Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | melanocortin 4 receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | acyl-CoA synthetase | 0.0019 | 0.0114 | 0.5 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0025 | 0.1149 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.1149 | 0.124 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0025 | 0.1149 | 0.5 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0025 | 0.1149 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0025 | 0.1149 | 0.5 |
Brugia malayi | Bromodomain containing protein | 0.004 | 0.3667 | 0.2845 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.9262 | 1 |
Brugia malayi | TAR-binding protein | 0.0066 | 0.7989 | 0.7728 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0025 | 0.1149 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0062 | 0.736 | 0.9213 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0018 | 0.0106 | 0.0114 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0024 | 0.0947 | 0.1186 |
Schistosoma mansoni | hypothetical protein | 0.0022 | 0.0618 | 0.0773 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.4417 | 0.4769 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0025 | 0.1149 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0038 | 0.3258 | 0.4078 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0114 | 0.0123 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.4087 | 0.4413 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0019 | 0.0114 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.1149 | 0.124 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0024 | 0.0947 | 0.1186 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0038 | 0.3258 | 0.4078 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0066 | 0.7989 | 0.7728 |
Mycobacterium ulcerans | hypothetical protein | 0.0025 | 0.1149 | 1 |
Brugia malayi | PHD-finger family protein | 0.0026 | 0.1356 | 0.0234 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.1149 | 0.124 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0025 | 0.1149 | 1 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0022 | 0.0618 | 0.0667 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0025 | 0.1149 | 1 |
Echinococcus granulosus | zinc finger protein | 0.002 | 0.0435 | 0.0545 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0114 | 0.0123 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0025 | 0.1149 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0114 | 0.0123 |
Echinococcus multilocularis | tar DNA binding protein | 0.0066 | 0.7989 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0114 | 0.0123 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.7989 | 1 |
Schistosoma mansoni | bromodomain containing protein | 0.0066 | 0.7978 | 0.9986 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.7989 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.7989 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0066 | 0.7989 | 0.8626 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.1149 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0025 | 0.1149 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.3679 | 0.3972 |
Echinococcus multilocularis | zinc finger protein | 0.002 | 0.0435 | 0.0545 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0025 | 0.1149 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.7989 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0025 | 0.1149 | 0.5 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0019 | 0.0114 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0114 | 0.0123 |
Schistosoma mansoni | zinc finger protein | 0.002 | 0.0435 | 0.0545 |
Onchocerca volvulus | 0.0025 | 0.1149 | 0.5 | |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0025 | 0.1149 | 0.5 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0024 | 0.0947 | 0.1186 |
Echinococcus granulosus | tar DNA binding protein | 0.0066 | 0.7989 | 1 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0025 | 0.1149 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.7989 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0066 | 0.7989 | 0.8626 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.1149 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0066 | 0.7989 | 0.8626 |
Brugia malayi | RNA binding protein | 0.0066 | 0.7989 | 0.7728 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.1149 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0062 | 0.736 | 0.9213 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.051 uM | Ability to decrease the intracellular cAMP levels induced by 1 nM NDP-MSH in HEK293/ hMC4 cells. | ChEMBL. | 15203150 |
IC50 (functional) | = 0.051 uM | Ability to decrease the intracellular cAMP levels induced by 1 nM NDP-MSH in HEK293/ hMC4 cells. | ChEMBL. | 15203150 |
Ki (binding) | = 0.18 uM | In vitro binding affinity towards melanocortin 4 receptor. | ChEMBL. | 15203150 |
Ki (binding) | = 0.18 uM | In vitro binding affinity towards melanocortin 4 receptor. | ChEMBL. | 15203150 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 15203150 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.