TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 376.109 | Formula: C21H17ClN4O
H donors: 2 H acceptors: 3 LogP: 3.95 Rotable bonds: 5
Rule of 5 violations (Lipinski): 0
SMILES: Clc1cccc(c1)[C@@H](NC(=O)c1ccc2c(c1)c(n[nH]2)c1ccncc1)C
InChi: InChI=1S/C21H17ClN4O/c1-13(15-3-2-4-17(22)11-15)24-21(27)16-5-6-19-18(12-16)20(26-25-19)14-7-9-23-10-8-14/h2-13H,1H3,(H,24,27)(H,25,26)/t13-/m0/s1
InChiKey: ZEKIJJKMJBIZDL-ZDUSSCGKSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	mitogen-activated protein kinase 1		References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania donovani	mitogen activated protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Cryptosporidium parvum	MAPK, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania braziliensis	mitogen activated protein kinase, putative,map kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Candida albicans	MAP kinase-like orf	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania braziliensis	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma brucei	mitogen activated protein kinase 4, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Candida albicans	MAP kinase-like orf	Get druggable targets OG5_126781	All targets in OG5_126781
Candida albicans	Serine/threonine protein kinase of MAP kinase family	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus granulosus	mitogen activated protein kinase 3	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma japonicum	Mitogen-activated protein kinase 3, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania mexicana	mitogen-activated protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma japonicum	Mitogen-activated protein kinase 3, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus multilocularis	mitogen activated protein kinase 3	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Cryptosporidium hominis	MAPK	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	Get druggable targets OG5_126781	All targets in OG5_126781
Brugia malayi	MAP kinase sur-1	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma congolense	tyrosine protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus granulosus	mitogen activated protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Candida albicans	MAP kinase implicated in PKC1-controlled signalling pathway	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma brucei gambiense	mitogen-activated protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania infantum	mitogen activated protein kinase, putative,map kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania mexicana	mitogen activated protein kinase, putative,map kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania donovani	mitogen-activated protein kinase 4	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma brucei	protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Giardia lamblia	Kinase, CMGC MAPK	Get druggable targets OG5_126781	All targets in OG5_126781
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus multilocularis	mitogen activated protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Candida albicans	Serine/threonine protein kinase of MAP kinase family	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania infantum	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma brucei gambiense	protein kinase, putative,tyrosine protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma japonicum	ko:K04371 extracellular signal-regulated kinase 1/2, putative	Get druggable targets OG5_126781	All targets in OG5_126781

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	mitogen-activated protein kinase 5	mitogen-activated protein kinase 1	360 aa	361 aa	33.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0128	0.4461	0.4575
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0048	0.1185	0.1216
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0054	0.1431	0.1467
Schistosoma mansoni	cell adhesion molecule	0.005	0.1302	0.1336
Trichomonas vaginalis	CMGC family protein kinase	0.0123	0.4241	0.5
Echinococcus granulosus	tyrosine protein kinase Src42A	0.004	0.0869	0.0891
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0018	0.0006	0.0006
Schistosoma mansoni	vesicular amine transporter	0.0039	0.0852	0.0873
Schistosoma mansoni	nephrin	0.0021	0.0117	0.012
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0969	0.0969
Echinococcus multilocularis		0.0076	0.2353	0.2413
Schistosoma mansoni	tyrosine kinase	0.0054	0.1431	0.1467
Loa Loa (eye worm)	hypothetical protein	0.0058	0.1592	0.1592
Echinococcus multilocularis	roundabout 2	0.0021	0.0117	0.012
Onchocerca volvulus		0.0021	0.0104	0.0123
Echinococcus multilocularis	neuroglian	0.0021	0.0117	0.012
Echinococcus multilocularis	epidermal growth factor receptor	0.0176	0.6378	0.6541
Brugia malayi	plexin A	0.0025	0.0259	0.0259
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0128	0.4461	0.4575
Echinococcus multilocularis	roundabout 2	0.0021	0.0117	0.012
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0123	0.4241	0.5
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0039	0.0852	0.0873
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0969	0.0969
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0969	0.0969
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0021	0.0117	0.0117
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0022	0.0162	0.0162
Echinococcus granulosus	defective proboscis extension response	0.0039	0.0852	0.0873
Schistosoma mansoni	serine/threonine protein kinase	0.0123	0.4241	0.435
Brugia malayi	Fibronectin type III domain containing protein	0.0042	0.0969	0.0969
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0123	0.4241	0.4241
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0176	0.6378	0.6541
Echinococcus granulosus	Immunoglobulin	0.0039	0.0852	0.0873
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0265	1	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0844	0.0844
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0128	0.4461	0.4575
Brugia malayi	Protein kinase domain containing protein	0.0223	0.828	0.828
Entamoeba histolytica	protein kinase, putative	0.0045	0.1067	0.5
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0019	0.0049	0.005
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0054	0.1431	0.1467
Loa Loa (eye worm)	TK protein kinase	0.0139	0.4867	0.4867
Echinococcus granulosus	neuroglian	0.0021	0.0117	0.012
Schistosoma mansoni	tyrosine kinase	0.0166	0.5995	0.6149
Echinococcus multilocularis	mitogen activated protein kinase	0.0123	0.4241	0.435
Brugia malayi	Protein kinase domain containing protein	0.0096	0.3131	0.3131
Echinococcus multilocularis	epidermal growth factor receptor	0.0259	0.9751	1
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0054	0.1431	0.1467
Loa Loa (eye worm)	SRC-1	0.0054	0.1431	0.1431
Brugia malayi	Plexin repeat family protein	0.0021	0.0104	0.0104
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0021	0.0117	0.012
Schistosoma mansoni	tyrosine kinase	0.0223	0.828	0.8491
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0018	0.0006	0.0006
Brugia malayi	protein-tyrosine kinase	0.0049	0.1251	0.1251
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0049	0.1251	0.1283
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0042	0.0969	0.0969
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0123	0.4241	0.5
Loa Loa (eye worm)	TK/ROR protein kinase	0.0019	0.0049	0.0049
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0021	0.0117	0.0117
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0054	0.1431	0.1467
Brugia malayi	hypothetical protein	0.0042	0.0969	0.0969
Echinococcus granulosus	epidermal growth factor receptor	0.0176	0.6378	0.6541
Giardia lamblia	Kinase, CMGC MAPK	0.0123	0.4241	0.5
Echinococcus granulosus	epidermal growth factor receptor	0.0259	0.9751	1
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0123	0.4241	0.5
Echinococcus multilocularis	insulin receptor	0.0223	0.828	0.8491
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0852	0.0852
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0123	0.4241	0.5
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0019	0.0049	0.005
Echinococcus granulosus	plexin a4	0.0025	0.0259	0.0265
Echinococcus granulosus	roundabout 2	0.0021	0.0117	0.012
Echinococcus multilocularis	plexin a4	0.0025	0.0259	0.0265
Echinococcus multilocularis	Immunoglobulin	0.0039	0.0852	0.0873
Schistosoma mansoni	tyrosine kinase	0.0128	0.4461	0.4575
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0054	0.1431	0.1467
Echinococcus granulosus	roundabout 2	0.0061	0.1709	0.1753
Brugia malayi	SRC-1	0.0054	0.1431	0.1431
Loa Loa (eye worm)	hypothetical protein	0.0077	0.2372	0.2372
Schistosoma mansoni	tyrosine kinase	0.0028	0.0382	0.0392
Onchocerca volvulus		0.0208	0.7692	0.907
Schistosoma mansoni	tyrosine kinase	0.0018	0.0006	0.0006
Schistosoma mansoni	tyrosine kinase	0.0018	0.0006	0.0006
Echinococcus granulosus	mitogen activated protein kinase	0.0123	0.4241	0.435
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0054	0.1431	0.1467
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0259	0.9751	0.9751
Loa Loa (eye worm)	plexin A	0.0025	0.0259	0.0259
Schistosoma mansoni	tyrosine kinase	0.0054	0.1431	0.1467
Schistosoma mansoni	neuroglian	0.0021	0.0117	0.012
Echinococcus granulosus	c src tyrosine kinase	0.0018	0.0006	0.0006
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0049	0.1251	0.1283
Loa Loa (eye worm)	TK protein kinase	0.0045	0.1067	0.1067
Echinococcus granulosus	ephrin type A receptor 4 A	0.0086	0.2754	0.2824
Trichomonas vaginalis	CMGC family protein kinase	0.0123	0.4241	0.5
Loa Loa (eye worm)	hypothetical protein	0.0058	0.1592	0.1592
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0049	0.1251	0.1283
Trichomonas vaginalis	CMGC family protein kinase	0.0123	0.4241	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0054	0.1431	0.1467
Echinococcus granulosus	neuroglian	0.0049	0.1258	0.129
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0054	0.1431	0.1467
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0054	0.1431	0.1467
Echinococcus granulosus	twitchin	0.005	0.1303	0.1337
Loa Loa (eye worm)	TK/INSR protein kinase	0.0223	0.828	0.828
Schistosoma mansoni	tyrosine kinase	0.0259	0.9751	1
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0123	0.4241	0.435
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0123	0.4241	0.5
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0852	0.0852
Schistosoma mansoni	plexin	0.0021	0.0104	0.0107
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0021	0.0117	0.0117
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0128	0.4461	0.4575
Echinococcus granulosus	tyrosine protein kinase Blk	0.0049	0.1251	0.1283
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0226	0.8397	0.8612
Schistosoma mansoni	cell adhesion molecule	0.0021	0.0117	0.012
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0054	0.1431	0.1467
Loa Loa (eye worm)	hypothetical protein	0.0048	0.1185	0.1185
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0021	0.0117	0.012
Echinococcus granulosus	roundabout 2	0.0021	0.0117	0.012
Echinococcus granulosus	tyrosine protein kinase HCK	0.0045	0.1067	0.1095
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0039	0.0852	0.0873
Schistosoma mansoni	nephrin	0.0052	0.1375	0.141
Echinococcus multilocularis	roundabout 2	0.0061	0.1709	0.1753
Echinococcus multilocularis	c src tyrosine kinase	0.0018	0.0006	0.0006
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.004	0.0869	0.0891
Trypanosoma brucei	protein kinase, putative	0.0123	0.4241	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0049	0.1251	0.1283
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0054	0.1431	0.1467
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0039	0.0852	0.0873
Echinococcus granulosus	mitogen activated protein kinase 3	0.0123	0.4241	0.435
Echinococcus multilocularis	contactin neuroglian septate junction protein	0.0021	0.0117	0.012
Loa Loa (eye worm)	hypothetical protein	0.0086	0.2749	0.2749
Loa Loa (eye worm)	TK/EPH protein kinase	0.0107	0.3607	0.3607
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0054	0.1431	0.1467
Brugia malayi	ephrin receptor 1 precursor	0.0046	0.1109	0.1109
Echinococcus granulosus	contactin	0.0021	0.0117	0.012
Schistosoma mansoni	tyrosine kinase	0.0176	0.6378	0.6541
Onchocerca volvulus	Tyrosine kinase homolog	0.0228	0.8481	1
Schistosoma mansoni	ephrin receptor	0.0086	0.2754	0.2824
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0018	0.0006	0.0006
Echinococcus granulosus	tyrosine kinase	0.0049	0.1251	0.1283
Brugia malayi	MAP kinase sur-1	0.0123	0.4241	0.4241
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0104	0.0104
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0086	0.2754	0.2824
Brugia malayi	Furin-like cysteine rich region family protein	0.0259	0.9751	0.9751
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0021	0.0117	0.012
Echinococcus multilocularis	neuroglian	0.0049	0.1258	0.129
Echinococcus granulosus	insulin receptor	0.0223	0.828	0.8491
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0021	0.0117	0.012
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0123	0.4241	0.5
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0055	0.1476	0.1514
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0021	0.0117	0.0117
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0054	0.1431	0.1467
Loa Loa (eye worm)	TK protein kinase	0.0049	0.1251	0.1251
Brugia malayi	Tyrosine-protein kinase abl-1	0.0018	0.0006	0.0006
Schistosoma mansoni	tyrosine kinase	0.0176	0.6378	0.6541
Schistosoma mansoni	tyrosine kinase	0.0166	0.5995	0.6149
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0139	0.4867	0.4867
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0018	0.0006	0.0006
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0123	0.4241	0.5
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0852	0.0852
Schistosoma mansoni	cell adhesion molecule	0.0021	0.0117	0.012
Trichomonas vaginalis	CMGC family protein kinase	0.0123	0.4241	0.5
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0117	0.0117
Schistosoma mansoni	tyrosine kinase	0.0223	0.828	0.8491
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0021	0.0117	0.012
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0045	0.1067	0.1095
Schistosoma mansoni	tyrosine kinase	0.0166	0.5995	0.6149
Echinococcus multilocularis	Immunoglobulin	0.0039	0.0852	0.0873
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0054	0.1431	0.1467
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0054	0.1431	0.1467
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0226	0.8397	0.8612
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0054	0.1431	0.1467
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0123	0.4241	0.5
Onchocerca volvulus		0.0077	0.2372	0.2797

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)		Inhibition of human recombinant GST-tagged ERK1 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured after 1 hr by Z-LYTE assay	ChEMBL.	27106711
IC50 (binding)	= 468.6 nM	Inhibition of human recombinant GST-tagged ERK2 expressed in Escherichia coli using ser/thr 3 Peptide as substrate preincubated for 1 hr measured after 1 hr by Z-LYTE assay	ChEMBL.	27106711

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3798137

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 2142518