Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | Curated by TDR Targets | References |
Cavia porcellus | Cholecystokinin A receptor | Starlite/ChEMBL | References |
Homo sapiens | cholecystokinin B receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.013 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.013 | 0 | 0.5 |
Onchocerca volvulus | 0.013 | 0 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0266 | 0.9522 | 0.9522 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.3701 | 0.5 |
Loa Loa (eye worm) | NNMT/PNMT/TEMT family protein | 0.0273 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0266 | 0.9522 | 0.9522 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.3701 | 0.5 |
Brugia malayi | sulfakinin receptor protein | 0.0266 | 0.9522 | 0.9522 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0183 | 0.3701 | 0.5 |
Mycobacterium ulcerans | thymidylate synthase | 0.013 | 0 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.013 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.013 | 0 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.3701 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.013 | 0 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.3701 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.3701 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 10.6 nM | In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]-BH-CCK-8 as radioligand | ChEMBL. | 7966138 |
IC50 (binding) | = 10.6 nM | In vitro affinity to the cholecystokinin type B receptor in guinea pig cortex assayed using [125I]-BH-CCK-8 as radioligand | ChEMBL. | 7966138 |
IC50 (binding) | = 460 nM | In vitro binding affinity for the cholecystokinin type A receptor in guinea pig pancreas assayed using [125I]-BH-CCK-8 as radioligand | ChEMBL. | 7966138 |
IC50 (binding) | = 460 nM | In vitro binding affinity for the cholecystokinin type A receptor in guinea pig pancreas assayed using [125I]-BH-CCK-8 as radioligand | ChEMBL. | 7966138 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.