Detailed information for compound 215331

Basic information

Technical information
  • TDR Targets ID: 215331
  • Name: 2-(4-aminophenyl)sulfonylguanidine
  • MW: 214.245 | Formula: C7H10N4O2S
  • H donors: 3 H acceptors: 2 LogP: -0.71 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1ccc(cc1)S(=O)(=O)N=C(N)N
  • InChi: 1S/C7H10N4O2S/c8-5-1-3-6(4-2-5)14(12,13)11-7(9)10/h1-4H,8H2,(H4,9,10,11)
  • InChiKey: BRBKOPJOKNSWSG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-sulfanilylguanidine
  • Sulfaguanidine
  • 61116-95-8
  • 57-67-0
  • IDI1_000633
  • DivK1c_000633
  • D02437
  • Sulfaguanidine (INN)
  • 4-amino-N-[amino(imino)methyl]benzenesulfonamide
  • ZINC03873927
  • ((4-Aminophenyl)sulfonyl)guanidine
  • ((p-Aminophenyl)sulfonyl)guanidine
  • 1-((p-Aminophenyl)sulfonyl)guanidine
  • 4-Amino-N-(aminoiminomethyl)benzenesulfonamide
  • 4-Amino-N-(diaminomethylene)benzenesulfonamide
  • AI3-01048
  • Benzenesulfonamide, 4-amino-N-(diaminomethylene)-
  • EINECS 200-345-9
  • Emerin (pharmaceutical) (VAN)
  • N(sup 1)-(Diaminomethylene)sulfanilamide
  • N(sup 1)-Amidinosulfanilamide
  • N(sup 1)-Guanylsulfanilamide
  • N-p-Aminobenzenesulphonylguanidine monohydrate
  • NSC 14041
  • SILFANILYL-GUANIDINE
  • Shigatox
  • Solfaguanidina [DCIT]
  • Sulfaguanidina [INN-Spanish]
  • Sulfaguanidine [INN]
  • Sulfaguanidinum [INN-Latin]
  • Sulfanilamide, N(sup 1)-amidino-
  • Sulfanilamide, N1-amidino- (8CI)
  • Sulginum
  • Sulphaguanidine
  • CAS-57-67-0
  • NCGC00016252-01
  • Prestwick_429
  • NCGC00024191-03
  • NCGC00024191-04
  • SPECTRUM1501146
  • KBio1_000633
  • 46818_RIEDEL
  • Sulfaguanidine monohydrate
  • ARONIS018061
  • Spectrum2_001420
  • SPBio_001940
  • Prestwick0_000010
  • Spectrum_001412
  • MLS000069712
  • SMR000058191
  • 1-Sulfanilylguanidine
  • 1-[(p-Aminophenyl)sulfonyl]guanidine
  • A-307
  • Abiguanil
  • Aterian
  • Benzenesulfonamide, 4-amino-N-(aminoiminomethyl)-
  • Diacta
  • Emerin (pharmaceutical)
  • Ganidan
  • Guamide
  • Guanicil
  • Guanidan
  • Guanidine, sulfanilyl-
  • N(sup1)-Amidinosulfanilamide
  • N(sup1)-Guanylsulfanilamide
  • N-Guanylsulfanilamide
  • N1-Amidinosulfanilamide
  • BPBio1_000021
  • Orgaguanidon
  • RP 2275
  • Resulfon
  • Ruocid
  • BSPBio_002951
  • Suganyl
  • Sulfaguamidine
  • Sulfaguanidin
  • Sulfaguanil
  • Sulfaguine
  • Sulfanilamide, N1-amidino-
  • Sulfanilamide, n(sup1)-amidino-
  • Sulfanilguanidine
  • Sulfanilylguanidine
  • Sulfentidine
  • Sulfoguanidine
  • Sulfoguanil
  • Sulfoguanyl
  • Sulfoguenil
  • Sulfoquanidine
  • Sulgin
  • WLN: ZR DSWMYZUM
  • [(4-Aminophenyl)sulfonyl]guanidine
  • [(p-Aminophenyl)sulfonyl]guanidine
  • p-Aminobenzenesulfoguanidide
  • p-Aminobenzenesulfonylguanidine
  • NINDS_000633
  • Spectrum4_000429
  • Prestwick1_000010
  • AIDS-008154
  • AIDS008154
  • Prestwick2_000010
  • KBioSS_001892
  • Spectrum3_001456
  • SMP1_000283
  • KBio2_001892
  • KBio2_004460
  • KBio2_007028
  • KBioGR_000758
  • 4-Amino-N-guanylbenzenesulfonamide
  • S8751_SIGMA
  • KBio3_002451
  • Spectrum5_001197
  • NSC14041
  • Prestwick3_000010
  • A0400/0018450
  • BSPBio_000019
  • SPBio_001500
  • S-Guanidine
  • STK064640

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens protease, serine, 1 (trypsin 1) References
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens protease, serine, 3 Starlite/ChEMBL References
Homo sapiens coagulation factor II (thrombin) Starlite/ChEMBL References
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens protease, serine, 2 (trypsin 2) References
Homo sapiens lamin A/C Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Onchocerca volvulus Get druggable targets OG5_126639 All targets in OG5_126639
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) Get druggable targets OG5_126639 All targets in OG5_126639
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) Get druggable targets OG5_126639 All targets in OG5_126639
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K09639 transmembrane protease, serine 8, putative Get druggable targets OG5_126639 All targets in OG5_126639
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K09639 transmembrane protease, serine 8, putative Get druggable targets OG5_126639 All targets in OG5_126639
Onchocerca volvulus Get druggable targets OG5_126639 All targets in OG5_126639
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126639 All targets in OG5_126639
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Trypsin family protein Get druggable targets OG5_126639 All targets in OG5_126639
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126639 All targets in OG5_126639
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Brugia malayi Trypsin family protein protease, serine, 1 (trypsin 1) 247 aa 287 aa 21.6 %
Schistosoma mansoni cercarial elastase (S01 family) protease, serine, 2 (trypsin 2) 247 aa 240 aa 25.8 %
Schistosoma mansoni cercarial elastase (S01 family) protease, serine, 3 261 aa 234 aa 25.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0572 0.5
Brugia malayi beta-lactamase family protein 0.0043 0.0572 0.0572
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0572 0.5
Loa Loa (eye worm) hypothetical protein 0.0043 0.0572 0.0572
Brugia malayi beta-lactamase 0.0043 0.0572 0.0572
Echinococcus granulosus acetylcholinesterase 0.0132 0.3353 0.5965
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0344 1 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0572 0.0572
Loa Loa (eye worm) beta-lactamase 0.0043 0.0572 0.0572
Onchocerca volvulus 0.0043 0.0572 0.0572
Loa Loa (eye worm) carboxylesterase 0.0132 0.3353 0.3353
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0132 0.3353 0.3353
Loa Loa (eye worm) hypothetical protein 0.0043 0.0572 0.0572
Echinococcus granulosus intermediate filament protein 0.0033 0.023 0.0409
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0572 0.5
Mycobacterium ulcerans lipase LipD 0.0043 0.0572 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0572 0.5
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.023 0.023
Loa Loa (eye worm) intermediate filament protein 0.0033 0.023 0.023
Schistosoma mansoni hypothetical protein 0.0205 0.5621 0.5621
Loa Loa (eye worm) hypothetical protein 0.0344 1 1
Echinococcus multilocularis lamin dm0 0.0033 0.023 0.0409
Mycobacterium ulcerans beta-lactamase 0.0043 0.0572 1
Echinococcus multilocularis acetylcholinesterase 0.0132 0.3353 0.5965
Echinococcus granulosus carboxylesterase 5A 0.0132 0.3353 0.5965
Loa Loa (eye worm) hypothetical protein 0.0132 0.3353 0.3353
Loa Loa (eye worm) hypothetical protein 0.0132 0.3353 0.3353
Onchocerca volvulus 0.0344 1 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0572 0.5
Mycobacterium leprae Probable lipase LipE 0.0043 0.0572 0.5
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0572 0.5
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0572 0.5
Schistosoma mansoni lamin 0.0033 0.023 0.023
Onchocerca volvulus 0.0319 0.921 0.921
Loa Loa (eye worm) hypothetical protein 0.0043 0.0572 0.0572
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0572 0.5
Brugia malayi Carboxylesterase family protein 0.0132 0.3353 0.3353
Trichomonas vaginalis esterase, putative 0.0043 0.0572 0.5
Echinococcus granulosus geminin 0.0205 0.5621 1
Echinococcus multilocularis acetylcholinesterase 0.0132 0.3353 0.5965
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.7913 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.023 0.023
Loa Loa (eye worm) acetylcholinesterase 1 0.0132 0.3353 0.3353
Loa Loa (eye worm) hypothetical protein 0.0043 0.0572 0.0572
Loa Loa (eye worm) hypothetical protein 0.0032 0.0211 0.0211
Brugia malayi beta-lactamase family protein 0.0043 0.0572 0.0572
Onchocerca volvulus 0.0033 0.023 0.023
Echinococcus granulosus acetylcholinesterase 0.0132 0.3353 0.5965
Echinococcus multilocularis lamin 0.0033 0.023 0.0409
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0572 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0572 0.0572
Schistosoma mansoni intermediate filament proteins 0.0033 0.023 0.023
Echinococcus multilocularis carboxylesterase 5A 0.0132 0.3353 0.5965
Loa Loa (eye worm) hypothetical protein 0.0344 1 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0572 1
Leishmania major hypothetical protein, conserved 0.0043 0.0572 0.5
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0572 0.1018
Brugia malayi Carboxylesterase family protein 0.0132 0.3353 0.3353
Echinococcus multilocularis musashi 0.0033 0.023 0.0409
Onchocerca volvulus 0.0043 0.0572 0.0572
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0572 0.0572
Mycobacterium ulcerans hypothetical protein 0.0043 0.0572 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0572 0.0572
Echinococcus multilocularis geminin 0.0205 0.5621 1
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0572 0.5
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0344 1 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0572 0.0572
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.023 0.023
Echinococcus granulosus lamin dm0 0.0033 0.023 0.0409
Schistosoma mansoni lamin 0.0033 0.023 0.023
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0572 0.0572
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0572 0.1018
Onchocerca volvulus 0.0033 0.023 0.023
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0572 0.5
Echinococcus granulosus lamin 0.0033 0.023 0.0409
Brugia malayi intermediate filament protein 0.0033 0.023 0.023
Onchocerca volvulus 0.0043 0.0572 0.0572
Schistosoma mansoni hypothetical protein 0.0205 0.5621 0.5621
Toxoplasma gondii ABC1 family protein 0.0043 0.0572 0.5

Activities

Activity type Activity value Assay description Source Reference
-Log alpha (ADMET) = -2.98 Negative log of Langmuir's alpha constant (-log alpha), which is inversely proportional to the effective binding constant (protein binding) ChEMBL. 6864729
-Log C (functional) = 1.81 Minimum inhibitory concentration (bacteriostatic) against E. coli at pH 7.2 (Sauterne''s medium) ChEMBL. 6864729
-Log C (functional) = 1.81 Minimum inhibitory concentration (bacteriostatic) against E. coli at pH 7.2 (Sauterne''s medium) ChEMBL. 6864729
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
Activity (binding) Inhibition of human liver MAOA ChEMBL. 18834112
EII50 (binding) = 10.2 Inhibition of E. coli (K12J53) Dihydopteroate synthase. ChEMBL. 7021831
GII50 (functional) = 38500 In vitro inhibition of E. coli (K12J53) growth. ChEMBL. 7021831
GII50 (functional) = 38500 In vitro inhibition of E. coli (K12J53) growth. ChEMBL. 7021831
IC50 (binding) > 100 uM Inhibitory concentration against human cystolic isozyme II of Carbonic anhydrase ChEMBL. 15482952
IC50 (binding) > 100 uM Inhibitory concentration against human cystolic isozyme V of Carbonic anhydrase ChEMBL. 15482952
IC50 (binding) > 100 uM Inhibitory concentration against human cystolic isozyme II of Carbonic anhydrase ChEMBL. 15482952
IC50 (binding) > 100 uM Inhibitory concentration against human cystolic isozyme V of Carbonic anhydrase ChEMBL. 15482952
Inhibition (ADMET) = 107.9625732 % Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM ChEMBL. 23571415
Inhibition (ADMET) = 119.1864043 % Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM ChEMBL. 23571415
IZ (functional) = 10 mm Antibacterial activity against Salmonella enteritidis at 20 mg/ml by paper disc method ChEMBL. 17110110
IZ (functional) = 15 mm Antibacterial activity against Salmonella enteritidis at 30 mg/ml by paper disc method ChEMBL. 17110110
IZ (functional) = 18 mm Antibacterial activity against Salmonella enteritidis at 40 mg/ml by paper disc method ChEMBL. 17110110
IZ (functional) = 20 mm Antibacterial activity against Pasteurella multocida at 20 mg/ml by paper disc method ChEMBL. 17110110
IZ (functional) = 25 mm Antibacterial activity against Pasteurella multocida at 30 mg/ml by paper disc method ChEMBL. 17110110
IZ (functional) = 25 mm Antibacterial activity against Pasteurella multocida at40 mg/ml by paper disc method ChEMBL. 17110110
Ki (binding) = 0.000069 M Enzymatic activity of the compound was determined ChEMBL. 6317859
Ki (binding) = 95 nM Inhibitory activity against human thrombin (using Chromozym TH as the substrate) ChEMBL. 10794696
Ki (binding) = 95 nM Inhibitory activity against human thrombin (using Chromozym TH as the substrate) ChEMBL. 10794696
Ki (binding) = 1350 nM Inhibitory activity against human trypsin (using Chromozym TH as the substrate) ChEMBL. 10794696
Ki (binding) = 1350 nM Inhibitory activity against human trypsin (using Chromozym TH as the substrate) ChEMBL. 10794696
Log K = -0.00612 Compound is evaluated for ionization constant log k ChEMBL. 6864729
pKa = 12 pKa value of the compound is evaluated ChEMBL. 6864729
Potency (functional) = 0.0178 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.92 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Zone of inhibition (functional) mM Antibacterial activity of the compound against Escherichia coli at a concentration of 80 ug/mL; no data ChEMBL. 14552772
Zone of inhibition (functional) mM Antibacterial activity of the compound against Escherichia coli at a concentration of 40 ug/mL; no data ChEMBL. 14552772
Zone of inhibition (functional) mM Antibacterial activity of the compound against Escherichia coli at a concentration of 10 ug/mL; no data ChEMBL. 14552772
Zone of inhibition (functional) mM Antibacterial activity of the compound against Escherichia coli at a concentration of 20 ug/mL; no data ChEMBL. 14552772
Zone of inhibition (functional) 0 mM Antibacterial activity of the compound against Escherichia coli at a concentration of 10 ug/mL; no data ChEMBL. 14552772
Zone of inhibition (functional) 0 mM Antibacterial activity of the compound against Escherichia coli at a concentration of 20 ug/mL; no data ChEMBL. 14552772
Zone of inhibition (functional) 0 mM Antibacterial activity of the compound against Escherichia coli at a concentration of 40 ug/mL; no data ChEMBL. 14552772
Zone of inhibition (functional) 0 mM Antibacterial activity of the compound against Escherichia coli at a concentration of 80 ug/mL; no data ChEMBL. 14552772
Zone of inhibition (functional) 0 mM Antibacterial activity of the compound against Klebsiella pneumoniae at a concentration of 40 ug/mL; no data ChEMBL. 14552772
Zone of inhibition (functional) 0 mM Antibacterial activity of the compound against Klebsiella pneumoniae at a concentration of 80 ug/mL; no data ChEMBL. 14552772
Zone of inhibition (functional) 0 mM Antibacterial activity of the compound against Klebsiella pneumoniae at a concentration of 120 ug/mL; no data ChEMBL. 14552772
Zone of inhibition (functional) 0 mM Antibacterial activity of the compound against Klebsiella pneumoniae at a concentration of 160 ug/mL; no data ChEMBL. 14552772
Zone of inhibition (functional) 0 mM Antibacterial activity of the compound against Bacillus subtilis at a concentration of 40 ug/mL; no data ChEMBL. 14552772
Zone of inhibition (functional) 0 mM Antibacterial activity of the compound against Bacillus subtilis at a concentration of 80 ug/mL; no data ChEMBL. 14552772
Zone of inhibition (functional) 0 mM Antibacterial activity of the compound against Bacillus subtilis at a concentration of 120 ug/mL; no data ChEMBL. 14552772
Zone of inhibition (functional) 0 mM Antibacterial activity of the compound against Bacillus subtilis at a concentration of 160 ug/mL; no data ChEMBL. 14552772
Zone of inhibition (functional) = 10.9 mm Antibacterial activity of compound against Bacillus subtilis at 20 ug/mL expressed as zone of inhibition ChEMBL. 15603963
Zone of inhibition (functional) = 11.23 mm Antibacterial activity of compound against Bacillus subtilis at 10 ug/mL expressed as zone of inhibition ChEMBL. 15603963
Zone of inhibition (functional) = 17.9 mm Antibacterial activity of compound against Bacillus subtilis at 40 ug/mL expressed as zone of inhibition ChEMBL. 15603963
Zone of inhibition (functional) = 21.76 mm Antibacterial activity of compound against Bacillus subtilis at 80 ug/mL expressed as zone of inhibition ChEMBL. 15603963

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

14 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.