Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) | 259 aa | 254 aa | 25.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | glutamate receptor NMDA | 0.0164 | 0.0328 | 0.3248 |
Echinococcus multilocularis | serotonin receptor | 0.0126 | 0.0134 | 0.176 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0287 | 0.0946 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0189 | 0.0451 | 0.0896 |
Echinococcus multilocularis | serotonin receptor | 0.0126 | 0.0134 | 0.176 |
Brugia malayi | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 | 0.0189 | 0.0451 | 0.0896 |
Onchocerca volvulus | 0.0242 | 0.0719 | 0.5 | |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.0189 | 0.0451 | 0.5 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0164 | 0.0328 | 0.431 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0214 | 0.0578 | 0.7155 |
Loa Loa (eye worm) | hypothetical protein | 0.0126 | 0.0134 | 0.0266 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0214 | 0.0578 | 0.7602 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0212 | 0.0571 | 0.1133 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0123 | 0.012 | 0.1573 |
Brugia malayi | Pre-SET motif family protein | 0.0212 | 0.0571 | 0.1133 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0126 | 0.0134 | 0.0222 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0123 | 0.012 | 0.1573 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0188 | 0.0448 | 0.5883 |
Echinococcus granulosus | nmda type glutamate receptor | 0.025 | 0.0761 | 1 |
Treponema pallidum | DNA-directed RNA polymerase subunit beta | 0.2086 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0562 | 0.2332 | 0.4628 |
Entamoeba histolytica | steroid 5-alpha reductase, putative | 0.0189 | 0.0451 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.025 | 0.0761 | 1 |
Trichomonas vaginalis | set domain proteins, putative | 0.0242 | 0.0719 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0126 | 0.0134 | 0.0266 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.11 | 0.5038 | 1 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0126 | 0.0134 | 0.1415 |
Loa Loa (eye worm) | hypothetical protein | 0.11 | 0.5038 | 1 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0188 | 0.0448 | 0.5115 |
Mycobacterium tuberculosis | DNA-directed RNA polymerase (beta chain) RpoB (transcriptase beta chain) (RNA polymerase beta subunit) | 0.2086 | 1 | 0.5 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0214 | 0.0578 | 0.6114 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0123 | 0.012 | 0.1573 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0123 | 0.012 | 0.1573 |
Mycobacterium ulcerans | DNA-directed RNA polymerase subunit beta | 0.2086 | 1 | 1 |
Plasmodium falciparum | DNA-directed RNA polymerase subunit beta, putative | 0.2086 | 1 | 0.5 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.11 | 0.5038 | 1 |
Wolbachia endosymbiont of Brugia malayi | DNA-directed RNA polymerase subunit beta/beta' | 0.2086 | 1 | 0.5 |
Leishmania major | C-8 sterol isomerase-like protein | 0.11 | 0.5038 | 1 |
Mycobacterium leprae | DNA-DIRECTED RNA POLYMERASE (BETA CHAIN) RPOB (TRANSCRIPTASE BETA CHAIN) (RNA POLYMERASE BETA SUBUNIT) | 0.2086 | 1 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0123 | 0.012 | 0.1573 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.11 | 0.5038 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4300 nM | Inhibition of recombinant Steroid 5-alpha-reductase type I expressed in CHO cells | ChEMBL. | 11020287 |
IC50 (binding) | = 4300 nM | Inhibition of recombinant Steroid 5-alpha-reductase type I expressed in CHO cells | ChEMBL. | 11020287 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.