Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0537 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.3371 | 0.9657 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0637 | 0.0343 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0637 | 0.0343 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.3371 | 0.9657 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | > 3000 ug kg-1 | Effective dose after subcutaneous administration to TPTX rats for 50% reduction of hypercalcemia | ChEMBL. | 12166945 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.