Detailed information for compound 217801

Basic information

Technical information
  • TDR Targets ID: 217801
  • Name: [6-chloro-3-(4-fluorophenyl)-4H-imidazo[1,5-a ]quinoxalin-5-yl]-(3,5-dimethylpiperazin-1-yl )methanone
  • MW: 439.913 | Formula: C23H23ClFN5O
  • H donors: 1 H acceptors: 2 LogP: 3.25 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1NC(C)CN(C1)C(=O)N1Cc2c(ncn2c2c1c(Cl)ccc2)c1ccc(cc1)F
  • InChi: 1S/C23H23ClFN5O/c1-14-10-28(11-15(2)27-14)23(31)29-12-20-21(16-6-8-17(25)9-7-16)26-13-30(20)19-5-3-4-18(24)22(19)29/h3-9,13-15,27H,10-12H2,1-2H3
  • InChiKey: QFHHBHRTSRHQEF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • [6-chloro-3-(4-fluorophenyl)-4H-imidazo[1,5-a]quinoxalin-5-yl]-(3,5-dimethyl-1-piperazinyl)methanone
  • [6-chloro-3-(4-fluorophenyl)-4H-imidazo[1,5-a]quinoxalin-5-yl]-(3,5-dimethylpiperazino)methanone
  • [6-chloro-3-(4-fluorophenyl)-4H-imidazo[5,1-c]quinoxalin-5-yl]-(3,5-dimethylpiperazin-1-yl)methanone
  • [6-chloro-3-(4-fluorophenyl)-4H-imidazo[5,1-c]quinoxalin-5-yl]-(3,5-dimethyl-1-piperazinyl)methanone

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus GABA-A receptor; anion channel Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) hypothetical protein GABA-A receptor; anion channel   467 aa 446 aa 29.1 %
Echinococcus granulosus glycine receptor subunit alpha 1 GABA-A receptor; anion channel   467 aa 430 aa 32.3 %
Loa Loa (eye worm) hypothetical protein GABA-A receptor; anion channel   467 aa 494 aa 25.5 %
Onchocerca volvulus Eukaryotic initiation factor 4A-III homolog GABA-A receptor; anion channel   467 aa 453 aa 26.9 %
Onchocerca volvulus Gamma-aminobutyric acid receptor subunit beta homolog GABA-A receptor; anion channel   467 aa 433 aa 34.6 %
Onchocerca volvulus Large subunit GTPase 1 homolog GABA-A receptor; anion channel   467 aa 496 aa 26.0 %
Onchocerca volvulus GABA-A receptor; anion channel   467 aa 446 aa 28.0 %
Onchocerca volvulus GABA-A receptor; anion channel   467 aa 468 aa 28.6 %
Onchocerca volvulus GABA-A receptor; anion channel   467 aa 454 aa 30.4 %
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative GABA-A receptor; anion channel   467 aa 384 aa 19.5 %
Echinococcus multilocularis glycine receptor subunit alpha 1 GABA-A receptor; anion channel   467 aa 430 aa 32.3 %
Echinococcus granulosus glycine receptor subunit beta GABA-A receptor; anion channel   467 aa 439 aa 29.6 %
Brugia malayi Cation transporter family protein GABA-A receptor; anion channel   467 aa 453 aa 28.5 %
Loa Loa (eye worm) hypothetical protein GABA-A receptor; anion channel   467 aa 441 aa 33.8 %
Loa Loa (eye worm) hypothetical protein GABA-A receptor; anion channel   467 aa 461 aa 27.8 %
Onchocerca volvulus GABA-A receptor; anion channel   467 aa 434 aa 26.7 %
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein GABA-A receptor; anion channel   467 aa 454 aa 29.5 %
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein GABA-A receptor; anion channel   467 aa 375 aa 21.9 %
Schistosoma mansoni Cys-loop ligand gated ion channel subunit GABA-A receptor; anion channel   467 aa 479 aa 29.2 %
Onchocerca volvulus Acetylcholine receptor subunit alpha-type homolog GABA-A receptor; anion channel   467 aa 418 aa 19.6 %
Onchocerca volvulus GABA-A receptor; anion channel   467 aa 435 aa 29.7 %
Echinococcus multilocularis glycine receptor subunit beta GABA-A receptor; anion channel   467 aa 478 aa 28.7 %
Onchocerca volvulus GABA-A receptor; anion channel   467 aa 447 aa 25.7 %
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit GABA-A receptor; anion channel   467 aa 379 aa 19.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.1077 0.6744 0.6744
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0027 0.0082 0.0082
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.008 0.0417 0.0417
Loa Loa (eye worm) animal heme peroxidase 0.159 1 1
Onchocerca volvulus 0.0032 0.0109 0.0077
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0023 0.0051 0.0051
Brugia malayi hypothetical protein 0.0019 0.0031 0.0031
Loa Loa (eye worm) ACC-1 protein 0.0023 0.0051 0.0051
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0032 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.0023 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.159 1 1
Brugia malayi Animal haem peroxidase family protein 0.159 1 1
Brugia malayi Kelch motif family protein 0.0037 0.0142 0.0142
Trichomonas vaginalis conserved hypothetical protein 0.1397 0.8771 1
Echinococcus multilocularis mitogen activated protein kinase 14 0.0127 0.0713 0.0713
Loa Loa (eye worm) hypothetical protein 0.0301 0.1817 0.1817
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0023 0.0051 0.0051
Schistosoma mansoni cytochrome c oxidase subunit II 0.012 0.0671 0.0671
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0027 0.0082 0.0082
Schistosoma mansoni hypothetical protein 0.0301 0.1817 0.1817
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0023 0.0051 0.0051
Onchocerca volvulus Cytochrome c oxidase subunit 2 homolog 0.0044 0.019 0.0159
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0027 0.0082 0.0082
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0023 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0301 0.1817 0.1817
Echinococcus multilocularis fibropellin Ia 0.0301 0.1817 0.1817
Brugia malayi Cadherin domain containing protein 0.0301 0.1817 0.1817
Loa Loa (eye worm) hypothetical protein 0.0027 0.0082 0.0082
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0027 0.0082 0.0082
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0116 0.0646 0.0646
Brugia malayi Cadherin domain containing protein 0.0301 0.1817 0.1817
Loa Loa (eye worm) hypothetical protein 0.0027 0.0082 0.0082
Trypanosoma brucei Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0032 0.0112 0.0091
Brugia malayi Protein kinase domain containing protein 0.0017 0.0018 0.0018
Onchocerca volvulus 0.0301 0.1817 0.1791
Echinococcus multilocularis mitogen activated protein kinase 11 0.0127 0.0713 0.0713
Loa Loa (eye worm) hypothetical protein 0.0035 0.013 0.013
Schistosoma mansoni hypothetical protein 0.0301 0.1817 0.1817
Onchocerca volvulus 0.0023 0.0051 0.002
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0023 0.0051 0.0051
Echinococcus multilocularis notch 0.0301 0.1817 0.1817
Mycobacterium ulcerans transmembrane carbonic anhydrase, SulP 0.0032 0.0112 0.0069
Loa Loa (eye worm) hypothetical protein 0.0023 0.0051 0.0051
Plasmodium vivax sulfate transporter, putative 0.0032 0.0112 0.1523
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0023 0.0051 0.0051
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0023 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.159 1 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0027 0.0082 0.0082
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0023 0.0051 0.0051
Leishmania major carbonic anhydrase-like protein 0.1077 0.6744 0.8936
Loa Loa (eye worm) hypothetical protein 0.0023 0.0051 0.0051
Echinococcus granulosus glycine receptor subunit alpha 1 0.0023 0.0051 0.0051
Onchocerca volvulus Cytochrome c oxidase subunit 2 homolog 0.0044 0.019 0.0159
Echinococcus multilocularis nAChR subunit 0.0023 0.0051 0.0051
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.003 0.0097 0.0068
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0127 0.0713 0.0884
Onchocerca volvulus 0.159 1 1
Schistosoma mansoni RAR-like nuclear receptor 0.0027 0.0082 0.0082
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.1077 0.6744 0.6744
Schistosoma mansoni voltage-gated cation channel 0.004 0.016 0.016
Plasmodium falciparum transporter, putative 0.008 0.0417 0.1213
Brugia malayi EGF-like domain containing protein 0.0301 0.1817 0.1817
Echinococcus granulosus nAChR subunit 0.0023 0.0051 0.0051
Echinococcus granulosus glycine receptor subunit alpha 1 0.0023 0.0051 0.0051
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0161 0.0163
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0023 0.0051 0.0051
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.004 0.016 0.016
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0031 0.0031
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.1077 0.6744 1
Loa Loa (eye worm) hypothetical protein 0.008 0.0417 0.0417
Onchocerca volvulus 0.0301 0.1817 0.1791
Brugia malayi Cation transporter family protein 0.0023 0.0051 0.0051
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0027 0.0082 0.0082
Schistosoma mansoni lipoxygenase 0.0116 0.0646 0.0646
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0027 0.0082 0.0082
Mycobacterium tuberculosis Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) 0.067 0.416 0.6855
Schistosoma mansoni sodium/chloride dependent transporter 0.008 0.0417 0.0417
Schistosoma mansoni nAChR subunit 0.0023 0.0051 0.0051
Onchocerca volvulus 0.0023 0.0051 0.002
Onchocerca volvulus Neurogenic locus notch homolog 0.0301 0.1818 0.1792
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0027 0.0082 0.0082
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.008 0.0417 0.0417
Echinococcus granulosus glycine receptor subunit beta 0.0023 0.0051 0.0051
Loa Loa (eye worm) steroid hormone receptor 0.0027 0.0082 0.0082
Echinococcus multilocularis glycine receptor subunit beta 0.0023 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0301 0.1817 0.1817
Schistosoma mansoni coup transcription factor 0.0027 0.0082 0.0082
Schistosoma mansoni notch 0.0301 0.1817 0.1817
Onchocerca volvulus Peroxidase homolog 0.159 1 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.013 0.013
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0023 0.0051 0.0051
Schistosoma mansoni hypothetical protein 0.0124 0.0696 0.0696
Onchocerca volvulus 0.0301 0.1817 0.1791
Loa Loa (eye worm) hypothetical protein 0.159 1 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0027 0.0082 0.0051
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0027 0.0082 0.0082
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0031 0.0031
Onchocerca volvulus Deterin homolog 0.0032 0.0109 0.0077
Loa Loa (eye worm) hypothetical protein 0.0027 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0023 0.0051 0.0051
Loa Loa (eye worm) Notch2 0.0301 0.1817 0.1817
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0023 0.0051 0.0051
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0023 0.0051 0.0051
Brugia malayi Sodium:neurotransmitter symporter family protein 0.008 0.0417 0.0417
Toxoplasma gondii MAPEG family protein 0.0219 0.1299 0.3858
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0027 0.0082 0.0082
Echinococcus multilocularis sodium and chloride dependent glycine 0.008 0.0417 0.0417
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0027 0.0082 0.0082
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.0069 0.0348 0.2761
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0473 0.2908 0.2908
Loa Loa (eye worm) hypothetical protein 0.0301 0.1817 0.1817
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0088 0.0469 0.0469
Loa Loa (eye worm) hypothetical protein 0.0301 0.1817 0.1817
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0031 0.0031
Onchocerca volvulus Peroxidasin homolog 0.159 1 1
Echinococcus multilocularis protein jagged 1 0.0301 0.1817 0.1817
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.003 0.0097 0.0097
Onchocerca volvulus Bile acid receptor homolog 0.0027 0.0082 0.0051
Echinococcus multilocularis geminin 0.0167 0.0968 0.0968
Trichomonas vaginalis AGC family protein kinase 0.0286 0.1726 0.1652
Schistosoma mansoni hypothetical protein 0.0301 0.1817 0.1817
Echinococcus multilocularis integrin beta 2 0.018 0.1049 0.1049
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0032 0.0112 0.0091
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.008 0.0417 0.0417
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0073 0.0369 0.0369
Schistosoma mansoni hypothetical protein 0.0019 0.0031 0.0031
Echinococcus multilocularis neurogenic locus notch protein 0.0301 0.1817 0.1817
Toxoplasma gondii EGF family domain-containing protein 0.0301 0.1817 0.5522
Echinococcus multilocularis neurogenic locus notch protein 4 0.0301 0.1817 0.1817
Loa Loa (eye worm) hypothetical protein 0.0301 0.1817 0.1817
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0037 0.0142 0.0142
Loa Loa (eye worm) hypothetical protein 0.0521 0.3212 0.3212
Brugia malayi notch-like transmembrane receptor 0.0301 0.1817 0.1817
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0027 0.0082 0.0082
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0027 0.0082 0.0082
Echinococcus granulosus voltage dependent calcium channel 0.004 0.016 0.016
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.008 0.0417 0.0417
Schistosoma mansoni cytochrome-c oxidase 0.0044 0.019 0.019
Echinococcus granulosus carbonic anhydrase 0.0521 0.3212 0.3212
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0127 0.0713 0.0713
Schistosoma mansoni septate junction protein 0.0301 0.1817 0.1817
Echinococcus granulosus neurogenic locus notch protein 0.0301 0.1817 0.1817
Loa Loa (eye worm) hypothetical protein 0.159 1 1
Brugia malayi Animal haem peroxidase family protein 0.159 1 1
Schistosoma mansoni notch 0.0301 0.1817 0.1817
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0023 0.0051 0.0051
Echinococcus granulosus neurogenic locus notch protein 0.0301 0.1817 0.1817
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.008 0.0417 0.0417
Echinococcus granulosus peroxidasin 0.159 1 1
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.004 0.016 0.016
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.008 0.0417 0.0417
Loa Loa (eye worm) hypothetical protein 0.0027 0.0082 0.0082
Echinococcus granulosus nuclear factor of activated T cells 5 0.0073 0.0369 0.0369
Onchocerca volvulus 0.0023 0.0051 0.002
Onchocerca volvulus 0.0044 0.019 0.0159
Echinococcus granulosus protein jagged 2 0.0301 0.1817 0.1817
Loa Loa (eye worm) hypothetical protein 0.0301 0.1817 0.1817
Onchocerca volvulus Dual oxidase homolog 0.159 1 1
Echinococcus multilocularis voltage dependent calcium channel 0.004 0.016 0.016
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0473 0.2908 0.2908
Loa Loa (eye worm) hypothetical protein 0.0301 0.1817 0.1817
Loa Loa (eye worm) hypothetical protein 0.0027 0.0082 0.0082
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.008 0.0417 0.0417
Brugia malayi Calcium binding EGF domain containing protein 0.0301 0.1817 0.1817
Mycobacterium tuberculosis Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) 0.0161 0.0931 0.132
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0127 0.0713 0.0989
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0161 0.0163
Schistosoma mansoni hypothetical protein 0.0167 0.0968 0.0968
Mycobacterium ulcerans carbonic anhydrase 0.1203 0.7541 0.859
Echinococcus multilocularis carbonic anhydrase 0.0521 0.3212 0.3212
Echinococcus multilocularis serotonin transporter 0.0473 0.2908 0.2908
Mycobacterium leprae CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) 0.1203 0.7541 1
Echinococcus granulosus uncharacterized sodium dependent transporter 0.008 0.0417 0.0417
Onchocerca volvulus 0.008 0.0417 0.0387
Onchocerca volvulus 0.0027 0.0082 0.0051
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0027 0.0082 0.0082
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.1077 0.6744 0.6744
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0023 0.0051 0.0051
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0027 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0023 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0301 0.1817 0.1817
Mycobacterium ulcerans transferase 0.0067 0.0331 0.0321
Echinococcus granulosus delta-like protein 1 0.0301 0.1817 0.1817
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0032 0.0109 0.0109
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0023 0.0051 0.0051
Leishmania major hypothetical protein, conserved 0.004 0.0161 0.0146
Schistosoma mansoni rab6-interacting 0.0019 0.0031 0.0031
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0027 0.0082 0.0082
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0124 0.0696 0.0696
Entamoeba histolytica protein kinase, putative 0.0286 0.1726 0.2121
Echinococcus granulosus protein jagged 1 0.0301 0.1817 0.1817
Brugia malayi Cation transporter family protein 0.0023 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0023 0.0052 0.0052
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0301 0.1817 0.1791
Schistosoma mansoni steroid hormone receptor ad4bp 0.0027 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.008 0.0417 0.0417
Echinococcus granulosus mitogen activated protein kinase 14 0.0127 0.0713 0.0713
Loa Loa (eye worm) hypothetical protein 0.0037 0.0142 0.0142
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0027 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0023 0.0051 0.0051
Trypanosoma brucei carbonic anhydrase-like protein 0.1077 0.6744 1
Mycobacterium leprae PROBABLE NAPHTHOATE SYNTHASE MENB (DIHYDROXYNAPHTHOIC ACID SYNTHETASE) (DHNA SYNTHETASE) 0.0191 0.1119 0.1396
Loa Loa (eye worm) hypothetical protein 0.0301 0.1817 0.1817
Loa Loa (eye worm) cytochrome oxidase subunit 2 0.0027 0.0077 0.0077
Schistosoma mansoni peroxidasin 0.159 1 1
Loa Loa (eye worm) hypothetical protein 0.0301 0.1817 0.1817
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.008 0.0417 0.103
Loa Loa (eye worm) ACC-1 protein 0.0023 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0023 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0027 0.0082 0.0082
Plasmodium falciparum amino acid transporter, putative 0.008 0.0417 0.1213
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0031 0.0031
Mycobacterium leprae PROBABLE TRANSFERASE 0.0067 0.0331 0.0341
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0027 0.0082 0.0082
Loa Loa (eye worm) animal heme peroxidase 0.159 1 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0051 0.0051
Echinococcus multilocularis peroxidasin 0.159 1 1
Schistosoma mansoni thyroid hormone receptor 0.0152 0.087 0.087
Echinococcus multilocularis inhibitor of apoptosis protein 0.0032 0.0109 0.0109
Onchocerca volvulus Cytochrome c oxidase subunit 2 homolog 0.0044 0.019 0.0159
Schistosoma mansoni microsomal glutathione s-transferase 0.0219 0.1299 0.1299
Mycobacterium ulcerans transmembrane cytochrome C oxidase (subunit II) CtaC 0.0044 0.019 0.0159
Loa Loa (eye worm) hypothetical protein 0.008 0.0417 0.0417
Schistosoma mansoni hypothetical protein 0.0301 0.1817 0.1817
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0102 0.0558 1
Schistosoma mansoni thyroid hormone receptor 0.0152 0.087 0.087
Echinococcus granulosus inhibitor of apoptosis protein 0.0032 0.0109 0.0109
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.004 0.016 0.016
Mycobacterium tuberculosis Probable serine acetyltransferase CysE (sat) 0.0069 0.0348 0.0322
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0023 0.0051 0.0051
Echinococcus granulosus protein jagged 1 0.0301 0.1817 0.1817
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0027 0.0082 0.0082
Echinococcus granulosus slit 2 protein 0.0301 0.1817 0.1817
Plasmodium vivax amine transporter, putative 0.008 0.0417 0.7326
Echinococcus granulosus cytochrome c oxidase subunit II 0.0147 0.084 0.084
Schistosoma mansoni laminin gamma-3 chain 0.0301 0.1817 0.1817
Echinococcus granulosus sodium and chloride dependent glycine 0.008 0.0417 0.0417
Toxoplasma gondii cytochrome C oxidase subunit IIb, putative 0.0044 0.019 0.0299
Loa Loa (eye worm) hypothetical protein 0.0301 0.1817 0.1817
Loa Loa (eye worm) hypothetical protein 0.0027 0.0082 0.0082
Schistosoma mansoni rab6-interacting 0.0019 0.0031 0.0031
Mycobacterium ulcerans epoxide hydrolase EphA 0.0161 0.0931 0.1009
Loa Loa (eye worm) hypothetical protein 0.1104 0.6913 0.6913
Echinococcus multilocularis thyroid hormone receptor alpha 0.0152 0.087 0.087
Schistosoma mansoni slit 0.0301 0.1817 0.1817
Brugia malayi Doublecortin family protein 0.0019 0.0031 0.0031
Schistosoma mansoni loxhd1 0.0019 0.0031 0.0031
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0301 0.1817 0.1817
Loa Loa (eye worm) cytochrome c oxidase subunit II 0.0018 0.0021 0.0021
Entamoeba histolytica ankyrin, putative 0.0069 0.0349 0.0255
Loa Loa (eye worm) hypothetical protein 0.0023 0.0051 0.0051
Onchocerca volvulus 0.008 0.0417 0.0387
Loa Loa (eye worm) hypothetical protein 0.008 0.0417 0.0417
Brugia malayi EGF-like domain containing protein 0.0301 0.1817 0.1817
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0027 0.0082 0.0082
Toxoplasma gondii transporter, cation channel family protein 0.004 0.016 0.0203
Loa Loa (eye worm) animal heme peroxidase 0.159 1 1
Brugia malayi cytochrome c oxidase subunit II 0.0018 0.0021 0.0021
Brugia malayi Delta serrate ligand family protein 0.0301 0.1817 0.1817
Echinococcus multilocularis protein jagged 2 0.0301 0.1817 0.1817
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0051 0.0051
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.004 0.016 0.016
Schistosoma mansoni cell polarity protein 0.0301 0.1817 0.1817
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.0082 0.0082
Brugia malayi Animal haem peroxidase family protein 0.159 1 1
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0286 0.1726 0.1726
Loa Loa (eye worm) carbonic anhydrase 3 0.1077 0.6744 0.6744
Brugia malayi Integrin beta pat-3 precursor 0.0208 0.123 0.123
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0023 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0023 0.0051 0.0051
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0161 0.0163
Echinococcus granulosus neurogenic locus protein delta 0.0301 0.1817 0.1817
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.008 0.0417 0.0417
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0023 0.0051 0.0051
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0023 0.0051 0.0051
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.008 0.0417 0.0417
Loa Loa (eye worm) hypothetical protein 0.0023 0.0051 0.0051
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0023 0.0051 0.0051
Brugia malayi hypothetical protein 0.008 0.0417 0.0417
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.004 0.016 0.016
Brugia malayi Putative carbonic anhydrase 5 precursor 0.1077 0.6744 0.6744
Loa Loa (eye worm) integrin beta-2 0.0208 0.123 0.123
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0032 0.0109 0.0109
Schistosoma mansoni nAChR subunit 0.0023 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.008 0.0417 0.0417
Onchocerca volvulus 0.0023 0.0051 0.002
Mycobacterium ulcerans carbonic anhydrase 0.1397 0.8771 1
Brugia malayi phosphoinositide-dependent protein kinase I 0.0286 0.1726 0.1726
Onchocerca volvulus Slit protein homolog 0.0301 0.1817 0.1791
Loa Loa (eye worm) hypothetical protein 0.159 1 1
Loa Loa (eye worm) hypothetical protein 0.0301 0.1817 0.1817
Loa Loa (eye worm) hypothetical protein 0.0019 0.0031 0.0031
Echinococcus multilocularis glycine receptor subunit beta 0.0023 0.0051 0.0051
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.1077 0.6744 0.6744
Schistosoma mansoni lipoxygenase 0.0081 0.0424 0.0424
Echinococcus granulosus dynactin 5 p25 0.0069 0.0348 0.0348
Echinococcus granulosus Dipeptidyl peptidase 9 0.003 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.0301 0.1817 0.1817
Brugia malayi Cytochrome P450 family protein 0.0051 0.0233 0.0233
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.004 0.016 0.016
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0023 0.0051 0.0051
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0088 0.0469 0.0469
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0027 0.0082 0.0082
Onchocerca volvulus 0.0023 0.0051 0.002
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0521 0.3212 0.3212
Schistosoma mansoni inhibitor of apoptosis protein 0.0032 0.0109 0.0109
Entamoeba histolytica carbonic anhydrase, putative 0.1203 0.7541 1
Schistosoma mansoni sodium/chloride dependent transporter 0.0083 0.0437 0.0437
Onchocerca volvulus 0.0473 0.2908 0.2886
Plasmodium falciparum carbonic anhydrase 0.0521 0.3212 1
Loa Loa (eye worm) prolyl oligopeptidase 0.0088 0.0469 0.0469
Echinococcus granulosus sodium and chloride dependent glycine 0.008 0.0417 0.0417
Loa Loa (eye worm) hypothetical protein 0.0473 0.2908 0.2908
Wolbachia endosymbiont of Brugia malayi cytochrome c oxidase, subunit 2 0.0147 0.084 1
Echinococcus granulosus microsomal glutathione S transferase 3 0.0219 0.1299 0.1299
Brugia malayi nuclear receptor NHR-88 0.0027 0.0082 0.0082
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0027 0.0082 0.0082
Schistosoma mansoni nuclear hormone receptor 0.0027 0.0082 0.0082
Mycobacterium tuberculosis Naphthoate synthase MenB (dihydroxynaphthoic acid synthetase) (DHNA synthetase) 0.0191 0.1119 0.1644
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0023 0.0051 0.0051
Plasmodium vivax hypothetical protein, conserved 0.008 0.0417 0.7326
Echinococcus granulosus serotonin transporter 0.0473 0.2908 0.2908
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0023 0.0051 0.0051
Brugia malayi Protein kinase domain containing protein 0.0286 0.1726 0.1726
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0521 0.3212 0.3212
Loa Loa (eye worm) hypothetical protein 0.0301 0.1817 0.1817
Loa Loa (eye worm) hypothetical protein 0.0521 0.3212 0.3212
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0023 0.0051 0.0051
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0032 0.0112 0.0091
Loa Loa (eye worm) LGC-31 protein 0.0023 0.0051 0.0051
Mycobacterium tuberculosis Beta-carbonic anhydrase CanB 0.0765 0.4766 0.7893
Onchocerca volvulus 0.0067 0.0331 0.0301
Brugia malayi Sodium:neurotransmitter symporter family protein 0.008 0.0417 0.0417
Loa Loa (eye worm) hypothetical protein 0.0301 0.1817 0.1817
Brugia malayi Animal haem peroxidase family protein 0.159 1 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0027 0.0082 0.0082
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.0364 0.2215 0.2215
Toxoplasma gondii hypothetical protein 0.0035 0.013 0.0106
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0023 0.0051 0.0051
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.008 0.0417 0.0417
Brugia malayi nuclear hormone receptor 0.0027 0.0082 0.0082
Loa Loa (eye worm) norepinephrine transporter 0.0473 0.2908 0.2908
Onchocerca volvulus Protein ultraspiracle homolog 0.0027 0.0082 0.0051
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0233 0.1384 0.2097
Brugia malayi Animal haem peroxidase family protein 0.159 1 1
Brugia malayi steroid hormone receptor 0.0027 0.0082 0.0082
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.008 0.0417 0.0417
Schistosoma mansoni sodium-dependent amino acid transporter 0.008 0.0417 0.0417
Echinococcus multilocularis fat cadherin tumor suppressor 0.0301 0.1817 0.1817
Loa Loa (eye worm) hypothetical protein 0.0301 0.1817 0.1817
Echinococcus multilocularis carbonic anhydrase II 0.1077 0.6744 0.6744
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0286 0.1726 0.1726
Brugia malayi EGF-like domain containing protein 0.0301 0.1817 0.1817
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0023 0.0051 0.0051
Plasmodium falciparum cytochrome c oxidase subunit 2, putative 0.0044 0.019 0.0498
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0521 0.3212 0.3212
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0023 0.0051 0.0051
Schistosoma mansoni carbonic anhydrase 0.0521 0.3212 0.3212
Brugia malayi GCC2 and GCC3 family protein 0.0301 0.1817 0.1817
Loa Loa (eye worm) hypothetical protein 0.0023 0.0051 0.0051
Mycobacterium leprae Probable transmembrane transport protein 0.0233 0.1384 0.1751
Mycobacterium ulcerans transmembrane carbonic anhydrase, SulP 0.0032 0.0112 0.0069
Brugia malayi hypothetical protein 0.0019 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.159 1 1
Loa Loa (eye worm) hypothetical protein 0.004 0.016 0.016
Echinococcus granulosus ecdysone induced protein 78C 0.0027 0.0082 0.0082
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0238 0.1417 0.1417
Schistosoma mansoni notch 0.0301 0.1817 0.1817
Leishmania major carbonic anhydrase family protein, putative 0.1203 0.7541 1
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0088 0.0469 0.0439
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0023 0.0051 0.0051
Onchocerca volvulus 0.0201 0.1186 0.1158
Echinococcus multilocularis FTZ F1 alpha 0.0027 0.0082 0.0082
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0031 0.0031
Schistosoma mansoni notch 0.0301 0.1817 0.1817
Schistosoma mansoni carbonic anhydrase-related 0.0521 0.3212 0.3212
Mycobacterium ulcerans integral membrane transporter 0.0032 0.0112 0.0069
Brugia malayi hypothetical protein 0.0037 0.0142 0.0142
Loa Loa (eye worm) hypothetical protein 0.0301 0.1817 0.1817
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0088 0.0469 0.0469
Loa Loa (eye worm) animal heme peroxidase 0.159 1 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.0023 0.0051 0.0051
Brugia malayi Cation transporter family protein 0.0023 0.0051 0.0051
Echinococcus multilocularis neurogenic locus notch protein 0.0301 0.1817 0.1817
Onchocerca volvulus 0.008 0.0417 0.0387
Echinococcus granulosus integrin beta 2 0.018 0.1049 0.1049
Echinococcus multilocularis neural cadherin 0.0301 0.1817 0.1817
Onchocerca volvulus Peroxidase homolog 0.159 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0027 0.0082 0.0082
Schistosoma mansoni nAChR subunit 0.0023 0.0051 0.0051
Echinococcus granulosus neural cadherin 0.0301 0.1817 0.1817
Echinococcus multilocularis mitogen activated protein kinase 14 0.0127 0.0713 0.0713
Toxoplasma gondii hypothetical protein 0.008 0.0417 0.103
Loa Loa (eye worm) notch protein 0.0301 0.1817 0.1817
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.008 0.0417 0.0417
Brugia malayi Muscle positioning protein 4 0.0301 0.1817 0.1817
Loa Loa (eye worm) hypothetical protein 0.008 0.0417 0.0417
Wolbachia endosymbiont of Brugia malayi 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase 0.0069 0.0348 0.2761
Echinococcus granulosus mitogen activated protein kinase 11 0.0127 0.0713 0.0713
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0023 0.0051 0.0051
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.003 0.0097 0.0068
Loa Loa (eye worm) hypothetical protein 0.0301 0.1817 0.1817
Trichomonas vaginalis AGC family protein kinase 0.0286 0.1726 0.1652
Loa Loa (eye worm) hypothetical protein 0.159 1 1
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0023 0.0051 0.0051
Echinococcus multilocularis mitogen activated protein kinase 11 0.0127 0.0713 0.0713
Loa Loa (eye worm) cytochrome P450 family protein 0.0051 0.0233 0.0233
Toxoplasma gondii hypothetical protein 0.008 0.0417 0.103
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0027 0.0082 0.0082
Echinococcus granulosus FTZ F1 alpha 0.0027 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.159 1 1
Giardia lamblia High cysteine protein 0.0301 0.1817 0.5
Loa Loa (eye worm) hypothetical protein 0.0301 0.1817 0.1817
Loa Loa (eye worm) calcium channel 0.004 0.016 0.016
Brugia malayi P38 map kinase family protein 2 0.0127 0.0713 0.0713
Echinococcus multilocularis ecdysone induced protein 78C 0.0027 0.0082 0.0082
Schistosoma mansoni sodium/chloride dependent transporter 0.0473 0.2908 0.2908
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0027 0.0082 0.0082
Brugia malayi EGF-like domain containing protein 0.0301 0.1817 0.1817
Schistosoma mansoni retinoic acid receptor RXR 0.0027 0.0082 0.0082
Brugia malayi Blistered cuticle protein 3 0.159 1 1
Schistosoma mansoni hypothetical protein 0.0521 0.3212 0.3212
Onchocerca volvulus Putative cubilin 0.0301 0.1817 0.1791
Brugia malayi hypothetical protein 0.0023 0.0052 0.0052
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0023 0.0051 0.0051
Schistosoma mansoni peroxidasin 0.159 1 1
Brugia malayi Calcium binding EGF domain containing protein 0.0301 0.1817 0.1817
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.1077 0.6744 1
Brugia malayi EGF-like domain containing protein 0.0301 0.1817 0.1817
Echinococcus multilocularis carbonic anhydrase 0.0521 0.3212 0.3212
Loa Loa (eye worm) hypothetical protein 0.159 1 1
Echinococcus multilocularis neurogenic locus protein delta 0.0301 0.1817 0.1817
Loa Loa (eye worm) hypothetical protein 0.159 1 1
Toxoplasma gondii inorganic anion transporter, sulfate permease (SulP) family protein 0.0032 0.0112 0.0048
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0023 0.0051 0.0051
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.008 0.0417 0.0417
Schistosoma mansoni hypothetical protein 0.0301 0.1817 0.1817
Echinococcus multilocularis protein jagged 1 0.0301 0.1817 0.1817
Loa Loa (eye worm) hypothetical protein 0.159 1 1
Onchocerca volvulus Cytochrome c oxidase subunit 2 homolog 0.0044 0.019 0.0159
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0023 0.0051 0.0051
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0023 0.0051 0.0051
Brugia malayi Calcium binding EGF domain containing protein 0.0301 0.1817 0.1817
Echinococcus granulosus glycine receptor subunit alpha 1 0.0023 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0473 0.2908 0.2908
Echinococcus multilocularis Dipeptidyl peptidase 9 0.003 0.0097 0.0097
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0031 0.0031
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0027 0.0082 0.0082
Mycobacterium ulcerans naphthoate synthase 0.0191 0.1119 0.1225
Loa Loa (eye worm) hypothetical protein 0.0023 0.0051 0.0051
Echinococcus granulosus carbonic anhydrase 0.0521 0.3212 0.3212
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0521 0.3212 0.3212
Schistosoma mansoni membrane associated proteins in eicosanoid and glutathione metabolism family member 0.0956 0.5976 0.5976
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.008 0.0417 1
Echinococcus granulosus notch 0.0301 0.1817 0.1817
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0027 0.0082 0.0082
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0286 0.1726 0.1726
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.008 0.0417 0.0417
Brugia malayi EGF-like domain containing protein 0.0301 0.1817 0.1817
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.008 0.0417 0.103
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0027 0.0082 0.0082
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0032 0.0109 0.0109
Echinococcus granulosus voltage dependent calcium channel 0.004 0.016 0.016
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0521 0.3212 0.3212
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0023 0.0051 0.0051
Schistosoma mansoni nAChR subunit 0.0023 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.159 1 1
Brugia malayi ecdysteroid receptor 0.0027 0.0082 0.0082
Brugia malayi photoreceptor-specific nuclear receptor 0.0027 0.0082 0.0082
Echinococcus granulosus carbonic anhydrase 0.0521 0.3212 0.3212
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.008 0.0417 0.103
Onchocerca volvulus 0.0023 0.0051 0.002
Schistosoma mansoni hypothetical protein 0.0301 0.1817 0.1817
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0023 0.0051 0.0051
Onchocerca volvulus 0.0301 0.1817 0.1791
Echinococcus granulosus carbonic anhydrase II 0.1077 0.6744 0.6744
Onchocerca volvulus Putative sulfate transporter 0.0201 0.1186 0.1158
Echinococcus granulosus RUN 0.0019 0.0031 0.0031
Brugia malayi Cytochrome P450 family protein 0.0023 0.0051 0.0051
Echinococcus granulosus fibropellin Ia 0.0301 0.1817 0.1817
Echinococcus multilocularis microsomal glutathione S transferase 3 0.0219 0.1299 0.1299
Echinococcus granulosus neurogenic locus notch protein 4 0.0301 0.1817 0.1817
Loa Loa (eye worm) serotonin transporter b 0.0473 0.2908 0.2908
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.008 0.0417 0.0417
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0027 0.0082 0.0082
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0301 0.1817 0.1817
Loa Loa (eye worm) hypothetical protein 0.0023 0.0051 0.0051
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0032 0.0109 0.0109
Toxoplasma gondii hypothetical protein 0.0521 0.3212 1
Schistosoma mansoni carbonic anhydrase 0.1203 0.7541 0.7541
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0521 0.3212 0.3212
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.004 0.016 0.016
Loa Loa (eye worm) voltage-dependent calcium channel 0.004 0.016 0.016
Brugia malayi Peroxidasin 0.159 1 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0027 0.0082 0.0082
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0027 0.0082 0.0082
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.003 0.0097 0.0068
Loa Loa (eye worm) hypothetical protein 0.0019 0.0031 0.0031
Schistosoma mansoni nAChR subunit 0.0023 0.0051 0.0051
Schistosoma mansoni nAChR subunit 0.0023 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0027 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.004 0.016 0.016
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0051 0.0051
Trichomonas vaginalis AGC family protein kinase 0.0286 0.1726 0.1652
Treponema pallidum sodium- and chloride- dependent transporter 0.0473 0.2908 0.5
Onchocerca volvulus Peroxidasin homolog 0.159 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0286 0.1726 0.1726
Loa Loa (eye worm) hypothetical protein 0.0023 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0301 0.1817 0.1817
Loa Loa (eye worm) hypothetical protein 0.159 1 1
Brugia malayi Sodium:neurotransmitter symporter family protein 0.008 0.0417 0.0417
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0027 0.0082 0.0082
Schistosoma mansoni carbonic anhydrase-related 0.0521 0.3212 0.3212
Onchocerca volvulus Putative nachr subunit 0.0023 0.0051 0.002
Loa Loa (eye worm) hypothetical protein 0.0032 0.0109 0.0109
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0023 0.0051 0.0051
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.004 0.016 0.0163
Schistosoma mansoni nAChR subunit 0.0023 0.0051 0.0051
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.008 0.0417 0.0417
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0031 0.0031
Brugia malayi prolyl oligopeptidase family protein 0.003 0.0097 0.0097
Brugia malayi excitatory GABA receptor EXP-1A 0.0023 0.0051 0.0051
Echinococcus granulosus geminin 0.0167 0.0968 0.0968
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0027 0.0082 0.0082
Schistosoma mansoni hypothetical protein 0.0301 0.1817 0.1817
Echinococcus granulosus protein jagged 2 0.0301 0.1817 0.1817
Onchocerca volvulus 0.0301 0.1817 0.1791
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0023 0.0051 0.0051
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0023 0.0051 0.0051
Mycobacterium tuberculosis Beta-carbonic anhydrase 0.0959 0.5995 1
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0023 0.0051 0.0051
Brugia malayi follicle stimulating hormone receptor 0.0238 0.1417 0.1417
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0027 0.0082 0.0082
Plasmodium falciparum inorganic anion exchanger, inorganic anion antiporter 0.0032 0.0112 0.0252
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0127 0.0713 0.0989
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0023 0.0051 0.0051
Loa Loa (eye worm) solute carrier family 6 member 4 0.0473 0.2908 0.2908
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0023 0.0051 0.0051
Schistosoma mansoni carbonic anhydrase-related 0.0521 0.3212 0.3212
Plasmodium vivax cytochrome c oxidase subunit 2, putative 0.0044 0.019 0.3006
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0027 0.0082 0.0082
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.004 0.016 0.016
Loa Loa (eye worm) hypothetical protein 0.008 0.0417 0.0417
Schistosoma mansoni hypothetical protein 0.0032 0.0109 0.0109
Mycobacterium tuberculosis Probable transmembrane cytochrome C oxidase (subunit II) CtaC 0.0044 0.019 0.005
Schistosoma mansoni notch 0.0301 0.1818 0.1818
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0023 0.0051 0.0051
Onchocerca volvulus 0.159 1 1
Echinococcus granulosus glycine receptor subunit beta 0.0023 0.0051 0.0051
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.004 0.016 0.016
Echinococcus multilocularis voltage dependent calcium channel 0.004 0.016 0.016
Echinococcus granulosus uncharacterized sodium dependent transporter 0.008 0.0417 0.0417
Echinococcus multilocularis slit 2 protein 0.0301 0.1817 0.1817
Loa Loa (eye worm) hypothetical protein 0.159 1 1
Schistosoma mansoni polycystin 1-related 0.0019 0.0031 0.0031
Schistosoma mansoni hypothetical protein 0.0167 0.0968 0.0968
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0027 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0023 0.0051 0.0051
Entamoeba histolytica acetyltransferase, putative 0.0069 0.0348 0.0254
Loa Loa (eye worm) hypothetical protein 0.0023 0.0051 0.0051
Brugia malayi prolyl oligopeptidase family protein 0.0088 0.0469 0.0469
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0116 0.0646 0.0646
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0023 0.0051 0.0051
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.004 0.016 0.0163
Loa Loa (eye worm) hypothetical protein 0.0023 0.0051 0.0051
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0066 0.0328 0.0328
Schistosoma mansoni integrin beta subunit 0.0143 0.0815 0.0815
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0124 0.0696 0.0696
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.003 0.0097 0.0061
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0473 0.2908 0.2908
Echinococcus multilocularis sodium and chloride dependent glycine 0.008 0.0417 0.0417
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.004 0.016 0.016
Brugia malayi EGF-like domain containing protein 0.0301 0.1817 0.1817
Onchocerca volvulus 0.159 1 1
Trichomonas vaginalis conserved hypothetical protein 0.1397 0.8771 1
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.003 0.0097 0.0068
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0023 0.0051 0.0051
Echinococcus multilocularis carbonic anhydrase 0.0521 0.3212 0.3212
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0127 0.0713 0.0989
Echinococcus multilocularis neurogenic locus protein delta 0.0301 0.1817 0.1817
Echinococcus multilocularis RUN 0.0019 0.0031 0.0031
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0027 0.0082 0.0082
Schistosoma mansoni notch 0.0301 0.1817 0.1817
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0023 0.0051 0.0051
Brugia malayi Steroid receptor seven-up type 2 0.0027 0.0082 0.0082
Mycobacterium ulcerans hypothetical protein 0.004 0.0161 0.0125
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0286 0.1726 0.1726
Loa Loa (eye worm) blistered cuticle protein 3 0.159 1 1
Brugia malayi Cytochrome P450 family protein 0.0023 0.0051 0.0051
Onchocerca volvulus Chorion peroxidase homolog 0.159 1 1
Loa Loa (eye worm) hypothetical protein 0.0301 0.1817 0.1817
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0027 0.0082 0.0082

Activities

Activity type Activity value Assay description Source Reference
Cl - current change (functional) = 0.93 In vitro efficacy calculated by chlorine current assay on alpha1-beta2-gamma2 (GABA-A) receptor subtype ChEMBL. 8809170
Cl - current change (functional) = 0.93 In vitro efficacy calculated by chlorine current assay on alpha1-beta2-gamma2 (GABA-A) receptor subtype ChEMBL. 8809170
ED50 (functional) = 1.8 mg kg-1 Ability to antagonize metrazole-induced seizures (clonic and tonic) in mice after intraperitoneal injection ChEMBL. 8809170
ED50 (functional) = 1.8 mg kg-1 Ability to antagonize metrazole-induced seizures (clonic and tonic) in mice after intraperitoneal injection ChEMBL. 8809170
ED50 (functional) > 30 mg kg-1 Antagonism of benzodiazepine traction in mice ChEMBL. 8809170
ED50 (functional) > 30 mg kg-1 Antagonism of benzodiazepine traction in mice ChEMBL. 8809170
Ki (binding) = 33.4 nM Binding affinity against benzodiazepine receptor (BzR) in rat cortical membranes determined by competition experiments with radiolabeled [3H]-flunitrazepam (Fnz) ChEMBL. 8809170
Ki (binding) = 33.4 nM Binding affinity against benzodiazepine receptor (BzR) in rat cortical membranes determined by competition experiments with radiolabeled [3H]-flunitrazepam (Fnz) ChEMBL. 8809170
TBPS shift (binding) = 0.31 In vitro efficacy by [35S]-t-butyl-bicyclophosphorothionate (TBPS) binding to the picrotoxin convulsant site on the GABA-A receptor chloride complex. ChEMBL. 8809170
TBPS shift (binding) = 0.31 In vitro efficacy by [35S]-t-butyl-bicyclophosphorothionate (TBPS) binding to the picrotoxin convulsant site on the GABA-A receptor chloride complex. ChEMBL. 8809170

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.