Detailed information for compound 214589

Basic information

Technical information
  • TDR Targets ID: 214589
  • Name: 1-[(2R)-4-(6-butoxyindol-1-yl)-1-hydroxybutan -2-yl]imidazole-4-carboxamide
  • MW: 370.445 | Formula: C20H26N4O3
  • H donors: 2 H acceptors: 3 LogP: 1.79 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCOc1ccc2c(c1)n(CC[C@@H](n1cnc(c1)C(=O)N)CO)cc2
  • InChi: 1S/C20H26N4O3/c1-2-3-10-27-17-5-4-15-6-8-23(19(15)11-17)9-7-16(13-25)24-12-18(20(21)26)22-14-24/h4-6,8,11-12,14,16,25H,2-3,7,9-10,13H2,1H3,(H2,21,26)/t16-/m1/s1
  • InChiKey: HKEHYJMEICETAY-MRXNPFEDSA-N  


Substructure search Similarity search

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Synonyms

  • 1-[(1R)-3-(6-butoxyindol-1-yl)-1-(hydroxymethyl)propyl]imidazole-4-carboxamide
  • 1-[(1R)-3-(6-butoxy-1-indolyl)-1-(hydroxymethyl)propyl]-4-imidazolecarboxamide
  • 1-[(2R)-4-(6-butoxyindol-1-yl)-1-hydroxy-butan-2-yl]imidazole-4-carboxamide
  • 1-[(1R)-3-(6-butoxyindol-1-yl)-1-methylol-propyl]imidazole-4-carboxamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens adenosine deaminase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans similar to S. cerevisiae AAH1 (YNL141W) adenine aminohydrolase Get druggable targets OG5_127245 All targets in OG5_127245
Leishmania braziliensis adenine aminohydrolase Get druggable targets OG5_127245 All targets in OG5_127245
Trichomonas vaginalis adenosine deaminase, putative Get druggable targets OG5_127245 All targets in OG5_127245
Mycobacterium leprae Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) Get druggable targets OG5_127245 All targets in OG5_127245
Babesia bovis adenosine deaminase, putative Get druggable targets OG5_127245 All targets in OG5_127245
Trichomonas vaginalis adenosine deaminase, putative Get druggable targets OG5_127245 All targets in OG5_127245
Toxoplasma gondii Adenosine/AMP deaminase domain-containing protein Get druggable targets OG5_127245 All targets in OG5_127245
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127245 All targets in OG5_127245
Leishmania mexicana adenine aminohydrolase Get druggable targets OG5_127245 All targets in OG5_127245
Neospora caninum Adenosine deaminase (EC 3.5.4.4), related Get druggable targets OG5_127245 All targets in OG5_127245
Plasmodium yoelii adenosine deaminase Get druggable targets OG5_127245 All targets in OG5_127245
Mycobacterium tuberculosis Probable adenosine deaminase Add (adenosine aminohydrolase) Get druggable targets OG5_127245 All targets in OG5_127245
Onchocerca volvulus Adenosine deaminase homolog Get druggable targets OG5_127245 All targets in OG5_127245
Plasmodium falciparum adenosine deaminase Get druggable targets OG5_127245 All targets in OG5_127245
Schistosoma japonicum ko:K01488 adenosine deaminase [EC3.5.4.4], putative Get druggable targets OG5_127245 All targets in OG5_127245
Leishmania major adenine aminohydrolase Get druggable targets OG5_127245 All targets in OG5_127245
Schistosoma mansoni adenosine deaminase-related Get druggable targets OG5_127245 All targets in OG5_127245
Echinococcus granulosus adenosine deaminase Get druggable targets OG5_127245 All targets in OG5_127245
Treponema pallidum adenosine deaminase Get druggable targets OG5_127245 All targets in OG5_127245
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127245 All targets in OG5_127245
Schistosoma mansoni adenosine deaminase Get druggable targets OG5_127245 All targets in OG5_127245
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127245 All targets in OG5_127245
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127245 All targets in OG5_127245
Schistosoma japonicum ko:K01488 adenosine deaminase [EC3.5.4.4], putative Get druggable targets OG5_127245 All targets in OG5_127245
Entamoeba histolytica adenosine deaminase, putative Get druggable targets OG5_127245 All targets in OG5_127245
Toxoplasma gondii Adenosine/AMP deaminase domain-containing protein Get druggable targets OG5_127245 All targets in OG5_127245
Candida albicans similar to S. cerevisiae AAH1 (YNL141W) adenine aminohydrolase Get druggable targets OG5_127245 All targets in OG5_127245
Leishmania donovani adenine aminohydrolase Get druggable targets OG5_127245 All targets in OG5_127245
Echinococcus multilocularis adenosine deaminase Get druggable targets OG5_127245 All targets in OG5_127245
Brugia malayi Adenosine/AMP deaminase family protein Get druggable targets OG5_127245 All targets in OG5_127245
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127245 All targets in OG5_127245
Plasmodium knowlesi adenosine deaminase, putative Get druggable targets OG5_127245 All targets in OG5_127245
Leishmania infantum adenine aminohydrolase Get druggable targets OG5_127245 All targets in OG5_127245
Plasmodium vivax adenosine deaminase, putative Get druggable targets OG5_127245 All targets in OG5_127245
Entamoeba histolytica adenosine deaminase, putative Get druggable targets OG5_127245 All targets in OG5_127245
Mycobacterium ulcerans adenosine deaminase Get druggable targets OG5_127245 All targets in OG5_127245
Plasmodium berghei adenosine deaminase, putative Get druggable targets OG5_127245 All targets in OG5_127245
Neospora caninum adenosine/AMP deaminase domain containing protein, putative Get druggable targets OG5_127245 All targets in OG5_127245
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0155 1 1
Brugia malayi Intermediate filament tail domain containing protein 0.0019 0.0604 0.0604
Loa Loa (eye worm) hypothetical protein 0.0155 1 1
Loa Loa (eye worm) intermediate filament protein 0.0019 0.0604 0.0604
Schistosoma mansoni histamine h1 receptor 0.0155 1 1
Leishmania major AMP deaminase, putative,adenosine monophosphate deaminase-like protein 0.0034 0.1629 0.2452
Echinococcus granulosus g protein coupled receptor 0.0155 1 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0602 0.054
Loa Loa (eye worm) hypothetical protein 0.0155 1 1
Echinococcus granulosus adenosine deaminase 0.0104 0.6445 0.6422
Schistosoma mansoni hypothetical protein 0.0119 0.7481 0.7465
Echinococcus multilocularis fmrfamide receptor 0.0155 1 1
Loa Loa (eye worm) hypothetical protein 0.0155 1 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0155 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0155 1 1
Plasmodium vivax adenosine/AMP deaminase, putative 0.0034 0.1629 0.2452
Loa Loa (eye worm) hypothetical protein 0.0155 1 1
Onchocerca volvulus 0.0155 1 1
Trypanosoma cruzi AMP deaminase, putative 0.0034 0.1629 1
Trypanosoma cruzi AMP deaminase, putative 0.0034 0.1629 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0155 1 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0023 0.0863 0.0863
Echinococcus granulosus hypothetical protein 0.0155 1 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0155 1 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0155 1 1
Loa Loa (eye worm) hypothetical protein 0.0155 1 1
Echinococcus granulosus neuropeptide receptor 0.0155 1 1
Echinococcus granulosus g-protein coupled receptor 0.0155 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0155 1 1
Echinococcus granulosus orexin receptor type 2 0.0155 1 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0155 1 1
Brugia malayi hypothetical protein 0.0155 1 1
Brugia malayi hypothetical protein 0.0155 1 1
Trypanosoma brucei adenosine monophosphate deaminase, putative 0.0034 0.1629 1
Echinococcus multilocularis neuropeptide receptor A26 0.0155 1 1
Echinococcus granulosus lamin dm0 0.0019 0.0604 0.0543
Brugia malayi neuropeptide F receptor 0.0155 1 1
Loa Loa (eye worm) hypothetical protein 0.0155 1 1
Echinococcus multilocularis G protein coupled receptor 139 0.0155 1 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0155 1 1
Onchocerca volvulus 0.0155 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0023 0.0863 0.0803
Echinococcus multilocularis fmrfamide receptor 0.0155 1 1
Onchocerca volvulus 0.0155 1 1
Brugia malayi G-protein coupled receptor 0.0155 1 1
Toxoplasma gondii Adenosine/AMP deaminase domain-containing protein 0.0104 0.6445 1
Brugia malayi isocitrate dehydrogenase 0.0011 0.0065 0.0065
Echinococcus multilocularis rhodopsin orphan GPCR 0.0155 1 1
Onchocerca volvulus 0.0155 1 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0155 1 1
Loa Loa (eye worm) hypothetical protein 0.0155 1 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0155 1 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.341 0.341
Echinococcus granulosus tm gpcr rhodopsin 0.0155 1 1
Schistosoma mansoni biogenic amine receptor 0.0155 1 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0155 1 1
Brugia malayi hypothetical protein 0.0155 1 1
Echinococcus granulosus 7tm_1 domain containing protein 0.0155 1 1
Echinococcus granulosus g protein coupled receptor 0.0155 1 1
Onchocerca volvulus 0.0155 1 1
Echinococcus granulosus neuropeptide Y receptor 0.0155 1 1
Echinococcus granulosus neuropeptide receptor 0.0155 1 1
Echinococcus granulosus neuropeptide Y receptor 0.0155 1 1
Echinococcus granulosus dro:myosuppressin receptor 0.0155 1 1
Loa Loa (eye worm) hypothetical protein 0.0155 1 1
Toxoplasma gondii Adenosine/AMP deaminase domain-containing protein 0.0104 0.6445 1
Plasmodium vivax adenosine deaminase, putative 0.0104 0.6445 1
Brugia malayi G protein-coupled receptor 0.0155 1 1
Trypanosoma cruzi adenosine monophosphate deaminase, putative 0.0034 0.1629 1
Echinococcus multilocularis musashi 0.0019 0.0604 0.0543
Loa Loa (eye worm) hypothetical protein 0.0155 1 1
Echinococcus multilocularis serotonin receptor 0.0155 1 1
Schistosoma mansoni lamin 0.0019 0.0604 0.0543
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0155 1 1
Brugia malayi sulfakinin receptor protein 0.0155 1 1
Loa Loa (eye worm) hypothetical protein 0.007 0.4118 0.4118
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0155 1 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0155 1 1
Toxoplasma gondii AMP deaminase 0.0034 0.1629 0.2452
Brugia malayi AKH receptor 0.0155 1 1
Loa Loa (eye worm) AMP deaminase 0.0034 0.1629 0.1629
Echinococcus granulosus intermediate filament protein 0.0019 0.0604 0.0543
Trypanosoma brucei AMP deaminase, putative 0.0034 0.1629 1
Schistosoma mansoni adenoreceptor 0.0155 1 1
Loa Loa (eye worm) hypothetical protein 0.0155 1 1
Echinococcus granulosus allatostatin A receptor 0.0155 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0155 1 1
Schistosoma mansoni hypothetical protein 0.0155 1 1
Loa Loa (eye worm) hypothetical protein 0.0155 1 1
Loa Loa (eye worm) hypothetical protein 0.0155 1 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0155 1 1
Loa Loa (eye worm) hypothetical protein 0.0155 1 1
Echinococcus multilocularis neuropeptides capa receptor 0.0155 1 1
Brugia malayi Adenosine/AMP deaminase family protein 0.0104 0.6445 0.6445
Loa Loa (eye worm) hypothetical protein 0.0155 1 1
Loa Loa (eye worm) hypothetical protein 0.007 0.4118 0.4118
Brugia malayi hypothetical protein 0.0155 1 1
Entamoeba histolytica adenosine deaminase, putative 0.0104 0.6445 1
Loa Loa (eye worm) hypothetical protein 0.0155 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0155 1 1
Leishmania major AMP deaminase, putative 0.0034 0.1629 0.2452
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0155 1 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0155 1 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0155 1 1
Brugia malayi Isocitrate dehydrogenase 0.0011 0.0065 0.0065
Echinococcus granulosus fmrfamide receptor 0.0155 1 1
Onchocerca volvulus 0.0155 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0023 0.0863 0.0803
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0155 1 1
Onchocerca volvulus 0.0155 1 1
Brugia malayi intermediate filament protein 0.0019 0.0604 0.0604
Loa Loa (eye worm) hypothetical protein 0.0155 1 1
Brugia malayi Dopamine receptor 0.0155 1 1
Echinococcus multilocularis sex peptide receptor 0.0155 1 1
Schistosoma mansoni lamin 0.0019 0.0604 0.0543
Brugia malayi hypothetical protein 0.0155 1 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0155 1 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0155 1 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0155 1 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0602 0.0602
Trypanosoma brucei AMP deaminase, putative 0.0034 0.1629 1
Schistosoma mansoni biogenic amine receptor 0.0155 1 1
Mycobacterium tuberculosis Probable adenosine deaminase Add (adenosine aminohydrolase) 0.0104 0.6445 1
Leishmania major adenine aminohydrolase 0.0104 0.6445 1
Schistosoma mansoni amine GPCR 0.0155 1 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0581 0.0581
Loa Loa (eye worm) hypothetical protein 0.0155 1 1
Schistosoma mansoni hypothetical protein 0.0019 0.0602 0.054
Brugia malayi putative neuropeptide receptor NPR1 0.0155 1 1
Schistosoma mansoni amine GPCR 0.0155 1 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.1629 0.1629
Echinococcus granulosus neuropeptide s receptor 0.0155 1 1
Loa Loa (eye worm) hypothetical protein 0.0155 1 1
Brugia malayi hypothetical protein 0.0155 1 1
Brugia malayi hypothetical protein 0.0155 1 1
Trypanosoma cruzi adenosine monophosphate deaminase-like protein, putative 0.0034 0.1629 1
Schistosoma mansoni adenosine deaminase-related 0.0104 0.6445 0.6422
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0602 0.0602
Onchocerca volvulus 0.0155 1 1
Echinococcus granulosus sex peptide receptor 0.0155 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.0155 1 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0155 1 1
Schistosoma mansoni hypothetical protein 0.0019 0.0602 0.054
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0155 1 1
Loa Loa (eye worm) hypothetical protein 0.0155 1 1
Loa Loa (eye worm) neuropeptide F receptor 0.0155 1 1
Schistosoma mansoni AMP deaminase 0.0034 0.1629 0.1574
Schistosoma mansoni amine GPCR 0.0155 1 1
Onchocerca volvulus 0.0155 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.211 0.211
Loa Loa (eye worm) hypothetical protein 0.0019 0.0602 0.0602
Echinococcus multilocularis rhodopsin orphan GPCR 0.0155 1 1
Leishmania major adenosine monophosphate deaminase, putative,AMP deaminase, putative 0.0034 0.1629 0.2452
Echinococcus granulosus rhodopsin orphan GPCR 0.0155 1 1
Trypanosoma cruzi AMP deaminase, putative 0.0034 0.1629 1
Echinococcus multilocularis GPCR, family 2 0.0019 0.0602 0.054
Loa Loa (eye worm) hypothetical protein 0.0019 0.0604 0.0604
Schistosoma mansoni neuropeptide receptor 0.0155 1 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0155 1 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0155 1 1
Leishmania major AMP deaminase, putative,amp deaminase-like protein 0.0034 0.1629 0.2452
Brugia malayi hypothetical protein 0.0155 1 1
Schistosoma mansoni hypothetical protein 0.0019 0.0602 0.054
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0155 1 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0155 1 1
Loa Loa (eye worm) hypothetical protein 0.0155 1 1
Brugia malayi follicle stimulating hormone receptor 0.0155 1 1
Echinococcus multilocularis neuropeptide s receptor 0.0155 1 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0602 0.054
Schistosoma mansoni adenosine deaminase 0.0104 0.6445 0.6422
Loa Loa (eye worm) hypothetical protein 0.0155 1 1
Echinococcus granulosus lamin 0.0019 0.0604 0.0543
Schistosoma mansoni alpha-1 adrenergic receptor 0.0155 1 1
Echinococcus multilocularis serotonin receptor 0.0155 1 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0155 1 1
Echinococcus granulosus GPCR family 2 0.0019 0.0602 0.054
Mycobacterium leprae Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) 0.0104 0.6445 0.5
Brugia malayi Serotonin receptor 0.0155 1 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0155 1 1
Echinococcus granulosus serotonin receptor 0.0155 1 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0011 0.0065 0.0065
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0155 1 1
Echinococcus multilocularis orexin receptor type 2 0.0155 1 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0155 1 1
Schistosoma mansoni intermediate filament proteins 0.0019 0.0604 0.0543
Brugia malayi Melatonin receptor type 1A 0.0155 1 1
Loa Loa (eye worm) hypothetical protein 0.0155 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.0155 1 1
Loa Loa (eye worm) hypothetical protein 0.0155 1 1
Schistosoma mansoni hypothetical protein 0.0155 1 1
Loa Loa (eye worm) hypothetical protein 0.0155 1 1
Loa Loa (eye worm) TYRA-2 protein 0.0155 1 1
Loa Loa (eye worm) hypothetical protein 0.0104 0.6445 0.6445
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0155 1 1
Echinococcus multilocularis neuropeptide Y receptor 0.0155 1 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0155 1 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.341 0.341
Schistosoma mansoni neuropeptide f receptor 76f 0.0155 1 1
Echinococcus multilocularis lamin 0.0019 0.0604 0.0543
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0155 1 1
Loa Loa (eye worm) hypothetical protein 0.0155 1 1
Onchocerca volvulus 0.0155 1 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0155 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0155 1 1
Echinococcus multilocularis neuropeptide receptor 0.0155 1 1
Brugia malayi RE15519p 0.0155 1 1
Trichomonas vaginalis adenosine deaminase, putative 0.0104 0.6445 0.5
Echinococcus multilocularis neuropeptides capa receptor 0.0155 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0155 1 1
Schistosoma mansoni neuropeptide F-like receptor 0.0155 1 1
Echinococcus multilocularis g protein coupled receptor 0.0155 1 1
Loa Loa (eye worm) hypothetical protein 0.0155 1 1
Schistosoma mansoni neuropeptide receptor 0.0155 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0155 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0023 0.0863 0.0803
Schistosoma mansoni biogenic amine (5HT) receptor 0.0155 1 1
Loa Loa (eye worm) hypothetical protein 0.007 0.4118 0.4118
Brugia malayi neuropeptide F receptor 0.0155 1 1
Echinococcus granulosus geminin 0.0119 0.7481 0.7465
Echinococcus multilocularis g protein coupled receptor 0.0155 1 1
Echinococcus granulosus AMP deaminase 2 0.0034 0.1629 0.1574
Echinococcus granulosus rhodopsin orphan GPCR 0.0155 1 1
Loa Loa (eye worm) G-protein coupled receptor 0.0155 1 1
Echinococcus granulosus somatostatin receptor 0.0155 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0155 1 1
Brugia malayi G-protein coupled receptor 0.0155 1 1
Schistosoma mansoni opsin-like receptor 0.0155 1 1
Schistosoma mansoni amine GPCR 0.0155 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0155 1 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0155 1 1
Onchocerca volvulus 0.0155 1 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0019 0.0604 0.0604
Echinococcus multilocularis adenosine deaminase 0.0104 0.6445 0.6422
Echinococcus multilocularis neuropeptide receptor 0.0155 1 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0155 1 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0155 1 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0155 1 1
Plasmodium falciparum adenosine deaminase 0.0104 0.6445 1
Loa Loa (eye worm) hypothetical protein 0.0155 1 1
Schistosoma mansoni opsin-like receptor 0.0155 1 1
Onchocerca volvulus 0.0034 0.1629 0.1091
Echinococcus multilocularis g-protein coupled receptor 0.0155 1 1
Schistosoma mansoni hypothetical protein 0.0155 1 1
Loa Loa (eye worm) hypothetical protein 0.006 0.341 0.341
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0155 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0023 0.0863 0.0803
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0023 0.0863 0.0803
Loa Loa (eye worm) hypothetical protein 0.0155 1 1
Loa Loa (eye worm) hypothetical protein 0.0155 1 1
Echinococcus multilocularis geminin 0.0119 0.7481 0.7465
Echinococcus multilocularis neuropeptide FF receptor 2 0.0155 1 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0602 0.054
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0602 0.0602
Entamoeba histolytica adenosine deaminase, putative 0.0104 0.6445 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0155 1 1
Loa Loa (eye worm) hypothetical protein 0.0155 1 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0155 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0155 1 1
Onchocerca volvulus 0.0155 1 1
Echinococcus granulosus neuropeptides capa receptor 0.0155 1 1
Echinococcus multilocularis AMP deaminase 2 0.0034 0.1629 0.1574
Loa Loa (eye worm) neuropeptide F receptor 0.0155 1 1
Echinococcus multilocularis lamin dm0 0.0019 0.0604 0.0543
Echinococcus multilocularis rhodopsin orphan GPCR 0.0155 1 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0155 1 1
Trichomonas vaginalis adenosine deaminase, putative 0.0104 0.6445 0.5
Loa Loa (eye worm) hypothetical protein 0.0155 1 1
Echinococcus multilocularis neuropeptide Y receptor 0.0155 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0155 1 1
Treponema pallidum adenosine deaminase 0.0104 0.6445 0.5
Loa Loa (eye worm) hypothetical protein 0.0155 1 1
Schistosoma mansoni hypothetical protein 0.0155 1 1
Brugia malayi Dopamine receptor protein 2 0.0155 1 1
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.211 0.211
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0155 1 1
Schistosoma mansoni opsin-like receptor 0.0155 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0155 1 1
Echinococcus granulosus neuropeptide receptor A26 0.0155 1 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0155 1 1
Loa Loa (eye worm) hypothetical protein 0.0155 1 1
Loa Loa (eye worm) hypothetical protein 0.0155 1 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0155 1 1
Schistosoma mansoni hypothetical protein 0.0019 0.0602 0.054
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0155 1 1
Echinococcus granulosus neuropeptides capa receptor 0.0155 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0155 1 1
Schistosoma mansoni myosin xvIII 0.0155 1 1
Loa Loa (eye worm) hypothetical protein 0.0155 1 1
Loa Loa (eye worm) hypothetical protein 0.0155 1 1
Schistosoma mansoni biogenic amine receptor 0.0155 1 1
Loa Loa (eye worm) hypothetical protein 0.0155 1 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0155 1 1
Brugia malayi Serotonin receptor 0.0155 1 1
Echinococcus multilocularis g protein coupled receptor 0.0155 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0155 1 1
Loa Loa (eye worm) hypothetical protein 0.0155 1 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0155 1 1
Brugia malayi GnHR receptor homolog 0.0155 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0155 1 1
Trypanosoma cruzi AMP deaminase, putative 0.0034 0.1629 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0155 1 1
Trypanosoma cruzi AMP deaminase, putative 0.0034 0.1629 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0155 1 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.341 0.341
Echinococcus multilocularis rhodopsin orphan GPCR 0.0155 1 1
Onchocerca volvulus 0.0155 1 1
Onchocerca volvulus 0.0155 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0023 0.0863 0.0803
Mycobacterium ulcerans adenosine deaminase 0.0104 0.6445 0.5
Brugia malayi larval opioid receptor 0.0155 1 1
Echinococcus multilocularis somatostatin receptor 0.0155 1 1
Plasmodium falciparum AMP deaminase, putative 0.0034 0.1629 0.2452
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0155 1 1
Loa Loa (eye worm) hypothetical protein 0.0155 1 1
Onchocerca volvulus 0.0155 1 1
Echinococcus multilocularis allatostatin A receptor 0.0155 1 1
Loa Loa (eye worm) hypothetical protein 0.0155 1 1
Loa Loa (eye worm) G-protein coupled receptor 0.0155 1 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0602 0.054
Loa Loa (eye worm) hypothetical protein 0.007 0.4118 0.4118
Schistosoma mansoni amine GPCR 0.0155 1 1
Brugia malayi putative neuropeptide receptor 0.0155 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0155 1 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0155 1 1
Brugia malayi adenosine monophosphate deaminase 0.0034 0.1629 0.1629
Schistosoma mansoni neuropeptide F-like receptor 0.0155 1 1
Leishmania major hypothetical protein, conserved 0.0034 0.1629 0.2452
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0155 1 1
Loa Loa (eye worm) hypothetical protein 0.0155 1 1
Schistosoma mansoni hypothetical protein 0.0041 0.211 0.2058
Loa Loa (eye worm) hypothetical protein 0.0155 1 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0155 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0023 0.0863 0.0803
Brugia malayi ORL1-like opioid receptor 0.0155 1 1
Brugia malayi Dopamine receptor protein 1 0.0155 1 1
Loa Loa (eye worm) hypothetical protein 0.0155 1 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0155 1 1
Brugia malayi hypothetical protein 0.0155 1 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0023 0.0863 0.0863
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0155 1 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0155 1 1
Loa Loa (eye worm) hypothetical protein 0.0155 1 1
Schistosoma mansoni hypothetical protein 0.0119 0.7481 0.7465
Onchocerca volvulus AMP deaminase 2 homolog 0.0034 0.1629 0.1091
Onchocerca volvulus Adenosine deaminase homolog 0.0104 0.6445 0.6217
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0155 1 1
Schistosoma mansoni neuropeptide receptor 0.0155 1 1
Loa Loa (eye worm) hypothetical protein 0.0155 1 1
Onchocerca volvulus 0.0155 1 1
Trypanosoma brucei AMP deaminase, putative 0.0034 0.1629 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0155 1 1
Onchocerca volvulus 0.0155 1 1
Schistosoma mansoni neuropeptide receptor 0.0155 1 1
Echinococcus granulosus G protein coupled receptor 139 0.0155 1 1
Trypanosoma cruzi AMP deaminase 2, putative 0.0034 0.1629 1
Echinococcus granulosus g protein coupled receptor 0.0155 1 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0155 1 1

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 240 nM Inhibition of human adenosine deaminase (ADA) ChEMBL. 15239652
Ki (binding) = 240 nM Inhibition of human adenosine deaminase (ADA) ChEMBL. 15239652

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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