Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0041 | 0.0875 | 0.0875 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0041 | 0.0875 | 1 |
Loa Loa (eye worm) | GoLoco domain-containing protein family protein | 0.0012 | 0.0123 | 0.0126 |
Echinococcus granulosus | cpg binding protein | 0.003 | 0.0578 | 0.0578 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0319 | 0.0429 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0012 | 0.0129 | 0.5 |
Brugia malayi | GoLoco motif family protein | 0.0012 | 0.0123 | 0.0126 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0875 | 0.1285 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0012 | 0.0129 | 0.0136 |
Schistosoma mansoni | hypothetical protein | 0.0401 | 1 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0041 | 0.0875 | 0.0875 |
Brugia malayi | nuclear receptor NHR-88 | 0.0041 | 0.0875 | 0.1285 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.002 | 0.0319 | 0.0319 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0578 | 0.0578 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0041 | 0.0875 | 0.1285 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0319 | 0.0429 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0053 | 0.1176 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0319 | 0.0429 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0041 | 0.0875 | 0.1285 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0759 | 0.1106 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0041 | 0.0875 | 0.0875 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0663 | 0.0958 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0041 | 0.0875 | 0.0875 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0041 | 0.0875 | 0.0875 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0041 | 0.0875 | 0.1285 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0875 | 0.1285 |
Brugia malayi | steroid hormone receptor | 0.0041 | 0.0875 | 0.1285 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.006 | 0.1338 | 0.1338 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0378 | 0.052 |
Echinococcus multilocularis | G protein signaling modulator 2 | 0.0012 | 0.0123 | 0.0123 |
Echinococcus multilocularis | geminin | 0.0166 | 0.4039 | 0.4039 |
Brugia malayi | tailless protein | 0.002 | 0.0319 | 0.0428 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0378 | 0.052 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.002 | 0.0319 | 0.0319 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0012 | 0.0129 | 0.0136 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0875 | 0.1285 |
Brugia malayi | hypothetical protein | 0.002 | 0.0319 | 0.0428 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0041 | 0.0875 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0319 | 0.0429 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.002 | 0.0319 | 0.0319 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0041 | 0.0875 | 0.0875 |
Echinococcus granulosus | raf serine:threonine protein kinase | 0.0042 | 0.0896 | 0.0896 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.002 | 0.0319 | 0.0319 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0012 | 0.0129 | 0.0136 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0041 | 0.0875 | 0.0875 |
Brugia malayi | nuclear receptor RXR | 0.002 | 0.0319 | 0.0428 |
Schistosoma mansoni | nuclear receptor | 0.002 | 0.0319 | 0.0319 |
Brugia malayi | hypothetical protein | 0.0022 | 0.0378 | 0.052 |
Brugia malayi | nuclear receptor NHR-88 | 0.002 | 0.0319 | 0.0428 |
Echinococcus granulosus | small conductance calcium activated potassium | 0.0108 | 0.2575 | 0.2575 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0123 | 0.0126 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0041 | 0.0875 | 0.0875 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.002 | 0.0319 | 0.0428 |
Brugia malayi | hypothetical protein | 0.002 | 0.0319 | 0.0428 |
Loa Loa (eye worm) | histone methyltransferase | 0.0009 | 0.0044 | 0.0005 |
Brugia malayi | Cytochrome P450 family protein | 0.0012 | 0.0129 | 0.0135 |
Brugia malayi | nuclear receptor NHR-67 | 0.002 | 0.0319 | 0.0428 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0022 | 0.0378 | 0.052 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.002 | 0.0319 | 0.0319 |
Schistosoma mansoni | hypothetical protein | 0.0292 | 0.7226 | 0.7226 |
Schistosoma mansoni | zinc finger protein | 0.002 | 0.0319 | 0.0319 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0041 | 0.0875 | 0.0875 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0319 | 0.0429 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0028 | 0.0537 | 0.0765 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.002 | 0.0319 | 0.0319 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0041 | 0.0875 | 0.0875 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0378 | 0.052 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0041 | 0.0875 | 0.1285 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.002 | 0.0319 | 0.0319 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0041 | 0.0875 | 0.1285 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0875 | 0.1285 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0041 | 0.0875 | 0.0875 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0041 | 0.0875 | 0.0875 |
Brugia malayi | conserved hypotetical protein | 0.002 | 0.0319 | 0.0428 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0041 | 0.0875 | 0.1285 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.4039 | 0.4039 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0041 | 0.0875 | 0.1285 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.002 | 0.0319 | 0.0319 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0319 | 0.0429 |
Echinococcus granulosus | geminin | 0.0166 | 0.4039 | 0.4039 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0041 | 0.0875 | 0.1285 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.002 | 0.0319 | 0.0429 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0041 | 0.0875 | 0.0875 |
Schistosoma mansoni | hypothetical protein | 0.0012 | 0.0123 | 0.0123 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0401 | 1 | 1 |
Brugia malayi | ecdysone receptor | 0.002 | 0.0319 | 0.0428 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0875 | 0.1285 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0041 | 0.0875 | 0.1285 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.002 | 0.0319 | 0.0319 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.002 | 0.0319 | 0.0319 |
Echinococcus multilocularis | cpg binding protein | 0.003 | 0.0578 | 0.0578 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.002 | 0.0319 | 0.0319 |
Schistosoma mansoni | nuclear hormone receptor | 0.002 | 0.0319 | 0.0319 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0041 | 0.0875 | 0.1285 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0578 | 0.0578 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0378 | 0.052 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0041 | 0.0875 | 0.1285 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0022 | 0.0378 | 0.052 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0041 | 0.0875 | 0.1285 |
Schistosoma mansoni | nuclear hormone receptor | 0.0041 | 0.0875 | 0.0875 |
Schistosoma mansoni | thyroid hormone receptor | 0.0333 | 0.8278 | 0.8278 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0022 | 0.0378 | 0.0378 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0041 | 0.0875 | 0.0875 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0041 | 0.0875 | 0.1285 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0041 | 0.0875 | 0.0875 |
Schistosoma mansoni | coup transcription factor | 0.0041 | 0.0875 | 0.0875 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0041 | 0.0875 | 0.1285 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.002 | 0.0319 | 0.0319 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0041 | 0.0875 | 0.0875 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0022 | 0.0378 | 0.052 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.002 | 0.0319 | 0.0319 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.4039 | 0.4039 |
Loa Loa (eye worm) | indoleamine 2,3-dioxygenase | 0.0264 | 0.6534 | 1 |
Brugia malayi | indoleamine 2,3-dioxygenase | 0.0264 | 0.6534 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0022 | 0.0378 | 0.0378 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0378 | 0.052 |
Echinococcus multilocularis | indoleamine 2,3 dioxygenase 2 | 0.0264 | 0.6534 | 0.6534 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0333 | 0.8278 | 0.8278 |
Brugia malayi | Nuclear hormone receptor E75 | 0.002 | 0.0319 | 0.0428 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0875 | 0.1285 |
Echinococcus multilocularis | raf serine:threonine protein kinase | 0.0042 | 0.0896 | 0.0896 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0041 | 0.0875 | 0.1285 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0041 | 0.0875 | 0.0875 |
Brugia malayi | nuclear hormone receptor | 0.0041 | 0.0875 | 0.1285 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0042 | 0.0896 | 0.0896 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0041 | 0.0875 | 0.0875 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.2575 | 0.3904 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0022 | 0.0378 | 0.0378 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0875 | 0.1285 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0012 | 0.0129 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0041 | 0.0875 | 0.1285 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0041 | 0.0875 | 0.0875 |
Leishmania major | cytochrome p450-like protein | 0.0012 | 0.0129 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0041 | 0.0875 | 0.1285 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0041 | 0.0875 | 0.1285 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0041 | 0.0875 | 0.0875 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0044 | 0.0044 |
Schistosoma mansoni | nuclear receptor | 0.002 | 0.0319 | 0.0319 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0319 | 0.0429 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0041 | 0.0875 | 0.0875 |
Brugia malayi | Raf kinase | 0.0042 | 0.0896 | 0.1317 |
Brugia malayi | ecdysteroid receptor | 0.0041 | 0.0875 | 0.1285 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0319 | 0.0429 |
Brugia malayi | nuclear hormone receptor | 0.002 | 0.0319 | 0.0428 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0875 | 0.1285 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0319 | 0.0429 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0041 | 0.0875 | 0.1285 |
Schistosoma mansoni | nuclear hormone receptor | 0.002 | 0.0319 | 0.0319 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.002 | 0.0319 | 0.0319 |
Echinococcus granulosus | indoleamine 23 dioxygenase 2 | 0.0264 | 0.6534 | 0.6534 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0012 | 0.0129 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.002 | 0.0319 | 0.0319 |
Echinococcus granulosus | FTZ F1 alpha | 0.0041 | 0.0875 | 0.0875 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0041 | 0.0875 | 0.0875 |
Brugia malayi | CXXC zinc finger family protein | 0.0028 | 0.0537 | 0.0764 |
Onchocerca volvulus | 0.0041 | 0.0875 | 1 | |
Brugia malayi | Nuclear hormone receptor E75 | 0.002 | 0.0319 | 0.0428 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.002 | 0.0319 | 0.0428 |
Echinococcus granulosus | G protein signaling modulator 2 | 0.0012 | 0.0123 | 0.0123 |
Echinococcus multilocularis | small conductance calcium activated potassium | 0.0108 | 0.2575 | 0.2575 |
Onchocerca volvulus | 0.0028 | 0.0537 | 0.3924 | |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0044 | 0.0044 |
Schistosoma mansoni | thyroid hormone receptor | 0.0333 | 0.8278 | 0.8278 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0292 | 0.7226 | 0.7226 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0292 | 0.7226 | 0.7226 |
Schistosoma mansoni | hypothetical protein | 0.0264 | 0.6534 | 0.6534 |
Trypanosoma brucei | cytochrome P450, putative | 0.0012 | 0.0129 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0041 | 0.0875 | 0.1285 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0319 | 0.0429 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0041 | 0.0875 | 0.0875 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.002 | 0.0319 | 0.0429 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0708 | 0.1028 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0041 | 0.0875 | 0.0875 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0041 | 0.0875 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0264 | 0.6534 | 0.6534 |
Brugia malayi | GoLoco motif family protein | 0.0012 | 0.0123 | 0.0126 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0041 | 0.0875 | 0.1285 |
Loa Loa (eye worm) | DR-78 | 0.002 | 0.0319 | 0.0429 |
Schistosoma mansoni | hypothetical protein | 0.0108 | 0.2575 | 0.2575 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.002 | 0.0319 | 0.0428 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.002 | 0.0319 | 0.0428 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0041 | 0.0875 | 0.1285 |
Brugia malayi | nuclear receptor RXR | 0.0022 | 0.0378 | 0.052 |
Brugia malayi | hypothetical protein | 0.0022 | 0.0378 | 0.052 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0041 | 0.0875 | 0.1285 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0022 | 0.0378 | 0.0378 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0108 | 0.2575 | 0.2575 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0319 | 0.0429 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0041 | 0.0875 | 0.1285 |
Loa Loa (eye worm) | raf kinase | 0.0042 | 0.0896 | 0.1317 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0319 | 0.0429 |
Schistosoma mansoni | calcium-activated potassium channel | 0.007 | 0.1599 | 0.1599 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.002 | 0.0319 | 0.0429 |
Brugia malayi | Cytochrome P450 family protein | 0.0012 | 0.0129 | 0.0135 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0041 | 0.0875 | 0.0875 |
Schistosoma mansoni | cpg binding protein | 0.0028 | 0.0537 | 0.0537 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0319 | 0.0429 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
clogP | = 7.65 | Calculated partition coefficient (clogP) | ChEMBL. | 15203172 |
ID50 (functional) | = 4.5 uM | In vitro inhibitory dose against epimastigote form of Trypanosoma cruzi Brener strain | ChEMBL. | 15203172 |
ID50 (functional) | = 4.5 uM | In vitro inhibitory dose against epimastigote form of Trypanosoma cruzi Brener strain | ChEMBL. | 15203172 |
ID50 (functional) | = 6.5 uM | In vitro inhibitory dose against epimastigote form of Trypanosoma cruzi Tulahuen strain | ChEMBL. | 15203172 |
ID50 (functional) | = 6.5 uM | In vitro inhibitory dose against epimastigote form of Trypanosoma cruzi Tulahuen strain | ChEMBL. | 15203172 |
PGI (functional) | = 93 % | In vitro percent inhibition of growth against epimastigote form of Trypanosoma cruzi (Tulahuen strain) at 25 microM | ChEMBL. | 15203172 |
PGI (functional) | = 93 % | In vitro percent inhibition of growth against epimastigote form of Trypanosoma cruzi (Tulahuen strain) at 25 microM | ChEMBL. | 15203172 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.