Detailed information for compound 214997

Basic information

Technical information
  • TDR Targets ID: 214997
  • Name: benzyl N-[(2S,5S,11bR)-5-[[(2R)-1-amino-1-oxo -3-phenylpropan-2-yl]carbamoyl]-3-oxo-1,2,5,6 ,11,11b-hexahydroindolo[3,2-g]indolizin-2-yl] carbamate
  • MW: 565.619 | Formula: C32H31N5O5
  • H donors: 4 H acceptors: 4 LogP: 3.17 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(N[C@H]1C[C@H]2N(C1=O)[C@@H](Cc1c2[nH]c2c1cccc2)C(=O)N[C@@H](C(=O)N)Cc1ccccc1)OCc1ccccc1
  • InChi: 1S/C32H31N5O5/c33-29(38)24(15-19-9-3-1-4-10-19)35-30(39)27-16-22-21-13-7-8-14-23(21)34-28(22)26-17-25(31(40)37(26)27)36-32(41)42-18-20-11-5-2-6-12-20/h1-14,24-27,34H,15-18H2,(H2,33,38)(H,35,39)(H,36,41)/t24-,25+,26-,27+/m1/s1
  • InChiKey: USFVHFFEUZVHCE-RAVGUYNFSA-N  


Substructure search Similarity search

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Synonyms

  • benzyl N-[(2S,5S,11bR)-5-[[(1R)-2-amino-1-benzyl-2-oxo-ethyl]carbamoyl]-3-oxo-1,2,5,6,11,11b-hexahydroindolo[3,2-g]indolizin-2-yl]carbamate
  • N-[(2S,5S,11bR)-5-[[[(1R)-2-amino-1-benzyl-2-oxoethyl]amino]-oxomethyl]-3-oxo-1,2,5,6,11,11b-hexahydroindolo[3,2-g]indolizin-2-yl]carbamic acid benzyl ester
  • phenylmethyl N-[(2S,5S,11bR)-5-[[(2R)-1-azanyl-1-oxo-3-phenyl-propan-2-yl]carbamoyl]-3-oxo-1,2,5,6,11,11b-hexahydroindolo[3,2-g]indolizin-2-yl]carbamate
  • N-[(2S,5S,11bR)-5-[[(1R)-2-amino-1-benzyl-2-keto-ethyl]carbamoyl]-3-keto-1,2,5,6,11,11b-hexahydropyrrolo[2,1-a]$b-carbolin-2-yl]carbamic acid benzyl ester
  • phenylmethyl N-[(2S,5S,11bR)-5-[[(2R)-1-amino-1-oxo-3-phenylpropan-2-yl]carbamoyl]-3-oxo-1,2,5,6,11,11b-hexahydroindolo[3,2-g]indolizin-2-yl]carbamate
  • phenylmethyl N-[(2S,5S,11bR)-5-[[(1R)-2-amino-2-oxo-1-(phenylmethyl)ethyl]carbamoyl]-3-oxo-1,2,5,6,11,11b-hexahydroindolo[3,2-g]indolizin-2-yl]carbamate
  • N-[(2S,5S,11bR)-5-[[[(1R)-2-amino-2-oxo-1-(phenylmethyl)ethyl]amino]-oxomethyl]-3-oxo-1,2,5,6,11,11b-hexahydroindolo[3,2-g]indolizin-2-yl]carbamic acid phenylmethyl ester
  • N-[(2S,5S,11bR)-5-[[(1R)-2-amino-1-(benzyl)-2-keto-ethyl]carbamoyl]-3-keto-1,2,5,6,11,11b-hexahydropyrrolo[5,1-a]$b-carbolin-2-yl]carbamic acid benzyl ester
  • phenylmethyl N-[(2S,5S,11bR)-5-[[(2R)-1-amino-1-oxo-3-phenyl-propan-2-yl]carbamoyl]-3-oxo-1,2,5,6,11,11b-hexahydroindolo[3,2-g]indolizin-2-yl]carbamate

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Cholecystokinin A receptor Starlite/ChEMBL References
Trypanosoma cruzi cysteine peptidase, putative Curated by TDR Targets References
Rattus norvegicus Cholecystokinin B receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi sulfakinin receptor protein Get druggable targets OG5_132882 All targets in OG5_132882
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi hypothetical protein Get druggable targets OG5_132882 All targets in OG5_132882
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132882 All targets in OG5_132882
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis neuropeptides capa receptor Cholecystokinin A receptor   444 aa 400 aa 21.0 %
Schistosoma japonicum ko:K04145 dopamine receptor D2, putative Cholecystokinin A receptor   444 aa 395 aa 24.6 %
Schistosoma mansoni biogenic amine (5HT) receptor Cholecystokinin A receptor   444 aa 362 aa 28.2 %
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Cholecystokinin A receptor   444 aa 374 aa 24.6 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Cholecystokinin A receptor   444 aa 364 aa 28.6 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Cholecystokinin A receptor   444 aa 379 aa 24.8 %
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor Cholecystokinin A receptor   444 aa 383 aa 21.7 %
Schistosoma mansoni amine GPCR Cholecystokinin A receptor   444 aa 412 aa 26.2 %
Echinococcus multilocularis orexin receptor type 2 Cholecystokinin A receptor   444 aa 362 aa 22.4 %
Loa Loa (eye worm) hypothetical protein Cholecystokinin B receptor   452 aa 389 aa 31.4 %
Echinococcus multilocularis serotonin receptor Cholecystokinin A receptor   444 aa 468 aa 22.4 %
Schistosoma mansoni rhodopsin-like orphan GPCR Cholecystokinin A receptor   444 aa 380 aa 24.2 %
Echinococcus multilocularis g protein coupled receptor Cholecystokinin A receptor   444 aa 396 aa 23.2 %
Echinococcus granulosus orexin receptor type 2 Cholecystokinin A receptor   444 aa 366 aa 23.5 %
Echinococcus granulosus rhodopsin orphan GPCR Cholecystokinin A receptor   444 aa 363 aa 19.6 %
Echinococcus granulosus g protein coupled receptor Cholecystokinin A receptor   444 aa 396 aa 23.5 %
Onchocerca volvulus Cholecystokinin A receptor   444 aa 385 aa 28.6 %
Schistosoma japonicum FMRFamide receptor, putative Cholecystokinin A receptor   444 aa 363 aa 21.2 %
Echinococcus granulosus g protein coupled receptor Cholecystokinin A receptor   444 aa 399 aa 23.3 %
Echinococcus multilocularis g protein coupled receptor Cholecystokinin A receptor   444 aa 403 aa 24.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0039 0.0154
Toxoplasma gondii aldehyde dehydrogenase 0.0068 0.0709 0.2691
Loa Loa (eye worm) hypothetical protein 0.003 0.0172 0.0172
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0039 0.0154
Leishmania major cathepsin L-like protease 0.002 0.0039 0.0116
Onchocerca volvulus 0.002 0.0039 0.0076
Onchocerca volvulus 0.002 0.0039 0.0076
Leishmania major cathepsin L-like protease 0.0077 0.083 0.2472
Onchocerca volvulus 0.0162 0.2017 0.394
Trypanosoma cruzi metacaspase, putative 0.0199 0.2534 1
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.083 0.3275
Trypanosoma cruzi metacaspase 5, putative 0.0199 0.2534 1
Loa Loa (eye worm) hypothetical protein 0.0186 0.2343 0.2343
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0199 0.2534 1
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0259 0.3358 0.4731
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0551 0.2175
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0199 0.2534 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0039 0.0154
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.083 0.3275
Brugia malayi Cell death protein 3 precursor 0.0385 0.5119 0.5119
Onchocerca volvulus 0.0057 0.0551 0.1076
Schistosoma mansoni lamin 0.003 0.018 0.0254
Chlamydia trachomatis dehyroquinate synthase 0.0207 0.2636 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0199 0.2534 1
Onchocerca volvulus 0.002 0.0039 0.0076
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0551 0.2175
Echinococcus granulosus lamin dm0 0.003 0.018 0.0254
Plasmodium vivax hypothetical protein, conserved 0.0199 0.2534 1
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0257 1
Trichomonas vaginalis guanylate cyclase, putative 0.0057 0.0551 0.2175
Brugia malayi hypothetical protein 0.0022 0.0061 0.0061
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0257 0.1237
Echinococcus multilocularis caspase 0.0527 0.7098 1
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0551 0.2175
Trichomonas vaginalis conserved hypothetical protein 0.0199 0.2534 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.083 0.3275
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0039 0.0154
Mycobacterium ulcerans 3-dehydroquinate synthase 0.0207 0.2636 0.7849
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0039 0.0055
Plasmodium vivax metacaspase 1, putative 0.0199 0.2534 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.083 0.3275
Trypanosoma cruzi metacaspase, putative 0.0199 0.2534 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0259 0.3358 1
Leishmania major cathepsin L-like protease 0.0077 0.083 0.2472
Trichomonas vaginalis conserved hypothetical protein 0.0199 0.2534 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0057 0.0551 0.2175
Plasmodium vivax vivapain-2 0.002 0.0039 0.0154
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0259 0.3358 1
Plasmodium vivax vivapain-2 0.002 0.0039 0.0154
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.0709 0.0999
Echinococcus granulosus apoptotic protease activating factor 1 0.0186 0.2343 0.3301
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0167 0.2078 0.8203
Loa Loa (eye worm) hypothetical protein 0.0261 0.3393 0.3393
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.083 0.3275
Leishmania major cathepsin L-like protease 0.002 0.0039 0.0116
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.06 0.237
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0057 0.0551 0.2175
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0205 0.0777
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.083 0.3275
Echinococcus granulosus arachidonate 5 lipoxygenase 0.013 0.1573 0.2217
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0111 0.1305 0.3619
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0167 0.2078 0.2928
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0114 0.0448
Leishmania major cytochrome p450-like protein 0.0026 0.0114 0.0338
Loa Loa (eye worm) inositol-1 0.0036 0.0257 0.0257
Trypanosoma cruzi metacaspase 5, putative 0.0199 0.2534 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0057 0.0551 0.2175
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0039 0.0055
Onchocerca volvulus 0.0022 0.0061 0.0119
Loa Loa (eye worm) CYP4Cod1 0.0026 0.0114 0.0114
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0167 0.2078 1
Schistosoma mansoni rab6-interacting 0.0022 0.0061 0.0086
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0057 0.0551 0.2175
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0039 0.0154
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0257 0.0975
Onchocerca volvulus 0.002 0.0039 0.0076
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0039 0.0154
Loa Loa (eye worm) intermediate filament protein 0.003 0.018 0.018
Brugia malayi Cathepsin L-like precursor 0.002 0.0039 0.0039
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0167 0.2078 0.2928
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0057 0.0551 0.2175
Schistosoma mansoni aryl hydrocarbon receptor 0.0219 0.2811 0.396
Echinococcus granulosus aryl hydrocarbon receptor 0.0057 0.0551 0.0776
Mycobacterium tuberculosis 3-phosphoshikimate 1-carboxyvinyltransferase AroA (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (EPSPS) 0.0111 0.1305 0.3888
Echinococcus multilocularis lamin 0.003 0.018 0.0254
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0257 0.0362
Echinococcus granulosus caspase 0.0527 0.7098 1
Trypanosoma brucei Metacaspase-4 0.0199 0.2534 1
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0039 0.0154
Brugia malayi hypothetical protein 0.0022 0.0061 0.0061
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0167 0.2078 0.2928
Echinococcus granulosus cathepsin l1 0.002 0.0039 0.0055
Brugia malayi Doublecortin family protein 0.0022 0.0061 0.0061
Leishmania major protein kinase, putative 0.0057 0.0551 0.1641
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.083 0.3275
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0257 0.0765
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0111 0.1305 0.3888
Leishmania major metacaspase, putative 0.0199 0.2534 0.7546
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0257 0.0765
Echinococcus multilocularis musashi 0.003 0.018 0.0254
Echinococcus multilocularis caspase 3 0.0328 0.4322 0.6089
Schistosoma mansoni caspase-7 (C14 family) 0.0385 0.5119 0.7213
Loa Loa (eye worm) fibroinase 0.002 0.0039 0.0039
Onchocerca volvulus 0.0022 0.0061 0.0119
Brugia malayi Cytochrome P450 family protein 0.0026 0.0114 0.0114
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.0039 0.0154
Echinococcus granulosus Polycystic kidney disease protein 0.0022 0.0061 0.0086
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0057 0.0551 0.2175
Trypanosoma brucei metacaspase MCA2 0.0199 0.2534 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0039 0.0154
Trichomonas vaginalis adenylate cyclase, putative 0.0057 0.0551 0.2175
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0039 0.0154
Schistosoma mansoni lipoxygenase 0.0091 0.1027 0.1447
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.013 0.1573 0.2217
Brugia malayi Inositol-1 0.0036 0.0257 0.0257
Brugia malayi Cathepsin L-like precursor 0.002 0.0039 0.0039
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0259 0.3358 1
Brugia malayi bHLH-PAS transcription factor 0.0162 0.2017 0.2017
Loa Loa (eye worm) hypothetical protein 0.0167 0.2078 0.2078
Loa Loa (eye worm) hypoxia-induced factor 1 0.0679 0.9207 0.9207
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0167 0.2078 0.8203
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0068 0.0709 0.2112
Brugia malayi Cytochrome P450 family protein 0.0026 0.0114 0.0114
Echinococcus multilocularis Polycystic kidney disease protein 0.0022 0.0061 0.0086
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0068 0.0709 0.2112
Onchocerca volvulus 0.003 0.018 0.0352
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.018 0.018
Echinococcus multilocularis lamin dm0 0.003 0.018 0.0254
Trypanosoma brucei cytochrome P450, putative 0.0026 0.0114 0.0448
Leishmania major protein kinase, putative 0.0057 0.0551 0.1641
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0259 0.3358 0.4731
Loa Loa (eye worm) hypothetical protein 0.003 0.018 0.018
Loa Loa (eye worm) hypothetical protein 0.0385 0.5119 0.5119
Trypanosoma brucei metacaspase 0.0199 0.2534 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.083 0.3275
Onchocerca volvulus 0.002 0.0039 0.0076
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0527 0.7098 1
Echinococcus granulosus caspase 2 0.0385 0.5119 0.7213
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0167 0.2078 1
Schistosoma mansoni lipoxygenase 0.013 0.1573 0.2217
Entamoeba histolytica cysteine protease, putative 0.002 0.0039 0.0188
Trichomonas vaginalis conserved hypothetical protein 0.0199 0.2534 1
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0057 0.0551 0.2175
Echinococcus multilocularis ubiquitin specific protease 41 0.0167 0.2078 0.2928
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0167 0.2078 0.2078
Schistosoma mansoni intermediate filament proteins 0.003 0.018 0.0254
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.083 0.3275
Brugia malayi hypoxia-induced factor 1 0.0679 0.9207 0.9207
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.083 0.3275
Echinococcus multilocularis cysteine protease 0.002 0.0039 0.0055
Leishmania major cathepsin L-like protease 0.002 0.0039 0.0116
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0114 0.0448
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0199 0.2534 0.357
Onchocerca volvulus Cathepsin L homolog 0.002 0.0039 0.0076
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0111 0.1305 0.4953
Trichomonas vaginalis guanylate cyclase, putative 0.0057 0.0551 0.2175
Echinococcus multilocularis caspase 2 0.0385 0.5119 0.7213
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0039 0.0039
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0167 0.2078 0.2928
Trypanosoma brucei metacaspase 5, putative 0.0199 0.2534 1
Onchocerca volvulus 0.0186 0.2343 0.4577
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0057 0.0551 0.0551
Onchocerca volvulus Cathepsin F homolog 0.002 0.0039 0.0076
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0259 0.3358 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0061 0.0086
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.083 0.3275
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0167 0.2078 0.8203
Schistosoma mansoni inositol monophosphatase 0.0036 0.0257 0.0362
Loa Loa (eye worm) hypothetical protein 0.0199 0.2534 0.2534
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0167 0.2078 0.619
Onchocerca volvulus Cathepsin L homolog 0.002 0.0039 0.0076
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.0039 0.0154
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0257 0.1014
Trypanosoma cruzi metacaspase, putative 0.0199 0.2534 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0061
Mycobacterium leprae Possible regulatory protein 0.0057 0.0551 0.2091
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0167 0.2078 0.8203
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0039 0.0154
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0039 0.0055
Schistosoma mansoni rab6-interacting 0.0022 0.0061 0.0086
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0199 0.2534 0.2534
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0039 0.0154
Schistosoma mansoni caspase-3 (C14 family) 0.0527 0.7098 1
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0257 0.0362
Loa Loa (eye worm) hypothetical protein 0.0057 0.0551 0.0551
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0199 0.2534 1
Echinococcus multilocularis aryl hydrocarbon receptor 0.0057 0.0551 0.0776
Brugia malayi PAS domain containing protein 0.0219 0.2811 0.2811
Trichomonas vaginalis conserved hypothetical protein 0.0199 0.2534 1
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0259 0.3358 0.4731
Loa Loa (eye worm) ctsf protein 0.002 0.0039 0.0039
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0257 0.1014
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0199 0.2534 1
Schistosoma mansoni caspase-7 (C14 family) 0.0527 0.7098 1
Trichomonas vaginalis conserved hypothetical protein 0.0167 0.2078 0.8203
Plasmodium falciparum LCCL domain-containing protein 0.0022 0.0061 0.0241
Schistosoma mansoni single-minded 0.0219 0.2811 0.396
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0026 0.0114 0.0338
Mycobacterium ulcerans putative regulatory protein 0.0162 0.2017 0.6007
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0199 0.2534 1
Echinococcus multilocularis apoptotic protease activating factor 1 0.0186 0.2343 0.3301
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0057 0.0551 0.2175
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0039 0.0154
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0039 0.0039
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0039 0.0188
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0199 0.2534 1
Leishmania major cathepsin L-like protease 0.002 0.0039 0.0116
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0257 0.1014
Echinococcus granulosus RUN 0.0022 0.0061 0.0086
Echinococcus granulosus caspase 3 0.0328 0.4322 0.6089
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0207 0.2636 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0068 0.0709 0.0999
Echinococcus granulosus ubiquitin specific protease 41 0.0167 0.2078 0.2928
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0039 0.0039
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0199 0.2534 0.9614
Onchocerca volvulus 0.003 0.018 0.0352
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0199 0.2534 0.9614
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0039 0.0188
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.083 0.3275
Onchocerca volvulus 0.002 0.0039 0.0076
Echinococcus multilocularis cysteine protease 0.002 0.0039 0.0055
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0114 0.0114
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.0709 0.0999
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0527 0.7098 1
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0057 0.0551 0.2175
Leishmania major cysteine peptidase A (CPA) 0.002 0.0039 0.0116
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0039 0.0154
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0039 0.0055
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0039 0.0055
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0199 0.2534 1
Schistosoma mansoni 3-dehydroquinate synthase 0.0207 0.2636 0.3713
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0039 0.0154
Brugia malayi hypothetical protein 0.0186 0.2343 0.2343
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0057 0.0551 0.0776
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.0709 0.2112
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0039 0.0154
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0039 0.0154
Plasmodium vivax multidomain scavenger receptor, putative 0.0022 0.0061 0.0241
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0039 0.0154
Schistosoma mansoni inositol monophosphatase 0.0036 0.0257 0.0362
Schistosoma mansoni loxhd1 0.0022 0.0061 0.0086
Brugia malayi Cathepsin L-like precursor 0.002 0.0039 0.0039
Schistosoma mansoni polycystin 1-related 0.0022 0.0061 0.0086
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0039 0.0154
Leishmania major cathepsin L-like protease 0.0077 0.083 0.2472
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.083 0.3275
Echinococcus multilocularis RUN 0.0022 0.0061 0.0086
Echinococcus granulosus caspase 8 0.0199 0.2534 0.357
Onchocerca volvulus Cell death protein 3 homolog 0.0385 0.5119 1
Echinococcus multilocularis caspase 8 0.0199 0.2534 0.357
Plasmodium falciparum metacaspase-like protein 0.0199 0.2534 1
Mycobacterium tuberculosis 3-dehydroquinate synthase AroB 0.0207 0.2636 0.7849
Plasmodium falciparum metacaspase 1 0.0199 0.2534 1
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0167 0.2078 0.2928
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0039 0.0154
Toxoplasma gondii cathepsin CPL 0.002 0.0039 0.0148
Brugia malayi Cathepsin L-like precursor 0.002 0.0039 0.0039
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0039 0.0154
Schistosoma mansoni lamin 0.003 0.018 0.0254
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0257 0.1014
Brugia malayi hypothetical protein 0.0261 0.3393 0.3393
Trichomonas vaginalis conserved hypothetical protein 0.0199 0.2534 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.0737 0.2908
Schistosoma mansoni hypothetical protein 0.0186 0.2343 0.3301
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.0039 0.0154
Trypanosoma cruzi metacaspase, putative 0.0199 0.2534 1
Onchocerca volvulus 0.002 0.0039 0.0076
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.0709 0.2112
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0167 0.2078 0.8203
Brugia malayi Cathepsin L-like precursor 0.002 0.0039 0.0039
Echinococcus granulosus lamin 0.003 0.018 0.0254
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0199 0.2534 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0061 0.0086
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0057 0.0551 0.1641
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0257 0.1014
Echinococcus granulosus single minded 2 0.0162 0.2017 0.2842
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0039 0.0055
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0259 0.3358 0.3358
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0039 0.0154
Trypanosoma brucei metacaspase MCA3 0.0199 0.2534 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0114 0.0114
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0057 0.0551 0.2175
Loa Loa (eye worm) doublecortin family protein 0.0022 0.0061 0.0061
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0039 0.0154
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0241 0.3115 0.3115
Echinococcus multilocularis transfer RNA-Lys 0.0162 0.2017 0.2842
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0039 0.0154
Brugia malayi intermediate filament protein 0.003 0.018 0.018
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0257 0.1014
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0057 0.0551 0.2175
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0199 0.2534 0.9614
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0167 0.2078 0.2928
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0057 0.0551 0.0776
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0061
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0205 0.061
Loa Loa (eye worm) cysteine protease 0.002 0.0039 0.0039
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0039 0.0154
Mycobacterium leprae 3-dehydroquinate synthase AroB 0.0207 0.2636 1
Brugia malayi sulfakinin receptor protein 0.0261 0.3393 0.3393
Schistosoma mansoni hypothetical protein 0.0022 0.0061 0.0086
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0039 0.0154
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.0709 0.2112
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.018 0.018
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0039 0.0154
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.083 0.3275
Echinococcus granulosus intermediate filament protein 0.003 0.018 0.0254
Loa Loa (eye worm) hypothetical protein 0.0736 1 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0039 0.0039
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0061 0.0086
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.083 0.3275
Leishmania major cathepsin L-like protease 0.002 0.0039 0.0116
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0039 0.0055
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0039 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.0199 0.2534 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0039 0.0039
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0068 0.0709 0.0999
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0061 0.0086

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 1000 nM In vitro inhibition of [3H]-propionyl-CCK-8 binding to rat pancreatic membranes at Cholecystokinin type A receptor. ChEMBL. 11020292
IC50 (binding) > 1000 nM In vitro inhibition of [3H]-propionyl-CCK-8 binding to rat pancreatic membranes at Cholecystokinin type A receptor. ChEMBL. 11020292
IC50 (binding) > 10000 nM In vitro inhibition of [3H]-propionyl-CCK-8 binding to rat cerebral cortex membranes at Cholecystokinin type B receptor. ChEMBL. 11020292
IC50 (binding) > 10000 nM In vitro inhibition of [3H]-propionyl-CCK-8 binding to rat cerebral cortex membranes at Cholecystokinin type B receptor. ChEMBL. 11020292

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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