Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | thymidylate synthase | 0.1445 | 0.9086 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0687 | 0 | 0.5 |
Brugia malayi | thymidylate synthase | 0.1445 | 0.9086 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1445 | 0.9086 | 0.5 |
Mycobacterium ulcerans | thymidylate synthase | 0.1445 | 0.9086 | 0.5 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.1445 | 0.9086 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1521 | 1 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1521 | 1 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.1445 | 0.9086 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.1445 | 0.9086 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1521 | 1 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.1445 | 0.9086 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1521 | 1 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1521 | 1 | 0.5 |
Onchocerca volvulus | 0.1445 | 0.9086 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | >= 10 % | Inhibition of collagen-induced platelet aggregation in male SD rats; Inhibition >= 10% but < aspirin (34-96%). | ChEMBL. | 3373489 |
Reduction (functional) | = -6 % | Hypolipidemic activity of the compound was expressed as percent decrease in triglycerides in Sprague-Dawley rats | ChEMBL. | 3373489 |
Reduction (functional) | = 9 % | Hypolipidemic activity of the compound was expressed as percent decrease in serum cholesterol in Sprague-Dawley rats | ChEMBL. | 3373489 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.