Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.0175 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0059 | 0.2112 | 1 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.0175 | 1 | 0.5 |
Leishmania major | dihydroorotate dehydrogenase | 0.0175 | 1 | 1 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0068 | 0.2747 | 0.5 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0068 | 0.2747 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.0175 | 1 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0175 | 1 | 1 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.0068 | 0.2747 | 0.2747 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0068 | 0.2747 | 0.5 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.0175 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0068 | 0.2747 | 0.5 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0175 | 1 | 1 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.0175 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.0175 | 1 | 0.5 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0175 | 1 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0175 | 1 | 1 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.0175 | 1 | 0.5 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.0175 | 1 | 1 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0068 | 0.2747 | 0.5 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0068 | 0.2747 | 0.5 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.0175 | 1 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0059 | 0.2112 | 0.2112 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0068 | 0.2747 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0068 | 0.2747 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0068 | 0.2747 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0068 | 0.2747 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0068 | 0.2747 | 0.2747 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0068 | 0.2747 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 46 nM | Inhibition of oncogene product p185 erbB-2 from human breast cancer cells(SK-BR-3 cells) at 50 mg/kg dose. | ChEMBL. | 7562911 |
IC50 (functional) | = 46 nM | Inhibition of oncogene product p185 erbB-2 from human breast cancer cells(SK-BR-3 cells) at 50 mg/kg dose. | ChEMBL. | 7562911 |
Inhibition (functional) | = 31 % | In vitro inhibition of phospho-p185erbB-2 expression in human breast cancer cells(SK-BR-3 cells) at 100 mg/kg dose. | ChEMBL. | 7562911 |
Inhibition (functional) | = 31 % | In vitro inhibition of phospho-p185erbB-2 expression in human breast cancer cells(SK-BR-3 cells) at 100 mg/kg dose. | ChEMBL. | 7562911 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 7562911 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.