TDR Targets

Basic information

Technical information

TDR Targets ID: 2149823
Name: 4-(4-naphthalen-2-yloxybutoxy)furo[3,2-g]chro men-7-one
MW: 400.131 | Formula: C25H20O5
H donors: 0 H acceptors: 1 LogP: 5.56 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: O=c1ccc2c(o1)cc1c(c2OCCCCOc2ccc3c(c2)cccc3)cco1
InChi: InChI=1S/C25H20O5/c26-24-10-9-20-23(30-24)16-22-21(11-14-28-22)25(20)29-13-4-3-12-27-19-8-7-17-5-1-2-6-18(17)15-19/h1-2,5-11,14-16H,3-4,12-13H2
InChiKey: YKIBVKRKPFXXFH-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4-[4-(2-naphthyloxy)butoxy]furo[3,2-g]chromen-7-one
4-[4-(2-naphthyloxy)butoxy]-7-furo[3,2-g]chromenone

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	potassium voltage-gated channel, shaker-related subfamily, member 5		No references
Homo sapiens	potassium voltage-gated channel, shaker-related subfamily, member 3		No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	potassium voltage gated channel protein	Get druggable targets OG5_127659	All targets in OG5_127659
Brugia malayi	Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit	Get druggable targets OG5_127659	All targets in OG5_127659
Echinococcus multilocularis	potassium voltage gated channel subfamily A	Get druggable targets OG5_127659	All targets in OG5_127659
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127659	All targets in OG5_127659
Schistosoma mansoni	voltage-gated potassium channel	Get druggable targets OG5_127659	All targets in OG5_127659
Schistosoma japonicum	Potassium voltage-gated channel subfamily A member 5, putative	Get druggable targets OG5_127659	All targets in OG5_127659
Echinococcus granulosus	potassium voltage gated channel subfamily A	Get druggable targets OG5_127659	All targets in OG5_127659
Schistosoma japonicum	ko:K04876 potassium voltage-gated channel, Shaker-related subfamily A, member, putative	Get druggable targets OG5_127659	All targets in OG5_127659
Echinococcus multilocularis	potassium voltage gated channel protein	Get druggable targets OG5_127659	All targets in OG5_127659
Schistosoma japonicum	Potassium voltage-gated channel protein Shaker, putative	Get druggable targets OG5_127659	All targets in OG5_127659
Schistosoma mansoni	voltage-gated potassium channel	Get druggable targets OG5_127659	All targets in OG5_127659

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus multilocularis	voltage gated potassium channel	potassium voltage-gated channel, shaker-related subfamily, member 5	613 aa	521 aa	34.9 %
Echinococcus granulosus	shaker cognate	potassium voltage-gated channel, shaker-related subfamily, member 3	575 aa	465 aa	34.4 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Giardia lamblia	Cathepsin B precursor	0.014	0	0.5
Trichomonas vaginalis	glucosylceramidase, putative	0.0205	0.1047	0.1047
Plasmodium vivax	vivapain-2	0.0758	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.039	0.4054	0.4054
Brugia malayi	cathepsin L-like precursor	0.0507	0.5946	0.5946
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0758	1	1
Entamoeba histolytica	cysteine protease, putative	0.039	0.4054	0.4054
Entamoeba histolytica	cysteine protease, putative	0.039	0.4054	0.4054
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0251	0.1791	0.1791
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0758	1	1
Echinococcus multilocularis	cysteine protease	0.0758	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0758	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0758	1	1
Echinococcus granulosus	potassium voltage gated channel subfamily A	0.0397	0.4163	0.4163
Entamoeba histolytica	cysteine proteinase 2	0.039	0.4054	0.4054
Giardia lamblia	Cysteine protease	0.014	0	0.5
Entamoeba histolytica	cysteine protease, putative	0.039	0.4054	0.4054
Schistosoma mansoni	voltage-gated potassium channel	0.0397	0.4163	0.4163
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0758	1	1
Brugia malayi	Cathepsin L-like precursor	0.0507	0.5946	0.5946
Trichomonas vaginalis	glucosylceramidase, putative	0.0216	0.1226	0.1226
Echinococcus granulosus	cysteine protease	0.039	0.4054	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.039	0.4054	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0758	1	1
Loa Loa (eye worm)	hypothetical protein	0.0251	0.1791	0.1791
Schistosoma mansoni	voltage-gated potassium channel	0.0397	0.4163	0.4163
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0507	0.5946	0.5946
Plasmodium vivax	unspecified product	0.0251	0.1791	0.1791
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0758	1	1
Schistosoma mansoni	cathepsin s	0.0251	0.1791	0.1791
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0758	1	1
Giardia lamblia	Cathepsin B precursor	0.014	0	0.5
Brugia malayi	Cathepsin L-like precursor	0.0758	1	1
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.014	0	0.5
Leishmania major	cathepsin L-like protease	0.0758	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0758	1	1
Leishmania major	cathepsin L-like protease	0.0758	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.039	0.4054	0.4054
Entamoeba histolytica	cysteine proteinase, putative	0.039	0.4054	0.4054
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.039	0.4054	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0143	0.0048	0.0048
Trichomonas vaginalis	glucosylceramidase, putative	0.0312	0.2782	0.2782
Echinococcus granulosus	potassium voltage gated channel protein	0.0397	0.4163	0.4163
Trypanosoma cruzi	cysteine proteinase, putative	0.039	0.4054	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0507	0.5946	0.5946
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0758	1	1
Entamoeba histolytica	cysteine protease, putative	0.039	0.4054	0.4054
Echinococcus multilocularis	cathepsin L	0.039	0.4054	0.4054
Entamoeba histolytica	cysteine protease, putative	0.039	0.4054	0.4054
Trypanosoma cruzi	cysteine peptidase, putative	0.039	0.4054	0.4054
Trypanosoma cruzi	cysteine peptidase, putative	0.0758	1	1
Entamoeba histolytica	cysteine protease, putative	0.039	0.4054	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0758	1	1
Brugia malayi	Cathepsin L-like precursor	0.0758	1	1
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0758	1	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0758	1	1
Giardia lamblia	Cathepsin B precursor	0.014	0	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0758	1	1
Plasmodium vivax	vivapain-2	0.0758	1	1
Echinococcus granulosus	cathepsin l1	0.0758	1	1
Giardia lamblia	Cathepsin L-like protease	0.014	0	0.5
Onchocerca volvulus		0.0758	1	1
Loa Loa (eye worm)	fibroinase	0.0758	1	1
Entamoeba histolytica	cysteine protease, putative	0.039	0.4054	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0758	1	1
Echinococcus multilocularis	potassium voltage gated channel subfamily A	0.0376	0.3815	0.3815
Onchocerca volvulus		0.0507	0.5946	0.5946
Giardia lamblia	Cathepsin B precursor	0.014	0	0.5
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.014	0	0.5
Echinococcus granulosus	cathepsin L cysteine protease	0.039	0.4054	0.4054
Leishmania major	cathepsin L-like protease	0.0758	1	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0251	0.1791	0.1791
Trichomonas vaginalis	glucosylceramidase, putative	0.0312	0.2782	0.2782
Leishmania major	cathepsin L-like protease	0.0758	1	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0758	1	1
Entamoeba histolytica	cysteine protease, putative	0.039	0.4054	0.4054
Trichomonas vaginalis	glucosylceramidase, putative	0.0312	0.2782	0.2782
Brugia malayi	hypothetical protein	0.0535	0.639	0.639
Loa Loa (eye worm)	hypothetical protein	0.0507	0.5946	0.5946
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0758	1	1
Loa Loa (eye worm)	hypothetical protein	0.0353	0.344	0.344
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0251	0.1791	0.1791
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0758	1	1
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0312	0.2782	0.2782
Loa Loa (eye worm)	hypothetical protein	0.0251	0.1791	0.1791
Trichomonas vaginalis	glucosylceramidase, putative	0.0205	0.1047	0.1047
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0758	1	1
Brugia malayi	Cathepsin L-like precursor	0.0758	1	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0758	1	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0758	1	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0205	0.1047	0.1047
Plasmodium vivax	vivapain-3	0.039	0.4054	0.4054
Giardia lamblia	Cathepsin L precursor	0.014	0	0.5
Leishmania major	cathepsin L-like protease	0.0758	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0758	1	1
Giardia lamblia	Cathepsin L-like protease	0.014	0	0.5
Loa Loa (eye worm)	ctsf protein	0.0758	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.039	0.4054	0.4054
Trichomonas vaginalis	glucosylceramidase, putative	0.0205	0.1047	0.1047
Echinococcus granulosus	small conductance calcium activated potassium	0.0353	0.344	0.344
Echinococcus granulosus	cathepsin l1	0.0507	0.5946	0.5946
Trichomonas vaginalis	glucosylceramidase, putative	0.0205	0.1047	0.1047
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0758	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0758	1	1
Entamoeba histolytica	cysteine protease, putative	0.0758	1	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0758	1	1
Entamoeba histolytica	cysteine protease, putative	0.039	0.4054	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0758	1	1
Giardia lamblia	Cysteine protease	0.014	0	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0758	1	1
Plasmodium falciparum	cysteine proteinase falcipain 1	0.039	0.4054	0.4054
Echinococcus multilocularis	small conductance calcium activated potassium	0.0353	0.344	0.344
Onchocerca volvulus	Glucosylceramidase homolog	0.0205	0.1047	0.1047
Trichomonas vaginalis	glucosylceramidase, putative	0.0205	0.1047	0.1047
Trichomonas vaginalis	glucosylceramidase, putative	0.0312	0.2782	0.2782
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0507	0.5946	0.5946
Brugia malayi	Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit	0.0397	0.4163	0.4163
Onchocerca volvulus		0.0758	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0758	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0758	1	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0312	0.2782	0.2782
Echinococcus multilocularis	potassium voltage gated channel protein	0.0397	0.4163	0.4163
Schistosoma mansoni	calcium-activated potassium channel	0.0353	0.344	0.344
Trypanosoma cruzi	cysteine protease, putative	0.039	0.4054	0.4054
Entamoeba histolytica	cysteine protease, putative	0.039	0.4054	0.4054
Onchocerca volvulus		0.0758	1	1
Brugia malayi	Cathepsin L-like precursor	0.0507	0.5946	0.5946
Giardia lamblia	Hypothetical protein	0.014	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0251	0.1791	0.1791
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.039	0.4054	0.4054
Giardia lamblia	Cathepsin L precursor	0.014	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0507	0.5946	0.5946
Giardia lamblia	Cathepsin L precursor	0.014	0	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0758	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0758	1	1
Schistosoma mansoni	calcium-activated potassium channel	0.0271	0.2122	0.2122
Entamoeba histolytica	cysteine protease, putative	0.039	0.4054	0.4054
Schistosoma mansoni	cathepsin F (C01 family)	0.0507	0.5946	0.5946
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0758	1	1
Onchocerca volvulus		0.0535	0.639	0.639
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0758	1	1
Giardia lamblia	Cathepsin B precursor	0.014	0	0.5
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.039	0.4054	0.4054
Plasmodium vivax	vivapain-1	0.039	0.4054	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0758	1	1
Onchocerca volvulus		0.0758	1	1
Giardia lamblia	Cathepsin L precursor	0.014	0	0.5
Entamoeba histolytica	cysteine proteinase, putative	0.0758	1	1
Loa Loa (eye worm)	cysteine protease	0.0758	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0758	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0758	1	1
Loa Loa (eye worm)	hypothetical protein	0.0535	0.639	0.639
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0758	1	1
Leishmania major	cathepsin L-like protease	0.0758	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0507	0.5946	0.5946
Onchocerca volvulus		0.0758	1	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0758	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0758	1	1
Leishmania major	cysteine peptidase A (CPA)	0.0758	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.039	0.4054	0.4054
Trichomonas vaginalis	glucosylceramidase, putative	0.0205	0.1047	0.1047
Brugia malayi	cathepsin F-like cysteine proteinase	0.0251	0.1791	0.1791
Giardia lamblia	Cathepsin B precursor	0.014	0	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0758	1	1
Loa Loa (eye worm)	hypothetical protein	0.0535	0.639	0.639
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0758	1	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.039	0.4054	0.4054
Echinococcus granulosus	cathepsin L	0.039	0.4054	0.4054
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.039	0.4054	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0758	1	1
Giardia lamblia	Hypothetical protein	0.014	0	0.5
Entamoeba histolytica	cysteine proteinase, putative	0.0758	1	1
Loa Loa (eye worm)	hypothetical protein	0.0397	0.4163	0.4163
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.014	0	0.5
Brugia malayi	Papain family cysteine protease containing protein	0.039	0.4054	0.4054
Giardia lamblia	Cathepsin L precursor	0.014	0	0.5
Onchocerca volvulus		0.0758	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0758	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0758	1	1
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0312	0.2782	0.2782
Trypanosoma cruzi	cysteine peptidase, putative	0.0251	0.1791	0.1791
Onchocerca volvulus	Cathepsin F homolog	0.0758	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0758	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0758	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0758	1	1
Onchocerca volvulus	Cathepsin L homolog	0.0758	1	1
Giardia lamblia	Cathepsin L precursor	0.014	0	0.5
Schistosoma mansoni	cathepsin F (C01 family)	0.0758	1	1
Giardia lamblia	Cathepsin B precursor	0.014	0	0.5
Entamoeba histolytica	cysteine protease, putative	0.039	0.4054	0.4054
Entamoeba histolytica	cysteine proteinase 1, putative	0.039	0.4054	0.4054
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0758	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.039	0.4054	0.4054
Onchocerca volvulus		0.0758	1	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0507	0.5946	0.5946
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0758	1	1
Giardia lamblia	Cysteine protease	0.014	0	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0758	1	1
Entamoeba histolytica	cysteine protease, putative	0.039	0.4054	0.4054
Schistosoma mansoni	hypothetical protein	0.0353	0.344	0.344
Loa Loa (eye worm)	hypothetical protein	0.0758	1	1
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.014	0	0.5
Leishmania major	cathepsin L-like protease	0.0758	1	1
Giardia lamblia	Cathepsin B precursor	0.014	0	0.5
Echinococcus multilocularis	cysteine protease	0.0758	1	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0758	1	1
Onchocerca volvulus	Cathepsin L homolog	0.0758	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0758	1	1
Brugia malayi	Cathepsin L-like precursor	0.0758	1	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0312	0.2782	0.2782
Giardia lamblia	Cysteine protease	0.014	0	0.5
Toxoplasma gondii	cathepsin CPL	0.0758	1	1
Brugia malayi	Cathepsin L-like precursor	0.0251	0.1791	0.1791
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0507	0.5946	0.5946
Brugia malayi	Cathepsin L-like precursor	0.0758	1	1
Plasmodium vivax	unspecified product	0.039	0.4054	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0758	1	1
Leishmania major	cathepsin L-like protease	0.0758	1	1
Trypanosoma cruzi	cysteine proteinase, putative	0.039	0.4054	0.4054
Trichomonas vaginalis	glucosylceramidase, putative	0.0216	0.1226	0.1226
Giardia lamblia	Encystation-specific protease	0.014	0	0.5
Brugia malayi	Papain family cysteine protease containing protein	0.039	0.4054	0.4054

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (binding)	= 12 nM	Inhibition of Kv1	PATENT.	No reference
EC50 (binding)	= 80 nM	Inhibition of Kv1	PATENT.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3985258

Bibliographic References

No literature references available for this target.

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Detailed information for compound 2149823