Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | hepatocyte nuclear factor 4, alpha | No references | |
Rattus norvegicus | Hepatocyte nuclear factor 4-alpha | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | Transcription factor HNF-4 homolog, putative | Get druggable targets OG5_131038 | All targets in OG5_131038 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | Get druggable targets OG5_131038 | All targets in OG5_131038 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | Get druggable targets OG5_131038 | All targets in OG5_131038 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | Get druggable targets OG5_131038 | All targets in OG5_131038 |
Schistosoma japonicum | Hepatocyte nuclear factor 4-beta, putative | Get druggable targets OG5_131038 | All targets in OG5_131038 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | Get druggable targets OG5_131038 | All targets in OG5_131038 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | Get druggable targets OG5_131038 | All targets in OG5_131038 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0024 | 0 | 0.5 | |
Onchocerca volvulus | Bile acid receptor homolog | 0.0024 | 0 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0024 | 0 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0284 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0284 | 1 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0284 | 1 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0024 | 0 | 0.5 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0271 | 0.9502 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Efficacy (functional) | = 118 % | Antagonist activity against rat HNF4alpha1 expressed in African green monkey CV1 cells assessed as reduction in endogenous agoinst-induced luciferase expression incubated for 24 hrs by firefly luciferase reporter gene assay relative to control | ChEMBL. | No reference |
IC50 (functional) | = 35 nM | Antagonist activity against rat HNF4alpha1 expressed in African green monkey CV1 cells assessed as reduction in endogenous agoinst-induced luciferase expression incubated for 24 hrs by firefly luciferase reporter gene assay | ChEMBL. | No reference |
Ki (binding) | = 966 nM | Displacement of [3H]methyl4-[5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-ethyloxy-2-naphthalenyl]benzoyl benzoate from HNF4alpha (unknown origin) by radioligand binding assay | ChEMBL. | No reference |
Ki (binding) | > 30000 nM | Displacement of [3H]9-cis-retinoic acid from RXRalpha (unknown origin) by radioligand binding assay | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.