Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Nitric-oxide synthase, brain | References | |
Homo sapiens | nitric oxide synthase 1 (neuronal) | References | |
Mus musculus | nitric oxide synthase 2, inducible | References | |
Bos taurus | Nitric-oxide synthase, endothelial | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0118 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0118 | 1 | 0.5 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0118 | 1 | 0.5 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0118 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0118 | 1 | 0.5 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0073 | 0.2407 | 0.2407 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0118 | 1 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0118 | 1 | 1 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0118 | 1 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.006 | 0.0151 | 0.0151 |
Brugia malayi | FAD binding domain containing protein | 0.0118 | 1 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0118 | 1 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0118 | 1 | 0.5 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0118 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0105 | 0.7743 | 0.5 |
Chlamydia trachomatis | sulfite reductase | 0.0073 | 0.2407 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0059 | 0 | 0.5 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0118 | 1 | 0.5 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0118 | 1 | 0.5 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0105 | 0.7743 | 0.5 |
Trypanosoma cruzi | p450 reductase, putative | 0.0118 | 1 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0059 | 0 | 0.5 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0118 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 1 | 1 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0118 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0118 | 1 | 1 |
Leishmania major | p450 reductase, putative | 0.0118 | 1 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0118 | 1 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0118 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.043 uM | Inhibition of wild type recombinant rat nNOS expressed in Escherichia coli assessed as nitric oxide production by hemoglobin capture assay | ChEMBL. | 26469213 |
Ki (binding) | = 0.507 uM | Inhibition of recombinant human nNOS expressed in Escherichia coli assessed as nitric oxide production by hemoglobin capture assay | ChEMBL. | 26469213 |
Ki (binding) | = 3.31 uM | Inhibition of recombinant bovine eNOS expressed in Escherichia coli assessed as nitric oxide production by hemoglobin capture assay | ChEMBL. | 26469213 |
Ki (binding) | = 13.5 uM | Inhibition of recombinant murine iNOS expressed in Escherichia coli assessed as nitric oxide production by hemoglobin capture assay | ChEMBL. | 26469213 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.