Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0175 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.3022 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.8908 | 0.9266 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0061 | 0.7269 | 0.7503 |
Schistosoma mansoni | hypothetical protein | 0.0075 | 0.9613 | 0.9922 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0075 | 0.9613 | 1 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0075 | 0.9613 | 1 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0075 | 0.9613 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.9613 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.4641 | 0.4545 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0175 | 0.0181 |
Brugia malayi | TAR-binding protein | 0.0065 | 0.7989 | 0.7953 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.0175 | 0.0182 |
Schistosoma mansoni | hypothetical protein | 0.0021 | 0.0618 | 0.0638 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.3022 | 1 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0023 | 0.0947 | 0.0986 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0018 | 0.0094 | 0.0097 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0175 | 0.0181 |
Brugia malayi | Kringle domain containing protein | 0.0075 | 0.9613 | 0.9606 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0054 | 0.6068 | 0.5998 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.4641 | 0.4828 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.3217 | 0.332 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0037 | 0.3258 | 0.3389 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.7989 | 0.8246 |
Brugia malayi | Trypsin family protein | 0.0071 | 0.8908 | 0.8889 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.3022 | 0.3119 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.8908 | 0.9266 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0037 | 0.3258 | 0.3389 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.3022 | 1 |
Schistosoma mansoni | zinc finger protein | 0.002 | 0.0435 | 0.0449 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0075 | 0.9613 | 1 |
Brugia malayi | Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit | 0.0061 | 0.7269 | 0.7221 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0054 | 0.6068 | 0.5998 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.7989 | 0.8246 |
Echinococcus multilocularis | potassium voltage gated channel protein | 0.0061 | 0.7269 | 0.7562 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.3022 | 1 |
Brugia malayi | RNA binding protein | 0.0065 | 0.7989 | 0.7953 |
Loa Loa (eye worm) | RNA binding protein | 0.0065 | 0.7989 | 0.831 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0018 | 0.0106 | 0.011 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0021 | 0.0618 | 0.0643 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0019 | 0.0175 | 0.0182 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0175 | 0.5 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.0175 | 0.5 |
Echinococcus granulosus | zinc finger protein | 0.002 | 0.0435 | 0.0453 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0075 | 0.9689 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.3217 | 0.3346 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.4641 | 0.4828 |
Echinococcus granulosus | potassium voltage gated channel protein | 0.0061 | 0.7269 | 0.7562 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0061 | 0.7269 | 0.7503 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.4641 | 0.479 |
Onchocerca volvulus | 0.0075 | 0.9613 | 1 | |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0019 | 0.0175 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.4641 | 0.479 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0054 | 0.6068 | 0.6312 |
Brugia malayi | Bromodomain containing protein | 0.0039 | 0.3667 | 0.3554 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.3022 | 0.3119 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0023 | 0.0947 | 0.0986 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0071 | 0.8908 | 0.9194 |
Leishmania major | hypothetical protein, conserved | 0.0075 | 0.9613 | 1 |
Brugia malayi | PHD-finger family protein | 0.0026 | 0.1356 | 0.1202 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0075 | 0.9613 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.7989 | 0.8246 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0075 | 0.9613 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0.0175 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0065 | 0.7989 | 0.831 |
Toxoplasma gondii | kringle domain-containing protein | 0.0075 | 0.9613 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.0175 | 0.5 |
Echinococcus granulosus | potassium voltage gated channel subfamily A | 0.0061 | 0.7269 | 0.7562 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.3679 | 0.3827 |
Echinococcus multilocularis | potassium voltage gated channel subfamily A | 0.0058 | 0.6823 | 0.7098 |
Echinococcus multilocularis | tar DNA binding protein | 0.0065 | 0.7989 | 0.831 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.7989 | 0.8246 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.4417 | 0.4595 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0023 | 0.0947 | 0.0978 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.7269 | 0.7562 |
Onchocerca volvulus | 0.0071 | 0.8908 | 0.7893 | |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.4641 | 0.479 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.4641 | 0.4828 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.6068 | 0.6312 |
Brugia malayi | hypothetical protein | 0.0036 | 0.3022 | 0.2898 |
Schistosoma mansoni | bromodomain containing protein | 0.0065 | 0.7978 | 0.8234 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.3022 | 0.3144 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0.0175 | 0.5 |
Echinococcus multilocularis | zinc finger protein | 0.002 | 0.0435 | 0.0453 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.9262 | 0.9635 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0037 | 0.3217 | 0.3096 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0.0175 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.4087 | 0.4252 |
Loa Loa (eye worm) | TAR-binding protein | 0.0065 | 0.7989 | 0.831 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0061 | 0.736 | 0.7656 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.3022 | 0.3144 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.4641 | 0.4828 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0019 | 0.0175 | 0.0182 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0061 | 0.736 | 0.7656 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0065 | 0.7989 | 0.7953 |
Brugia malayi | Protein kinase domain containing protein | 0.0075 | 0.9613 | 0.9606 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.7989 | 0.8246 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.4641 | 0.4828 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0065 | 0.7989 | 0.831 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.