Detailed information for compound 216884

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 420.628 | Formula: C25H44N2O3
  • H donors: 1 H acceptors: 2 LogP: 4.46 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC[C@H]([C@@]1(C)CCC2C(C1=O)CC[C@@H]1[C@]2(C)CC[C@@H](C1)O)C/C=N/OCCN(C)C
  • InChi: 1S/C25H44N2O3/c1-6-18(11-14-26-30-16-15-27(4)5)25(3)13-10-22-21(23(25)29)8-7-19-17-20(28)9-12-24(19,22)2/h14,18-22,28H,6-13,15-17H2,1-5H3/b26-14+/t18-,19-,20-,21?,22?,24-,25+/m0/s1
  • InChiKey: DUBHNQVGESAENE-XNXMERMISA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATPase, Na+/K+ transporting, beta 1 polypeptide Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit Get druggable targets OG5_131864 All targets in OG5_131864
Echinococcus granulosus sodium:potassium dependent atpase beta subunit Get druggable targets OG5_131864 All targets in OG5_131864
Echinococcus multilocularis sodium:potassium transporting ATPase subunit Get druggable targets OG5_131864 All targets in OG5_131864
Echinococcus granulosus nervana 2 Get druggable targets OG5_131864 All targets in OG5_131864
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit Get druggable targets OG5_131864 All targets in OG5_131864
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit Get druggable targets OG5_131864 All targets in OG5_131864
Schistosoma japonicum ko:K01540 Na+/K+-exchanging ATPase beta subunit [EC3.6.3.9B], putative Get druggable targets OG5_131864 All targets in OG5_131864
Schistosoma japonicum ko:K01540 Na+/K+-exchanging ATPase beta subunit [EC3.6.3.9B], putative Get druggable targets OG5_131864 All targets in OG5_131864
Onchocerca volvulus Get druggable targets OG5_131864 All targets in OG5_131864
Echinococcus granulosus nervana 2 Get druggable targets OG5_131864 All targets in OG5_131864
Schistosoma japonicum Sodium/potassium-transporting ATPase subunit beta-1, putative Get druggable targets OG5_131864 All targets in OG5_131864
Echinococcus granulosus sodium:potassium dependent atpase beta subunit Get druggable targets OG5_131864 All targets in OG5_131864
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit Get druggable targets OG5_131864 All targets in OG5_131864
Echinococcus multilocularis nervana 2 Get druggable targets OG5_131864 All targets in OG5_131864
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131864 All targets in OG5_131864
Schistosoma mansoni transmemberane protein Get druggable targets OG5_131864 All targets in OG5_131864
Echinococcus granulosus sodium:potassium transporting ATPase subunit Get druggable targets OG5_131864 All targets in OG5_131864
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131864 All targets in OG5_131864
Echinococcus multilocularis nervana 2 Get druggable targets OG5_131864 All targets in OG5_131864
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0042 0.0069 0.0245
Brugia malayi hypothetical protein 0.0051 0.0094 0.0391
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0019 0.006
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0053 0.0099 0.1427
Mycobacterium tuberculosis Possible oxidoreductase 0.0258 0.0661 0.0711
Toxoplasma gondii histone lysine-specific demethylase 0.0258 0.0661 1
Echinococcus granulosus multidrug resistance protein 1 0.0042 0.0069 0.0244
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0051 0.0094 0.1383
Echinococcus granulosus multidrug resistance protein 1 0.0042 0.0069 0.0244
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0042 0.0069 0.0245
Echinococcus multilocularis ATP binding cassette sub family B 0.002 0.0008 0.0006
Echinococcus granulosus chromobox protein 1 0.0073 0.0153 0.0569
Toxoplasma gondii aminopeptidase n, putative 0.0051 0.0094 0.1343
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0041 0.0065 0.0136
Echinococcus multilocularis 0.0258 0.0661 0.1498
Echinococcus granulosus ATP binding cassette sub family B 0.0019 0.0006 0.0003
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative 0.0032 0.0041 0.022
Onchocerca volvulus 0.0085 0.0187 0.0678
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0038 0.0058 0.0202
Entamoeba histolytica P-glycoprotein-5 0.0042 0.0069 0.0398
Entamoeba histolytica plasma membrane calcium-transporting ATPase 1, putative 0.0022 0.0015 0.0056
Echinococcus granulosus histone lysine methyltransferase setb 0.0121 0.0284 0.1076
Brugia malayi Calcitonin receptor-like protein seb-1 0.0149 0.0362 0.1581
Brugia malayi bZIP transcription factor family protein 0.0093 0.021 0.0905
Entamoeba histolytica ATP-binding cassette protein, putative 0.0053 0.0099 0.0591
Plasmodium falciparum multidrug resistance-associated protein 2 0.002 0.0008 0.0087
Mycobacterium tuberculosis Iron-regulated transporter IrtA 0.002 0.0008 0.0009
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0042 0.0069 0.0245
Plasmodium vivax multidrug resistance protein 1, putative 0.0042 0.0069 0.1003
Mycobacterium tuberculosis Conserved protein 0.0036 0.0053 0.0058
Loa Loa (eye worm) hypothetical protein 0.0279 0.0718 0.2762
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0113 0.0264 0.0998
Plasmodium vivax JmjC domain containing protein 0.0038 0.0058 0.0842
Mycobacterium ulcerans ion transport protein 0.0081 0.0175 0.0172
Schistosoma mansoni multidrug resistance protein 0.0053 0.0099 0.0361
Echinococcus granulosus nervana 2 0.0279 0.0718 0.2754
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0042 0.0069 0.0245
Brugia malayi TATA binding protein associated factor 0.0051 0.0094 0.0391
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0051 0.0094 0.0201
Loa Loa (eye worm) hypothetical protein 0.0149 0.0362 0.1386
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0019 0.0086
Brugia malayi jmjC domain containing protein 0.0038 0.0058 0.0233
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0051 0.0094 0.1383
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0018
Schistosoma mansoni aminopeptidase A (M01 family) 0.0051 0.0094 0.034
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0014 0.0018
Echinococcus multilocularis multidrug resistance associated protein 1 0.0053 0.0099 0.0214
Echinococcus granulosus multidrug resistance protein 1 0.0023 0.0016 0.0039
Toxoplasma gondii E1-E2 ATPase subfamily protein 0.0027 0.0027 0.0323
Brugia malayi Peptidase family M1 containing protein 0.0051 0.0094 0.0391
Onchocerca volvulus 0.0036 0.0053 0.0156
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0019 0.0006 0.0003
Plasmodium falciparum protoporphyrinogen oxidase 0.0258 0.0661 1
Toxoplasma gondii plasma membrane-type Ca(2+)-ATPase A1 PMCAA1 0.0054 0.0102 0.1465
Loa Loa (eye worm) hypothetical protein 0.0036 0.0053 0.0196
Trichomonas vaginalis cation-transporting ATPase, putative 0.0049 0.0088 0.032
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0028 0.0031 0.0425
Echinococcus granulosus ATP binding cassette sub family B 0.002 0.0008 0.001
Giardia lamblia Multidrug resistance-associated protein 1 0.0052 0.0097 0.0579
Echinococcus multilocularis chromobox protein 1 0.0073 0.0153 0.0337
Brugia malayi multidrug resistance protein 3 0.0042 0.0069 0.028
Trypanosoma cruzi aminopeptidase, putative 0.0051 0.0094 0.1343
Brugia malayi jmjC domain containing protein 0.0038 0.0058 0.0233
Brugia malayi Cytochrome P450 family protein 0.0024 0.002 0.0065
Echinococcus multilocularis plasma membrane calcium transporting ATPase 0.0054 0.0102 0.0219
Brugia malayi jmjC domain containing protein 0.0038 0.0058 0.0233
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0054 0.01 0.0108
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0019 0.0208
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0122 0.0287 0.0308
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0053 0.0184
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0083 0.0297
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0085 0.0187 0.0702
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0596 0.1588 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0041 0.0065 0.023
Treponema pallidum fructose-bisphosphate aldolase 0.0596 0.1588 1
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0085 0.1207
Brugia malayi Peptidase family M1 containing protein 0.0051 0.0094 0.0391
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0053 0.0186
Trypanosoma brucei trypanothione reductase 0.0048 0.0085 0.8239
Schistosoma mansoni hypothetical protein 0.0169 0.0416 0.1585
Onchocerca volvulus 0.0032 0.0041 0.0108
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0042 0.0069 0.0144
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.002 0.0008 0.0041
Echinococcus multilocularis protoporphyrinogen oxidase 0.0258 0.0661 0.1498
Brugia malayi Cytochrome P450 family protein 0.0058 0.0112 0.0473
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0053 0.0058
Plasmodium vivax SET domain protein, putative 0.0121 0.0284 0.4273
Onchocerca volvulus 0.0279 0.0718 0.2749
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0049 0.0088 0.1256
Loa Loa (eye worm) hypothetical protein 0.0038 0.0058 0.0214
Schistosoma mansoni hypothetical protein 0.0118 0.0278 0.1051
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.002 0.0068
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0596 0.1588 0.6157
Loa Loa (eye worm) beta-lactamase 0.0036 0.0053 0.0196
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.002 0.0008 0.0041
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0049 0.0088 0.0318
Brugia malayi Pre-SET motif family protein 0.0841 0.2258 1
Schistosoma mansoni hypothetical protein 0.0039 0.0059 0.0208
Trypanosoma brucei aminopeptidase, putative 0.0051 0.0094 0.9163
Brugia malayi amine oxidase, flavin-containing family protein 0.0258 0.0661 0.291
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0038 0.0058 0.0799
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.002 0.0008 0.0041
Toxoplasma gondii ABC transporter family protein 0.002 0.0008 0.0041
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0051 0.0094 0.0342
Plasmodium falciparum ABC transporter B family member 4, putative 0.002 0.0008 0.0087
Loa Loa (eye worm) hypothetical protein 0.0053 0.0099 0.0373
Echinococcus multilocularis GPCR, family 2 0.0047 0.0083 0.0176
Onchocerca volvulus 0.0024 0.0019 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0033 0.0105
Loa Loa (eye worm) voltage-gated potassium channel 0.0107 0.0248 0.0947
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0054 0.0102 0.0371
Loa Loa (eye worm) hypothetical protein 0.0024 0.0019 0.0064
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0003 0.0003
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0053 0.0185
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0083 0.0297
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0085 0.0187 0.0702
Echinococcus multilocularis muscleblind protein 1 0.0151 0.0368 0.0829
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0019 0.0086
Echinococcus multilocularis Polycystic kidney disease protein 0.0022 0.0014 0.0018
Schistosoma mansoni amine oxidase 0.0258 0.0661 0.2533
Brugia malayi calcium ATPase 0.0027 0.0028 0.01
Brugia malayi glutathione reductase 0.0048 0.0085 0.0351
Entamoeba histolytica calcium-transporting P-type ATPase, putative 0.0054 0.0102 0.0607
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0038 0.0058 0.012
Schistosoma mansoni hypothetical protein 0.0169 0.0416 0.1585
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0082 0.0177 0.2655
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0053 0.0058
Schistosoma mansoni jumonji/arid domain-containing protein 0.0143 0.0346 0.1315
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0082 0.0177 0.2655
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0038 0.0058 0.5456
Echinococcus granulosus peregrin 0.0118 0.0278 0.1051
Loa Loa (eye worm) hypothetical protein 0.0258 0.0661 0.2542
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0035 0.0049 0.0169
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0083 0.0176
Entamoeba histolytica P-glycoprotein 5, putative 0.0042 0.0069 0.0398
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0258 0.0661 1
Entamoeba histolytica ATP-binding cassette protein, putative 0.0053 0.0099 0.0591
Loa Loa (eye worm) hypothetical protein 0.0142 0.0344 0.1316
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0042 0.0069 0.0074
Plasmodium falciparum ABC transporter B family member 7, putative 0.002 0.0008 0.0087
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.3408 0.9292 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0042 0.0069 0.0245
Onchocerca volvulus 0.0085 0.0187 0.0678
Brugia malayi follicle stimulating hormone receptor 0.0237 0.0603 0.2653
Mycobacterium leprae Probable lipase LipE 0.0036 0.0053 0.0606
Trypanosoma brucei vacuolar-type Ca2+-ATPase, putative 0.0049 0.0088 0.8571
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0041 0.0065 0.0264
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0042 0.0069 0.0144
Brugia malayi F/Y-rich N-terminus family protein 0.0043 0.0072 0.0292
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0051 0.0094 0.0201
Loa Loa (eye worm) glutathione reductase 0.0048 0.0085 0.0317
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0019 0.0208
Plasmodium falciparum thioredoxin reductase 0.0048 0.0085 0.1248
Trypanosoma brucei Aminopeptidase M1, putative 0.0051 0.0094 0.9163
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0596 0.1588 0.6157
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0006 0.0003
Onchocerca volvulus 0.0258 0.0661 0.2527
Mycobacterium ulcerans aminopeptidase N PepN 0.0051 0.0094 0.0091
Trypanosoma brucei calcium-transporting ATPase, putative 0.0034 0.0048 0.4385
Plasmodium vivax ABC transporter B family member 5, putative 0.002 0.0008 0.0087
Plasmodium vivax ABC transporter B family member 3, putative 0.002 0.0008 0.0087
Trypanosoma cruzi UDP-galactopyranose mutase 0.0258 0.0661 1
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0051 0.0094 0.034
Echinococcus granulosus nervana 2 0.0279 0.0718 0.2754
Loa Loa (eye worm) hypothetical protein 0.0034 0.0048 0.0174
Echinococcus multilocularis phd:f box containing protein 0.0038 0.0058 0.012
Trichomonas vaginalis cation-transporting ATPase, putative 0.0049 0.0088 0.032
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0031 0.0425
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0019 0.0021
Trichomonas vaginalis abcb9, putative 0.0042 0.0069 0.0245
Brugia malayi multidrug Resistance Protein family member (mrp-5), putative 0.002 0.0008 0.0012
Loa Loa (eye worm) hypothetical protein 0.0079 0.0171 0.0651
Trypanosoma brucei vacuolar-type Ca2+-ATPase 1 0.0049 0.0088 0.8571
Echinococcus multilocularis ATP binding cassette sub family B 0.002 0.0008 0.0006
Brugia malayi hypothetical protein 0.002 0.0008 0.0012
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.002 0.0008 0.0006
Entamoeba histolytica ATP-binding cassette protein, putative 0.0053 0.0099 0.0591
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0053 0.0184
Brugia malayi AF-10 protein 0.0039 0.0059 0.0238
Echinococcus multilocularis RUN 0.0022 0.0014 0.0018
Leishmania major p-glycoprotein 0.0042 0.0069 0.0961
Schistosoma mansoni ATPase 0.0049 0.0088 0.0318
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0058 0.0214
Schistosoma mansoni rab6-interacting 0.0022 0.0014 0.0031
Mycobacterium ulcerans aminopeptidase N PepN 0.0051 0.0094 0.0091
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0006 0.0006
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0019 0.0017
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0258 0.0661 0.8776
Trypanosoma cruzi Calcium ATPase SERCA-like 0.0049 0.0088 0.1256
Giardia lamblia ABC transporter, putative 0.0053 0.0099 0.0591
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0042 0.0069 0.0244
Trypanosoma cruzi P-type H+-ATPase, putative 0.0027 0.0027 0.0323
Echinococcus granulosus lysine specific demethylase 5A 0.0143 0.0346 0.1315
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0596 0.1588 0.6157
Loa Loa (eye worm) calcium ATPase 0.0027 0.0028 0.0099
Brugia malayi ABC transporter family protein 0.002 0.0008 0.0012
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.002 0.0008 0.0006
Schistosoma mansoni lipoxygenase 0.0092 0.0205 0.077
Schistosoma mansoni loxhd1 0.0022 0.0014 0.0031
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0039 0.0059 0.5593
Echinococcus multilocularis multidrug resistance associated protein 4 0.0033 0.0044 0.0088
Loa Loa (eye worm) hypothetical protein 0.0151 0.0368 0.1412
Onchocerca volvulus Alhambra homolog 0.0118 0.0278 0.103
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0042 0.0069 0.0245
Schistosoma mansoni transmemberane protein 0.0279 0.0718 0.2754
Toxoplasma gondii sarco/endoplasmic reticulum Ca2+-ATPase 0.0054 0.0102 0.1465
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0082 0.0177 0.0175
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0051 0.0094 0.034
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0387 0.1015 0.2307
Echinococcus granulosus peptidase Clp S14 family 0.0054 0.01 0.0366
Schistosoma mansoni smdr2 0.0042 0.0069 0.0244
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0042 0.0069 0.0245
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0113 0.0264 0.1147
Mycobacterium ulcerans metal cation transporter p-type ATPase a 0.0137 0.033 0.0327
Loa Loa (eye worm) calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0034 0.0048 0.0174
Loa Loa (eye worm) hypothetical protein 0.0258 0.0661 0.2542
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0051 0.0094 0.0342
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0051 0.0094 0.1343
Mycobacterium ulcerans beta-lactamase 0.0036 0.0053 0.0051
Brugia malayi Muscleblind-like protein 0.0151 0.0368 0.1611
Schistosoma mansoni hypothetical protein 0.0047 0.0083 0.0297
Loa Loa (eye worm) heterochromatin protein 1 0.0073 0.0153 0.058
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0053 0.0058
Loa Loa (eye worm) hypothetical protein 0.002 0.0008 0.0022
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0051 0.0094 0.1343
Giardia lamblia Hypothetical protein 0.0019 0.0006 0.0005
Toxoplasma gondii ABC transporter, putative 0.002 0.0008 0.0041
Brugia malayi ABC transporter family protein 0.0042 0.0069 0.028
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0085 0.0317
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0291 0.0752 0.0809
Plasmodium falciparum ABC transporter B family member 6, putative 0.002 0.0008 0.0087
Entamoeba histolytica hypothetical protein 0.0036 0.0053 0.0301
Echinococcus multilocularis jumonji domain containing protein 0.0165 0.0405 0.0912
Echinococcus multilocularis lysine specific demethylase 5A 0.0143 0.0346 0.0777
Toxoplasma gondii ABC1 family protein 0.0036 0.0053 0.0729
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0053 0.0099 0.0373
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0049 0.0088 0.052
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.3666 1 1
Loa Loa (eye worm) hypothetical protein 0.0088 0.0195 0.0744
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0149 0.0362 0.1386
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0051 0.0094 0.034
Loa Loa (eye worm) hypothetical protein 0.0039 0.0059 0.0219
Schistosoma mansoni chromobox protein 0.0073 0.0153 0.0569
Brugia malayi hypothetical protein 0.0022 0.0014 0.0035
Loa Loa (eye worm) hypothetical protein 0.0053 0.0099 0.0373
Loa Loa (eye worm) cytochrome P450 family protein 0.0058 0.0112 0.0423
Schistosoma mansoni jumonji domain containing protein 0.0038 0.0058 0.0202
Leishmania major cytochrome p450-like protein 0.0024 0.002 0.0224
Entamoeba histolytica ABC transporter, putative 0.0053 0.0099 0.0591
Loa Loa (eye worm) hypothetical protein 0.0022 0.0014 0.0042
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.0253 0.0272
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.0053 0.0099 0.1427
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0054 0.0102 0.0374
Mycobacterium ulcerans hypothetical protein 0.0024 0.0019 0.0017
Schistosoma mansoni multidrug resistance protein 0.0053 0.0099 0.0361
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0131 0.0313 0.1189
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.0253 0.0272
Trypanosoma brucei cytochrome P450, putative 0.0024 0.002 0.1531
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0596 0.1588 0.6157
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0258 0.0661 1
Plasmodium vivax multidrug resistance-associated protein 1, putative 0.002 0.0008 0.0087
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.002 0.0008 0.0041
Schistosoma mansoni hypothetical protein 0.0102 0.0233 0.0877
Trypanosoma cruzi UDP-galactopyranose mutase 0.0258 0.0661 1
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0963 0.2593 1
Plasmodium vivax ABC transporter B family member 6, putative 0.002 0.0008 0.0087
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0042 0.0069 0.0245
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0042 0.0069 0.0961
Brugia malayi Pre-SET motif family protein 0.0121 0.0284 0.1236
Giardia lamblia Fructose-bisphosphate aldolase 0.0596 0.1588 1
Leishmania major P-type H -ATPase, putative 0.0027 0.0027 0.0323
Brugia malayi ABC transporter family protein 0.002 0.0008 0.0012
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0841 0.2258 0.8706
Echinococcus granulosus GPCR family 2 0.0047 0.0083 0.0297
Entamoeba histolytica P-glycoprotein 6, putative 0.002 0.0008 0.0017
Loa Loa (eye worm) hypothetical protein 0.0258 0.0661 0.2542
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0019 0.0017
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0118 0.0278 0.1051
Loa Loa (eye worm) hypothetical protein 0.0036 0.0053 0.0196
Schistosoma mansoni hypothetical protein 0.0047 0.0083 0.0297
Toxoplasma gondii PHD-finger domain-containing protein 0.0118 0.0278 0.4149
Echinococcus multilocularis multidrug resistance protein 1 0.0023 0.0016 0.0023
Plasmodium falciparum ABC transporter B family member 5, putative 0.002 0.0008 0.0087
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0053 0.0186
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0231 0.0586 0.2243
Trypanosoma brucei ABC transporter, mitochondrial, putative 0.002 0.0008 0.028
Trypanosoma cruzi cytochrome P450, putative 0.0024 0.002 0.0224
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0085 0.0181
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0258 0.0661 0.2533
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0258 0.0661 1
Toxoplasma gondii P-type ATPase4, putative 0.0054 0.0102 0.1465
Loa Loa (eye worm) hypothetical protein 0.0258 0.0661 0.2542
Giardia lamblia Potassium-transporting ATPase alpha chain 1 0.0142 0.0344 0.2135
Loa Loa (eye worm) sodium potassium adenosine triphosphatase 0.0027 0.0027 0.0093
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0018
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0049 0.0088 0.0188
Loa Loa (eye worm) hypothetical protein 0.0082 0.0177 0.0675
Brugia malayi PHD-finger family protein 0.0039 0.0059 0.0238
Loa Loa (eye worm) hypothetical protein 0.0036 0.0052 0.0189
Echinococcus granulosus nervana 2 0.0231 0.0586 0.2243
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0049 0.0088 0.032
Mycobacterium tuberculosis Conserved protein 0.0036 0.0053 0.0058
Echinococcus multilocularis peregrin 0.0118 0.0278 0.0621
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1615 0.4381 1
Trichomonas vaginalis ABC transporter, putative 0.0042 0.0069 0.0245
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0051 0.0094 0.034
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0042 0.0069 0.0245
Loa Loa (eye worm) PHD-finger family protein 0.0118 0.0278 0.1061
Toxoplasma gondii ATP-binding cassette sub-family B member 5 0.002 0.0008 0.0041
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0042 0.0069 0.0245
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0049 0.0088 0.052
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0042 0.0069 0.0144
Giardia lamblia Multidrug resistance-associated protein 1 0.0053 0.0099 0.0591
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0113 0.0264 0.059
Trichomonas vaginalis cation-transporting ATPase, putative 0.0049 0.0088 0.032
Onchocerca volvulus 0.0048 0.0086 0.0283
Loa Loa (eye worm) jmjC domain-containing protein 0.0244 0.0623 0.2394
Trypanosoma brucei p-glycoprotein 0.0053 0.0099 0.9739
Onchocerca volvulus 0.0036 0.0053 0.0156
Echinococcus granulosus chromobox protein 1 0.0073 0.0153 0.0569
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0082 0.0177 0.2273
Plasmodium vivax multidrug resistance-associated protein 2, putative 0.002 0.0008 0.0087
Trypanosoma cruzi P-type H+-ATPase, putative 0.0027 0.0027 0.0323
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0258 0.0661 0.2533
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0014 0.0031
Brugia malayi ABC transporter transmembrane region family protein 0.0019 0.0006 0.0003
Echinococcus multilocularis peptidase Clp (S14 family) 0.0054 0.01 0.0216
Echinococcus granulosus lysine specific histone demethylase 1A 0.0258 0.0661 0.2533
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0279 0.0718 0.1628
Toxoplasma gondii aminopeptidase N protein 0.0051 0.0094 0.1343
Echinococcus multilocularis ATP binding cassette sub family B 0.002 0.0008 0.0006
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0054 0.0102 0.0371
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0231 0.0586 0.2243
Echinococcus granulosus calcium transporting atpase 0.0054 0.0102 0.0371
Schistosoma mansoni protein phosphatase 2C 0.0038 0.0058 0.0202
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0083 0.0176
Echinococcus granulosus multidrug resistance protein 1 0.0042 0.0069 0.0244
Mycobacterium ulcerans component linked with the assembly of cytochrome transport transmembrane ATP-binding protein ABC transporter CydD 0.002 0.0008 0.0006
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0053 0.0109
Brugia malayi jmjC domain containing protein 0.0143 0.0346 0.151
Brugia malayi beta-lactamase 0.0036 0.0053 0.0212
Trypanosoma brucei Aminopeptidase M1, putative 0.0051 0.0094 0.9163
Loa Loa (eye worm) hypothetical protein 0.0052 0.0097 0.0365
Schistosoma mansoni multidrug resistance protein 0.0053 0.0099 0.0361
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0049 0.0088 0.052
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0054 0.0102 0.1465
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0042 0.0069 0.0245
Brugia malayi SWIRM domain containing protein 0.0258 0.0661 0.291
Leishmania major pentamidine resistance protein 1 0.0053 0.0099 0.1427
Chlamydia trachomatis protoporphyrinogen oxidase 0.0258 0.0661 1
Toxoplasma gondii hypothetical protein 0.0028 0.0031 0.038
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0059 0.0862
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0051 0.0094 0.0342
Echinococcus granulosus lysine specific histone demethylase 1A 0.0258 0.0661 0.2533
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0121 0.0284 0.1076
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0093 0.021 0.0466
Onchocerca volvulus 0.0036 0.0053 0.0156
Trypanosoma cruzi calcium-translocating P-type ATPase, putative 0.0022 0.0015 0.0136
Schistosoma mansoni ATPase 0.0049 0.0088 0.0318
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0082 0.0177 0.0175
Plasmodium falciparum multidrug resistance protein 1 0.0042 0.0069 0.1003
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0042 0.0069 0.0245
Schistosoma mansoni sodium / potassium ATPase beta chain 0.0231 0.0586 0.2243
Trypanosoma cruzi multidrug resistance protein E, putative 0.0053 0.0099 0.1427
Trichomonas vaginalis esterase, putative 0.0036 0.0053 0.0186
Loa Loa (eye worm) hypothetical protein 0.0085 0.0187 0.0713
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0053 0.0099 0.1427
Echinococcus granulosus PHD finger protein rhinoceros 0.0118 0.0278 0.1051
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0121 0.0284 0.4246
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0279 0.0718 0.2754
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0053 0.0729
Entamoeba histolytica P-glycoprotein 6, putative 0.002 0.0008 0.0017
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0053 0.0729
Echinococcus multilocularis calcium transporting atpase 0.0054 0.0102 0.0219
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0963 0.2593 0.5914
Toxoplasma gondii thioredoxin reductase 0.0048 0.0085 0.1207
Onchocerca volvulus 0.0085 0.0187 0.0678
Schistosoma mansoni ATP-binding cassette sub-family B member 6 mitochondrial precursor (abc6) 0.0019 0.0006 0.0003
Loa Loa (eye worm) hypothetical protein 0.0047 0.0083 0.0309
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0054 0.0102 0.0219
Toxoplasma gondii calcium-translocating P-type ATPase, PMCA-type protein 0.0049 0.0088 0.1256
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0237 0.0603 0.2318
Brugia malayi Peptidase family M1 containing protein 0.0051 0.0094 0.0391
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0042 0.0069 0.0245
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0131 0.0313 0.0703
Loa Loa (eye worm) hypothetical protein 0.0036 0.0053 0.0196
Entamoeba histolytica hypothetical protein 0.0036 0.0053 0.0301
Echinococcus granulosus nervana 2 0.0231 0.0586 0.2243
Trichomonas vaginalis taga, putative 0.0042 0.0069 0.0245
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0596 0.1588 0.6157
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0082 0.0177 0.2621
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0038 0.0058 0.0799
Trichomonas vaginalis ABC transporter, putative 0.0042 0.0069 0.0245
Brugia malayi Cation transporter family protein 0.0085 0.0187 0.0807
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0149 0.0362 0.1581
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0279 0.0718 0.2754
Plasmodium vivax multidrug resistance protein 2, putative 0.002 0.0008 0.0087
Schistosoma mansoni calcium-transporting atpase 2 (atpase 2) 0.0054 0.0102 0.0371
Trypanosoma brucei P-type H+-ATPase, putative 0.0027 0.0027 0.2204
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0051 0.0094 0.0201
Trypanosoma cruzi hypothetical protein 0.0033 0.0044 0.0589
Brugia malayi Sodium/potassium-transporting ATPase alpha-3 chain, putative 0.0027 0.0027 0.0094
Brugia malayi P-glycoprotein-like protein 0.002 0.0008 0.0012
Brugia malayi jmjC domain containing protein 0.0387 0.1015 0.4482
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0082 0.0177 0.2621
Loa Loa (eye worm) hypothetical protein 0.0051 0.0094 0.0351
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0053 0.0196
Brugia malayi ABC transporter 0.002 0.0008 0.0012
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0042 0.0069 0.0144
Mycobacterium ulcerans oxidoreductase 0.0258 0.0661 0.0658
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.0253 0.0272
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0039 0.0059 0.0862
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0051 0.0094 0.034
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0053 0.4975
Plasmodium vivax hypothetical protein, conserved 0.0258 0.0661 1
Loa Loa (eye worm) hypothetical protein 0.0121 0.0284 0.1086
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0058 0.0214
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0051 0.0094 0.034
Echinococcus granulosus multidrug resistance associated protein 1 0.0053 0.0099 0.0361
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0053 0.0186
Loa Loa (eye worm) CYP4Cod1 0.0024 0.002 0.0068
Giardia lamblia MRP-like ABC transporter 0.0053 0.0099 0.0591
Onchocerca volvulus 0.0073 0.0155 0.055
Echinococcus multilocularis nervana 2 0.0231 0.0586 0.1326
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0053 0.0058
Brugia malayi Thioredoxin reductase 0.0048 0.0085 0.0351
Onchocerca volvulus 0.0137 0.033 0.1234
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0133 0.0317 0.1202
Schistosoma mansoni chromobox protein 0.0073 0.0153 0.0569
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0051 0.0094 0.1383
Onchocerca volvulus 0.0051 0.0094 0.0313
Schistosoma mansoni smdr1 0.002 0.0008 0.001
Schistosoma mansoni multidrug resistance protein 0.0053 0.0099 0.0361
Echinococcus granulosus lysine specific demethylase 6a 0.0038 0.0058 0.0202
Giardia lamblia Multidrug resistance-associated protein Mrp2 0.0019 0.0006 0.0005
Brugia malayi Probable calcium-transporting ATPase KIAA0703 0.0034 0.0048 0.0187
Brugia malayi Membrane calcium atpase protein 3 0.0054 0.0102 0.0426
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0006 0.0003
Echinococcus multilocularis ATP binding cassette sub family B 0.0041 0.0067 0.014
Loa Loa (eye worm) hypothetical protein 0.0024 0.0019 0.0064
Loa Loa (eye worm) hypothetical protein 0.0024 0.0019 0.0064
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.0285 0.109
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0053 0.0606
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0053 0.0099 0.9739
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0038 0.0058 0.0202
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0023 0.0016 0.0039
Echinococcus granulosus JmjC domain containing protein 4 0.0038 0.0058 0.0202
Plasmodium vivax ABC transporter B family member 4, putative 0.002 0.0008 0.0087
Loa Loa (eye worm) jmjC domain-containing protein 0.0143 0.0346 0.1325
Schistosoma mansoni multidrug resistance protein 0.002 0.0008 0.001
Schistosoma mansoni ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7) 0.002 0.0008 0.001
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0019 0.0006 0.0003
Echinococcus multilocularis chromobox protein 1 0.0073 0.0153 0.0337
Loa Loa (eye worm) hypothetical protein 0.0036 0.0053 0.0196
Schistosoma mansoni hypothetical protein 0.0076 0.0162 0.0603
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0279 0.0718 0.1628
Loa Loa (eye worm) hypothetical protein 0.0151 0.0368 0.1412
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0049 0.0088 0.032
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0035 0.0049 0.0169
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0121 0.0284 0.0636
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0258 0.0661 1
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative 0.0027 0.0028 0.0143
Loa Loa (eye worm) hypothetical protein 0.0041 0.0067 0.0248
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0082 0.0177 0.2655
Brugia malayi jmjC domain containing protein 0.0038 0.0058 0.0233
Echinococcus multilocularis aminopeptidase N 0.0051 0.0094 0.0201
Plasmodium vivax glutathione reductase, putative 0.0048 0.0085 0.1248
Echinococcus multilocularis jun protein 0.0093 0.021 0.0466
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0387 0.1015 0.3902
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0039 0.0059 0.5593
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0051 0.0094 0.0201
Echinococcus multilocularis geminin 0.0169 0.0416 0.0938
Loa Loa (eye worm) hypothetical protein 0.0102 0.0233 0.0887
Leishmania major ATP-binding cassette protein subfamily B, member 1, putative 0.002 0.0008 0.0041
Trypanosoma brucei ABC transporter of the mitochondrion, putative 0.002 0.0008 0.028
Brugia malayi latrophilin 2 splice variant baaae 0.0102 0.0233 0.1007
Mycobacterium tuberculosis Conserved protein 0.0036 0.0053 0.0058
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0291 0.0752 0.075
Leishmania major ATP-binding cassette protein subfamily B, member 3, putative 0.002 0.0008 0.0041
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0019 0.0006 0.0003
Loa Loa (eye worm) hypothetical protein 0.0036 0.0053 0.0196
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0051 0.0094 0.1343
Leishmania major calcium-transporting ATPase, putative 0.0054 0.0102 0.1465
Mycobacterium leprae PROBABLE CATION-TRANSPORTER ATPASE I CTPI 0.0118 0.0276 0.3597
Schistosoma mansoni multidrug resistance protein 0.0042 0.0069 0.0244
Brugia malayi Cytochrome P450 family protein 0.0024 0.002 0.0065
Mycobacterium ulcerans dehydrogenase 0.0258 0.0661 0.0658
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0054 0.01 0.1236
Wolbachia endosymbiont of Brugia malayi ABC-type protease secretion system, ATPase and permease component, AprD 0.002 0.0008 0.0156
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.0142 0.0344 0.1316
Loa Loa (eye worm) hypothetical protein 0.0042 0.0069 0.0255
Mycobacterium ulcerans hypothetical protein 0.0036 0.0053 0.0051
Entamoeba histolytica P-glycoprotein-1 0.0042 0.0069 0.0398
Echinococcus granulosus jun protein 0.0093 0.021 0.0788
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0279 0.0718 0.2754
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0053 0.0109
Loa Loa (eye worm) hypothetical protein 0.0118 0.0278 0.1061
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0963 0.2593 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0082 0.0177 0.1085
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0006 0.0046
Loa Loa (eye worm) hypothetical protein 0.0051 0.0094 0.0351
Toxoplasma gondii PHD-finger domain-containing protein 0.0039 0.0059 0.082
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.0053 0.0099 0.1427
Onchocerca volvulus 0.0051 0.0094 0.0313
Plasmodium vivax hypothetical protein, conserved 0.0258 0.0661 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0019 0.0086
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0019 0.0017
Schistosoma mansoni polycystin 1-related 0.0022 0.0014 0.0031
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0053 0.0186
Giardia lamblia Multidrug resistance-associated protein 1 0.0053 0.0099 0.0591
Trichomonas vaginalis cation-transporting ATPase, putative 0.0027 0.0027 0.0082
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0038 0.0058 0.0799
Brugia malayi Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0054 0.0102 0.0426
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0053 0.0051
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0039 0.0059 0.082
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0065 0.0202
Mycobacterium ulcerans metal cation-transporting p-type ATPase F, CtpF 0.0054 0.0102 0.0099
Echinococcus granulosus phd:f box containing protein 0.0038 0.0058 0.0202
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0054 0.0102 0.0219
Echinococcus multilocularis Ca2+ transporting ATPase plasma membrane 0.0054 0.0102 0.0219
Entamoeba histolytica P-glycoprotein 5, putative 0.0019 0.0006 0.0005
Echinococcus multilocularis nervana 2 0.0279 0.0718 0.1628
Trypanosoma cruzi calcium-transporting ATPase, putative 0.0034 0.0048 0.0642
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0051 0.0094 0.0201
Echinococcus multilocularis sodium:potassium transporting ATPase subunit 0.0279 0.0718 0.1628
Trypanosoma cruzi ABC transporter of the mitochondrion, putative 0.002 0.0008 0.0041
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0082 0.0177 0.2655
Schistosoma mansoni amine oxidase 0.0258 0.0661 0.2533
Onchocerca volvulus 0.0231 0.0586 0.2234
Schistosoma mansoni jun-related protein 0.0076 0.0162 0.0603
Leishmania major calcium motive p-type ATPase, putative 0.0054 0.0102 0.1465
Schistosoma mansoni hypothetical protein 0.0022 0.0014 0.0031
Plasmodium falciparum glutathione reductase 0.0048 0.0085 0.1248
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.0253 0.0272
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.0053 0.0099 0.1427
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0122 0.0287 0.374
Plasmodium vivax ABC transporter B family member 7, putative 0.002 0.0008 0.0087
Echinococcus granulosus aminopeptidase N 0.0051 0.0094 0.034
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.0285 0.109
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0121 0.0284 0.1076
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0051 0.0094 0.1343
Onchocerca volvulus 0.0957 0.2576 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0065 0.0242
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0231 0.0586 0.1326
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0053 0.0772
Trichomonas vaginalis abcb9, putative 0.0042 0.0069 0.0245
Echinococcus granulosus multidrug resistance associated protein 7 0.0053 0.0099 0.0361
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.002 0.0008 0.0041
Entamoeba histolytica P-glycoprotein-2 0.0042 0.0069 0.0398
Leishmania major trypanothione reductase 0.0048 0.0085 0.1207
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0054 0.01 0.0108
Onchocerca volvulus 0.0051 0.0094 0.0313
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0053 0.0186
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.002 0.0008 0.001
Loa Loa (eye worm) aminopeptidase N 0.0051 0.0094 0.0351
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0038 0.0058 0.0799
Echinococcus multilocularis nervana 2 0.0231 0.0586 0.1326
Entamoeba histolytica multidrug resistance protein, putative 0.0053 0.0099 0.0591
Brugia malayi ABC transporter transmembrane region family protein 0.002 0.0008 0.0012
Schistosoma mansoni lipoxygenase 0.0131 0.0313 0.1189
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0053 0.0185
Schistosoma mansoni multidrug resistance protein 0.0042 0.0069 0.0244
Onchocerca volvulus 0.0042 0.0069 0.0215
Wolbachia endosymbiont of Brugia malayi ABC-type multidrug transport system, ATPase and permease component 0.002 0.0008 0.0156
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0041 0.0065 0.0242
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0086 0.0311
Leishmania major UDP-galactopyranose mutase 0.0258 0.0661 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0085 0.0306
Trypanosoma cruzi calcium-translocating P-type ATPase, putative 0.0027 0.0027 0.0323
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0006 0.0046
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0082 0.0177 1
Mycobacterium ulcerans monoamine oxidase 0.0258 0.0661 0.0658
Schistosoma mansoni phosphatidylserine receptor 0.0038 0.0058 0.0202
Loa Loa (eye worm) ABC transporter 0.002 0.0008 0.0022
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0051 0.0094 0.1343
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0042 0.0069 0.0245
Loa Loa (eye worm) doublecortin family protein 0.0022 0.0014 0.0042
Trichomonas vaginalis chromobox protein, putative 0.0073 0.0153 0.0573
Plasmodium falciparum LCCL domain-containing protein 0.0022 0.0014 0.0166
Leishmania major p-glycoprotein e 0.0053 0.0099 0.1427
Loa Loa (eye worm) multidrug resistance protein 3 0.0042 0.0069 0.0255
Loa Loa (eye worm) hypothetical protein 0.0085 0.0187 0.0713
Mycobacterium tuberculosis Probable oxidoreductase 0.0122 0.0287 0.0308
Echinococcus multilocularis lysine specific demethylase 6a 0.0038 0.0058 0.012
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0109 0.0253 0.329
Leishmania major P-type H -ATPase, putative 0.0027 0.0027 0.0323
Trichomonas vaginalis cation-transporting ATPase fungi, putative 0.0049 0.0088 0.032
Entamoeba histolytica P-glycoprotein-2, putative 0.0019 0.0006 0.0005
Entamoeba histolytica aminopeptidase, putative 0.0051 0.0094 0.0556
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase 0.0054 0.0102 0.1505
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0121 0.0284 0.1076
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0054 0.0102 0.0371
Schistosoma mansoni multidrug resistance protein 0.0019 0.0006 0.0003
Brugia malayi ABC transporter family protein 0.002 0.0008 0.0012
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0082 0.0177 0.0393
Loa Loa (eye worm) hypothetical protein 0.0051 0.0094 0.0351
Trypanosoma cruzi aminopeptidase, putative 0.0051 0.0094 0.1343
Trichomonas vaginalis ABC transporter, putative 0.0042 0.0069 0.0245
Brugia malayi hypothetical protein 0.0443 0.1167 0.5157
Trichomonas vaginalis chromobox protein, putative 0.0073 0.0153 0.0573
Trypanosoma brucei multidrug resistance protein E 0.0053 0.0099 0.9739
Brugia malayi E1-E2 ATPase family protein 0.0032 0.0041 0.0155
Echinococcus multilocularis nervana 2 0.0279 0.0718 0.1628
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0042 0.0069 0.0245
Brugia malayi calcium ATPase 0.0027 0.0027 0.0094
Entamoeba histolytica ATP-binding cassette protein, putative 0.0053 0.0099 0.0591
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0014 0.0031
Schistosoma mansoni phd/f-box containing protein 0.0038 0.0058 0.0202
Echinococcus granulosus geminin 0.0169 0.0416 0.1585
Loa Loa (eye worm) hypothetical protein 0.0038 0.0058 0.0214
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0053 0.0212
Brugia malayi multidrug resistance related protein 1 0.0053 0.0099 0.0415
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0083 0.0342
Trichomonas vaginalis ABC transporter, putative 0.0042 0.0069 0.0245
Loa Loa (eye worm) hypothetical protein 0.0032 0.0041 0.0149
Onchocerca volvulus 0.0133 0.0317 0.1183
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0049 0.0088 0.1256
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0596 0.1588 1
Plasmodium falciparum ABC transporter B family member 3, putative 0.002 0.0008 0.0087
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.0053 0.0099 0.1427
Echinococcus multilocularis multidrug resistance protein 1 0.0042 0.0069 0.0144
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.0253 0.0272
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.0075 0.0267
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0065 0.0232
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.002 0.0068
Entamoeba histolytica P-glycoprotein-2 0.0042 0.0069 0.0398
Loa Loa (eye worm) E1-E2 ATPase 0.0027 0.0027 0.0093
Echinococcus granulosus RUN 0.0022 0.0014 0.0031
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0258 0.0661 0.1498
Brugia malayi ABC transporter transmembrane region family protein 0.0053 0.0099 0.0415
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0083 0.0309
Echinococcus multilocularis ATP binding cassette sub family B 0.002 0.0008 0.0006
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0054 0.0102 0.0374
Echinococcus granulosus multidrug resistance protein 1 0.0023 0.0016 0.0039
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0053 0.0099 0.9739
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0042 0.0069 0.0244
Echinococcus multilocularis PHD finger protein rhinoceros 0.0118 0.0278 0.0621
Loa Loa (eye worm) ABC transporter 0.002 0.0008 0.0022
Schistosoma mansoni hypothetical protein 0.0047 0.0083 0.0297
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0082 0.0177 0.0664
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0019 0.006
Mycobacterium tuberculosis Probable drugs-transport transmembrane ATP-binding protein ABC transporter 0.002 0.0008 0.0009
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0054 0.0102 0.1465
Echinococcus multilocularis JmjC domain containing protein 4 0.0038 0.0058 0.012
Echinococcus multilocularis Na+:K+ ATPase alpha subunit 0.0142 0.0344 0.0772
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0019 0.0147
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0042 0.0069 0.0245
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0019 0.0208
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0041 0.0067 0.0236
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0596 0.1588 0.6157
Loa Loa (eye worm) hypothetical protein 0.0095 0.0215 0.0819
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0028 0.0031 0.0299
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0053 0.0185
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0053 0.0058
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0083 0.0342
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0042 0.0069 0.0245
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0049 0.0088 0.052
Trypanosoma brucei vacuolar-type Ca2+-ATPase 2 0.0049 0.0088 0.8571
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0051 0.0094 0.0201
Plasmodium falciparum JmjC domain-containing protein, putative 0.0038 0.0058 0.0842
Loa Loa (eye worm) ABC transporter 0.002 0.0008 0.0022
Plasmodium falciparum multidrug resistance-associated protein 1 0.002 0.0008 0.0087
Plasmodium vivax P-type ATPase4, putative 0.0054 0.0102 0.1505
Entamoeba histolytica hypothetical protein 0.0036 0.0053 0.0301
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0596 0.1588 0.6157
Trypanosoma brucei P-type H+-ATPase, putative 0.0027 0.0027 0.2204
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0043 0.0072 0.0255
Echinococcus granulosus Na:K ATPase alpha subunit 0.0142 0.0344 0.1306
Echinococcus granulosus jumonji domain containing protein 0.0165 0.0405 0.1542
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.0075 0.0267
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0006 0.0012
Trichomonas vaginalis abcb9, putative 0.0042 0.0069 0.0245
Loa Loa (eye worm) hypothetical protein 0.0019 0.0006 0.0015
Entamoeba histolytica hypothetical protein 0.0053 0.0099 0.0591
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0049 0.0088 0.032
Brugia malayi beta-lactamase family protein 0.0036 0.0053 0.0212
Leishmania major ABC-thiol transporter 0.0053 0.0099 0.1427
Loa Loa (eye worm) hypothetical protein 0.0091 0.0203 0.0772
Echinococcus granulosus Polycystic kidney disease protein 0.0022 0.0014 0.0031
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha 0.0123 0.029 0.1108
Leishmania major ATP-binding cassette protein subfamily C, member 8, putative 0.002 0.0008 0.0041
Schistosoma mansoni peptidase Clp (S14 family) 0.0082 0.0177 0.0664
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0049 0.0088 0.1256
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0019 0.0017
Plasmodium falciparum multidrug resistance protein 2 0.002 0.0008 0.0087
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0085 0.0091
Brugia malayi Probable ClpP-like protease 0.0082 0.0177 0.0763
Entamoeba histolytica hypothetical protein 0.0036 0.0053 0.0301
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0053 0.0051
Echinococcus granulosus tumor protein p63 0.0331 0.086 0.3301
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0093 0.021 0.0788
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0014 0.0018
Echinococcus granulosus plasma membrane calcium transporting ATPase 0.0054 0.0102 0.0371
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0121 0.0284 0.0636
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.002 0.0008 0.0006
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0053 0.0099 0.1427
Echinococcus multilocularis 0.002 0.0008 0.0006
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0233 0.0592 0.0638
Echinococcus multilocularis muscleblind protein 0.0151 0.0368 0.0829
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0085 0.1248
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0054 0.0102 0.0371
Brugia malayi hypothetical protein 0.0036 0.0053 0.0212
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0074 0.0265
Leishmania major P-type ATPase, putative 0.0054 0.0102 0.1465
Echinococcus granulosus multidrug resistance associated protein 4 0.0033 0.0044 0.0149
Echinococcus multilocularis jumonji domain containing 1A 0.0038 0.0058 0.012
Schistosoma mansoni jumonji/arid domain-containing protein 0.0143 0.0346 0.1315
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0142 0.0344 0.1306
Echinococcus multilocularis tumor protein p63 0.0331 0.086 0.1952
Schistosoma mansoni rab6-interacting 0.0022 0.0014 0.0031
Echinococcus multilocularis multidrug resistance associated protein 7 0.0053 0.0099 0.0214
Trypanosoma cruzi Aminopeptidase M1, putative 0.0051 0.0094 0.1343
Brugia malayi Heterochromatin protein 1 0.0073 0.0153 0.0654
Echinococcus granulosus muscleblind protein 0.0151 0.0368 0.1402
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0291 0.0752 1
Schistosoma mansoni na+/k+ atpase alpha subunit 0.0142 0.0344 0.1306
Loa Loa (eye worm) hypothetical protein 0.0279 0.0718 0.2762
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0051 0.0094 0.1343
Trypanosoma brucei calcium-translocating P-type ATPase 0.0054 0.0102 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0258 0.0661 0.0711
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0051 0.0094 0.034
Schistosoma mansoni hypothetical protein 0.0047 0.0083 0.0297
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0074 0.0265
Loa Loa (eye worm) hypothetical protein 0.0027 0.0027 0.0093
Brugia malayi Na,K-ATPase alpha subunit 0.0142 0.0344 0.15
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0051 0.0094 0.1343
Brugia malayi hypothetical protein 0.0258 0.0661 0.291
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0019 0.006
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0116 0.0272 0.1029
Mycobacterium tuberculosis Probable reductase 0.0109 0.0253 0.0272
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0113 0.0264 0.0998
Brugia malayi Bromodomain containing protein 0.0118 0.0278 0.1207
Trypanosoma cruzi cytochrome P450, putative 0.0024 0.002 0.0224
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0053 0.0058
Toxoplasma gondii aminopeptidase N, putative 0.0051 0.0094 0.1343
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0042 0.0069 0.0244
Echinococcus granulosus leukotriene A 4 hydrolase 0.0963 0.2593 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0053 0.0196
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0042 0.0069 0.0244
Leishmania major hypothetical protein, conserved 0.0036 0.0053 0.0729
Mycobacterium tuberculosis Possible metal cation transporting P-type ATPase CtpH 0.0029 0.0034 0.0037
Entamoeba histolytica P-glyco protein 6, putative 0.0042 0.0069 0.0398
Schistosoma mansoni jumonji domain containing protein 0.0308 0.0797 0.3058
Leishmania major calcium-translocating P-type ATPase 0.0049 0.0088 0.1256
Plasmodium vivax multidomain scavenger receptor, putative 0.0022 0.0014 0.0166
Loa Loa (eye worm) hypothetical protein 0.0258 0.0661 0.2542
Trypanosoma cruzi P-type H+-ATPase, putative 0.0027 0.0027 0.0323
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0042 0.0069 0.0245
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0019 0.0021
Plasmodium falciparum calcium-transporting ATPase 0.0054 0.0102 0.1505
Echinococcus granulosus ATP binding cassette sub family B 0.002 0.0008 0.001
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0054 0.0102 0.0371
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0042 0.0069 0.0255
Plasmodium vivax hypothetical protein, conserved 0.0118 0.0278 0.4176
Loa Loa (eye worm) TATA binding protein associated factor 0.0051 0.0094 0.0351
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0031 0.0158
Mycobacterium ulcerans cation-transporter ATPase I CtpI 0.0029 0.0034 0.0031
Brugia malayi PHD-finger family protein 0.0118 0.0278 0.1207
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0074 0.0235
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0019 0.0017
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0042 0.0069 0.0245
Plasmodium falciparum phd finger protein, putative 0.0118 0.0278 0.4176
Schistosoma mansoni hypothetical protein 0.0036 0.0053 0.0184
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0042 0.0069 0.0245
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0024 0.002 0.0018
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0122 0.0287 0.0308
Loa Loa (eye worm) hypothetical protein 0.0203 0.0509 0.1956
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0042 0.0069 0.0245
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0033 0.0105
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0051 0.0094 0.034
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0049 0.0088 0.1256
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0042 0.0069 0.0245
Brugia malayi hypothetical protein 0.0022 0.0014 0.0035
Trypanosoma brucei calcium motive p-type ATPase, putative 0.0054 0.0102 1
Brugia malayi ABC transporter 0.0019 0.0006 0.0003
Loa Loa (eye worm) hypothetical protein 0.0048 0.0086 0.0322
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0051 0.0094 0.1343
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0054 0.0102 0.0371
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative 0.0123 0.029 0.1261
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0279 0.0718 0.2754
Echinococcus granulosus sodium:potassium transporting ATPase subunit 0.0279 0.0718 0.2754
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0051 0.0094 0.034
Loa Loa (eye worm) hypothetical protein 0.0042 0.0069 0.0255
Entamoeba histolytica P-glycoprotein-2, putative 0.0042 0.0069 0.0398
Schistosoma mansoni multidrug resistance protein 0.0042 0.0069 0.0244
Loa Loa (eye worm) hypothetical protein 0.0258 0.0661 0.2542
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0058 0.0214
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0065 0.0232
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0051 0.0094 0.9163
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0042 0.0069 0.1003
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0596 0.1588 0.6157
Toxoplasma gondii PHD-finger domain-containing protein 0.0118 0.0278 0.4149
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0049 0.0088 0.052
Leishmania major hypothetical protein, conserved 0.0038 0.0058 0.0799
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0042 0.0069 0.0961
Brugia malayi chromobox protein homolog 3 0.0041 0.0065 0.0265
Trypanosoma cruzi ABC transporter, mitochondrial, putative 0.002 0.0008 0.0041
Loa Loa (eye worm) peptidase family M1 containing protein 0.0051 0.0094 0.0351
Brugia malayi hypothetical protein 0.0073 0.0155 0.0661
Brugia malayi MH2 domain containing protein 0.0121 0.0285 0.1241
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0053 0.0058
Trypanosoma cruzi plasma-membrane proton-efflux P-type ATPase, putative 0.0027 0.0027 0.0323
Loa Loa (eye worm) multidrug resistance-associated protein 0.0034 0.0046 0.0168
Mycobacterium ulcerans drugs-transport transmembrane ATP-binding protein ABC transporter 0.002 0.0008 0.0006
Loa Loa (eye worm) hypothetical protein 0.0111 0.0256 0.098
Brugia malayi Doublecortin family protein 0.0022 0.0014 0.0035
Brugia malayi beta-lactamase family protein 0.0036 0.0053 0.0212
Mycobacterium ulcerans lipase LipD 0.0036 0.0053 0.0051
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0051 0.0094 0.1383
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0019 0.0017
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0258 0.0661 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0019 0.0147
Echinococcus granulosus jumonji domain containing 1A 0.0038 0.0058 0.0202
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0051 0.0094 0.1343
Giardia lamblia PHD finger protein 15 0.0118 0.0278 0.1718
Echinococcus multilocularis multidrug resistance protein 1 0.0042 0.0069 0.0144
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0042 0.0069 0.0144
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0027 0.0028 0.01
Brugia malayi hypothetical protein 0.0051 0.0094 0.0391
Echinococcus granulosus Ca2 transporting ATPase plasma membrane 0.0054 0.0102 0.0371
Loa Loa (eye worm) hypothetical protein 0.0049 0.0088 0.0329
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0258 0.0661 0.0658
Trichomonas vaginalis set domain proteins, putative 0.0957 0.2576 1
Toxoplasma gondii P-type ATPase PMA1 0.0027 0.0027 0.0323
Plasmodium vivax calcium-transporting ATPase, putative 0.0054 0.0102 0.1505
Loa Loa (eye worm) hypothetical protein 0.0022 0.0014 0.0042
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0019 0.0017
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0042 0.0069 0.0961
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0049 0.0088 0.032

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.25 uM Binding affinity towards Na+,K+ -ATPase isolated from dog kidney. ChEMBL. 11689068
IC50 (binding) = 0.25 uM Binding affinity towards Na+,K+ -ATPase isolated from dog kidney. ChEMBL. 11689068

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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