Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | hepatocyte nuclear factor 4, alpha | No references | |
Rattus norvegicus | Hepatocyte nuclear factor 4-alpha | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | Get druggable targets OG5_131038 | All targets in OG5_131038 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | Get druggable targets OG5_131038 | All targets in OG5_131038 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | Get druggable targets OG5_131038 | All targets in OG5_131038 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | Get druggable targets OG5_131038 | All targets in OG5_131038 |
Schistosoma japonicum | Transcription factor HNF-4 homolog, putative | Get druggable targets OG5_131038 | All targets in OG5_131038 |
Schistosoma japonicum | Hepatocyte nuclear factor 4-beta, putative | Get druggable targets OG5_131038 | All targets in OG5_131038 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | Get druggable targets OG5_131038 | All targets in OG5_131038 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0284 | 1 | 1 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0271 | 0.9502 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0024 | 0 | 0.5 |
Onchocerca volvulus | 0.0024 | 0 | 0.5 | |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0284 | 1 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0024 | 0 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0024 | 0 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0284 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 2645 nM | Agonist activity at rat HNF4alpha1 expressed in African green monkey CV1 cells incubated for 24 hrs by firefly luciferase reporter gene assay | ChEMBL. | No reference |
Efficacy (functional) | = 103 % | Agonist activity at rat HNF4alpha1 expressed in African green monkey CV1 cells incubated for 24 hrs by firefly luciferase reporter gene assay relative to LG0100695 | ChEMBL. | No reference |
Ki (binding) | = 710 nM | Displacement of [3H]methyl4-[5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-ethyloxy-2-naphthalenyl]benzoyl benzoate from HNF4alpha (unknown origin) by radioligand binding assay | ChEMBL. | No reference |
Ki (binding) | > 30000 nM | Displacement of [3H]9-cis-retinoic acid from RXRalpha (unknown origin) by radioligand binding assay | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.