TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 488.171 | Formula: C21H27F3N4O4S
H donors: 2 H acceptors: 6 LogP: 2.03 Rotable bonds: 7
Rule of 5 violations (Lipinski): 0
SMILES: OCc1cnc(nc1C(F)(F)F)N1CCN(C[C@H]1C(C)C)c1ccc(c(c1)S(=O)(=O)C)CO
InChi: InChI=1S/C21H27F3N4O4S/c1-13(2)17-10-27(16-5-4-14(11-29)18(8-16)33(3,31)32)6-7-28(17)20-25-9-15(12-30)19(26-20)21(22,23)24/h4-5,8-9,13,17,29-30H,6-7,10-12H2,1-3H3/t17-/m0/s1
InChiKey: FPVIRRAMNBCEDK-KRWDZBQOSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Bibliographic reference
Homo sapiens	nuclear receptor subfamily 1, group H, member 2	References
Homo sapiens	nuclear receptor subfamily 3, group C, member 2	References
Homo sapiens	cytochrome P450, family 3, subfamily A, polypeptide 4	References
Homo sapiens	nuclear receptor subfamily 1, group I, member 2	References
Homo sapiens	RAR-related orphan receptor A	References
Homo sapiens	retinoid X receptor, beta	References
Homo sapiens	cytochrome P450, family 2, subfamily C, polypeptide 9	References
Homo sapiens	retinoid X receptor, gamma	References
Homo sapiens	retinoid X receptor, alpha	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Candida albicans	similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11	Get druggable targets OG5_126554	All targets in OG5_126554
Loa Loa (eye worm)	cytochrome P450 family protein	Get druggable targets OG5_126554	All targets in OG5_126554
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126554	All targets in OG5_126554
Candida albicans	cytochrome P450 56	Get druggable targets OG5_126554	All targets in OG5_126554
Candida albicans	cytochrome P450 556	Get druggable targets OG5_126554	All targets in OG5_126554
Candida albicans	closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA	Get druggable targets OG5_126554	All targets in OG5_126554
Brugia malayi	Cytochrome P450 family protein	Get druggable targets OG5_126554	All targets in OG5_126554
Trypanosoma cruzi	cytochrome P450, putative	Get druggable targets OG5_126554	All targets in OG5_126554
Leishmania donovani	cytochrome p450-like protein	Get druggable targets OG5_126554	All targets in OG5_126554
Leishmania infantum	cytochrome p450-like protein	Get druggable targets OG5_126554	All targets in OG5_126554
Trypanosoma brucei	cytochrome P450, putative	Get druggable targets OG5_126554	All targets in OG5_126554
Loa Loa (eye worm)	cytochrome P450 family protein	Get druggable targets OG5_126582	All targets in OG5_126582
Trypanosoma brucei gambiense	cytochrome P450, putative	Get druggable targets OG5_126554	All targets in OG5_126554
Brugia malayi	Cytochrome P450 family protein	Get druggable targets OG5_126554	All targets in OG5_126554
Schistosoma mansoni	retinoic acid receptor RXR	Get druggable targets OG5_130073	All targets in OG5_130073
Leishmania mexicana	cytochrome p450-like protein	Get druggable targets OG5_126554	All targets in OG5_126554
Echinococcus granulosus	retinoic acid receptor rxr beta a	Get druggable targets OG5_130073	All targets in OG5_130073
Trypanosoma cruzi	cytochrome P450, putative	Get druggable targets OG5_126554	All targets in OG5_126554
Leishmania braziliensis	cytochrome p450-like protein	Get druggable targets OG5_126554	All targets in OG5_126554
Brugia malayi	Cytochrome P450 family protein	Get druggable targets OG5_126582	All targets in OG5_126582
Candida albicans	similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11	Get druggable targets OG5_126554	All targets in OG5_126554
Schistosoma japonicum	ko:K08524 nuclear receptor, subfamily 2, group B, member 1, putative	Get druggable targets OG5_130073	All targets in OG5_130073
Leishmania major	cytochrome p450-like protein	Get druggable targets OG5_126554	All targets in OG5_126554
Trypanosoma congolense	cytochrome P450, putative	Get druggable targets OG5_126554	All targets in OG5_126554
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	Get druggable targets OG5_130073	All targets in OG5_130073
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	Get druggable targets OG5_126554	All targets in OG5_126554
Loa Loa (eye worm)	cytochrome P450 family protein	Get druggable targets OG5_126554	All targets in OG5_126554
Loa Loa (eye worm)	CYP4Cod1	Get druggable targets OG5_126554	All targets in OG5_126554

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	ecdysteroid receptor	retinoid X receptor, alpha	435 aa	352 aa	23.9 %
Mycobacterium tuberculosis	Probable cytochrome P450 136 Cyp136	cytochrome P450, family 2, subfamily C, polypeptide 9	490 aa	441 aa	21.8 %
Brugia malayi	ecdysteroid receptor	retinoid X receptor, gamma	340 aa	338 aa	24.6 %
Brugia malayi	ecdysteroid receptor	nuclear receptor subfamily 1, group I, member 2	434 aa	427 aa	25.1 %
Brugia malayi	cytochrome P450	cytochrome P450, family 3, subfamily A, polypeptide 4	502 aa	492 aa	24.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Nuclear hormone receptor-like 1	0.008	0.0996	1
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.008	0.0996	0.0967
Loa Loa (eye worm)	hypothetical protein	0.008	0.0996	1
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.008	0.0996	0.0967
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.008	0.0996	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.008	0.0996	1
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.008	0.0996	1
Brugia malayi	ecdysteroid receptor	0.008	0.0996	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.008	0.0996	1
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.008	0.0996	1
Brugia malayi	hypothetical protein	0.0033	0.0031	0.0314
Onchocerca volvulus		0.008	0.0996	1
Loa Loa (eye worm)	hypothetical protein	0.008	0.0996	1
Brugia malayi	Nuclear hormone receptor E75	0.0033	0.0031	0.0314
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0031	0.0314
Loa Loa (eye worm)	hypothetical protein	0.008	0.0996	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.008	0.0996	0.0967
Brugia malayi	hypothetical protein	0.0047	0.0313	0.314
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.008	0.0996	0.1071
Loa Loa (eye worm)	hypothetical protein	0.008	0.0996	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0047	0.0313	0.314
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0031	0.0314
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0313	0.314
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.008	0.0996	1
Brugia malayi	conserved hypotetical protein	0.0033	0.0031	0.0314
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0047	0.0313	0.0313
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.008	0.0996	1
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.008	0.0996	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0047	0.0313	0.314
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.008	0.0996	0.1071
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.008	0.0996	0.0967
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0313	0.314
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0313	0.314
Brugia malayi	tailless protein	0.0033	0.0031	0.0314
Echinococcus multilocularis	FTZ F1 alpha	0.008	0.0996	0.1071
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.008	0.0996	0.0967
Echinococcus multilocularis	ecdysone induced protein 78C	0.008	0.0996	0.1071
Brugia malayi	steroid hormone receptor	0.008	0.0996	1
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0047	0.0313	0.0282
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0031	0.0314
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.008	0.0996	1
Onchocerca volvulus	Protein ultraspiracle homolog	0.008	0.0996	1
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.008	0.0996	1
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0033	0.0031	0.0314
Brugia malayi	Nuclear hormone receptor E75	0.0033	0.0031	0.0314
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.008	0.0996	1
Loa Loa (eye worm)	DR-78	0.0033	0.0031	0.0314
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.008	0.0996	0.0967
Loa Loa (eye worm)	hypothetical protein	0.008	0.0996	1
Brugia malayi	nuclear receptor RXR	0.0047	0.0313	0.314
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.008	0.0996	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0031	0.0314
Brugia malayi	nuclear hormone receptor	0.0033	0.0031	0.0314
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0031	0.0314
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.008	0.0996	0.1071
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0047	0.0313	0.0282
Schistosoma mansoni	nuclear hormone receptor	0.008	0.0996	0.0967
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.008	0.0996	1
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0047	0.0313	0.0282
Loa Loa (eye worm)	hypothetical protein	0.008	0.0996	1
Echinococcus granulosus	ecdysone induced protein 78C	0.008	0.0996	0.0967
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0031	0.0314
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.008	0.0996	0.0967
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0031	0.0314
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.008	0.0996	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.008	0.0996	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.008	0.0996	1
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.008	0.0996	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0313	0.314
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0031	0.0314
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.008	0.0996	0.0967
Loa Loa (eye worm)	hypothetical protein	0.008	0.0996	1
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0033	0.0031	0.0314
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0033	0.0031	0.0314
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.008	0.0996	1
Brugia malayi	nuclear receptor NHR-67	0.0033	0.0031	0.0314
Loa Loa (eye worm)	hypothetical protein	0.008	0.0996	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0031	0.0314
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0031	0.0314
Schistosoma mansoni	RAR-like nuclear receptor	0.008	0.0996	0.0967
Brugia malayi	nuclear hormone receptor	0.008	0.0996	1
Schistosoma mansoni	retinoic acid receptor RXR	0.0516	1	1
Brugia malayi	nuclear receptor NHR-88	0.0033	0.0031	0.0314
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.008	0.0996	0.0967
Brugia malayi	nuclear hormone receptor family member odr-7	0.0033	0.0031	0.0314
Brugia malayi	orphan nuclear receptor NR2E1	0.0033	0.0031	0.0314
Brugia malayi	Steroid receptor seven-up type 2	0.008	0.0996	1
Loa Loa (eye worm)	nuclear hormone receptor	0.0033	0.0031	0.0314
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.008	0.0996	0.1071
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0031	0.0314
Schistosoma mansoni	coup transcription factor	0.008	0.0996	0.0967
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.008	0.0996	1
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.008	0.0996	0.0967
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0031	0.0314
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.008	0.0996	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.008	0.0996	0.0967
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0313	0.314
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.008	0.0996	0.1071
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.008	0.0996	0.0967
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.008	0.0996	0.0967
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.047	0.9036	1
Brugia malayi	ecdysone receptor	0.0033	0.0031	0.0314
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.008	0.0996	0.1071
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0033	0.0031	0.0314
Brugia malayi	hypothetical protein	0.0033	0.0031	0.0314
Schistosoma mansoni	thyroid hormone receptor	0.008	0.0996	0.0967
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.008	0.0996	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.008	0.0996	0.1071
Loa Loa (eye worm)	steroid hormone receptor	0.008	0.0996	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0031	0.0314
Echinococcus granulosus	FTZ F1 alpha	0.008	0.0996	0.0967
Onchocerca volvulus	Bile acid receptor homolog	0.008	0.0996	1
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0047	0.0313	0.314
Brugia malayi	nuclear receptor NHR-88	0.008	0.0996	1
Brugia malayi	hypothetical protein	0.0047	0.0313	0.314
Brugia malayi	nuclear receptor RXR	0.0033	0.0031	0.0314
Brugia malayi	photoreceptor-specific nuclear receptor	0.008	0.0996	1
Schistosoma mansoni	thyroid hormone receptor	0.008	0.0996	0.0967

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (binding)		Agonist activity at LXR in human HepG2 cells assessed as upregulation of SREBP1C gene expression after 24 hrs by RT-PCR analysis	ChEMBL.	26990539
Activity (binding)		Agonist activity at LXR in human THP1 cells assessed as upregulation of ABCA1 gene expression after 24 hrs by RT-PCR analysis	ChEMBL.	26990539
EC50 (binding)	= 4 nM	Agonist activity at LXR in human THP1 cells assessed as upregulation of ABCA1 gene expression after 24 hrs by RT-PCR analysis	ChEMBL.	26990539
EC50 (binding)	= 6 nM	Agonist activity at LXR in human HepG2 cells assessed as upregulation of SREBP1C gene expression after 24 hrs by RT-PCR analysis	ChEMBL.	26990539
EC50 (binding)	= 21 nM	Agonist activity at human LXRbeta ligand binding domain(155 to 460 residues) transfected in HEK293 cells after 16 hrs by Gal4-luciferase reporter gene assay	ChEMBL.	26990539
EC50 (binding)	= 21 nM	Agonist activity at LXRbeta LBD (unknown origin) fused with Gal4-DNA binding domain expressed in HEK293 cells assessed as modulation of receptor transcription activity by luciferase reporter gene assay	LITERATURE.	27599745
Efficacy (binding)	= 56 %	Agonist activity at LXRbeta LBD (unknown origin) fused with Gal4-DNA binding domain expressed in HEK293 cells assessed as modulation of receptor transcription activity by luciferase reporter gene assay relative to T0901317	LITERATURE.	27599745
Efficacy (binding)	= 56 %	Agonist activity at human LXRbeta ligand binding domain(155 to 460 residues) transfected in HEK293 cells after 16 hrs by Gal4-luciferase reporter gene assay relative to TO901317	ChEMBL.	26990539
Efficacy (binding)	= 91 %	Agonist activity at LXR in human HepG2 cells assessed as upregulation of SREBP1C gene expression after 24 hrs by RT-PCR analysis	ChEMBL.	26990539
Efficacy (binding)	= 101 %	Agonist activity at LXR in human THP1 cells assessed as upregulation of ABCA1 gene expression after 24 hrs by RT-PCR analysis	ChEMBL.	26990539
FC (binding)	= 1.32	Agonist activity at LXR in human HepG2 cells assessed as upregulation of SREBP1C gene expression at 1 nM after 24 hrs by RT-PCR analysis relative to control	ChEMBL.	26990539
FC (binding)	= 1.62	Agonist activity at LXR in human THP1 cells assessed as upregulation of ABCA1 gene expression at 1 nM after 24 hrs by RT-PCR analysis relative to control	ChEMBL.	26990539
FC (binding)	= 1.87	Agonist activity at LXR in human HepG2 cells assessed as upregulation of SREBP1C gene expression at 2 nM after 24 hrs by RT-PCR analysis relative to control	ChEMBL.	26990539
FC (binding)	= 2.43	Agonist activity at LXR in human THP1 cells assessed as upregulation of ABCA1 gene expression at 2 nM after 24 hrs by RT-PCR analysis relative to control	ChEMBL.	26990539
FC (binding)	= 2.67	Agonist activity at LXR in human HepG2 cells assessed as upregulation of SREBP1C gene expression at 6 nM after 24 hrs by RT-PCR analysis relative to control	ChEMBL.	26990539
FC (binding)	= 2.86	Agonist activity at LXR in human THP1 cells assessed as upregulation of ABCA1 gene expression at 5 nM after 24 hrs by RT-PCR analysis relative to control	ChEMBL.	26990539
FC (binding)	= 3.05	Agonist activity at LXR in human HepG2 cells assessed as upregulation of SREBP1C gene expression at 19 nM after 24 hrs by RT-PCR analysis relative to control	ChEMBL.	26990539
FC (binding)	= 3.5	Agonist activity at LXR in human HepG2 cells assessed as upregulation of SREBP1C gene expression at 56 nM after 24 hrs by RT-PCR analysis relative to control	ChEMBL.	26990539
FC (binding)	= 3.72	Agonist activity at LXR in human THP1 cells assessed as upregulation of ABCA1 gene expression at 16 nM after 24 hrs by RT-PCR analysis relative to control	ChEMBL.	26990539
FC (binding)	= 3.78	Agonist activity at LXR in human HepG2 cells assessed as upregulation of SREBP1C gene expression at 167 nM after 24 hrs by RT-PCR analysis relative to control	ChEMBL.	26990539
FC (binding)	= 4.3	Agonist activity at LXR in human THP1 cells assessed as upregulation of ABCA1 gene expression at 50 nM after 24 hrs by RT-PCR analysis relative to control	ChEMBL.	26990539
FC (binding)	= 4.47	Agonist activity at LXR in human HepG2 cells assessed as upregulation of SREBP1C gene expression at 500 nM after 24 hrs by RT-PCR analysis relative to control	ChEMBL.	26990539
FC (binding)	= 4.87	Agonist activity at LXR in human THP1 cells assessed as upregulation of ABCA1 gene expression at 158 nM after 24 hrs by RT-PCR analysis relative to control	ChEMBL.	26990539
FC (binding)	= 5.45	Agonist activity at LXR in human THP1 cells assessed as upregulation of ABCA1 gene expression at 500 nM after 24 hrs by RT-PCR analysis relative to control	ChEMBL.	26990539
IC50 (ADMET)		Inhibition of CYP2D6 in human liver microsomes	ChEMBL.	26990539
IC50 (ADMET)	= 608 nM	Inhibition of CYP2C9 (unknown origin)	LITERATURE.	27599745
IC50 (ADMET)	= 610 nM	Inhibition of recombinant CYP2C9 (unknown origin)	ChEMBL.	26990539
IC50 (ADMET)	= 2200 nM	Inhibition of CYP2C9 in human liver microsomes	ChEMBL.	26990539
IC50 (ADMET)	= 6600 nM	Inhibition of CYP3A4 in human liver microsomes	ChEMBL.	26990539
IC50 (binding)	> 10000 nM	Inhibition of RXR (unknown origin)	ChEMBL.	26990539
IC50 (binding)	> 10000 nM	Inhibition of Mineralocorticoid receptor (unknown origin)	ChEMBL.	26990539
IC50 (binding)	> 10000 nM	Inhibition of PXR (unknown origin)	ChEMBL.	26990539
IC50 (binding)	> 10000 nM	Inhibition of RORalpha receptor (unknown origin)	ChEMBL.	26990539
IC50 (ADMET)	= 29430 nM	Inhibition of recombinant CYP3A4 (unknown origin)	ChEMBL.	26990539
IC50 (ADMET)	= 29450 nM	Inhibition of CYP3A4 (unknown origin)	LITERATURE.	27599745
IC50 (ADMET)	> 30000 nM	Inhibition of CYP2D6 (unknown origin)	LITERATURE.	27599745
IC50 (ADMET)	> 30000 nM	Inhibition of recombinant CYP2D6 (unknown origin)	ChEMBL.	26990539
Ki (binding)	= 3 nM	Displacement of [3H]TO901317 from LXRbeta ligand binding domain (unknown origin) after 30 mins by liquid scintillation counting	ChEMBL.	26990539
Ki (binding)	= 3 nM	Displacement of radiolabeled T0901317 from LXRbeta LBD (unknown origin)	LITERATURE.	27599745

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3814206

Bibliographic References

2 literature references were collected for this gene.

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Detailed information for compound 2166692