Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | topoisomerase (DNA) II alpha 170kDa | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0061 | 0.0422 | 0.0402 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0063 | 0.0452 | 0.0432 |
Mycobacterium ulcerans | two component transcriptional regulatory protein DevR | 0.0399 | 0.6993 | 1 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0554 | 1 | 1 |
Mycobacterium leprae | PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN | 0.0399 | 0.6993 | 0.5 |
Trypanosoma brucei | metacaspase 5, putative | 0.0048 | 0.0174 | 0.2686 |
Echinococcus multilocularis | enteropeptidase | 0.0104 | 0.1265 | 0.1265 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0061 | 0.0422 | 0.0402 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.1265 | 0.1247 |
Schistosoma mansoni | caspase-3 (C14 family) | 0.0127 | 0.1714 | 0.1696 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0104 | 0.1265 | 0.1247 |
Brugia malayi | hypoxia-induced factor 1 | 0.0164 | 0.2425 | 0.2425 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0104 | 0.1265 | 0.1247 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0048 | 0.0174 | 0.2123 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0554 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0554 | 1 | 1 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0104 | 0.1265 | 0.1247 |
Echinococcus granulosus | Peptidase S1 S6 chymotrypsin Hap | 0.0104 | 0.1265 | 0.1265 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0063 | 0.0452 | 0.0432 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0554 | 1 | 1 |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.0104 | 0.1265 | 0.1265 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0048 | 0.0174 | 0.2123 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.1265 | 0.1247 |
Echinococcus granulosus | subfamily S1A unassigned peptidase S01 family | 0.0104 | 0.1265 | 0.1265 |
Mycobacterium ulcerans | putative regulatory protein | 0.0399 | 0.6993 | 1 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0048 | 0.0174 | 0.2123 |
Brugia malayi | mucosa associated lymphoid tissue lymphoma translocation protein 1 | 0.0048 | 0.0174 | 0.0174 |
Onchocerca volvulus | Cell death protein 3 homolog | 0.0093 | 0.1046 | 0.1046 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0048 | 0.0174 | 0.2123 |
Onchocerca volvulus | 0.0104 | 0.1265 | 0.1265 | |
Trypanosoma cruzi | metacaspase 5, putative | 0.0048 | 0.0174 | 0.0154 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0056 | 0.033 | 0.033 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0104 | 0.1265 | 0.1247 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0104 | 0.1265 | 0.1247 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0048 | 0.0174 | 0.2123 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0104 | 0.1265 | 0.1247 |
Echinococcus multilocularis | ubiquitin carboxyl terminal hydrolase 8 | 0.004 | 0.0021 | 0.0021 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0104 | 0.1265 | 0.1247 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0104 | 0.1265 | 0.1247 |
Brugia malayi | Trypsin-like protease protein 5 | 0.0104 | 0.1265 | 0.1265 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.007 | 0.0592 | 0.0573 |
Mycobacterium tuberculosis | Probable transcriptional regulatory protein (LuxR-family) | 0.0399 | 0.6993 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.1265 | 0.1247 |
Echinococcus granulosus | ubiquitin specific protease 41 | 0.004 | 0.0021 | 0.0021 |
Brugia malayi | Trypsin family protein | 0.0104 | 0.1265 | 0.1265 |
Echinococcus granulosus | caspase | 0.0127 | 0.1714 | 0.1714 |
Onchocerca volvulus | 0.0104 | 0.1265 | 0.1265 | |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0164 | 0.2425 | 0.2409 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.011 | 0.0089 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0048 | 0.0174 | 0.2123 |
Echinococcus granulosus | enteropeptidase | 0.0104 | 0.1265 | 0.1265 |
Brugia malayi | Trypsin family protein | 0.0104 | 0.1265 | 0.1265 |
Echinococcus multilocularis | Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 | 0.004 | 0.0021 | 0.0021 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0048 | 0.0174 | 0.2123 |
Brugia malayi | Cell death protein 3 precursor | 0.0093 | 0.1046 | 0.1046 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0174 | 0.0154 |
Echinococcus multilocularis | transmembrane protease serine 3 | 0.0104 | 0.1265 | 0.1265 |
Brugia malayi | Kringle domain containing protein | 0.0554 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0104 | 0.1265 | 0.1247 |
Echinococcus multilocularis | Mastin | 0.0104 | 0.1265 | 0.1265 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0078 | 0.0744 | 0.0744 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0078 | 0.0744 | 1 |
Mycobacterium tuberculosis | Probable transcriptional regulatory protein | 0.0399 | 0.6993 | 1 |
Brugia malayi | Ubiquitin carboxyl-terminal hydrolase family protein | 0.004 | 0.0021 | 0.0021 |
Brugia malayi | PAS domain containing protein | 0.0053 | 0.0268 | 0.0268 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0061 | 0.0422 | 0.7024 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0104 | 0.1265 | 0.1247 |
Giardia lamblia | DNA topoisomerase II | 0.0074 | 0.0678 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.1046 | 0.1028 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0554 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0554 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0554 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0554 | 1 | 1 |
Trypanosoma brucei | Metacaspase-4 | 0.0048 | 0.0174 | 0.2686 |
Mycobacterium ulcerans | hypothetical protein | 0.0399 | 0.6993 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0048 | 0.0174 | 0.2123 |
Echinococcus granulosus | caspase 3 apoptosis cysteine peptidase | 0.0127 | 0.1714 | 0.1714 |
Echinococcus multilocularis | subfamily S1A unassigned peptidase (S01 family) | 0.0104 | 0.1265 | 0.1265 |
Trypanosoma cruzi | metacaspase, putative | 0.0048 | 0.0174 | 0.0154 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0048 | 0.0174 | 0.2123 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0078 | 0.0744 | 0.0744 |
Brugia malayi | Trypsin family protein | 0.0104 | 0.1265 | 0.1265 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.007 | 0.0592 | 0.0573 |
Echinococcus multilocularis | Peptidase S1 S6, chymotrypsin Hap | 0.0104 | 0.1265 | 0.1265 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0048 | 0.0174 | 0.2123 |
Trypanosoma cruzi | metacaspase, putative | 0.0048 | 0.0174 | 0.0154 |
Mycobacterium tuberculosis | Possible two component transcriptional regulatory protein (probably LuxR-family) | 0.0399 | 0.6993 | 1 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0063 | 0.0452 | 0.0647 |
Echinococcus granulosus | transmembrane protease serine 3 | 0.0104 | 0.1265 | 0.1265 |
Mycobacterium tuberculosis | Probable transcriptional regulatory protein (probably LuxR/UhpA-family) | 0.0399 | 0.6993 | 1 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0063 | 0.0452 | 0.0647 |
Brugia malayi | Trypsin family protein | 0.0104 | 0.1265 | 0.1265 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0248 | 0.0228 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.2693 | 0.2677 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0042 | 0.0055 | 0.5 |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.0104 | 0.1265 | 0.1265 |
Schistosoma mansoni | hypothetical protein | 0.0104 | 0.1265 | 0.1247 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0078 | 0.0744 | 0.0725 |
Onchocerca volvulus | 0.0104 | 0.1265 | 0.1265 | |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0078 | 0.0744 | 1 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0078 | 0.0744 | 0.058 |
Onchocerca volvulus | 0.0104 | 0.1265 | 0.1265 | |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0104 | 0.1265 | 0.1247 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0078 | 0.0744 | 0.0744 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0058 | 0.037 | 0.0351 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.1265 | 0.1247 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0104 | 0.1265 | 0.1247 |
Toxoplasma gondii | kringle domain-containing protein | 0.0554 | 1 | 1 |
Echinococcus multilocularis | caspase 3 | 0.0079 | 0.0777 | 0.0777 |
Echinococcus granulosus | Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 | 0.004 | 0.0021 | 0.0021 |
Echinococcus granulosus | apoptotic protease activating factor 1 | 0.0045 | 0.011 | 0.011 |
Schistosoma mansoni | subfamily C14A unassigned peptidase (C14 family) | 0.0048 | 0.0174 | 0.0154 |
Echinococcus multilocularis | caspase 3, apoptosis cysteine peptidase | 0.0127 | 0.1714 | 0.1714 |
Echinococcus multilocularis | caspase 8 | 0.0048 | 0.0174 | 0.0174 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0127 | 0.1714 | 0.1696 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0104 | 0.1265 | 0.1247 |
Brugia malayi | hypothetical protein | 0.0045 | 0.011 | 0.011 |
Mycobacterium tuberculosis | Possible nitrate/nitrite response transcriptional regulatory protein NarL | 0.0399 | 0.6993 | 1 |
Trypanosoma brucei | metacaspase MCA3 | 0.0048 | 0.0174 | 0.2686 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0061 | 0.0422 | 0.0402 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0048 | 0.0174 | 0.2123 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0063 | 0.0452 | 0.0452 |
Brugia malayi | hypothetical protein | 0.0178 | 0.2693 | 0.2693 |
Echinococcus granulosus | caspase 3 | 0.0079 | 0.0777 | 0.0777 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.1265 | 0.1247 |
Onchocerca volvulus | 0.0104 | 0.1265 | 0.1265 | |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.1265 | 0.1247 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.1265 | 0.1247 |
Trypanosoma brucei | metacaspase MCA2 | 0.0048 | 0.0174 | 0.2686 |
Schistosoma mansoni | single-minded | 0.0053 | 0.0268 | 0.0247 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0104 | 0.1265 | 0.1247 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0063 | 0.0452 | 0.0452 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0048 | 0.0174 | 0.2123 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0248 | 0.0228 |
Mycobacterium ulcerans | nitrate/nitrite response regulator protein NarL | 0.0399 | 0.6993 | 1 |
Trypanosoma brucei | metacaspase | 0.0048 | 0.0174 | 0.2686 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.007 | 0.0592 | 1 |
Echinococcus multilocularis | caspase 2 | 0.0093 | 0.1046 | 0.1046 |
Echinococcus multilocularis | caspase | 0.0127 | 0.1714 | 0.1714 |
Schistosoma mansoni | DNA topoisomerase II | 0.0078 | 0.0744 | 0.0725 |
Schistosoma mansoni | hypothetical protein | 0.0045 | 0.011 | 0.0089 |
Trypanosoma cruzi | metacaspase, putative | 0.0048 | 0.0174 | 0.0154 |
Trypanosoma cruzi | metacaspase, putative | 0.0048 | 0.0174 | 0.0154 |
Loa Loa (eye worm) | trypsin family protein | 0.0104 | 0.1265 | 0.1247 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0104 | 0.1265 | 0.1247 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0104 | 0.1265 | 0.1247 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0078 | 0.0744 | 0.0744 |
Echinococcus multilocularis | apoptotic protease activating factor 1 | 0.0045 | 0.011 | 0.011 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0048 | 0.0174 | 0.2123 |
Onchocerca volvulus | 0.0104 | 0.1265 | 0.1265 | |
Mycobacterium ulcerans | hypothetical protein | 0.0104 | 0.1265 | 0.1809 |
Onchocerca volvulus | 0.0045 | 0.011 | 0.011 | |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0554 | 1 | 1 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0063 | 0.0452 | 0.0452 |
Echinococcus granulosus | caspase 8 | 0.0048 | 0.0174 | 0.0174 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0056 | 0.033 | 0.033 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0048 | 0.0174 | 0.2123 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.0078 | 0.0744 | 0.058 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0048 | 0.0174 | 0.2123 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0093 | 0.1046 | 0.1028 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0104 | 0.1265 | 0.1247 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.007 | 0.0592 | 1 |
Echinococcus granulosus | caspase 2 | 0.0093 | 0.1046 | 0.1046 |
Leishmania major | DNA topoisomerase ii | 0.007 | 0.0592 | 0.0573 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.0078 | 0.0744 | 0.058 |
Brugia malayi | Probable DNA topoisomerase II | 0.0078 | 0.0744 | 0.0744 |
Echinococcus multilocularis | ubiquitin specific protease 41 | 0.004 | 0.0021 | 0.0021 |
Echinococcus granulosus | ubiquitin carboxyl terminal hydrolase 8 | 0.004 | 0.0021 | 0.0021 |
Mycobacterium tuberculosis | Possible transcriptional regulatory protein | 0.0399 | 0.6993 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0104 | 0.1265 | 0.1247 |
Trypanosoma cruzi | metacaspase 5, putative | 0.0048 | 0.0174 | 0.0154 |
Mycobacterium ulcerans | two component transcriptional regulator | 0.0399 | 0.6993 | 1 |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.0104 | 0.1265 | 0.1265 |
Leishmania major | metacaspase, putative | 0.0048 | 0.0174 | 0.0154 |
Echinococcus granulosus | Mastin | 0.0104 | 0.1265 | 0.1265 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0104 | 0.1265 | 0.1247 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0053 | 0.0268 | 0.0247 |
Onchocerca volvulus | 0.0554 | 1 | 1 | |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0056 | 0.033 | 0.033 |
Schistosoma mansoni | hypothetical protein | 0.0104 | 0.1265 | 0.1247 |
Brugia malayi | hypothetical protein | 0.0104 | 0.1265 | 0.1265 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Excess zone radius (functional) | = 0 mM | Antimicrobial activity of the compound was tested against gram negative Pseudomonas aeruginosa at a dose of 120 ug | ChEMBL. | No reference |
Excess zone radius (functional) | = 0 mM | Antimicrobial activity of the compound was tested against Trichophyton mentagrophytes fungus at a dose of 120 ug | ChEMBL. | No reference |
Excess zone radius (functional) | = 4.5 mM | In vitro cytotoxic activity of the compound was tested against non-malignant african green monkey kidney cell-line (BSC-1); ranges from 4.5-5 mm | ChEMBL. | No reference |
Excess zone radius (functional) | = 10 mM | Antimicrobial activity of the compound was tested against gram negative Escherichia coli at a dose of 120 ug | ChEMBL. | No reference |
Excess zone radius (functional) | = 10 mM | Antimicrobial activity of the compound was tested against Cladosporium resinae fungus at a dose of 120 ug | ChEMBL. | No reference |
Excess zone radius (functional) | = 10 mM | Antimicrobial activity of the compound was tested against gram negative Escherichia coli at a dose of 120 ug | ChEMBL. | No reference |
Excess zone radius (functional) | = 11 mM | Antimicrobial activity of the compound was tested against Candida albicans fungus at a dose of 120 microg | ChEMBL. | No reference |
Excess zone radius (functional) | = 11 mM | Antimicrobial activity of the compound was tested against Candida albicans fungus at a dose of 120 microg | ChEMBL. | No reference |
Excess zone radius (functional) | = 14 mM | Antimicrobial activity of the compound was tested against gram positive Bacillus subtilis at a dose of 120 ug | ChEMBL. | No reference |
GI50 (functional) | -7.431 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -7.234 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -7.207 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.999 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.846 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.804 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.764 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.73 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.723 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.637 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.31 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
HF (functional) | = 10 | Hypersensitivity Factor(HF) against DNA-double strand break repair deficient Chinese Hamster Ovary (CHO) cell-line xrs-6 versus wild type BR1(IC50 BRI/IC50 xrs-6) | ChEMBL. | No reference |
HF2 (functional) | = 1 | Hypersensitivity Factor (HF2) towards DNA-double strand break repair deficient Chinese Hamster Ovary (CHO) cell-line EM9 versus wild type BR1(IC50 EM9/IC50 xrs-6) | ChEMBL. | No reference |
IC50 (functional) | = 6 nM | In vitro cytotoxicity against human colon cell line HCT-15. | ChEMBL. | 12166949 |
IC50 (functional) | = 6 nM | In vitro cytotoxicity against human colon cell line HCT-15. | ChEMBL. | 12166949 |
IC50 (functional) | = 8 nM | In vitro cytotoxicity against human prostate cell line PC-3. | ChEMBL. | 12166949 |
IC50 (functional) | = 8 nM | In vitro cytotoxicity against human prostate cell line PC-3. | ChEMBL. | 12166949 |
IC50 (functional) | = 60 nM | In vitro cytotoxicity against human non small-cell-lung cell line A-427. | ChEMBL. | 12166949 |
IC50 (functional) | = 60 nM | In vitro cytotoxicity against human non small-cell-lung cell line A-427. | ChEMBL. | 12166949 |
IC50 (functional) | = 70 nM | In vitro cytotoxicity against human glioblastomas cell line U87MG. | ChEMBL. | 12166949 |
IC50 (functional) | = 70 nM | In vitro cytotoxicity against human breast cell line MCF-7. | ChEMBL. | 12166949 |
IC50 (functional) | = 70 nM | In vitro cytotoxicity against human glioblastomas cell line U87MG. | ChEMBL. | 12166949 |
IC50 (functional) | = 70 nM | In vitro cytotoxicity against human breast cell line MCF-7. | ChEMBL. | 12166949 |
IC50 (functional) | = 200 nM | In vitro cytotoxicity against human non small-cell-lung cell line A549. | ChEMBL. | 12166949 |
IC50 (functional) | = 200 nM | In vitro cytotoxicity against human non small-cell-lung cell line A549. | ChEMBL. | 12166949 |
IC50 (functional) | = 300 nM | In vitro cytotoxicity against human bladder cell line J82. | ChEMBL. | 12166949 |
IC50 (functional) | = 300 nM | In vitro cytotoxicity against human bladder cell line J82. | ChEMBL. | 12166949 |
IC50 (functional) | = 500 nM | In vitro cytotoxicity against human glioblastomas cell line U-373MG. | ChEMBL. | 12166949 |
IC50 (functional) | = 500 nM | In vitro cytotoxicity against human glioblastomas cell line U-373MG. | ChEMBL. | 12166949 |
IC50 (functional) | = 600 nM | In vitro cytotoxicity against human glioblastomas cell line SW1088. | ChEMBL. | 12166949 |
IC50 (functional) | = 600 nM | In vitro cytotoxicity against human breast cell line T-47D. | ChEMBL. | 12166949 |
IC50 (functional) | = 600 nM | In vitro cytotoxicity against human breast cell line T-47D. | ChEMBL. | 12166949 |
IC50 (functional) | = 800 nM | In vitro cytotoxicity against human bladder cell line T24. | ChEMBL. | 12166949 |
IC50 (functional) | = 800 nM | In vitro cytotoxicity against human bladder cell line T24. | ChEMBL. | 12166949 |
IC50 (functional) | = 900 nM | In vitro cytotoxicity against human colon cell line LoVo. | ChEMBL. | 12166949 |
IC50 (functional) | = 900 nM | In vitro cytotoxicity against human colon cell line LoVo. | ChEMBL. | 12166949 |
IC50 (functional) | < 0.04 ug ml-1 | Inhibitory concentration required to produce cytotoxicity against VERO cells | ChEMBL. | 16005211 |
IC50 (binding) | > 80 ug ml-1 | Inhibition of telomerase (unknown origin) by TRAP assay | ChEMBL. | No reference |
IC50 (functional) | = 0.03 uM | In vitro cytotoxic activity of the compound was tested against DNA-double strand break repair deficient Chinese Hamster Ovary (CHO) cell-line xrs-6 | ChEMBL. | No reference |
IC50 (functional) | = 0.032 uM | Antitrypanosomal activity against Trypanosoma brucei brucei | ChEMBL. | 22204643 |
IC50 (functional) | = 0.3 uM | In vitro cytotoxic activity of the compound was tested against human colon (HCT116) cell line | ChEMBL. | No reference |
IC50 (functional) | = 0.3 uM | In vitro cytotoxic activity of the compound was tested against human breast (MCF-7) cell line | ChEMBL. | No reference |
IC50 (functional) | = 0.3 uM | In vitro cytotoxic activity towards DNA-double strand break repair deficient Chinese Hamster Ovary (CHO) cell-line EM9 | ChEMBL. | No reference |
IC50 (functional) | = 0.3 uM | In vitro cytotoxic activity of the compound was tested against human colon (HCT116) cell line | ChEMBL. | No reference |
IC50 (functional) | = 0.3 uM | In vitro cytotoxic activity of the compound was tested against human breast (MCF-7) cell line | ChEMBL. | No reference |
IC50 (functional) | = 0.38 uM | Cytotoxicity against human A375 cells after 48 hrs by MTT assay | ChEMBL. | 23961991 |
IC50 (functional) | = 0.4 uM | In vitro cytotoxic activity of the compound was tested against mouse leukemia (P388 ) cell line | ChEMBL. | No reference |
IC50 (functional) | = 0.4 uM | In vitro cytotoxic activity of the compound was tested against mouse leukemia (P388 ) cell line | ChEMBL. | No reference |
IC50 (binding) | = 1.376 uM | Inhibition of DNA topoisomerase 2 (unknown origin) | ChEMBL. | No reference |
MIC (functional) | = 0.1 ug ml-1 | Minimum inhibitory concentration against Mycobacterium tuberculosis H37Rv pFPCA1 in green fluorescent protein microplate assay | ChEMBL. | 16005211 |
MIC (functional) | = 0.1 ug ml-1 | Minimum inhibitory concentration against Mycobacterium tuberculosis H37Rv pFPCA1 in green fluorescent protein microplate assay | ChEMBL. | 16005211 |
MIC (functional) | = 0.2 uM | Antibacterial activity against Escherichia coli after 24 hrs by liquid growth inhibition assay | ChEMBL. | 20491501 |
MIC (functional) | = 0.35 uM | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv | ChEMBL. | 22280816 |
MTD (functional) | = 20 mg kg-1 | Mean tolerated dose following single i.p. injection to B6D2F1/jico mice. | ChEMBL. | 12166949 |
Selectivity (functional) | < 0.4 | Selectivity ratio for IC50 of VERO cells to that of MIC of Mycobacterium tuberculosis H37Rv | ChEMBL. | 16005211 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | ||
Trypanosoma brucei gambiense | 22204643 | ||
Homo sapiens | ChEMBL23 | 12166949 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.