Detailed information for compound 215497

Basic information

Technical information
  • TDR Targets ID: 215497
  • Name: [(3R,5S,6R,7S,8E,10S,11S,12Z,14E)-6-hydroxy-5 ,11-dimethoxy-3,7,9,15-tetramethyl-16,20,22-t rioxo-21-(prop-2-ynylamino)-17-azabicyclo[16. 3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] ca rbamate
  • MW: 583.673 | Formula: C31H41N3O8
  • H donors: 4 H acceptors: 5 LogP: 2.12 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 2
  • SMILES: C#CCNC1=C2C[C@@H](C)C[C@H](OC)[C@H](O)[C@@H](C)/C=C(\C)/[C@@H]([C@H](/C=C\C=C(\C(=O)NC(=CC1=O)C2=O)/C)OC)OC(=O)N
  • InChi: 1S/C31H41N3O8/c1-8-12-33-26-21-13-17(2)14-25(41-7)27(36)19(4)15-20(5)29(42-31(32)39)24(40-6)11-9-10-18(3)30(38)34-22(28(21)37)16-23(26)35/h1,9-11,15-17,19,24-25,27,29,33,36H,12-14H2,2-7H3,(H2,32,39)(H,34,38)/b11-9-,18-10+,20-15+/t17-,19+,24+,25+,27-,29+/m1/s1
  • InChiKey: LWZDHLHMEOGKDZ-TXHRRWQRSA-N  


Substructure search Similarity search

Network

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Synonyms

  • carbamic acid [(3R,5S,6R,7S,8E,10S,11S,12Z,14E)-6-hydroxy-5,11-dimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-21-(prop-2-ynylamino)-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] ester
  • carbamic acid [(3R,5S,6R,7S,8E,10S,11S,12Z,14E)-6-hydroxy-16,20,22-triketo-5,11-dimethoxy-3,7,9,15-tetramethyl-21-(propargylamino)-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0066 0.1487 0.1487
Loa Loa (eye worm) AGC/PKN protein kinase 0.0074 0.1731 0.1731
Trichomonas vaginalis AGC family protein kinase 0.0079 0.1848 0.1543
Loa Loa (eye worm) RhoGAP domain-containing protein 0.007 0.1594 0.1594
Trichomonas vaginalis AGC family protein kinase 0.0079 0.1848 0.1543
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0038 0.0692 0.0222
Giardia lamblia Kinase, AGC PKA 0.0122 0.3105 0.5
Loa Loa (eye worm) hypothetical protein 0.0066 0.1487 0.1487
Leishmania major protein kinase A catalytic subunit isoform 1 0.0122 0.3105 0.1726
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0122 0.3105 0.2757
Trichomonas vaginalis AGC family protein kinase 0.0074 0.1731 0.0759
Echinococcus granulosus tyrosine protein kinase Blk 0.0035 0.0588 0.0112
Schistosoma mansoni serine/threonine protein kinase 0.0074 0.1731 0.1116
Schistosoma mansoni vav2 0.0074 0.1711 0.1095
Echinococcus multilocularis raf serine:threonine protein kinase 0.0068 0.1541 0.1114
Echinococcus granulosus tyrosine protein kinase Src64B 0.0038 0.0692 0.0222
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0081 0.1905 0.1496
Schistosoma mansoni serine/threonine protein kinase 0.0264 0.716 0.6949
Brugia malayi diacylglycerol kinase 0.0066 0.1487 0.1487
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0122 0.3105 0.2269
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0122 0.3105 0.2757
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0038 0.0692 0.0222
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.007 0.1594 0.117
Schistosoma mansoni serine/threonine protein kinase 0.0204 0.5438 0.5099
Trichomonas vaginalis AGC family protein kinase 0.0079 0.1848 0.1543
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0074 0.1731 0.1314
Echinococcus granulosus tyrosine protein kinase Src42A 0.0033 0.0534 0.0056
Entamoeba histolytica protein kinase, putative 0.0079 0.1848 0.4183
Echinococcus multilocularis Rac GTPase activating protein 1 0.0066 0.1487 0.1058
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0038 0.0692 0.0222
Brugia malayi Protein kinase domain containing protein 0.0079 0.1848 0.1848
Brugia malayi protein kinase C3,putative 0.0152 0.3943 0.3943
Schistosoma mansoni serine/threonine protein kinase 0.0074 0.1731 0.1116
Schistosoma mansoni tyrosine kinase 0.0079 0.1851 0.1245
Trypanosoma cruzi DNA topoisomerase IB, large subunit, putative 0.0272 0.7386 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0038 0.0692 0.0222
Echinococcus multilocularis tyrosine protein kinase Srms 0.0035 0.0588 0.0112
Brugia malayi Protein kinase c protein 2 0.0193 0.514 0.514
Schistosoma mansoni diacylglycerol kinase theta 0.0066 0.1487 0.0855
Loa Loa (eye worm) AGC/NDR protein kinase 0.0074 0.1731 0.1731
Schistosoma mansoni tyrosine kinase 0.0079 0.1851 0.1245
Plasmodium falciparum topoisomerase I 0.0363 1 1
Echinococcus multilocularis tyrosine protein kinase Blk 0.0035 0.0588 0.0112
Schistosoma mansoni rac gtpase activating protein 0.0066 0.1487 0.0855
Schistosoma mansoni DNA topoisomerase type I 0.0272 0.7386 0.7192
Trichomonas vaginalis AGC family protein kinase 0.0079 0.1848 0.1543
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0038 0.0692 0.0222
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0074 0.1731 0.1314
Schistosoma mansoni protein kinase C mu 0.0191 0.506 0.4693
Brugia malayi diacylglycerol kinase 0.0066 0.1487 0.1487
Echinococcus multilocularis unc 13 (munc13) 0.0072 0.1666 0.1245
Echinococcus multilocularis serine:threonine protein kinase N2 0.0211 0.5653 0.5433
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0074 0.1731 0.1314
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0048 0.0982 0.0527
Loa Loa (eye worm) TK protein kinase 0.0035 0.0588 0.0588
Echinococcus multilocularis N chimaerin 0.007 0.1594 0.117
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0118 0.2992 0.2638
Entamoeba histolytica protein kinase, putative 0.0079 0.1848 0.4183
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0117 0.296 0.2604
Brugia malayi Protein kinase domain containing protein 0.0204 0.5438 0.5438
Loa Loa (eye worm) raf kinase 0.0066 0.1487 0.1487
Entamoeba histolytica protein kinase, putative 0.0074 0.1731 0.3826
Echinococcus multilocularis myotubularin protein 13 0.007 0.1604 0.118
Echinococcus multilocularis protein kinase c eta type 0.0066 0.1487 0.1058
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0066 0.1487 0.1487
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0122 0.3105 0.2757
Trichomonas vaginalis AGC family protein kinase 0.0079 0.1848 0.1543
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0038 0.0692 0.0222
Loa Loa (eye worm) hypothetical protein 0.007 0.1604 0.1604
Echinococcus granulosus protein kinase c epsilon type 0.0284 0.7721 0.7606
Schistosoma mansoni atypical protein kinase C 0.0228 0.6135 0.5848
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0038 0.0692 0.0222
Schistosoma mansoni unc-13 (munc13) 0.0072 0.1666 0.1046
Leishmania major DNA topoisomerase IB, large subunit 0.0272 0.7386 1
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0264 0.716 0.7017
Entamoeba histolytica diacylglycerol kinase, putative 0.0066 0.1487 0.308
Entamoeba histolytica protein kinase, putative 0.0074 0.1731 0.3826
Echinococcus granulosus Rac GTPase activating protein 1 0.0066 0.1487 0.1058
Loa Loa (eye worm) SRC-1 0.0038 0.0692 0.0692
Loa Loa (eye worm) AGC/PKA protein kinase 0.0122 0.3105 0.3105
Leishmania major protein kinase A catalytic subunit isoform 2 0.0122 0.3105 0.1726
Echinococcus multilocularis DNA topoisomerase 1 0.0363 1 1
Echinococcus granulosus protein kinase c eta type 0.0066 0.1487 0.1058
Entamoeba histolytica PH domain containing protein kinase, putative 0.0145 0.3749 1
Brugia malayi Protein kinase domain containing protein 0.0048 0.0982 0.0982
Echinococcus granulosus epidermal growth factor receptor 0.0149 0.3866 0.3556
Trichomonas vaginalis AGC family protein kinase 0.0074 0.1731 0.0759
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0284 0.7721 0.7721
Schistosoma mansoni hypothetical protein 0.0066 0.1487 0.0855
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.007 0.1594 0.117
Echinococcus granulosus raf serine:threonine protein kinase 0.0068 0.1541 0.1114
Echinococcus granulosus myotubularin protein 13 0.007 0.1604 0.118
Schistosoma mansoni serine/threonine protein kinase 0.0068 0.1541 0.0913
Loa Loa (eye worm) hypothetical protein 0.0274 0.7442 0.7442
Brugia malayi RhoGAP domain containing protein 0.0066 0.1487 0.1487
Onchocerca volvulus 0.0191 0.5064 0.5883
Echinococcus granulosus tyrosine kinase 0.0035 0.0588 0.0112
Brugia malayi Protein kinase domain containing protein 0.007 0.16 0.16
Brugia malayi Pleckstrin Homology Domain 0.007 0.1604 0.1604
Loa Loa (eye worm) hypothetical protein 0.0122 0.3105 0.3105
Echinococcus granulosus unc 13 munc13 0.0072 0.1666 0.1245
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.007 0.16 0.1176
Brugia malayi p70 ribosomal S6 kinase beta 0.0074 0.1731 0.1731
Plasmodium vivax topoisomerase I, putative 0.0363 1 1
Toxoplasma gondii AGC kinase 0.0122 0.3105 0.19
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0128 0.3251 0.3251
Trichomonas vaginalis AGC family protein kinase 0.0079 0.1848 0.1543
Echinococcus granulosus RNA directed DNA polymerase 0.0117 0.296 0.2604
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0122 0.3105 0.2757
Echinococcus multilocularis insulin receptor 0.0048 0.0982 0.0527
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0191 0.506 0.506
Schistosoma mansoni serine/threonine protein kinase 0.007 0.16 0.0976
Entamoeba histolytica diacylglycerol kinase, putative 0.0066 0.1487 0.308
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0074 0.1731 0.1731
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0204 0.5438 0.5438
Schistosoma mansoni serine/threonine protein kinase 0.0284 0.7721 0.7551
Echinococcus granulosus DNA topoisomerase 1 0.0363 1 1
Echinococcus multilocularis serine threonine protein kinase 0.0198 0.5271 0.5032
Loa Loa (eye worm) hypothetical protein 0.0274 0.7442 0.7442
Brugia malayi SRC-1 0.0038 0.0692 0.0692
Loa Loa (eye worm) hypothetical protein 0.0066 0.1487 0.1487
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0038 0.0692 0.0222
Trichomonas vaginalis AGC family protein kinase 0.0079 0.1848 0.1543
Echinococcus granulosus protein kinase c iota type 0.0222 0.5963 0.5759
Echinococcus multilocularis serine:threonine protein kinase 38 0.0074 0.1731 0.1314
Schistosoma mansoni serine/threonine protein kinase 0.0074 0.1731 0.1116
Brugia malayi Hr1 repeat family protein 0.0074 0.1731 0.1731
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0074 0.1731 0.1731
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0125 0.317 0.317
Trichomonas vaginalis AGC family protein kinase 0.0074 0.1731 0.0759
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0122 0.3105 0.2269
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0122 0.3105 0.2757
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0122 0.3105 0.19
Loa Loa (eye worm) hypothetical protein 0.0066 0.1487 0.1487
Echinococcus multilocularis epidermal growth factor receptor 0.0149 0.3866 0.3556
Loa Loa (eye worm) hypothetical protein 0.0348 0.9575 0.9575
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0118 0.2992 0.2638
Echinococcus multilocularis protein kinase c iota type 0.0222 0.5963 0.5759
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0072 0.1666 0.1245
Loa Loa (eye worm) hypothetical protein 0.0072 0.1666 0.1666
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0074 0.1731 0.1314
Schistosoma mansoni protein kinase C mu 0.0066 0.1487 0.0855
Schistosoma mansoni serine/threonine protein kinase 0.0074 0.1731 0.1116
Brugia malayi RhoGEF domain containing protein 0.0066 0.1487 0.1487
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0035 0.0588 0.0112
Echinococcus multilocularis RNA directed DNA polymerase 0.0117 0.296 0.2604
Loa Loa (eye worm) AGC/PKA protein kinase 0.0122 0.3105 0.3105
Brugia malayi C1-like domain containing protein 0.0191 0.506 0.506
Echinococcus granulosus tyrosine protein kinase Fyn 0.0038 0.0692 0.0222
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0122 0.3105 0.1726
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0122 0.3105 0.1726
Trypanosoma brucei DNA topoisomerase type IB small subunit 0.0091 0.2212 0.0657
Onchocerca volvulus 0.0187 0.4947 0.5681
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0038 0.0692 0.0222
Schistosoma mansoni serine/threonine protein kinase 0.0122 0.3105 0.2592
Toxoplasma gondii DNA topoisomerase I, putative 0.0363 1 1
Loa Loa (eye worm) hypothetical protein 0.0187 0.4947 0.4947
Echinococcus granulosus insulin receptor 0.0048 0.0982 0.0527
Brugia malayi protein kinase C II. 0.0284 0.7721 0.7721
Loa Loa (eye worm) hypothetical protein 0.0121 0.3058 0.3058
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0038 0.0692 0.0222
Loa Loa (eye worm) hypothetical protein 0.0117 0.296 0.296
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0038 0.0692 0.0222
Echinococcus granulosus protein kinase C gamma type 0.0198 0.5271 0.5032
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0074 0.1731 0.1314
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0191 0.506 0.506
Loa Loa (eye worm) TK protein kinase 0.0031 0.0481 0.0481
Toxoplasma gondii AGC kinase 0.0074 0.1731 0.0286
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0122 0.3105 0.1726
Brugia malayi Furin-like cysteine rich region family protein 0.0149 0.3866 0.3866
Entamoeba histolytica hypothetical protein 0.0066 0.1487 0.308
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.007 0.1594 0.097
Entamoeba histolytica PH domain containing protein kinase, putative 0.0126 0.3221 0.8385
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0072 0.1666 0.1245
Schistosoma mansoni serine/threonine protein kinase 0.0122 0.3105 0.2592
Schistosoma mansoni tyrosine kinase 0.0081 0.1905 0.1303
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0074 0.1731 0.1314
Schistosoma mansoni serine/threonine kinase 0.0074 0.1731 0.1116
Echinococcus granulosus tyrosine protein kinase Lyn 0.0042 0.0805 0.034
Echinococcus multilocularis epidermal growth factor receptor 0.0081 0.1905 0.1496
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0122 0.3105 0.2757
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0074 0.1731 0.1731
Schistosoma mansoni serine/threonine protein kinase 0.007 0.16 0.0976
Echinococcus granulosus epidermal growth factor receptor 0.0081 0.1905 0.1496
Schistosoma mansoni tyrosine kinase 0.0048 0.0982 0.0312
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0122 0.3105 0.2757
Echinococcus granulosus N chimaerin 0.007 0.1594 0.117
Toxoplasma gondii AGC kinase 0.0122 0.3105 0.19
Trichomonas vaginalis AGC family protein kinase 0.0079 0.1848 0.1543
Brugia malayi Variant SH3 domain containing protein 0.007 0.1594 0.1594
Schistosoma mansoni tyrosine kinase 0.0081 0.1905 0.1303
Loa Loa (eye worm) hypothetical protein 0.0066 0.1487 0.1487
Onchocerca volvulus 0.0274 0.7442 1
Echinococcus multilocularis serine:threonine protein kinase N2 0.0074 0.1731 0.1314
Trichomonas vaginalis AGC family protein kinase 0.0122 0.3105 1
Echinococcus granulosus NDR protein kinase 0.0074 0.1731 0.1314
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0158 0.4115 0.4115
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0074 0.1731 0.1731
Loa Loa (eye worm) RasGEF domain-containing protein 0.0066 0.1487 0.1487
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0035 0.0588 0.0112
Echinococcus multilocularis Diacylglycerol kinase theta 0.0066 0.1487 0.1058
Onchocerca volvulus 0.0121 0.3058 0.241
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0122 0.3105 0.1726
Brugia malayi protein-tyrosine kinase 0.0035 0.0588 0.0588
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.007 0.16 0.1176
Loa Loa (eye worm) hypothetical protein 0.0274 0.7442 0.7442
Schistosoma mansoni tyrosine kinase 0.0048 0.0982 0.0312
Loa Loa (eye worm) DNA topoisomerase I 0.0363 1 1
Trypanosoma brucei DNA topoisomerase IB, large subunit 0.0272 0.7386 1
Echinococcus granulosus serine:threonine protein kinase N2 0.0141 0.3633 0.3311
Echinococcus granulosus serine:threonine protein kinase N2 0.0074 0.1731 0.1314
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0066 0.1487 0.1487
Schistosoma mansoni tyrosine kinase 0.0149 0.3866 0.341
Loa Loa (eye worm) hypothetical protein 0.0121 0.3058 0.3058
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.007 0.1594 0.097
Entamoeba histolytica PH domain containing protein kinase, putative 0.0126 0.3221 0.8385
Echinococcus granulosus tyrosine protein kinase Fyn 0.0038 0.0692 0.0222
Schistosoma mansoni DNA topoisomerase type I 0.0363 1 1
Loa Loa (eye worm) hypothetical protein 0.0066 0.1487 0.1487
Brugia malayi Protein kinase domain containing protein 0.0074 0.1731 0.1731
Echinococcus granulosus Diacylglycerol kinase theta 0.0066 0.1487 0.1058
Echinococcus multilocularis protein kinase c epsilon type 0.0284 0.7721 0.7606
Schistosoma mansoni protein kinase C 0.0072 0.1666 0.1046
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0122 0.3105 0.2269
Brugia malayi Protein kinase domain containing protein 0.0074 0.1731 0.1731
Schistosoma mansoni DNA topoisomerase type I 0.0272 0.7386 0.7192
Loa Loa (eye worm) AGC/AKT protein kinase 0.0079 0.1848 0.1848
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0033 0.0534 0.0056
Brugia malayi Ras association domain family 1 isoform A 0.0066 0.1487 0.1487
Loa Loa (eye worm) hypothetical protein 0.034 0.9331 0.9331
Leishmania major protein kinase A catalytic subunit 0.0122 0.3105 0.1726
Schistosoma mansoni serine/threonine protein kinase 0.0122 0.3105 0.2592
Loa Loa (eye worm) hypothetical protein 0.0191 0.5064 0.5064
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0048 0.0982 0.0527
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0122 0.3105 0.3105
Echinococcus granulosus tyrosine protein kinase Src42A 0.0038 0.0692 0.0222
Schistosoma mansoni serine/threonine protein kinase 0.0264 0.716 0.6949
Echinococcus granulosus Protein kinase C brain isozyme 0.0264 0.716 0.7017
Brugia malayi RhoGAP domain containing protein 0.007 0.1594 0.1594
Schistosoma mansoni tyrosine kinase 0.0079 0.1851 0.1245
Loa Loa (eye worm) hypothetical protein 0.0183 0.4849 0.4849
Loa Loa (eye worm) TK/INSR protein kinase 0.0048 0.0982 0.0982
Schistosoma mansoni diacylglycerol kinase theta 0.0066 0.1487 0.0855
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0038 0.0692 0.0222
Loa Loa (eye worm) TK/EGFR protein kinase 0.0149 0.3866 0.3866
Echinococcus multilocularis 0.0046 0.091 0.0451
Schistosoma mansoni unc-13 (munc13) 0.0072 0.1666 0.1046

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 26 nM Inhibition of oncogene product p185 erbB-2 from human breast cancer cells(SK-BR-3 cells) at 50 mg/kg dose. ChEMBL. 7562911
IC50 (functional) = 26 nM Inhibition of oncogene product p185 erbB-2 from human breast cancer cells(SK-BR-3 cells) at 50 mg/kg dose. ChEMBL. 7562911

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 7562911

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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