Detailed information for compound 2156407

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 288.209 | Formula: C19H28O2
  • H donors: 0 H acceptors: 1 LogP: 3.44 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 0
  • SMILES: O=C1CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2CC[C@]23[C@]1(C)CCC[C@@H]3O2
  • InChi: InChI=1S/C19H28O2/c1-17-10-8-14-12(13(17)5-6-15(17)20)7-11-19-16(21-19)4-3-9-18(14,19)2/h12-14,16H,3-11H2,1-2H3/t12-,13-,14-,16-,17-,18+,19-/m0/s1
  • InChiKey: RHKHISPXHVJNPF-QXROXWLYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cytochrome P450, family 19, subfamily A, polypeptide 1 References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma cruzi cytochrome P450, putative cytochrome P450, family 19, subfamily A, polypeptide 1 503 aa 425 aa 18.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum phd finger protein, putative 0.0028 0.0024 0.0056
Schistosoma mansoni aldehyde dehydrogenase 0.0116 0.0139 0.0139
Trichomonas vaginalis maltase-glucoamylase, putative 0.0015 0.0008 0.0141
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0084 0.0194
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0023 0.0023
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0004 0.0008
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.0174 0.0174
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0084 0.0072
Loa Loa (eye worm) hypothetical protein 0.0027 0.0023 0.0023
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.3325 0.4336 1
Echinococcus granulosus neuropeptide s receptor 0.0436 0.0558 0.0558
Onchocerca volvulus 0.0074 0.0084 0.1943
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0014 0.0033
Trypanosoma brucei unspecified product 0.0023 0.0017 0.0038
Brugia malayi intermediate filament protein 0.006 0.0065 0.0065
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0143 0.0174 0.0174
Schistosoma mansoni dihydrofolate reductase 0.7656 1 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0187 0.0232 0.0232
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.3325 0.4336 1
Echinococcus granulosus intermediate filament protein 0.006 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0037 0.0035 0.0035
Echinococcus multilocularis musashi 0.006 0.0065 0.0065
Schistosoma mansoni cpg binding protein 0.0029 0.0026 0.0026
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0014 0.0014
Entamoeba histolytica hypothetical protein 0.007 0.0079 0.3956
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0018 0.0018
Chlamydia trachomatis dihydrofolate reductase 0.7656 1 1
Schistosoma mansoni hypothetical protein 0.0067 0.0075 0.0075
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0037 0.0035 0.0035
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0014 0.0001
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0026 0.0026
Schistosoma mansoni nuclear hormone receptor 0.0017 0.001 0.001
Mycobacterium ulcerans aldehyde dehydrogenase 0.0116 0.0139 0.0138
Brugia malayi hypothetical protein 0.0017 0.001 0.001
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0018 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0028 0.0024 0.0024
Schistosoma mansoni hypothetical protein 0.0051 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0074 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0118 0.0142 0.0142
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0158 0.0194 1
Brugia malayi MH2 domain containing protein 0.0118 0.0142 0.0142
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0037 0.0035 0.0035
Mycobacterium ulcerans hypothetical protein 0.0027 0.0023 0.0023
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0082 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.001
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.0029 0.0065
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0143 0.0174 0.0174
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0025 0.0058
Trypanosoma cruzi DNA polymerase eta, putative 0.001 0.0001 0.0001
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0084 0.0084
Brugia malayi Intermediate filament tail domain containing protein 0.006 0.0065 0.0065
Echinococcus granulosus geminin 0.0347 0.0442 0.0442
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.0039 0.0039
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0026 0.0059
Loa Loa (eye worm) RecQ helicase 0.0023 0.0018 0.0018
Entamoeba histolytica hypothetical protein 0.0024 0.0019 0.0793
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0037 0.0035 0.0035
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0051 0.0054 0.0054
Brugia malayi hypothetical protein 0.0064 0.0072 0.0072
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0317 0.0403 0.039
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.002 0.0046
Schistosoma mansoni DNA polymerase IV / kappa 0.001 0.0001 0.0001
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0084 0.2845
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0074 0.0084 0.0084
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0042 0.1341
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0037 0.0035 0.0035
Echinococcus granulosus lamin dm0 0.006 0.0065 0.0065
Echinococcus multilocularis FTZ F1 alpha 0.0037 0.0035 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0037 0.0035 0.0035
Echinococcus granulosus Nuclear hormone receptor HR96 0.0017 0.001 0.001
Loa Loa (eye worm) steroid hormone receptor 0.0037 0.0035 0.0035
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0042 0.1341
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0084 0.2845
Trypanosoma cruzi DNA polymerase kappa, putative 0.0058 0.0064 0.0146
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.7656 1 1
Schistosoma mansoni retinoic acid receptor RXR 0.0037 0.0035 0.0035
Onchocerca volvulus Protein cycle homolog 0.0018 0.0011 0.0077
Echinococcus granulosus neutral alpha glucosidase AB 0.0042 0.0042 0.0042
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0029 0.0025 0.0025
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0037 0.0035 0.0035
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0015 0.0008 0.0141
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0008 0.0018
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0082 0.0095 0.0095
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0084 0.0084
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.0023 0.0023
Echinococcus granulosus aryl hydrocarbon receptor 0.0025 0.0021 0.0021
Mycobacterium ulcerans thymidylate synthase 0.0317 0.0403 0.0402
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0034 0.0078
Brugia malayi Glycosyl hydrolases family 31 protein 0.0015 0.0008 0.0008
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0042 0.1341
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.3325 0.4336 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.002 0.002
Schistosoma mansoni aldehyde dehydrogenase 0.0116 0.0139 0.0139
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0084 0.0084
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0008 0.0141
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0008 0.0141
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0018 0.0018
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0029 0.0065
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0037 0.0035 0.0035
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0023 0.0023
Toxoplasma gondii aldehyde dehydrogenase 0.0116 0.0139 0.0321
Plasmodium vivax importin-beta 2, putative 0.0029 0.0026 0.0058
Trypanosoma brucei DNA polymerase IV, putative 0.0058 0.0064 0.0146
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0023 0.1032
Echinococcus granulosus dihydrofolate reductase 0.7656 1 1
Brugia malayi ecdysteroid receptor 0.0037 0.0035 0.0035
Leishmania major glycosyl hydrolase-like protein 0.0015 0.0008 0.0017
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0015 0.0008 0.0211
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0084 0.0194
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0187 0.0232 0.0232
Onchocerca volvulus Protein ultraspiracle homolog 0.0037 0.0035 0.0703
Schistosoma mansoni jumonji domain containing protein 0.0073 0.0083 0.0083
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0002 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0064 0.0146
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0084 0.0084
Brugia malayi nuclear receptor NHR-88 0.0017 0.001 0.001
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.0142 0.0142
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0015 0.0008 0.0141
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0034 0.0034
Echinococcus multilocularis lamin dm0 0.006 0.0065 0.0065
Brugia malayi Cytochrome P450 family protein 0.0018 0.0012 0.0012
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0143 0.0174 0.0174
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0013
Brugia malayi tailless protein 0.0017 0.001 0.001
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0025 0.0058
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0064 0.0146
Echinococcus multilocularis neuropeptide receptor A26 0.0436 0.0558 0.0558
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0001 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0034 0.0078
Brugia malayi Pre-SET motif family protein 0.0202 0.0251 0.0251
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0084 0.2845
Giardia lamblia DINP protein human, muc B family 0.0039 0.0038 1
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.002 0.0047
Echinococcus multilocularis dna polymerase kappa 0.0058 0.0064 0.0064
Trypanosoma brucei DNA polymerase IV, putative 0.0052 0.0055 0.0127
Brugia malayi nuclear hormone receptor family member odr-7 0.0017 0.001 0.001
Echinococcus granulosus importin subunit beta 1 0.0029 0.0026 0.0026
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0037 0.0035 0.0035
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0037 0.0035 0.0035
Trichomonas vaginalis rotamase, putative 0.0032 0.003 0.0916
Brugia malayi hypothetical protein 0.0016 0.0009 0.0009
Trichomonas vaginalis esterase, putative 0.0074 0.0084 0.2845
Brugia malayi nuclear receptor RXR 0.0017 0.001 0.001
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0014 0.0014
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0038 0.0088
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0017 0.001 0.001
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.0023 0.0023
Echinococcus granulosus jumonji domain containing protein 0.0039 0.0039 0.0039
Mycobacterium ulcerans aldehyde dehydrogenase 0.0116 0.0139 0.0138
Trichomonas vaginalis conserved hypothetical protein 0.0151 0.0185 0.6386
Brugia malayi cytoplasmic intermediate filament protein 0.0032 0.0029 0.0029
Echinococcus granulosus snurportin 1 0.0315 0.0399 0.0399
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.0142 0.0142
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0039 0.0038 0.0026
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0064 0.0146
Loa Loa (eye worm) hypothetical protein 0.0117 0.014 0.014
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0037 0.0035 0.0035
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0017 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0048 0.0051 0.0051
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0024 0.0024
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0024 0.0024
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0014 0.003
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0037 0.0035 0.0035
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0116 0.0139 0.0126
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0051 0.0054 0.0054
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0026 0.0026
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0014 0.0031
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0016 0.0009 0.0021
Trypanosoma cruzi DNA polymerase kappa, putative 0.0058 0.0064 0.0146
Mycobacterium tuberculosis Conserved protein 0.0074 0.0084 0.0072
Loa Loa (eye worm) hypothetical protein 0.0118 0.0142 0.0142
Toxoplasma gondii ImpB/MucB/SamB family protein 0.001 0.0001 0.0002
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0026 0.0026
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0018 0.0012 0.0011
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.0174 0.0174
Schistosoma mansoni thyroid hormone receptor 0.0158 0.0195 0.0195
Loa Loa (eye worm) hypothetical protein 0.0037 0.0035 0.0035
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0014 0.0033
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0037 0.0035 0.0035
Loa Loa (eye worm) cytochrome P450 family protein 0.0018 0.0012 0.0012
Leishmania major DNA polymerase kappa, putative 0.0039 0.0038 0.0088
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0042 0.0042 0.0096
Loa Loa (eye worm) hypothetical protein 0.0033 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.001
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0019 0.0013 0.0013
Schistosoma mansoni RAR-like nuclear receptor 0.0037 0.0035 0.0035
Leishmania major alpha glucosidase II subunit, putative 0.0042 0.0042 0.0096
Trypanosoma brucei hypothetical protein, conserved 0.001 0.0001 0.0001
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0008 0.0141
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.0002
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0026 0.0026
Onchocerca volvulus Huntingtin homolog 0.0118 0.0142 0.3407
Trypanosoma brucei glucosidase, putative 0.0042 0.0042 0.0096
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0033 0.003 0.003
Brugia malayi photoreceptor-specific nuclear receptor 0.0037 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0008
Entamoeba histolytica hypothetical protein 0.007 0.0079 0.3956
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0807 0.1043 0.1032
Echinococcus granulosus Nuclear hormone receptor HR96 0.0017 0.001 0.001
Brugia malayi Importin beta-1 subunit 0.0029 0.0026 0.0026
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0315 0.0399 0.0399
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.0042 0.2005
Brugia malayi Nuclear hormone receptor E75 0.0017 0.001 0.001
Leishmania major hypothetical protein, conserved 0.0074 0.0084 0.0194
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0143 0.0174 0.0174
Trypanosoma cruzi DNA damage repair protein, putative 0.001 0.0001 0.0001
Toxoplasma gondii exonuclease III APE 0.002 0.0014 0.0031
Echinococcus multilocularis peregrin 0.0028 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.001
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0092 0.0108 0.0108
Entamoeba histolytica deoxycytidyl transferase, putative 0.0033 0.003 0.1394
Entamoeba histolytica acyl-coA synthetase, putative 0.0027 0.0023 0.1032
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.3325 0.4336 1
Schistosoma mansoni aryl hydrocarbon receptor nuclear translocator homolog (darnt) 0.0018 0.0011 0.0011
Mycobacterium ulcerans proteasome PrcA 0.0807 0.1043 0.1043
Trypanosoma cruzi DNA polymerase kappa, putative 0.0058 0.0064 0.0146
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.0023 0.0023
Onchocerca volvulus 0.0074 0.0084 0.1943
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0004 0.0008
Echinococcus granulosus dna polymerase kappa 0.0058 0.0064 0.0064
Brugia malayi beta-lactamase family protein 0.0074 0.0084 0.0084
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0084 0.0193
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0014 0.0346
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0001 0.0001
Trypanosoma brucei DNA polymerase IV, putative 0.0058 0.0064 0.0146
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0017 0.001 0.0061
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0018 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0158 0.0194 0.0194
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.0042 0.2005
Schistosoma mansoni cpg binding protein 0.0031 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0025 0.0021 0.0021
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0014 0.0518
Loa Loa (eye worm) hypothetical protein 0.0036 0.0034 0.0034
Onchocerca volvulus Huntingtin homolog 0.0118 0.0142 0.3407
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0013
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0143 0.0174 0.0174
Loa Loa (eye worm) hypothetical protein 0.0037 0.0035 0.0035
Leishmania major DNA polymerase eta, putative 0.0033 0.003 0.0069
Brugia malayi hypothetical protein 0.0025 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0037 0.0035 0.0035
Onchocerca volvulus 0.0029 0.0026 0.0464
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0018 0.001 0.001
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0084 0.2845
Echinococcus multilocularis dna polymerase eta 0.0033 0.003 0.003
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.0029 0.1317
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0014
Echinococcus granulosus thymidylate synthase 0.0317 0.0403 0.0403
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0037 0.0035 0.0035
Schistosoma mansoni nuclear receptor nhr-48 0.0017 0.001 0.001
Loa Loa (eye worm) latrophilin receptor protein 2 0.0051 0.0054 0.0054
Onchocerca volvulus 0.006 0.0065 0.1462
Brugia malayi thymidylate synthase 0.0317 0.0403 0.0403
Brugia malayi nuclear hormone receptor 0.0017 0.001 0.001
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0014 0.003
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0019 0.0043
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0037 0.0035 0.0035
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0001 0.0001
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0017 0.001 0.0061
Echinococcus granulosus expressed protein 0.0032 0.003 0.003
Brugia malayi hypothetical protein 0.0151 0.0185 0.0185
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.0251 0.0251
Schistosoma mansoni hypothetical protein 0.0122 0.0147 0.0147
Trypanosoma cruzi DNA polymerase eta, putative 0.0033 0.003 0.0069
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0002 0.0002
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0029 0.0065
Mycobacterium leprae probable proteasome (alpha subunit) PrcA 0.0807 0.1043 0.1022
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0028 0.0024 0.0024
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0013 0.0013
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.002 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.003 0.0916
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0013 0.0013
Brugia malayi Pre-SET motif family protein 0.0029 0.0026 0.0026
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0017 0.001 0.001
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0018 0.0498
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.0064 0.0064
Mycobacterium ulcerans aldehyde dehydrogenase 0.0116 0.0139 0.0138
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.7656 1 1
Mycobacterium ulcerans DNA polymerase IV 0.0058 0.0064 0.0063
Mycobacterium ulcerans beta-lactamase 0.0074 0.0084 0.0084
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0474 0.0607 0.0595
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0013 0.0013
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0026 0.0026
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0037 0.0035 0.0703
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0143 0.0174 0.0174
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0033 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0013
Schistosoma mansoni importin beta-1 0.0029 0.0026 0.0026
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0017 0.001 0.001
Loa Loa (eye worm) CYP4Cod1 0.0018 0.0012 0.0012
Brugia malayi hypothetical protein 0.0017 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0037 0.0035 0.0035
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0051 0.0054 0.0054
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0026 0.0026
Brugia malayi CXXC zinc finger family protein 0.0029 0.0026 0.0026
Loa Loa (eye worm) histone methyltransferase 0.001 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0013
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0064 0.0146
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.0023 0.0011
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0011 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0037 0.0035 0.0035
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.006 0.0065 0.0065
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0023 0.0023
Leishmania major DNA polymerase kappa, putative 0.001 0.0001 0.0001
Onchocerca volvulus Bile acid receptor homolog 0.0037 0.0035 0.0703
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0026 0.0026
Schistosoma mansoni zinc finger protein 0.0017 0.001 0.001
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0032 0.003 0.003
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0151 0.0185 0.0426
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.3325 0.4336 1
Brugia malayi Cytochrome P450 family protein 0.0018 0.0012 0.0012
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0026 0.006
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0084 0.0084
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0014 0.5
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0023 0.0023
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0122 0.0147 0.0147
Schistosoma mansoni ap endonuclease 0.002 0.0014 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0037 0.0035 0.0035
Schistosoma mansoni alpha-glucosidase 0.0161 0.0198 0.0198
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0011 0.0002 0.0004
Schistosoma mansoni jun-related protein 0.0067 0.0075 0.0075
Echinococcus granulosus nuclear receptor nhr 48 0.0017 0.001 0.001
Trypanosoma brucei unspecified product 0.0052 0.0055 0.0127
Brugia malayi conserved hypotetical protein 0.0017 0.001 0.001
Mycobacterium ulcerans hypothetical protein 0.0074 0.0084 0.0084
Onchocerca volvulus 0.0108 0.0129 0.3071
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0017 0.001 0.001
Trichomonas vaginalis DNA polymerase eta, putative 0.0058 0.0064 0.2116
Trypanosoma brucei hypothetical protein, conserved 0.001 0.0001 0.0001
Onchocerca volvulus Alhambra homolog 0.0028 0.0024 0.0421
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0037 0.0035 0.0035
Brugia malayi hypothetical protein 0.0118 0.0142 0.0142
Loa Loa (eye worm) hypothetical protein 0.008 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0027 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.001
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0023 0.0053
Brugia malayi steroid hormone receptor 0.0037 0.0035 0.0035
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0116 0.0139 0.0139
Brugia malayi bZIP transcription factor family protein 0.0082 0.0095 0.0095
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0037 0.0035 0.0035
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0039 0.0038 0.0088
Mycobacterium tuberculosis Conserved protein 0.0074 0.0084 0.0072
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0064 0.0146
Loa Loa (eye worm) DR-78 0.0017 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.001
Schistosoma mansoni hypothetical protein 0.0347 0.0442 0.0442
Brugia malayi Bromodomain containing protein 0.0028 0.0024 0.0024
Schistosoma mansoni hypothetical protein 0.0051 0.0054 0.0054
Plasmodium falciparum importin beta, putative 0.0029 0.0026 0.006
Loa Loa (eye worm) hypothetical protein 0.0074 0.0084 0.0084
Echinococcus multilocularis GPCR, family 2 0.0051 0.0054 0.0054
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0064 0.0146
Schistosoma mansoni nuclear receptor 0.0017 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0037 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0029 0.0026 0.0026
Schistosoma mansoni steroid hormone receptor ad4bp 0.0037 0.0035 0.0035
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.007 0.0079 0.0079
Loa Loa (eye worm) intermediate filament protein 0.006 0.0065 0.0065
Schistosoma mansoni lamin 0.006 0.0065 0.0065
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0032 0.003 0.003
Mycobacterium tuberculosis Hypothetical protein 0.0151 0.0185 0.0172
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.007 0.007
Loa Loa (eye worm) beta-lactamase 0.0074 0.0084 0.0084
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.002 0.0047
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0023 0.1032
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0122 0.0147 0.0147
Brugia malayi jmjC domain containing protein 0.0036 0.0034 0.0034
Schistosoma mansoni DNA polymerase eta 0.0033 0.003 0.003
Echinococcus granulosus ecdysone induced protein 78C 0.0037 0.0035 0.0035
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0084 0.0084
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0317 0.0403 0.0403
Onchocerca volvulus 0.0317 0.0403 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.0042 0.1341
Echinococcus multilocularis jun protein 0.0082 0.0095 0.0095
Schistosoma mansoni hypothetical protein 0.0347 0.0442 0.0442
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0037 0.0035 0.0035
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0074 0.0084 0.0084
Trypanosoma brucei chrX additional, unordered contigs 0.001 0.0001 0.0001
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.001 0.001
Mycobacterium leprae Probable lipase LipE 0.0074 0.0084 0.0061
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0037 0.0035 0.0035
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0023 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0037 0.0035 0.0035
Entamoeba histolytica hypothetical protein 0.007 0.0079 0.3956
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0014
Brugia malayi Glycosyl hydrolases family 31 protein 0.0042 0.0042 0.0042
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0023 0.0023
Echinococcus multilocularis thyroid hormone receptor alpha 0.0158 0.0195 0.0195
Brugia malayi nuclear hormone receptor 0.0037 0.0035 0.0035
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0001 0.0001
Brugia malayi nuclear receptor RXR 0.0019 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0014
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.0023 0.0011
Schistosoma mansoni intermediate filament proteins 0.006 0.0065 0.0065
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0037 0.0035 0.0035
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0014 0.0014
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0014 0.0013
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0023 0.0053
Brugia malayi RNA, U transporter 1 0.0084 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.0074 0.0084 0.0084
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0025 0.0021 0.0021
Echinococcus multilocularis microtubule associated protein 2 0.0666 0.0859 0.0859
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0015 0.0008 0.0017
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0042 0.0096
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0017 0.001 0.001
Schistosoma mansoni rotamase 0.0032 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0029 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.001
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0023 0.0053
Plasmodium vivax SET domain protein, putative 0.0029 0.0026 0.0058
Echinococcus multilocularis aryl hydrocarbon receptor 0.0025 0.0021 0.0021
Schistosoma mansoni microtubule-associated protein tau 0.0666 0.0859 0.0859
Loa Loa (eye worm) hypothetical protein 0.0059 0.0064 0.0064
Trypanosoma brucei glycosyl hydrolase-like protein 0.0015 0.0008 0.0017
Toxoplasma gondii ImpB/MucB/SamB family protein 0.001 0.0001 0.0002
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.0014 0.0014
Brugia malayi hypothetical protein 0.0018 0.0011 0.0011
Trypanosoma cruzi cytochrome P450, putative 0.0018 0.0012 0.0026
Mycobacterium leprae conserved hypothetical protein 0.0074 0.0084 0.0061
Brugia malayi Steroid receptor seven-up type 2 0.0037 0.0035 0.0035
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0058 0.0064 0.2116
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.001
Echinococcus granulosus lamin 0.006 0.0065 0.0065
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0017 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0001
Plasmodium falciparum DNA repair protein REV1, putative 0.001 0.0001 0.0002
Brugia malayi beta-lactamase 0.0074 0.0084 0.0084
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.0029 0.0066
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.0042 0.1341
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0014 0.0346
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0018 0.0011 0.0011
Brugia malayi nuclear receptor NHR-67 0.0017 0.001 0.001
Schistosoma mansoni transcription factor LCR-F1 0.007 0.0079 0.0079
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0026 0.0026
Trypanosoma brucei unspecified product 0.0023 0.0017 0.0038
Echinococcus granulosus microtubule associated protein 2 0.0666 0.0859 0.0859
Brugia malayi hypothetical protein 0.0019 0.0013 0.0013
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0029 0.0025 0.0025
Leishmania major importin beta-1 subunit, putative 0.0024 0.0019 0.0043
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0014
Echinococcus granulosus bloom syndrome protein 0.0023 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0161 0.0198 0.0198
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0034 0.0034
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0026 0.0059
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0014 0.003
Trichomonas vaginalis maltase-glucoamylase, putative 0.0042 0.0042 0.1341
Echinococcus multilocularis dihydrofolate reductase 0.7656 1 1
Schistosoma mansoni thyroid hormone receptor 0.0158 0.0195 0.0195
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0024 0.0056
Brugia malayi ImpB/MucB/SamB family protein 0.0033 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0037 0.0035 0.0035
Schistosoma mansoni hypothetical protein 0.007 0.0079 0.0079
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0019 0.0013 0.0013
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0019 0.0013 0.0013
Brugia malayi Nuclear hormone receptor E75 0.0017 0.001 0.001
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0033 0.003 0.003
Echinococcus multilocularis lysosomal alpha glucosidase 0.0187 0.0232 0.0232
Brugia malayi ImpB/MucB/SamB family protein 0.0033 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.001
Brugia malayi nuclear receptor NHR-88 0.0037 0.0035 0.0035
Brugia malayi Glycosyl hydrolases family 31 protein 0.0187 0.0232 0.0232
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.002 0.0047
Echinococcus multilocularis geminin 0.0347 0.0442 0.0442
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0025 0.0058
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0019 0.0013 0.0013
Trypanosoma brucei DNA damage repair protein, putative 0.001 0.0001 0.0001
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0008 0.0141
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0014 0.3513
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.001
Brugia malayi Dihydrofolate reductase 0.7656 1 1
Echinococcus multilocularis cpg binding protein 0.0031 0.0028 0.0028
Brugia malayi hypothetical protein 0.0019 0.0013 0.0013
Brugia malayi ecdysone receptor 0.0017 0.001 0.001
Echinococcus multilocularis thymidylate synthase 0.0317 0.0403 0.0403
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0042 0.1341
Mycobacterium ulcerans lipase LipD 0.0074 0.0084 0.0084
Schistosoma mansoni hypothetical protein 0.0315 0.0399 0.0399
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0032 0.0029 0.0029
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0042 0.0096
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0024 0.0056
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0018 0.0498
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0024 0.0054
Loa Loa (eye worm) hypothetical protein 0.011 0.0132 0.0132
Leishmania major DNA polymerase eta, putative 0.001 0.0001 0.0001
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0014 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0037 0.0035 0.0035
Onchocerca volvulus 0.0074 0.0084 0.1943
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0014 0.003
Schistosoma mansoni hypothetical protein 0.0011 0.0002 0.0002
Onchocerca volvulus 0.0064 0.0072 0.1617
Entamoeba histolytica hypothetical protein 0.007 0.0079 0.3956
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.002 0.0046
Loa Loa (eye worm) hypothetical protein 0.0027 0.0023 0.0023
Onchocerca volvulus 0.0029 0.0026 0.046
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0000000000057018 0.000000000013151
Brugia malayi hypothetical protein 0.007 0.0079 0.0079
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0019 0.053
Trypanosoma brucei DNA damage repair protein, putative 0.001 0.0001 0.0001
Echinococcus multilocularis neutral alpha glucosidase AB 0.0042 0.0042 0.0042
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.007 0.0079 0.0079
Onchocerca volvulus 0.0025 0.0021 0.033
Onchocerca volvulus 0.0037 0.0035 0.0703
Brugia malayi polk-prov protein 0.0036 0.0034 0.0034
Schistosoma mansoni nuclear hormone receptor 0.0017 0.001 0.001
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0317 0.0403 0.038
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0008 0.0141
Onchocerca volvulus 0.006 0.0065 0.1462
Loa Loa (eye worm) hypothetical protein 0.006 0.0065 0.0065
Brugia malayi jmjC domain containing protein 0.0092 0.0108 0.0108
Leishmania major cytochrome p450-like protein 0.0018 0.0012 0.0026
Trypanosoma brucei DNA polymerase eta, putative 0.0033 0.003 0.0069
Giardia lamblia PHD finger protein 15 0.0028 0.0024 0.6318
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0064 0.0146
Echinococcus granulosus neuropeptide receptor A26 0.0436 0.0558 0.0558
Schistosoma mansoni terminal deoxycytidyl transferase 0.0033 0.003 0.003
Brugia malayi Calcitonin receptor-like protein seb-1 0.0161 0.0198 0.0198
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0064 0.0146
Trypanosoma cruzi cytochrome P450, putative 0.0018 0.0012 0.0026
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.0018 0.0011 0.0011
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0084 0.0072
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0011 0.0002 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0037 0.0035 0.0035
Brugia malayi hypothetical protein 0.0018 0.0011 0.0011
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0017 0.001 0.001
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0037 0.0035 0.0035
Brugia malayi nuclear hormone receptor family member nhr-6 0.0017 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0011
Onchocerca volvulus 0.0017 0.001 0.0061
Echinococcus multilocularis ecdysone induced protein 78C 0.0037 0.0035 0.0035
Brugia malayi PHD-finger family protein 0.0011 0.0002 0.0002
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0161 0.0198 0.0198
Trichomonas vaginalis rotamase, putative 0.0032 0.0029 0.0881
Trypanosoma brucei cytochrome P450, putative 0.0018 0.0012 0.0026
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0037 0.0035 0.0035
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0062 0.0142
Loa Loa (eye worm) hypothetical protein 0.0029 0.0025 0.0025
Echinococcus multilocularis snurportin 1 0.0315 0.0399 0.0399
Mycobacterium tuberculosis Conserved protein 0.0074 0.0084 0.0072
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.0008 0.0017
Mycobacterium ulcerans DNA polymerase IV 0.0058 0.0064 0.0063
Loa Loa (eye worm) dihydrofolate reductase 0.7656 1 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0014 0.0014
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0014 0.0001
Brugia malayi orphan nuclear receptor NR2E1 0.0017 0.001 0.001
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0084 0.0072
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0037 0.0035 0.0035
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0158 0.0194 1
Trypanosoma cruzi DNA damage repair protein, putative 0.001 0.0001 0.0001
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.001 0.001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0037 0.0035 0.0035
Echinococcus granulosus GPCR family 2 0.0051 0.0054 0.0054
Echinococcus granulosus cpg binding protein 0.0031 0.0028 0.0028
Echinococcus granulosus dna polymerase eta 0.0033 0.003 0.003
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.0023 0.0023
Brugia malayi beta-lactamase family protein 0.0074 0.0084 0.0084
Toxoplasma gondii ABC1 family protein 0.0074 0.0084 0.0195
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.001
Schistosoma mansoni hypothetical protein 0.005 0.0053 0.0053
Schistosoma mansoni hypothetical protein 0.011 0.0132 0.0132
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0004 0.0008
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0037 0.0035 0.0035
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0037 0.0035 0.0035
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0034 0.0034
Echinococcus granulosus peregrin 0.0028 0.0024 0.0024
Echinococcus granulosus jun protein 0.0082 0.0095 0.0095
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0051 0.0054 0.0054
Echinococcus granulosus lysosomal alpha glucosidase 0.0187 0.0232 0.0232
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.001
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0051 0.0054 0.0054
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0084 0.2845
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0017 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.001
Schistosoma mansoni nuclear hormone receptor 0.0037 0.0035 0.0035
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0084 0.0194
Loa Loa (eye worm) nuclear hormone receptor 0.0017 0.001 0.001
Loa Loa (eye worm) cytochrome P450 family protein 0.0018 0.0012 0.0012
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0037 0.0035 0.0035
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0026 0.006
Trypanosoma cruzi DNA polymerase kappa, putative 0.0058 0.0064 0.0146
Loa Loa (eye worm) hypothetical protein 0.0074 0.0084 0.0084
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0014 0.0031
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0011 0.0011
Schistosoma mansoni lamin 0.006 0.0065 0.0065
Brugia malayi Nuclear hormone receptor-like 1 0.0037 0.0035 0.0035
Trichomonas vaginalis sucrase-isomaltase, putative 0.0042 0.0042 0.1341
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.002 0.0046
Echinococcus multilocularis expressed protein 0.0032 0.003 0.003
Echinococcus granulosus thyroid hormone receptor alpha 0.0017 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0051 0.0054 0.0054
Schistosoma mansoni alpha-glucosidase 0.0161 0.0198 0.0198
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0084 0.0084
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0024 0.0024
Leishmania major dihydrofolate reductase-thymidylate synthase 0.3325 0.4336 1
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.001 0 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0037 0.0035 0.0035
Schistosoma mansoni nuclear receptor 0.0017 0.001 0.001
Loa Loa (eye worm) nuclear receptor NHR-67 0.0017 0.001 0.001
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0019 0.053
Onchocerca volvulus 0.0027 0.0023 0.0394
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0092 0.0108 0.0108
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0037 0.0035 0.0035
Echinococcus multilocularis nuclear receptor nhr 48 0.0017 0.001 0.001
Loa Loa (eye worm) thymidylate synthase 0.0317 0.0403 0.0403
Leishmania major hypothetical protein, conserved 0.0025 0.002 0.0046
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0037 0.0035 0.0035
Leishmania major DNA damage repair protein, putative 0.001 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0051 0.0054 0.0054
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0014 0.003
Echinococcus multilocularis neuropeptide s receptor 0.0436 0.0558 0.0558
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0026 0.0026
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0034 0.0034
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0064 0.0146
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0037 0.0035 0.0035
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0037 0.0035 0.0035
Schistosoma mansoni alpha glucosidase 0.0042 0.0042 0.0042
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0084 0.0072
Schistosoma mansoni ap endonuclease 0.002 0.0014 0.0014
Brugia malayi hypothetical protein 0.0025 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0037 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0011
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0033 0.003 0.003
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.7656 1 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0116 0.0139 0.0139
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0002 0.0003
Schistosoma mansoni coup transcription factor 0.0037 0.0035 0.0035
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0084 0.0072
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0084 0.0072
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0084 0.0072
Loa Loa (eye worm) hypothetical protein 0.0028 0.0024 0.0024
Echinococcus multilocularis lamin 0.006 0.0065 0.0065
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0037 0.0035 0.0035
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0042 0.1341
Schistosoma mansoni hypothetical protein 0.0051 0.0054 0.0054
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.0174 0.0174
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0116 0.0139 0.032
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0032 0.0029 0.0065
Brugia malayi Latrophilin receptor protein 2 0.0051 0.0054 0.0054
Trichomonas vaginalis set domain proteins, putative 0.0229 0.0288 1
Onchocerca volvulus 0.0229 0.0288 0.7087
Giardia lamblia DNA damage repair protein 0.001 0.0001 0.0188
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0037 0.0035 0.0035
Echinococcus granulosus FTZ F1 alpha 0.0037 0.0035 0.0035
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0024 0.0024
Brugia malayi PHD-finger family protein 0.0028 0.0024 0.0024
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0161 0.0198 0.0198
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0019 0.0013 0.0013
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0019 0.053
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0014
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0015 0.0008 0.0017
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0084 0.0084
Brugia malayi latrophilin 2 splice variant baaae 0.011 0.0132 0.0132
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0037 0.0035 0.0035
Schistosoma mansoni cpg binding protein 0.0031 0.0028 0.0028
Onchocerca volvulus 0.0017 0.001 0.0061
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.001
Mycobacterium tuberculosis Conserved hypothetical protein 0.0033 0.003 0.0017
Schistosoma mansoni hypothetical protein 0.0028 0.0024 0.0024
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0042 0.0042 0.0042

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.53 uM Inhibition of aromatase in human placental microsomes using [1beta-3H]-androstenedione as substrate assessed as tritiated H2O release after 15 mins by liquid scintillation counting method ChEMBL. 27160054
Inhibition (binding) = 64.8 % Inhibition of human placental aromatase expressed in human MCF7 cells using [1beta-3H]-androstenedione as substrate assessed as tritiated H2O release at 10 uM after 1 hr by liquid scintillation counting method in presence of progesterone relative to control ChEMBL. 27160054
Inhibition (binding) = 85.54 % Inhibition of aromatase in human placental microsomes using [1beta-3H]-androstenedione as substrate assessed as tritiated H2O release at 2 uM after 15 mins by liquid scintillation counting method relative to control ChEMBL. 27160054

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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