Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0617 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0617 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0617 | 1 | 1 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0617 | 1 | 0.5 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0617 | 1 | 0.5 |
Toxoplasma gondii | kringle domain-containing protein | 0.0617 | 1 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0382 | 0.454 | 0.454 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0617 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0377 | 0.4421 | 0.5 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0617 | 1 | 1 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0617 | 1 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0377 | 0.4421 | 0.4421 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0617 | 1 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0377 | 0.4421 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0382 | 0.454 | 0.454 |
Brugia malayi | Kringle domain containing protein | 0.0617 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0382 | 0.454 | 0.0213 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0377 | 0.4421 | 0.4421 |
Brugia malayi | dihydrofolate reductase family protein | 0.0377 | 0.4421 | 0.4421 |
Echinococcus granulosus | acetylcholinesterase | 0.0382 | 0.454 | 0.0213 |
Onchocerca volvulus | 0.0617 | 1 | 1 | |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0382 | 0.454 | 0.454 |
Brugia malayi | Carboxylesterase family protein | 0.0382 | 0.454 | 0.454 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0382 | 0.454 | 0.0213 |
Loa Loa (eye worm) | hypothetical protein | 0.0382 | 0.454 | 0.454 |
Echinococcus granulosus | carboxylesterase 5A | 0.0382 | 0.454 | 0.0213 |
Echinococcus multilocularis | acetylcholinesterase | 0.0382 | 0.454 | 0.0213 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0377 | 0.4421 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0382 | 0.454 | 0.0213 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0382 | 0.454 | 0.454 |
Loa Loa (eye worm) | hypothetical protein | 0.0382 | 0.454 | 0.454 |
Schistosoma mansoni | dihydrofolate reductase | 0.0377 | 0.4421 | 0.4421 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0377 | 0.4421 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inactivation (binding) | = 0 % | Ability to inhibit Escherichia coli adenylate kinase II activity expressed as half maximal velocity | ChEMBL. | 6279845 |
Inhibition (binding) | = 0 % | Compound was tested for the lose of thymidine kinase activity after 6 h , at 0 degrees celsius , with 10 mM ATP derivative . values were expressed in percent | ChEMBL. | 7040662 |
Inhibition (binding) | = 0 % | Compound was tested for time dependent inhibition of hexokinase activity after 6 h , at 0 degrees celsius, with 10 mM ATP derivative in yeast hexokinase | ChEMBL. | 7040662 |
Inhibition (binding) | = 0 % | Time dependent inhibition of Hexokinase type I activity after 6 h, at 0 degrees celsius, at 10 mM compound | ChEMBL. | 7040662 |
Inhibition (binding) | = 0 % | Time dependent inhibition of hexokinase 2 activity after 6 h, at 10 mM compound | ChEMBL. | 7040662 |
Inhibition (binding) | = 0 % | Time dependent inhibition of Hexokinase type III activity after 6 h, at 0 degrees celsius, at 10 mM | ChEMBL. | 7040662 |
Inhibition (binding) | = 16 % | Compound was tested for the initial inhibition of thymidine kinase by 1.4 mM compound in the presence of 5.7 mM ATP in Escherichia coli | ChEMBL. | 7040662 |
Ki (binding) | = 1.8 mM | Ability to inhibit rat adenylate kinase II, activity expressed as Inhibition constant | ChEMBL. | 6279845 |
Ki (binding) | = 2.2 mM | Ability to inhibit rat adenylate kinase III, activity expressed as Inhibition constant; Competitive inhibition | ChEMBL. | 6279845 |
Relative velocity (binding) | = 0.85 | Substrate activity against Rat hexokinase II as 1:1 Mg complex at 5.0 mM | ChEMBL. | 7040662 |
Relative velocity (binding) | = 0.94 | Substrate activity against yeast hexokinase as 1:1 Mg complexes at 5.0 mM | ChEMBL. | 7040662 |
Relative velocity (binding) | = 1.66 | Substrate activity for rat hexokinase I as 1:1 Mg complex at 5.0 mM | ChEMBL. | 7040662 |
Relative velocity (binding) | = 2.06 | Substrate activity for rat hexokinase III as 1:1 Mg complex at 5.0 mM | ChEMBL. | 7040662 |
Velocity (binding) | = 57 % | Tested for the velocity of 2.8 mM compound relative to that of 2.8 mM MgATP in the assay | ChEMBL. | 7040662 |
Vmax (ADMET) | = 0 % | Ability to inhibit rat adenylate kinase II, activity expressed as Maximum velocity | ChEMBL. | 6279845 |
Vmax (ADMET) | = 0 % | Ability to inhibit rat adenylate kinase III, activity expressed as Maximum velocity | ChEMBL. | 6279845 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.