyclin B3 1	0.0188	0.0745	0.0938
Plasmodium vivax	hypothetical protein, conserved	0.0098	0.0264	0.3125
Schistosoma mansoni	neuropeptide f receptor 76f	0.0187	0.0738	0.0738
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0474	0.2277	0.3722
Trichomonas vaginalis	leucine-rich repeat protein, BspA family	0.0389	0.1818	0.2955
Loa Loa (eye worm)	melatonin receptor type 1A	0.0187	0.0738	0.0737
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0187	0.0738	0.093
Echinococcus multilocularis	g protein coupled receptor	0.0187	0.0738	0.093
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0051	0.0012	0.0012
Schistosoma mansoni	hypothetical protein	0.0102	0.0289	0.0289
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0738	0.0737
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0187	0.0738	0.0737
Leishmania major	CYC2-like cyclin, putative,cyclin 6, putative	0.0326	0.1482	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0187	0.0738	0.0693
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0738	0.0737
Onchocerca volvulus		0.0187	0.0738	0.249
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0187	0.0738	0.093
Leishmania major	cyclin	0.0326	0.1482	1
Trypanosoma cruzi	serine peptidase, clan SB, family S8-like protein	0.0086	0.02	0.134
Schistosoma mansoni	hypothetical protein	0.0187	0.0738	0.0738
Onchocerca volvulus		0.0187	0.0738	0.249
Brugia malayi	hypothetical protein	0.0187	0.0738	0.0693
Toxoplasma gondii	subtilisin SUB12	0.0086	0.02	0.1388
Loa Loa (eye worm)	hypothetical protein	0.0144	0.0509	0.0507
Echinococcus multilocularis	Peptidase S8 S53, subtilisin kexin sedolisin	0.0086	0.02	0.025
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0738	0.0737
Giardia lamblia	G2/mitotic-specific cyclin B	0.0326	0.1482	0.4079
Toxoplasma gondii	subtilisin SUB1	0.0086	0.02	0.1388
Brugia malayi	hypothetical protein	0.0187	0.0738	0.0693
Plasmodium vivax	subtilisin-like serine protease, putative	0.0086	0.02	0.185
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.1222	0.627	0.7912
Brugia malayi	hypothetical protein	0.0187	0.0738	0.0693
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0194	0.078	0.078
Echinococcus multilocularis	cyclin b3	0.0188	0.0745	0.0938
Echinococcus granulosus	membrane bound transcription factor site 1	0.0086	0.02	0.0152
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0187	0.0738	0.0738
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0187	0.0738	0.093
Trichomonas vaginalis	conserved hypothetical protein	0.0389	0.1818	0.2955
Schistosoma mansoni	hypothetical protein	0.0389	0.1818	0.1818
Echinococcus granulosus	g protein coupled receptor	0.0187	0.0738	0.0693
Echinococcus multilocularis	cyclins	0.0188	0.0745	0.0938
Trypanosoma brucei	serine peptidase, clan SB, family S8-like protein	0.0086	0.02	0.0425
Brugia malayi	ephrin receptor 1 precursor	0.0069	0.0109	0.006
Trichomonas vaginalis	hypothetical protein	0.0389	0.1818	0.2955
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0187	0.0738	0.093
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0086	0.02	0.0252
Leishmania major	3-hydroxy-3-methylglutaryl-CoA reductase	0.014	0.0489	0.2585
Trichomonas vaginalis	cyclin B3, putative	0.0188	0.0745	0.1162
Trypanosoma cruzi	cyclin, putative	0.0326	0.1482	1
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0527	0.0525
Brugia malayi	G protein-coupled receptor F59B2.13	0.0187	0.0738	0.0693
Brugia malayi	hypothetical protein	0.0187	0.0738	0.0693
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0738	0.0737
Loa Loa (eye worm)	aminopeptidase N	0.0075	0.0143	0.0141
Leishmania major	UDP-galactopyranose mutase	0.0098	0.0264	0.0906
Trypanosoma brucei	subtilisin peptidase	0.0086	0.02	0.0425
Toxoplasma gondii	subtilisin SUB10	0.0086	0.02	0.1388
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0098	0.0265	0.0265
Toxoplasma gondii	subtilisin SUB11	0.0086	0.02	0.1388
Brugia malayi	Peptidase family M1 containing protein	0.0255	0.1106	0.1063
Trypanosoma cruzi	3-hydroxy-3-methylglutaryl-CoA reductase, putative	0.014	0.0489	0.3293
Trichomonas vaginalis	conserved hypothetical protein	0.0389	0.1818	0.2955
Echinococcus multilocularis	lysine specific histone demethylase 1A	0.0482	0.2316	0.2921
Echinococcus multilocularis	somatostatin receptor	0.0187	0.0738	0.093
Loa Loa (eye worm)	hypothetical protein	0.192	1	1
Schistosoma mansoni	biogenic amine receptor	0.0187	0.0738	0.0738
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0187	0.0738	0.0738
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0738	0.0737
Trichomonas vaginalis	neuroendocrine convertase 2 precursor, putative	0.0389	0.1818	0.2955
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0187	0.0738	0.0738
Loa Loa (eye worm)	hypothetical protein	0.0482	0.2316	0.2315
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0738	0.0737
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0187	0.0738	0.0693
Echinococcus multilocularis	hydroxymethylglutaryl coenzyme A reductase	0.014	0.0489	0.0615
Brugia malayi	proprotein convertase 2	0.1217	0.6243	0.6224
Echinococcus multilocularis	G protein coupled receptor 139	0.0341	0.1566	0.1974
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0086	0.02	0.0252
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0187	0.0738	0.093
Echinococcus granulosus	peptidase s8 s53 subtilisin kexin sedolisin	0.0086	0.02	0.0152
Brugia malayi	hypothetical protein	0.0187	0.0738	0.0693
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0098	0.0264	0.111
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0527	0.0525
Schistosoma mansoni	amine oxidase	0.0098	0.0264	0.0264
Toxoplasma gondii	histone lysine-specific demethylase	0.0098	0.0264	0.2345
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0187	0.0738	0.0693
Echinococcus granulosus	aminopeptidase N	0.0255	0.1106	0.1063
Echinococcus granulosus	serotonin receptor	0.0187	0.0738	0.0693
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0098	0.0264	0.1775
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0163	0.0612	0.7918
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0075	0.0143	0.0094
Schistosoma mansoni	hypothetical protein	0.0051	0.0012	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0738	0.0737
Echinococcus multilocularis	g protein coupled receptor	0.0187	0.0738	0.093
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0738	0.0737
Schistosoma mansoni	neprilysin	0.0051	0.0012	0.0012
Trichomonas vaginalis	conserved hypothetical protein	0.0389	0.1818	0.2955
Echinococcus granulosus	cyclins	0.0188	0.0745	0.0699
Echinococcus multilocularis	orexin receptor type 2	0.0187	0.0738	0.093
Onchocerca volvulus	CoRest homolog	0.0184	0.0726	0.2437
Mycobacterium ulcerans	membrane-anchored mycosin MycP3	0.0086	0.02	0.0894
Echinococcus granulosus	cyclin B3 1	0.0188	0.0745	0.0699
Echinococcus multilocularis	cyclins	0.0188	0.0745	0.0938
Plasmodium falciparum	subtilisin-like protease 2	0.0086	0.02	0.1465
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0738	0.0737
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0187	0.0738	0.0737
Onchocerca volvulus		0.0187	0.0738	0.249
Trichomonas vaginalis	conserved hypothetical protein	0.0086	0.02	0.0252
Giardia lamblia	Cyclin A	0.0188	0.0745	0.1916
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0738	0.0737
Toxoplasma gondii	peptidase family M13 protein	0.0194	0.078	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0187	0.0738	0.093
Brugia malayi	follicle stimulating hormone receptor	0.0187	0.0738	0.0693
Mycobacterium tuberculosis	Probable zinc metalloprotease Zmp1	0.0194	0.078	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0187	0.0738	0.0738
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0086	0.02	0.0252
Plasmodium falciparum	subtilisin-like protease 1	0.0086	0.02	0.1465
Brugia malayi	Dopamine receptor protein 2	0.0187	0.0738	0.0693
Echinococcus multilocularis	cyclins	0.0188	0.0745	0.0938
Schistosoma mansoni	adenoreceptor	0.0187	0.0738	0.0738
Leishmania major	subtilisin-like serine peptidase	0.0086	0.02	0.0425
Brugia malayi	Serotonin receptor	0.0187	0.0738	0.0693
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0326	0.1482	0.144
Trichomonas vaginalis	conserved hypothetical protein	0.0086	0.02	0.0252
Schistosoma mansoni	subfamily S8B non-peptidase homologue (S08 family)	0.0474	0.2277	0.2277
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0738	0.0737
Plasmodium vivax	protoporphyrinogen oxidase, putative	0.0098	0.0264	0.3125
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0738	0.0737
Chlamydia trachomatis	protoporphyrinogen oxidase	0.0098	0.0264	0.5
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0086	0.02	0.0252
Mycobacterium ulcerans	oxidoreductase	0.0098	0.0264	0.1906
Schistosoma mansoni	hypothetical protein	0.0051	0.0012	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0527	0.0525
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0086	0.02	0.0252
Onchocerca volvulus		0.0187	0.0738	0.249
Plasmodium vivax	subtilisin-like protease 2, putative	0.0086	0.02	0.185
Onchocerca volvulus		0.0255	0.1106	0.403
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0738	0.0737
Brugia malayi	hypothetical protein	0.0187	0.0738	0.0693
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0738	0.0737
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0738	0.0737
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0139	0.0483	0.0481
Onchocerca volvulus		0.0187	0.0738	0.249
Echinococcus granulosus	dnaJ subfamily B	0.0799	0.4011	0.3981
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0187	0.0738	0.0693
Schistosoma mansoni	amine oxidase	0.0098	0.0264	0.0264
Echinococcus multilocularis	sex peptide receptor	0.0187	0.0738	0.093
Trichomonas vaginalis	cyclin B, putative	0.0326	0.1482	0.2394
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0188	0.0745	0.0699
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0098	0.0265	0.0265
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0187	0.0738	0.093
Echinococcus granulosus	tm gpcr rhodopsin	0.0187	0.0738	0.0693
Loa Loa (eye worm)	hypothetical protein	0.0184	0.0726	0.0724
Toxoplasma gondii	subtilisin SUB7	0.0086	0.02	0.1388
Onchocerca volvulus		0.0086	0.02	0.0238
Onchocerca volvulus		0.0187	0.0738	0.249
Brugia malayi	hypothetical protein	0.0098	0.0264	0.0216
Onchocerca volvulus		0.0187	0.0738	0.249
Loa Loa (eye worm)	hypothetical protein	0.0229	0.0965	0.0963
Echinococcus granulosus	tm gpcr rhodopsin	0.0187	0.0738	0.0693
Schistosoma mansoni	hypothetical protein	0.0187	0.0738	0.0738
Trichomonas vaginalis	conserved hypothetical protein	0.0086	0.02	0.0252
Echinococcus multilocularis	dnaJ subfamily B	0.0799	0.4011	0.5061
Mycobacterium tuberculosis	Possible oxidoreductase	0.0098	0.0264	0.111
Loa Loa (eye worm)	hypothetical protein	0.0144	0.0509	0.0507
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0187	0.0738	0.249
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0187	0.0738	0.0693
Brugia malayi	hypothetical protein	0.0187	0.0738	0.0693
Schistosoma mansoni	hypothetical protein	0.0051	0.0012	0.0012
Trichomonas vaginalis	cyclin A, putative	0.0326	0.1482	0.2394
Loa Loa (eye worm)	hypothetical protein	0.0742	0.3707	0.3706
Schistosoma mansoni	neuropeptide receptor	0.0187	0.0738	0.0738
Trypanosoma brucei	mitotic cyclin 6	0.0326	0.1482	1
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0326	0.1482	0.144
Brugia malayi	Dopamine receptor protein 1	0.0187	0.0738	0.0693
Brugia malayi	neuroendocrine convertase 1 precursor	0.1217	0.6243	0.6224
Schistosoma mansoni	opsin-like receptor	0.0187	0.0738	0.0738
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0187	0.0738	0.093
Echinococcus granulosus	rhodopsin orphan GPCR	0.0187	0.0738	0.0693
Brugia malayi	amine oxidase, flavin-containing family protein	0.0139	0.0482	0.0435
Entamoeba histolytica	cyclin, putative	0.0326	0.1482	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0187	0.0738	0.093
Schistosoma mansoni	opsin-like receptor	0.0187	0.0738	0.0738
Echinococcus granulosus	G2:mitotic specific cyclin B3	0.0188	0.0745	0.0699
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0187	0.0738	0.093
Echinococcus granulosus	g protein coupled receptor	0.0187	0.0738	0.0693
Echinococcus multilocularis	neuropeptide receptor A26	0.0187	0.0738	0.093
Brugia malayi	sulfakinin receptor protein	0.0187	0.0738	0.0693
Trichomonas vaginalis	cyclin B, putative	0.0188	0.0745	0.1162
Loa Loa (eye worm)	proprotein convertase 2	0.0474	0.2277	0.2275
Trypanosoma cruzi	CYC2-like cyclin, putative	0.0326	0.1482	1
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0738	0.0737
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0738	0.0737
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0187	0.0738	0.0738
Onchocerca volvulus		0.0187	0.0738	0.249
Trypanosoma cruzi	Aminopeptidase M1, putative	0.0075	0.0143	0.0955
Echinococcus granulosus	neuropeptide Y receptor	0.0187	0.0738	0.0693
Echinococcus multilocularis	neuropeptides capa receptor	0.0187	0.0738	0.093
Echinococcus multilocularis	Niemann Pick C1 protein	0.0058	0.0049	0.006
Mycobacterium leprae	probable zinc metalloprotease	0.0194	0.078	1
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0738	0.0737
Loa Loa (eye worm)	hypothetical protein	0.0326	0.1482	0.148
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0187	0.0738	0.093
Giardia lamblia	Hypothetical protein	0.0188	0.0745	0.1916
Schistosoma mansoni	hypothetical protein	0.0187	0.0738	0.0738
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0187	0.0738	0.0693
Echinococcus granulosus	cyclins	0.0188	0.0745	0.0699
Mycobacterium ulcerans	membrane-anchored serine protease (mycosin), MycP4	0.0086	0.02	0.0894
Schistosoma mansoni	Protoporphyrinogen oxidase chloroplast/mitochondrial precursor	0.0098	0.0264	0.0264
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0086	0.02	0.0252
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0738	0.0737
Schistosoma mansoni	tyrosine kinase	0.0139	0.0483	0.0483
Trichomonas vaginalis	cyclins, putative	0.0326	0.1482	0.2394
Brugia malayi	celfurPC protein	0.1531	0.7924	0.7913
Loa Loa (eye worm)	hypothetical protein	0.0138	0.0478	0.0477
Echinococcus granulosus	orexin receptor type 2	0.0187	0.0738	0.0693
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0049	0.0047
Loa Loa (eye worm)	neuropeptide F receptor	0.0187	0.0738	0.0737
Loa Loa (eye worm)	hypothetical protein	0.0179	0.0698	0.0696
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.1177	0.6034	1
Echinococcus multilocularis	cyclins	0.0188	0.0745	0.0938
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0086	0.02	0.0252
Toxoplasma gondii	subtilisin SUB8	0.0086	0.02	0.1388
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0086	0.02	0.0252
Trichomonas vaginalis	conserved hypothetical protein	0.0389	0.1818	0.2955
Echinococcus multilocularis	cyclins	0.0188	0.0745	0.0938
Trichomonas vaginalis	conserved hypothetical protein	0.0389	0.1818	0.2955
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0075	0.0143	0.0157
Echinococcus multilocularis	protoporphyrinogen oxidase	0.0098	0.0264	0.0332
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0187	0.0738	0.093
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.0086	0.02	0.02
Schistosoma mansoni	site-1 peptidase (S08 family)	0.0086	0.02	0.02
Echinococcus granulosus	neuropeptides capa receptor	0.0187	0.0738	0.0693
Onchocerca volvulus		0.0187	0.0738	0.249
Loa Loa (eye worm)	hypothetical protein	0.0086	0.02	0.0198
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0527	0.0525
Echinococcus granulosus	neuropeptide s receptor	0.0187	0.0738	0.0693
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0086	0.02	0.0252
Brugia malayi	RE15519p	0.0187	0.0738	0.0693
Echinococcus multilocularis	dro:myosuppressin receptor	0.0187	0.0738	0.093
Echinococcus multilocularis		0.1531	0.7924	1
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0075	0.0143	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0256	0.0254
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.192	1	1
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0738	0.0737
Mycobacterium ulcerans	protoporphyrinogen oxidase	0.0098	0.0264	0.1906
Echinococcus granulosus	cyclins	0.0188	0.0745	0.0699
Brugia malayi	G-protein coupled receptor	0.0187	0.0738	0.0693
Entamoeba histolytica	cyclin, putative	0.0188	0.0745	0.4494
Echinococcus granulosus	neuropeptides capa receptor	0.0187	0.0738	0.0693
Trichomonas vaginalis	conserved hypothetical protein	0.0389	0.1818	0.2955
Echinococcus granulosus	hydroxymethylglutaryl coenzyme A reductase	0.014	0.0489	0.0442
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0086	0.02	0.0252
Loa Loa (eye worm)	hypothetical protein	0.0482	0.2316	0.2315
Echinococcus granulosus	epidermal growth factor receptor	0.0139	0.0483	0.0436
Schistosoma mansoni	ephrin receptor	0.0144	0.0513	0.0513
Schistosoma mansoni	hypothetical protein	0.0799	0.4011	0.4011
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0187	0.0738	0.0738
Brugia malayi	Peptidase family M13 containing protein	0.0194	0.078	0.0734
Plasmodium vivax	lysine-specific histone demethylase 1, putative	0.0098	0.0264	0.3125
Echinococcus multilocularis	neuropeptide receptor	0.0341	0.1566	0.1974
Onchocerca volvulus		0.0187	0.0738	0.249
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0639	0.3154	0.3979
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0058	0.0049	0.0049
Trichomonas vaginalis	conserved hypothetical protein	0.0389	0.1818	0.2955
Trypanosoma cruzi	subtilisin peptidase	0.0086	0.02	0.134
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0187	0.0738	0.0738
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0187	0.0738	0.0693
Schistosoma mansoni	amine GPCR	0.0187	0.0738	0.0738
Loa Loa (eye worm)	hypothetical protein	0.0194	0.078	0.0778
Schistosoma mansoni	amine GPCR	0.0187	0.0738	0.0738
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0086	0.02	0.0252
Brugia malayi	Furin-like cysteine rich region family protein	0.0139	0.0483	0.0436
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.0066	0.0092	0.0072
Echinococcus granulosus	sex peptide receptor	0.0187	0.0738	0.0693
Brugia malayi	hypothetical protein	0.0187	0.0738	0.0693
Toxoplasma gondii	subtilisin SUB2	0.0086	0.02	0.1388
Brugia malayi	Subtilase family protein	0.0086	0.02	0.0152
Trichomonas vaginalis	conserved hypothetical protein	0.0086	0.02	0.0252
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0738	0.0737
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.1177	0.6034	1
Brugia malayi	Membrane-bound transcription factor site-1 protease precursor	0.0086	0.02	0.0152
Toxoplasma gondii	cathepsin CPC2	0.0163	0.0612	0.7504
Echinococcus multilocularis	serotonin receptor	0.0187	0.0738	0.093
Schistosoma mansoni	site-1 peptidase (S08 family)	0.0086	0.02	0.02
Echinococcus granulosus	neuropeptide FF receptor 2	0.0639	0.3154	0.312
Schistosoma mansoni	cyclin B	0.0326	0.1482	0.1482
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0187	0.0738	0.0738
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0187	0.0738	0.0738
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0075	0.0143	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0482	0.0481
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0098	0.0264	0.0216
Brugia malayi	hypothetical protein	0.0075	0.0143	0.0094
Brugia malayi	SWIRM domain containing protein	0.0523	0.2534	0.2497
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0738	0.0737
Echinococcus granulosus	7tm_1 domain containing protein	0.0187	0.0738	0.0693
Trichomonas vaginalis	conserved hypothetical protein	0.0389	0.1818	0.2955
Echinococcus multilocularis	cyclin B	0.0326	0.1482	0.1868
Schistosoma mansoni	neprilysin-2 (M13 family)	0.0098	0.0265	0.0265
Loa Loa (eye worm)	hypothetical protein	0.0144	0.0509	0.0507
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0738	0.0737
Echinococcus granulosus	rhodopsin orphan GPCR	0.0187	0.0738	0.0693
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0187	0.0738	0.093
Onchocerca volvulus		0.0187	0.0738	0.249
Brugia malayi	Hypothetical subtilase-type proteinase F21H12.6 in chromosome II	0.0086	0.02	0.0152
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0187	0.0738	0.0693
Echinococcus multilocularis	G2:mitotic specific cyclin B3	0.0188	0.0745	0.0938
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0738	0.0737
Loa Loa (eye worm)	endoprotease bli-4	0.192	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0187	0.0738	0.0693
Trichomonas vaginalis	conserved hypothetical protein	0.0389	0.1818	0.2955
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0086	0.02	0.0252
Toxoplasma gondii	hypothetical protein	0.0142	0.0503	0.5881
Onchocerca volvulus		0.0326	0.1482	0.5599
Schistosoma mansoni	neuropeptide F-like receptor	0.0187	0.0738	0.0738
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0187	0.0738	0.0737
Echinococcus granulosus	proprotein convertase subtilisin:kexin type 5	0.1177	0.6034	0.6014
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0738	0.0737
Loa Loa (eye worm)	G-protein coupled receptor	0.0187	0.0738	0.0737
Brugia malayi	AKH receptor	0.0187	0.0738	0.0693
Echinococcus granulosus	G protein coupled receptor 139	0.0187	0.0738	0.0693
Schistosoma mansoni	tripeptidyl-peptidase II (S08 family)	0.0086	0.02	0.02
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0187	0.0738	0.0738
Loa Loa (eye worm)	peptidase family M13 containing protein	0.0144	0.0509	0.0507
Loa Loa (eye worm)	hypothetical protein	0.0144	0.0509	0.0507
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0738	0.0737
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0474	0.2277	0.3722
Loa Loa (eye worm)	subtilase	0.0086	0.02	0.0198
Echinococcus multilocularis	proprotein convertase subtilisin:kexin type 5	0.1177	0.6034	0.7615
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0264	0.0263
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0086	0.02	0.0252
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0738	0.0737
Brugia malayi	Hypothetical zinc metalloproteinase T16A9.4	0.0194	0.078	0.0734
Schistosoma mansoni	serine-type protease inhibitor	0.0867	0.4373	0.4373
Echinococcus granulosus	g-protein coupled receptor	0.0187	0.0738	0.0693
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0187	0.0738	0.0738
Brugia malayi	neuropeptide F receptor	0.0187	0.0738	0.0693
Schistosoma mansoni	neuropeptide receptor	0.0187	0.0738	0.0738
Echinococcus granulosus	endothelin converting enzyme 1	0.0194	0.078	0.0734
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.0075	0.0143	0.0955
Entamoeba histolytica	cyclin family protein	0.0188	0.0745	0.4494
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0187	0.0738	0.0738
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0086	0.02	0.0252
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0086	0.02	0.0252
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0738	0.0737
Onchocerca volvulus		0.0187	0.0738	0.249
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0058	0.0049	0.0047
Toxoplasma gondii	subtilisin SUB5	0.0086	0.02	0.1388
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0081	0.0176	0.0176
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0086	0.02	0.0252
Echinococcus multilocularis	Peptidase M1, membrane alanine aminopeptidase, N terminal	0.0075	0.0143	0.0178
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0086	0.02	0.0252
Echinococcus granulosus	dro:myosuppressin receptor	0.0187	0.0738	0.0693
Schistosoma mansoni	myosin xvIII	0.0187	0.0738	0.0738
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0187	0.0738	0.0738
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0187	0.0738	0.0738
Schistosoma mansoni	growth hormone secretagogue receptor	0.0187	0.0738	0.0738
Echinococcus granulosus	rhodopsin orphan GPCR	0.0187	0.0738	0.0693
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.0066	0.0092	0.0072
Schistosoma mansoni	histamine h1 receptor	0.0187	0.0738	0.0738
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0187	0.0738	0.0693
Trypanosoma cruzi	aminopeptidase, putative	0.0075	0.0143	0.0955
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0474	0.2277	0.3722
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0482	0.2316	0.2278
Loa Loa (eye worm)	hypothetical protein	0.0143	0.0504	0.0503
Trichomonas vaginalis	conserved hypothetical protein	0.0086	0.02	0.0252
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0738	0.0737
Plasmodium falciparum	subtilisin-like protease 3	0.0086	0.02	0.1465
Schistosoma mansoni	cyclins	0.0188	0.0745	0.0745
Loa Loa (eye worm)	hypothetical protein	0.0194	0.078	0.0778
Trichomonas vaginalis	cyclins, putative	0.0326	0.1482	0.2394
Trypanosoma cruzi	cyclin 6, putative	0.0326	0.1482	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0187	0.0738	0.0693
Echinococcus granulosus	neuropeptide receptor	0.0341	0.1566	0.1524
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0086	0.02	0.0252
Schistosoma mansoni	family M1 non-peptidase homologue (M01 family)	0.0049	0.0002	0.0002
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0187	0.0738	0.0693
Echinococcus granulosus	allatostatin A receptor	0.0187	0.0738	0.0693
Echinococcus granulosus	7TM GPCR rhodopsin	0.0187	0.0738	0.0693
Trichomonas vaginalis	proprotein convertase subtilisin/kexin type, putative	0.0389	0.1818	0.2955
Brugia malayi	Peptidase family M1 containing protein	0.0075	0.0143	0.0094
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0075	0.0143	0.0157
Echinococcus granulosus	furin	0.192	1	1
Loa Loa (eye worm)	TK/EPH protein kinase	0.0184	0.0722	0.072
Echinococcus granulosus	neuropeptide receptor A26	0.0187	0.0738	0.0693
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0527	0.0525
Onchocerca volvulus		0.0096	0.0256	0.0471
Loa Loa (eye worm)	hypothetical protein	0.0326	0.1482	0.148
Echinococcus granulosus	fmrfamide receptor	0.0187	0.0738	0.0693
Loa Loa (eye worm)	TYRA-2 protein	0.0187	0.0738	0.0737
Echinococcus granulosus	neuropeptide Y receptor	0.0187	0.0738	0.0693
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0187	0.0738	0.093
Schistosoma mansoni	amine GPCR	0.0187	0.0738	0.0738
Trichomonas vaginalis	cyclin D, putative	0.0188	0.0745	0.1162
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0187	0.0738	0.0738
Echinococcus multilocularis	fmrfamide receptor	0.0187	0.0738	0.093
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0086	0.02	0.0252
Giardia lamblia	High cysteine membrane protein Group 2	0.0703	0.3499	1
Echinococcus multilocularis	protein patched	0.0058	0.0049	0.006
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0738	0.0737
Schistosoma mansoni	biogenic amine receptor	0.0187	0.0738	0.0738
Echinococcus multilocularis	neuropeptide Y receptor	0.0187	0.0738	0.093
Echinococcus multilocularis	membrane bound transcription factor site 1	0.0086	0.02	0.025
Schistosoma mansoni	cyclin B3	0.0188	0.0745	0.0745
Plasmodium vivax	hypothetical protein, conserved	0.0098	0.0264	0.3125
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0075	0.0143	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0738	0.0737
Brugia malayi	putative neuropeptide receptor	0.0187	0.0738	0.0693
Loa Loa (eye worm)	hypothetical protein	0.0639	0.3154	0.3153
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0086	0.02	0.0252
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0738	0.0737
Echinococcus granulosus	tm gpcr rhodopsin	0.1222	0.627	0.6251
Plasmodium vivax	subtilisin-like protease 1	0.0086	0.02	0.185
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0738	0.0737
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0086	0.02	0.0252
Onchocerca volvulus		0.0187	0.0738	0.249
Echinococcus granulosus	cyclins	0.0188	0.0745	0.0699
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0738	0.0737
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0187	0.0738	0.249
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0264	0.0263
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0187	0.0738	0.0693
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0187	0.0738	0.0738
Echinococcus multilocularis	neuropeptides capa receptor	0.0187	0.0738	0.093
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0187	0.0738	0.093
Loa Loa (eye worm)	G-protein coupled receptor	0.0187	0.0738	0.0737
Trichomonas vaginalis	conserved hypothetical protein	0.0389	0.1818	0.2955
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0474	0.2277	0.3722
Trichomonas vaginalis	cyclin B, putative	0.0326	0.1482	0.2394
Echinococcus multilocularis	sterol regulatory element binding protein	0.0058	0.0049	0.006
Trichomonas vaginalis	cyclins, putative	0.0326	0.1482	0.2394
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0187	0.0738	0.093
Toxoplasma gondii	histone lysine-specific demethylase LSD1/BHC110/KDMA1A	0.0098	0.0264	0.2345
Schistosoma mansoni	serine-type protease inhibitor	0.0867	0.4373	0.4373
Echinococcus granulosus	neuroendocrine convertase 2	0.1217	0.6243	0.6224
Trypanosoma cruzi	cyclin, putative	0.0326	0.1482	1
Trichomonas vaginalis	cyclins, putative	0.0326	0.1482	0.2394
Echinococcus multilocularis	cyclins	0.0188	0.0745	0.0938
Echinococcus granulosus	hypothetical protein	0.0187	0.0738	0.0693
Loa Loa (eye worm)	hypothetical protein	0.0194	0.078	0.0778
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0474	0.2277	0.3722
Brugia malayi	hypothetical protein	0.0187	0.0738	0.0693
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0075	0.0143	0.0178
Echinococcus granulosus	cyclin b3	0.0188	0.0745	0.0699
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0187	0.0738	0.0738
Echinococcus granulosus	rhodopsin orphan GPCR	0.0187	0.0738	0.0693
Trypanosoma cruzi	subtilisin-like serine peptidase, putative	0.0086	0.02	0.134
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0738	0.0737
Echinococcus multilocularis	Furin 1	0.0474	0.2277	0.2871
Schistosoma mansoni	biogenic amine receptor	0.0187	0.0738	0.0738
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0738	0.0737

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 50 nM	Inhibition of recombinant human N-terminal His6-tagged EphB4 kinase domain (E605 to E890 residues) expressed in baculovirus using poly-AEKY as substrate after 150 mins in presence of gamma33P-ATP by liquid scintillation spectrometry	PATENT.	No reference
IC50 (binding)	= 50 nM	Inhibition of recombinant human N-terminal His6-tagged EphA2 (N598 to R890 residues) expressed in baculovirus using poly-EY as substrate after 180 mins by luciferase coupled chemiluminescence assay	PATENT.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3966040

Bibliographic References

No literature references available for this target.

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Detailed information for compound 2138732