Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Adenosine A1 receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0162 | 1 | 1 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0162 | 1 | 1 |
Loa Loa (eye worm) | proteasome subunit beta type 1 | 0.0126 | 0.7224 | 0.7224 |
Toxoplasma gondii | proteasome subunit beta type 1, putative | 0.0126 | 0.7224 | 0.7224 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0078 | 0.3546 | 0.3546 |
Entamoeba histolytica | proteasome subunit beta type 1, putative | 0.0126 | 0.7224 | 0.7224 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0162 | 1 | 1 |
Onchocerca volvulus | Notchless protein homolog | 0.0032 | 0 | 0.5 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0162 | 1 | 1 |
Trypanosoma brucei | proteasome beta 6 subunit | 0.0126 | 0.7224 | 0.7224 |
Schistosoma mansoni | proteasome subunit beta 2 (T01 family) | 0.0078 | 0.3546 | 0.3546 |
Brugia malayi | proteasome subunit beta type 1 | 0.0126 | 0.7224 | 0.7224 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0162 | 1 | 1 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0162 | 1 | 1 |
Leishmania major | proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative | 0.0126 | 0.7224 | 0.7224 |
Toxoplasma gondii | proteasome subunit beta type 2, putative | 0.0078 | 0.3546 | 0.3546 |
Loa Loa (eye worm) | proteasome subunit beta type 2 | 0.0078 | 0.3546 | 0.3546 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0078 | 0.3546 | 0.3546 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.0126 | 0.7224 | 0.7224 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0162 | 1 | 1 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0162 | 1 | 1 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0162 | 1 | 1 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.0126 | 0.7224 | 0.7224 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0162 | 1 | 1 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0126 | 0.7224 | 0.7224 |
Plasmodium vivax | proteasome subunit beta type-1, putative | 0.0126 | 0.7224 | 0.7224 |
Plasmodium falciparum | proteasome subunit beta type-1, putative | 0.0126 | 0.7224 | 0.7224 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0162 | 1 | 1 |
Trypanosoma cruzi | 20S proteasome subunit | 0.0078 | 0.3546 | 0.3546 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.0078 | 0.3546 | 0.3546 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent protease peptidase subunit | 0.0032 | 0 | 0.5 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0162 | 1 | 1 |
Plasmodium vivax | proteasome subunit beta type-2, putative | 0.0078 | 0.3546 | 0.3546 |
Brugia malayi | proteasome subunit beta type 2 | 0.0078 | 0.3546 | 0.3546 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0162 | 1 | 1 |
Entamoeba histolytica | probable proteasome subunit beta type 2, putative | 0.0078 | 0.3546 | 0.3546 |
Plasmodium falciparum | proteasome subunit beta type-2, putative | 0.0078 | 0.3546 | 0.3546 |
Schistosoma mansoni | proteasome subunit beta 2 (T01 family) | 0.0078 | 0.3546 | 0.3546 |
Giardia lamblia | Proteasome subunit beta type 1 | 0.0126 | 0.7224 | 0.7224 |
Echinococcus granulosus | proteasome prosome macropain | 0.0162 | 1 | 1 |
Schistosoma mansoni | proteasome subunit beta 1 (T01 family) | 0.0126 | 0.7224 | 0.7224 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.0078 | 0.3546 | 0.3546 |
Trypanosoma brucei | proteasome subunit beta type-2, putative | 0.0078 | 0.3546 | 0.3546 |
Giardia lamblia | Proteasome subunit beta type 2 | 0.0078 | 0.3546 | 0.3546 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0126 | 0.7224 | 0.7224 |
Mycobacterium ulcerans | proteasome PrcB | 0.0162 | 1 | 1 |
Trypanosoma cruzi | proteasome subunit beta type-2, putative | 0.0078 | 0.3546 | 0.3546 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0126 | 0.7224 | 0.7224 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0162 | 1 | 1 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0162 | 1 | 1 |
Leishmania major | proteasome beta 2 subunit, putative | 0.0078 | 0.3546 | 0.3546 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 74 % | Afffinity for adenosine A2a receptor of rat striatal membrane using [3H]-CGS- 21680 at 10e-5 M | ChEMBL. | 9371242 |
Inhibition (binding) | = 74 % | Afffinity for adenosine A2a receptor of rat striatal membrane using [3H]-CGS- 21680 at 10e-5 M | ChEMBL. | 9371242 |
Ki (binding) | = 0.15 uM | Afffinity for adenosine A1 receptor was determined, in the presence of GTP in rat brain cortex | ChEMBL. | 9371242 |
Ki (binding) | = 0.15 uM | Afffinity for adenosine A1 receptor was determined, in the presence of GTP in rat brain cortex | ChEMBL. | 9371242 |
Ki (binding) | = 0.19 uM | Afffinity for adenosine A1 receptor was determined, in the absence of GTP in rat cortical membrane. | ChEMBL. | 9371242 |
Ki (binding) | = 0.19 uM | Afffinity for adenosine A1 receptor was determined, in the absence of GTP in rat cortical membrane. | ChEMBL. | 9371242 |
Ratio (binding) | = 0.8 | GTP shift ratio of the apparent Ki values in the presence and absence of GTP. | ChEMBL. | 9371242 |
Ratio (binding) | = 0.8 | GTP shift ratio of the apparent Ki values in the presence and absence of GTP. | ChEMBL. | 9371242 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.