Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | acetylcholinesterase | 0.084 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.084 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.084 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.084 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.084 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.084 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.084 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.084 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.084 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.084 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.084 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.084 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 0 | Inhibitory activity against human DNA topoisomerase I mediated DNA cleavage; Weak activity | ChEMBL. | 11020283 |
GI50 (functional) | = 3.4 uM | Antiproliferative activity was determined for 50% growth inhibition against human CNS SF-539 cell line | ChEMBL. | 11020283 |
GI50 (functional) | = 3.4 uM | Antiproliferative activity was determined for 50% growth inhibition against human CNS SF-539 cell line | ChEMBL. | 11020283 |
GI50 (functional) | = 5.37 uM | Antiproliferative activity was determined for 50% growth inhibition against human Prostate DU-145 cell line | ChEMBL. | 11020283 |
GI50 (functional) | = 5.37 uM | Antiproliferative activity was determined for 50% growth inhibition against human Prostate DU-145 cell line | ChEMBL. | 11020283 |
GI50 (functional) | = 6.51 uM | Antiproliferative activity was determined for 50% growth inhibition against human melanoma UACC-62 cell line | ChEMBL. | 11020283 |
GI50 (functional) | = 6.51 uM | Antiproliferative activity was determined for 50% growth inhibition against human melanoma UACC-62 cell line | ChEMBL. | 11020283 |
GI50 (functional) | = 12 uM | Antiproliferative activity was determined for 50% growth inhibition against human lung HOP-62 cell line | ChEMBL. | 11020283 |
GI50 (functional) | = 12 uM | Antiproliferative activity was determined for 50% growth inhibition against human lung HOP-62 cell line | ChEMBL. | 11020283 |
GI50 (functional) | = 13.2 uM | Antiproliferative activity was determined for 50% growth inhibition against human colon HCT-116 cell line | ChEMBL. | 11020283 |
GI50 (functional) | = 13.2 uM | Antiproliferative activity was determined for 50% growth inhibition against human colon HCT-116 cell line | ChEMBL. | 11020283 |
GI50 (functional) | = 21.7 uM | Antiproliferative activity was determined for 50% growth inhibition against human renal SN12C cell line | ChEMBL. | 11020283 |
GI50 (functional) | = 21.7 uM | Antiproliferative activity was determined for 50% growth inhibition against human renal SN12C cell line | ChEMBL. | 11020283 |
GI50 (functional) | = 91.9 uM | Antiproliferative activity was determined for 50% growth inhibition against human ovarian OVCAR-3 cell line | ChEMBL. | 11020283 |
GI50 (functional) | = 91.9 uM | Antiproliferative activity was determined for 50% growth inhibition against human ovarian OVCAR-3 cell line | ChEMBL. | 11020283 |
GI50 (functional) | = 92.4 uM | Antiproliferative activity was determined for 50% growth inhibition against human breast MDA-MB-435 cell line | ChEMBL. | 11020283 |
GI50 (functional) | = 92.4 uM | Antiproliferative activity was determined for 50% growth inhibition against human breast MDA-MB-435 cell line | ChEMBL. | 11020283 |
Inhibition (binding) | 0 | Inhibitory activity against DNA-Topoisomerase I | ChEMBL. | 15857129 |
MGM (functional) | = 21.3 | Mean graph midpoint for growth inhibition of all human cancer cell lines | ChEMBL. | 11020283 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.