Detailed information for compound 21569

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 326.214 | Formula: C7H10BrN4O2S2-
  • H donors: 1 H acceptors: 4 LogP: 1.95 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1nc2n(c1C)nc(s2)S(=O)(=O)N.[Br-]
  • InChi: 1S/C7H10N4O2S2.BrH/c1-3-5-4(2)11-6(9-5)14-7(10-11)15(8,12)13;/h3H2,1-2H3,(H2,8,12,13);1H/p-1
  • InChiKey: ZGAVAJRMEACHEA-UHFFFAOYSA-M  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni smad1 5 8 and 0.0035 0.0232 0.0232
Trypanosoma cruzi cysteine peptidase, putative 0.0019 0.0012 0.0163
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0054 0.0081
Schistosoma mansoni hypothetical protein 0.027 0.3382 0.3382
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0283 0.0918
Loa Loa (eye worm) MH1 domain-containing protein 0.0035 0.0232 0.035
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0022 0.0054 0.0081
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0283 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0019 0.0012 1
Leishmania major cathepsin L-like protease 0.0071 0.071 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0328 0.4147 0.6235
Schistosoma mansoni hypothetical protein 0.019 0.2303 0.2303
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0054 0.0054
Schistosoma mansoni smad1 5 8 and 0.0035 0.0232 0.0232
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.071 1
Brugia malayi ecdysteroid receptor 0.0022 0.0054 0.0081
Trypanosoma cruzi major cysteine proteinase, putative 0.0056 0.0507 0.7145
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0019 0.0012 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0032 0.0198 0.0297
Leishmania major cathepsin L-like protease 0.0071 0.071 1
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0054 0.0054
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0054 0.0054
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0328 0.4147 0.6235
Echinococcus granulosus lamin dm0 0.0061 0.0574 0.0574
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0054 0.0081
Schistosoma mansoni hypothetical protein 0.0121 0.1385 0.1385
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.071 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0039 0.0283 0.0426
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0104 0.115 0.115
Plasmodium vivax vivapain-2 0.0019 0.0012 0.0408
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0054 0.0054
Entamoeba histolytica hypothetical protein 0.0121 0.1385 1
Onchocerca volvulus 0.0039 0.0283 0.4828
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.071 1
Brugia malayi MH1 domain containing protein 0.0019 0.0023 0.0034
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0283 1
Plasmodium vivax vivapain-2 0.0019 0.0012 0.0408
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0012 0.0017
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0283 0.0283
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0065 0.0627 0.8843
Schistosoma mansoni hypothetical protein 0.0104 0.115 0.115
Loa Loa (eye worm) MH2 domain-containing protein 0.0515 0.6651 1
Schistosoma mansoni coup transcription factor 0.0022 0.0054 0.0054
Mycobacterium ulcerans hypothetical protein 0.0039 0.0283 0.5
Brugia malayi Cathepsin L-like precursor 0.0019 0.0012 0.0017
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0104 0.115 0.115
Brugia malayi Cathepsin L-like precursor 0.0019 0.0012 0.0017
Echinococcus multilocularis mothers against decapentaplegic 5 0.0035 0.0232 0.0232
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0283 0.3991
Loa Loa (eye worm) hypothetical protein 0.0022 0.0054 0.0081
Echinococcus granulosus GPCR family 2 0.0104 0.115 0.115
Brugia malayi MH1 domain containing protein 0.0035 0.0232 0.035
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0283 0.0918
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0283 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0012 0.0012
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0054 0.0054
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0054 0.0081
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0035 0.0232 0.0232
Echinococcus multilocularis lamin 0.0061 0.0574 0.0574
Onchocerca volvulus 0.0022 0.0054 0.0749
Echinococcus granulosus cathepsin L cysteine proteinase 0.0019 0.0012 0.0012
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.071 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0022 0.0054 0.0749
Mycobacterium leprae Probable lipase LipE 0.0039 0.0283 0.5
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0283 0.0283
Onchocerca volvulus 0.0039 0.0283 0.4828
Brugia malayi Cathepsin L-like precursor 0.0019 0.0012 0.0017
Loa Loa (eye worm) hypothetical protein 0.0022 0.0054 0.0081
Schistosoma mansoni smad1 5 8 and 0.0035 0.0232 0.0232
Echinococcus granulosus geminin 0.019 0.2303 0.2303
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0054 0.0081
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0029 0.0155 0.0155
Schistosoma mansoni lamin 0.0061 0.0574 0.0574
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0054 0.0081
Loa Loa (eye worm) hypothetical protein 0.0028 0.014 0.021
Schistosoma mansoni thyroid hormone receptor 0.0292 0.3673 0.3673
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0121 0.1385 0.1385
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.027 0.3382 0.3382
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0054 0.0054
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0054 0.0081
Echinococcus multilocularis smad 0.0035 0.0232 0.0232
Loa Loa (eye worm) hypothetical protein 0.0328 0.4147 0.6235
Onchocerca volvulus 0.0061 0.0574 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0054 0.0081
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0054 0.0054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.071 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0054 0.0054
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0022 0.0054 0.0749
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0054 0.0054
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0054 0.0081
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0283 0.0283
Loa Loa (eye worm) hypothetical protein 0.0022 0.0054 0.0081
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0061 0.0574 0.0863
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0054 0.0081
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0054 0.0081
Onchocerca volvulus 0.0039 0.0283 0.4828
Loa Loa (eye worm) transcription factor SMAD2 0.0515 0.6651 1
Loa Loa (eye worm) beta-lactamase 0.0039 0.0283 0.0426
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0104 0.115 0.115
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0104 0.115 0.115
Loa Loa (eye worm) hypothetical protein 0.0019 0.0023 0.0034
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0283 0.5
Loa Loa (eye worm) hypothetical protein 0.0022 0.0054 0.0081
Loa Loa (eye worm) intermediate filament protein 0.0061 0.0574 0.0863
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0283 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.0559 0.0841
Brugia malayi Cathepsin L-like precursor 0.0019 0.0012 0.0017
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.071 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.0574 0.0863
Entamoeba histolytica hypothetical protein 0.0121 0.1385 1
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0283 0.0918
Leishmania major hypothetical protein, conserved 0.0039 0.0283 0.3991
Toxoplasma gondii ABC1 family protein 0.0039 0.0283 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0012 0.0012
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0054 0.0054
Echinococcus granulosus mothers against decapentaplegic 5 0.0035 0.0232 0.0232
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.071 1
Onchocerca volvulus 0.0061 0.0574 1
Toxoplasma gondii cathepsin CPL 0.0019 0.0012 0.0408
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0054 0.0081
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0054 0.0081
Brugia malayi nuclear hormone receptor 0.0022 0.0054 0.0081
Entamoeba histolytica hypothetical protein 0.0121 0.1385 1
Loa Loa (eye worm) ctsf protein 0.0019 0.0012 0.0017
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0283 0.0426
Onchocerca volvulus Bile acid receptor homolog 0.0022 0.0054 0.0749
Echinococcus multilocularis GPCR, family 2 0.0104 0.115 0.115
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0054 0.0054
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0283 0.3991
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0035 0.0232 0.0232
Loa Loa (eye worm) Smad1 0.0035 0.0232 0.035
Leishmania major cathepsin L-like protease 0.0019 0.0012 0.0163
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0283 0.0918
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0054 0.0081
Schistosoma mansoni microtubule-associated protein tau 0.0765 1 1
Echinococcus multilocularis cysteine protease 0.0019 0.0012 0.0012
Leishmania major cathepsin L-like protease 0.0019 0.0012 0.0163
Brugia malayi latrophilin 2 splice variant baaae 0.0224 0.276 0.4149
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0019 0.0012 0.0017
Trichomonas vaginalis esterase, putative 0.0039 0.0283 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0283 0.0426
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0283 0.0283
Entamoeba histolytica hypothetical protein 0.0121 0.1385 1
Echinococcus multilocularis geminin 0.019 0.2303 0.2303
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0054 0.0081
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0054 0.0054
Echinococcus granulosus cathepsin l1 0.0019 0.0012 0.0012
Schistosoma mansoni lamin 0.0061 0.0574 0.0574
Trypanosoma cruzi cruzipain precursor, putative 0.0071 0.071 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0035 0.0232 0.0232
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0054 0.0081
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0054 0.0054
Plasmodium falciparum cysteine proteinase falcipain 3 0.0019 0.0012 1
Schistosoma mansoni hypothetical protein 0.0224 0.276 0.276
Echinococcus multilocularis lamin dm0 0.0061 0.0574 0.0574
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.071 1
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0054 0.0054
Echinococcus multilocularis microtubule associated protein 2 0.0765 1 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0054 0.0081
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0283 1
Mycobacterium tuberculosis Conserved protein 0.0039 0.0283 0.0918
Schistosoma mansoni hypothetical protein 0.019 0.2303 0.2303
Mycobacterium tuberculosis Conserved protein 0.0039 0.0283 0.0918
Echinococcus granulosus Smad4 0.0035 0.0232 0.0232
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0054 0.0054
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.027 0.3382 0.3382
Schistosoma mansoni hypothetical protein 0.0104 0.115 0.115
Echinococcus granulosus intermediate filament protein 0.0061 0.0574 0.0574
Loa Loa (eye worm) nuclear factor I 0.0019 0.0023 0.0034
Brugia malayi hypothetical protein 0.0121 0.1385 0.2082
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0054 0.0081
Brugia malayi Smad1 0.0035 0.0232 0.035
Brugia malayi MH1 domain containing protein 0.0019 0.0023 0.0034
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0054 0.0054
Brugia malayi Calcitonin receptor-like protein seb-1 0.0328 0.4147 0.6235
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0283 0.3991
Brugia malayi cytoplasmic intermediate filament protein 0.0032 0.0198 0.0297
Brugia malayi MH2 domain containing protein 0.0035 0.0232 0.035
Loa Loa (eye worm) hypothetical protein 0.0022 0.0054 0.0081
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0054 0.0081
Brugia malayi nuclear receptor NHR-88 0.0022 0.0054 0.0081
Schistosoma mansoni Smad4 0.0035 0.0232 0.0232
Echinococcus multilocularis musashi 0.0061 0.0574 0.0574
Brugia malayi beta-lactamase 0.0039 0.0283 0.0426
Schistosoma mansoni hypothetical protein 0.0104 0.115 0.115
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0054 0.0081
Echinococcus granulosus lamin 0.0061 0.0574 0.0574
Leishmania major cathepsin L-like protease 0.0019 0.0012 0.0163
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0054 0.0054
Echinococcus multilocularis cysteine protease 0.0019 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.0104 0.115 0.115
Schistosoma mansoni thyroid hormone receptor 0.0292 0.3673 0.3673
Mycobacterium ulcerans lipase LipD 0.0039 0.0283 0.5
Brugia malayi intermediate filament protein 0.0061 0.0574 0.0863
Leishmania major cathepsin L-like protease 0.0071 0.071 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0054 0.0081
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.071 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0283 0.0426
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0283 0.0918
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0054 0.0054
Echinococcus multilocularis Smad4 0.0035 0.0232 0.0232
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0054 0.0054
Brugia malayi beta-lactamase family protein 0.0039 0.0283 0.0426
Brugia malayi beta-lactamase family protein 0.0039 0.0283 0.0426
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0012 0.0012
Mycobacterium ulcerans beta-lactamase 0.0039 0.0283 0.5
Loa Loa (eye worm) fibroinase 0.0019 0.0012 0.0017
Brugia malayi steroid hormone receptor 0.0022 0.0054 0.0081
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0012 0.0012
Echinococcus granulosus cathepsin l cysteine peptidase 0.0019 0.0012 0.0012
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0054 0.0054
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0054 0.0081
Schistosoma mansoni transcription factor LCR-F1 0.0121 0.1385 0.1385
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0121 0.1385 0.1385
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0054 0.0054
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0283 0.0918
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0017
Brugia malayi MH2 domain containing protein 0.0035 0.0232 0.035
Brugia malayi Cathepsin L-like precursor 0.0019 0.0012 0.0017
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0283 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.071 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0054 0.0054
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0104 0.115 0.1729
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0054 0.0081
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0248 0.3086 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.071 1
Mycobacterium tuberculosis Conserved protein 0.0039 0.0283 0.0918
Leishmania major cathepsin L-like protease 0.0019 0.0012 0.0163
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0029 0.0155 0.0155
Brugia malayi Intermediate filament tail domain containing protein 0.0061 0.0574 0.0863
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0028 0.014 0.021
Echinococcus multilocularis thyroid hormone receptor alpha 0.0292 0.3673 0.3673
Loa Loa (eye worm) hypothetical protein 0.0104 0.115 0.1729
Loa Loa (eye worm) hypothetical protein 0.0224 0.276 0.4149
Brugia malayi MH2 domain containing protein 0.0515 0.6651 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0054 0.0081
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0054 0.0054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.071 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0039 0.0283 0.0426
Schistosoma mansoni smad 0.0035 0.0232 0.0232
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0019 0.0012 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0054 0.0081
Brugia malayi MH1 domain containing protein 0.0035 0.0232 0.035
Loa Loa (eye worm) hypothetical protein 0.0039 0.0283 0.0426
Loa Loa (eye worm) MH2 domain-containing protein 0.0035 0.0232 0.035
Leishmania major cathepsin L-like protease 0.0019 0.0012 0.0163
Echinococcus granulosus smad 0.0035 0.0232 0.0232
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0054 0.0054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.071 1
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0283 0.5
Schistosoma mansoni intermediate filament proteins 0.0061 0.0574 0.0574
Leishmania major cysteine peptidase A (CPA) 0.0019 0.0012 0.0163
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0283 0.0918
Loa Loa (eye worm) cysteine protease 0.0019 0.0012 0.0017
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.071 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0283 0.0426
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0283 0.5
Loa Loa (eye worm) hypothetical protein 0.0039 0.0283 0.0426
Brugia malayi Cathepsin L-like precursor 0.0019 0.0012 0.0017
Brugia malayi Latrophilin receptor protein 2 0.0104 0.115 0.1729
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0054 0.0081
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0054 0.0081
Loa Loa (eye worm) latrophilin receptor protein 2 0.0104 0.115 0.1729
Loa Loa (eye worm) hypothetical protein 0.0029 0.0155 0.0232
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0012 0.0012

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 8 mg kg-1 Protective dose against maximal electroshock in mice after peroral administration ChEMBL. 7359524
Potency ratio (functional) = 1 Anticonvulsant potency in mice relative to compound UK-12130 (ED50 of compound 24/compound) ChEMBL. 7359524

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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