Detailed information for compound 214957

Basic information

Technical information
  • TDR Targets ID: 214957
  • Name: benzohydrazide
  • MW: 136.151 | Formula: C7H8N2O
  • H donors: 2 H acceptors: 1 LogP: 0.45 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: NNC(=O)c1ccccc1
  • InChi: 1S/C7H8N2O/c8-9-7(10)6-4-2-1-3-5-6/h1-5H,8H2,(H,9,10)
  • InChiKey: WARCRYXKINZHGQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • benzoylhydrazine
  • 613-94-5
  • AIDS-009021
  • AIDS009021
  • AI3-52284
  • Benzoic acid hydrazide
  • Benzoyl hydrazine
  • CCRIS 1287
  • EINECS 210-363-9
  • HSDB 2737
  • Hydrazid kyseliny benzoove [Czech]
  • C6H5-CO-NH-NH2
  • CHEBI:38454
  • ZINC00115752
  • InChI=1/C7H8N2O/c8-9-7(10)6-4-2-1-3-5-6/h1-5H,8H2,(H,9,10
  • 12100_FLUKA
  • B13071_ALDRICH
  • ST5046188
  • Benzhydrazide
  • Benzohydrazine
  • Benzoic acid, hydrazide
  • Benzoic hydrazide
  • Benzoyl hydrazide
  • Hydrazine, benzoyl-
  • NSC 644
  • NSC644
  • WLN: ZMR XVQ

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) Curated by TDR Targets References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium yoelii enoyl-acyl carrier reductase Get druggable targets OG5_130466 All targets in OG5_130466
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase Get druggable targets OG5_130466 All targets in OG5_130466
Plasmodium knowlesi enoyl-acyl carrier reductase, putative Get druggable targets OG5_130466 All targets in OG5_130466
Plasmodium vivax enoyl-acyl carrier protein reductase Get druggable targets OG5_130466 All targets in OG5_130466
Neospora caninum enoyl-acyl carrier reductase, putative Get druggable targets OG5_130466 All targets in OG5_130466
Plasmodium falciparum enoyl-acyl carrier reductase Get druggable targets OG5_130466 All targets in OG5_130466
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) Get druggable targets OG5_130466 All targets in OG5_130466
Chlamydia trachomatis enoyl-acyl-carrier protein reductase Get druggable targets OG5_130466 All targets in OG5_130466
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase Get druggable targets OG5_130466 All targets in OG5_130466
Toxoplasma gondii enoyl-acyl carrier reductase ENR Get druggable targets OG5_130466 All targets in OG5_130466
Plasmodium berghei enoyl-acyl carrier reductase Get druggable targets OG5_130466 All targets in OG5_130466
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) Get druggable targets OG5_130466 All targets in OG5_130466
Trichomonas vaginalis hypothetical protein Get druggable targets OG5_130466 All targets in OG5_130466
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0019 0.0041 0.0164
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0223 0.3783 1
Echinococcus granulosus geminin 0.0119 0.1882 0.1875
Loa Loa (eye worm) hypothetical protein 0.0047 0.0566 0.2812
Brugia malayi AMP-binding enzyme family protein 0.0019 0.0041 0.0161
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0022 0.0096 0.0384
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0194 0.0772
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0594 0.3158
Onchocerca volvulus 0.0083 0.1209 1
Schistosoma mansoni zinc finger protein 0.0021 0.0084 0.0444
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0019 0.0041 0.0164
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.003 0.0243 0.097
Brugia malayi exodeoxyribonuclease III family protein 0.003 0.0243 0.1182
Brugia malayi AMP-binding enzyme family protein 0.0019 0.0041 0.0161
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0018 0.0034 0.0025
Leishmania major alpha glucosidase II subunit, putative 0.0027 0.0194 0.0772
Mycobacterium tuberculosis Conserved protein 0.004 0.0425 0.0896
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0039 0.0414 0.165
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0034 0.0182
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0425 0.1025
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0425 0.0896
Brugia malayi Bromodomain containing protein 0.008 0.1165 0.5837
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0104 0.0479
Leishmania major hypothetical protein, conserved 0.004 0.0425 0.1693
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0039 0.0414 0.165
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0073 0.1031 0.4106
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0253 0.4324 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.0675 0.3358
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0019 0.0041 0.0161
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0141 0.0132
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0425 0.0416
Schistosoma mansoni hypothetical protein 0.0017 0.0009 0.0049
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.003 0.0243 0.054
Leishmania major 4-coumarate:coa ligase-like protein 0.0063 0.0859 0.3422
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.0675 0.3358
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0154 0.251 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0027 0.0194 0.0408
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0594 0.0586
Loa Loa (eye worm) hypothetical protein 0.0053 0.0675 0.3358
Loa Loa (eye worm) hypothetical protein 0.004 0.0425 0.2098
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0425 0.0896
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0063 0.0859 0.2185
Loa Loa (eye worm) hypothetical protein 0.0047 0.0566 0.2812
Plasmodium falciparum acyl-CoA synthetase 0.0047 0.0566 0.1403
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0141 0.0751
Mycobacterium leprae conserved hypothetical protein 0.004 0.0425 0.1025
Mycobacterium ulcerans hypothetical protein 0.0081 0.1181 0.3045
Loa Loa (eye worm) hypothetical protein 0.0041 0.045 0.2227
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0425 0.0896
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0122 0.1921 0.9649
Trichomonas vaginalis sucrase-isomaltase, putative 0.0027 0.0194 0.0408
Mycobacterium ulcerans acyl-CoA synthetase 0.0063 0.0859 0.2185
Loa Loa (eye worm) hypothetical protein 0.0019 0.0041 0.0161
Brugia malayi PHD-finger family protein 0.0027 0.0188 0.0901
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0064 0.0867 0.0858
Mycobacterium tuberculosis Conserved protein 0.004 0.0425 0.0896
Trypanosoma brucei glucosidase, putative 0.0027 0.0194 0.0772
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0034 0.0025
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0027 0.0194 0.1866
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.0194 0.0408
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0063 0.0859 0.1909
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0063 0.0859 0.2185
Loa Loa (eye worm) hypothetical protein 0.0047 0.0566 0.2812
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0039 0.0414 0.22
Mycobacterium tuberculosis Conserved protein 0.004 0.0425 0.0896
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0034 0.0182
Schistosoma mansoni alpha glucosidase 0.0027 0.0194 0.103
Schistosoma mansoni hypothetical protein 0.0017 0.0009 0.0049
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.003 0.0243 0.097
Echinococcus granulosus histone lysine methyltransferase setb 0.0018 0.0034 0.0025
Mycobacterium ulcerans hypothetical protein 0.0063 0.0859 0.2185
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0367 0.1804
Onchocerca volvulus 0.0063 0.0859 0.7004
Mycobacterium ulcerans lipase LipD 0.004 0.0425 0.1025
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.003 0.0243 0.097
Trichomonas vaginalis ap endonuclease, putative 0.003 0.0243 0.054
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.003 0.0243 0.0472
Loa Loa (eye worm) hypothetical protein 0.0083 0.1209 0.6055
Loa Loa (eye worm) oxidoreductase 0.0019 0.0041 0.0161
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0425 0.1025
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0594 0.0586
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0223 0.3783 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.003 0.0243 0.2472
Loa Loa (eye worm) hypothetical protein 0.0063 0.0859 0.4289
Schistosoma mansoni hypothetical protein 0.0119 0.1882 1
Trichomonas vaginalis ap endonuclease, putative 0.003 0.0243 0.054
Schistosoma mansoni ap endonuclease 0.003 0.0243 0.1293
Schistosoma mansoni thyroid hormone receptor 0.0067 0.093 0.4942
Loa Loa (eye worm) hypothetical protein 0.0047 0.0566 0.2812
Mycobacterium leprae Probable lipase LipE 0.004 0.0425 0.1025
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0141 0.0132
Schistosoma mansoni hypothetical protein 0.0036 0.0367 0.1948
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0019 0.0041 0.0164
Entamoeba histolytica acyl-CoA synthetase, putative 0.0063 0.0859 1
Brugia malayi AMP-binding enzyme family protein 0.0019 0.0041 0.0161
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0045 0.0519 0.1116
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0019 0.0041 0.0164
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0063 0.0859 0.1909
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0034 0.0025
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.0194 0.0408
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0425 0.1025
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0027 0.0194 0.0408
Treponema pallidum exodeoxyribonuclease (exoA) 0.003 0.0243 0.5
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0154 0.251 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0063 0.0859 0.2185
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0034 0.0182
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.003 0.0243 0.097
Brugia malayi beta-lactamase family protein 0.004 0.0425 0.2098
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0039 0.0414 0.2044
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.003 0.0243 0.0234
Echinococcus granulosus transcription factor Dp 1 0.0023 0.0114 0.0105
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0154 0.251 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.0859 0.4289
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0223 0.3783 1
Schistosoma mansoni hypothetical protein 0.0062 0.0839 0.4457
Brugia malayi beta-lactamase 0.004 0.0425 0.2098
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0425 0.2258
Brugia malayi Glycosyl hydrolases family 31 protein 0.0122 0.1921 0.9649
Plasmodium vivax acyl-CoA synthetase, putative 0.0047 0.0566 0.1403
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0425 0.1025
Loa Loa (eye worm) hypothetical protein 0.004 0.0425 0.2098
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.003 0.0243 0.1182
Brugia malayi AMP-binding enzyme family protein 0.0063 0.0859 0.4289
Schistosoma mansoni bromodomain containing protein 0.0068 0.0937 0.4977
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0063 0.0859 0.2185
Loa Loa (eye worm) transcription factor SMAD2 0.0125 0.199 1
Brugia malayi AMP-binding enzyme family protein 0.0063 0.0859 0.4289
Mycobacterium ulcerans acyl-CoA synthetase 0.0063 0.0859 0.2185
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0425 0.1025
Echinococcus multilocularis lysosomal alpha glucosidase 0.0122 0.1921 0.1913
Echinococcus multilocularis geminin 0.0119 0.1882 0.1875
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0403 0.0394
Leishmania major acetyl-CoA synthetase, putative 0.0019 0.0041 0.0164
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.003 0.0243 0.054
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0027 0.0194 0.0408
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.0675 0.3358
Toxoplasma gondii ABC1 family protein 0.004 0.0425 0.1025
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0425 0.1693
Onchocerca volvulus 0.004 0.0425 0.3286
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0594 0.0586
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0425 0.0896
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.003 0.0243 0.0234
Echinococcus multilocularis zinc finger protein 0.0021 0.0084 0.0074
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0425 0.0896
Leishmania major acetyl-CoA synthetase, putative 0.0019 0.0041 0.0164
Schistosoma mansoni ap endonuclease 0.003 0.0243 0.1293
Schistosoma mansoni acetyl-CoA synthetase 0.0019 0.0041 0.0219
Echinococcus multilocularis neutral alpha glucosidase AB 0.0027 0.0194 0.0185
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0063 0.0859 0.2185
Loa Loa (eye worm) bromodomain containing protein 0.0019 0.0046 0.0187
Loa Loa (eye worm) hypothetical protein 0.0047 0.0566 0.2812
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0019 0.0041 0.0164
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0047 0.0566 0.1226
Loa Loa (eye worm) hypothetical protein 0.004 0.0425 0.2098
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0425 0.1693
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0594 0.2953
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0022 0.0096 0.0384
Leishmania major mitochondrial DNA polymerase beta 0.0154 0.251 1
Schistosoma mansoni alpha-glucosidase 0.0105 0.1612 0.8563
Loa Loa (eye worm) hypothetical protein 0.0076 0.1082 0.5415
Mycobacterium ulcerans beta-lactamase 0.004 0.0425 0.1025
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.0194 0.0408
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0425 0.1693
Onchocerca volvulus 0.004 0.0425 0.3286
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0403 0.0394
Echinococcus multilocularis thyroid hormone receptor alpha 0.0067 0.093 0.0922
Leishmania major 4-coumarate:coa ligase-like protein 0.0063 0.0859 0.3422
Schistosoma mansoni alpha-glucosidase 0.0105 0.1612 0.8563
Mycobacterium ulcerans hypothetical protein 0.004 0.0425 0.1025
Loa Loa (eye worm) hypothetical protein 0.0044 0.0497 0.246
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0019 0.0041 0.0164
Loa Loa (eye worm) hypothetical protein 0.0063 0.0859 0.4289
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0594 0.3158
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0027 0.0194 0.1866
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0022 0.0096 0.0384
Mycobacterium ulcerans acyl-CoA synthetase 0.0063 0.0859 0.2185
Loa Loa (eye worm) hypothetical protein 0.0046 0.0534 0.2648
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0063 0.0859 0.2185
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0425 0.2098
Echinococcus multilocularis transcription factor Dp 1 0.0023 0.0114 0.0105
Onchocerca volvulus 0.007 0.0985 0.8083
Brugia malayi Bromodomain containing protein 0.0041 0.0449 0.222
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.003 0.0243 0.054
Plasmodium vivax hypothetical protein, conserved 0.004 0.0425 0.1025
Brugia malayi beta-lactamase family protein 0.004 0.0425 0.2098
Loa Loa (eye worm) hypothetical protein 0.004 0.0425 0.2098
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0062 0.0839 0.083
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0039 0.0414 0.165
Brugia malayi AMP-binding enzyme family protein 0.0019 0.0041 0.0161
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0019 0.0041 0.0032
Plasmodium falciparum enoyl-acyl carrier reductase 0.0223 0.3783 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0026 0.0183 0.0728
Schistosoma mansoni thyroid hormone receptor 0.0067 0.093 0.4942
Trichomonas vaginalis hypothetical protein 0.0223 0.3783 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0125 0.199 1
Trichomonas vaginalis esterase, putative 0.004 0.0425 0.1025
Toxoplasma gondii exonuclease III APE 0.003 0.0243 0.054
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0039 0.0414 0.0405
Toxoplasma gondii hypothetical protein 0.0025 0.0154 0.0302
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0019 0.0041 0.0161
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0073 0.1031 0.4106
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0034 0.0182
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0022 0.0096 0.0384
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0019 0.0041 0.0032
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0045 0.0519 0.1116
Entamoeba histolytica acyl-CoA synthetase, putative 0.0063 0.0859 1
Brugia malayi MH2 domain containing protein 0.0125 0.199 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0064 0.0867 0.0858
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.0194 0.0408
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0425 0.2258
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0039 0.0414 0.4559
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0425 0.1025
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.0194 0.0408
Schistosoma mansoni cellular tumor antigen P53 0.0083 0.1209 0.6422
Loa Loa (eye worm) hypothetical protein 0.0018 0.0034 0.0126
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0223 0.3783 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0063 0.0859 0.3422
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0425 0.0416
Echinococcus granulosus neutral alpha glucosidase AB 0.0027 0.0194 0.0185
Schistosoma mansoni hypothetical protein 0.0022 0.0104 0.0553
Mycobacterium tuberculosis Conserved hypothetical protein 0.0081 0.1181 0.2661
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0019 0.0041 0.0164
Schistosoma mansoni hypothetical protein 0.0017 0.0009 0.0049
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0425 0.2098
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0019 0.0041 0.0161
Loa Loa (eye worm) hypothetical protein 0.0036 0.0367 0.1804
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0594 0.0586
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0425 0.0896
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0425 0.0896
Brugia malayi AMP-binding enzyme family protein 0.0063 0.0859 0.4289
Echinococcus multilocularis lysosomal alpha glucosidase 0.0122 0.1921 0.1913
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0073 0.1031 0.4106
Entamoeba histolytica acyl-coA synthetase, putative 0.0063 0.0859 1
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0223 0.3783 0.8737
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0045 0.0519 0.1116
Onchocerca volvulus 0.004 0.0425 0.3286
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.003 0.0243 0.5
Loa Loa (eye worm) hypothetical protein 0.004 0.0425 0.2098
Echinococcus multilocularis tumor protein p63 0.0564 1 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0039 0.0414 0.165
Echinococcus granulosus zinc finger protein 0.0021 0.0084 0.0074
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0039 0.0414 0.2044
Loa Loa (eye worm) hypothetical protein 0.0019 0.0041 0.0161
Brugia malayi Glycosyl hydrolases family 31 protein 0.0027 0.0194 0.0932
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0027 0.0194 0.0932
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0039 0.0414 0.0405
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0062 0.0839 0.083
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0594 0.3158
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0194 0.0772
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0594 0.2953
Schistosoma mansoni hypothetical protein 0.0119 0.1882 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0425 0.2098
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0045 0.0519 0.1116
Schistosoma mansoni hypothetical protein 0.0017 0.0009 0.0049
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0047 0.0566 0.1403
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0425 0.1025
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0019 0.0041 0.0161
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0223 0.3783 1
Loa Loa (eye worm) beta-lactamase 0.004 0.0425 0.2098
Trichomonas vaginalis maltase-glucoamylase, putative 0.0027 0.0194 0.0408
Echinococcus granulosus lysosomal alpha glucosidase 0.0122 0.1921 0.1913
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0223 0.3783 1

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 0.1 ug ml-1 Antitubercular activity against Mycobacterium tuberculosis H37Ra by alamar blue microplate assay ChEMBL. 17844996
MIC (functional) = 0.6 ug ml-1 Antitubercular activity against Mycobacterium tuberculosis ChEMBL. 24246731
pMIC (functional) = 3.22 Minimum inhibitory concentration against Mycobacterium tuberculosis var. bovis strain at 310K, with value expressed as pMIC i.e. -log of MIC (ug/mL). ChEMBL. 15239654
pMIC (functional) = 3.22 Minimum inhibitory concentration against Mycobacterium tuberculosis var. bovis strain at 310K, with value expressed as pMIC i.e. -log of MIC (ug/mL). ChEMBL. 15239654

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Targets
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from specific protein inhibition (ECO:0000020) Mycobacterium tuberculosis 6263  
Annotator: crowther@u.washington.edu Comment: 2007-12-07 References: 15239654

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

4 literature references were collected for this gene.

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