Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | poly (ADP-ribose) polymerase family, member 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.0191 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.6312 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0075 | 0.2747 | 0.5 |
Loa Loa (eye worm) | poly(ADP-ribose) polymerase | 0.0068 | 0.2351 | 0.3725 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.0191 | 1 | 0.5 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0191 | 1 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0191 | 1 | 1 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0075 | 0.2747 | 0.5 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.0191 | 1 | 1 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.0191 | 1 | 1 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.0191 | 1 | 1 |
Echinococcus multilocularis | poly (ADP ribose) polymerase 1 | 0.0174 | 0.8888 | 1 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0075 | 0.2747 | 0.2612 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.0191 | 1 | 1 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0095 | 0.4027 | 0.1181 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0191 | 1 | 1 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.0191 | 1 | 0.5 |
Trypanosoma cruzi | poly(ADP-ribose) polymerase, putative | 0.0095 | 0.4027 | 0.4027 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0191 | 1 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0065 | 0.2112 | 0.2112 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.0191 | 1 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0075 | 0.2747 | 0.2747 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0075 | 0.2747 | 0.5 |
Brugia malayi | WGR domain containing protein | 0.0174 | 0.8888 | 0.8888 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.4027 | 0.638 |
Entamoeba histolytica | poly(ADP-ribose) polymerase, putative | 0.0174 | 0.8888 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0075 | 0.2747 | 0.5 |
Trypanosoma cruzi | poly(ADP-ribose) polymerase, putative | 0.0095 | 0.4027 | 0.4027 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0174 | 0.8888 | 0.8358 |
Echinococcus granulosus | poly ADP ribose polymerase 1 | 0.0174 | 0.8888 | 1 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.0191 | 1 | 0.5 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.0075 | 0.2747 | 0.2747 |
Echinococcus multilocularis | poly (adp ribose) polymerase 2 | 0.0095 | 0.4027 | 0.4152 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0075 | 0.2747 | 0.1742 |
Brugia malayi | WGR domain containing protein | 0.0095 | 0.4027 | 0.4027 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0075 | 0.2747 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0065 | 0.2112 | 0.3345 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0075 | 0.2747 | 0.1742 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0075 | 0.2747 | 0.2612 |
Leishmania major | dihydroorotate dehydrogenase | 0.0191 | 1 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0075 | 0.2747 | 0.5 |
Trypanosoma brucei | poly(adp-ribose) polymerase | 0.0095 | 0.4027 | 0.4027 |
Echinococcus granulosus | poly adp ribose polymerase 2 | 0.0095 | 0.4027 | 0.3464 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.27 uM | Inhibition of the DNA repair Poly (ADP-ribose) polymerase 1, in permeabilised L1210 murine leukemia cells | ChEMBL. | 9857092 |
IC50 (binding) | = 0.27 uM | poly(ADP-ribose)polymerase(PARP) inhibition | ChEMBL. | 11689065 |
IC50 (binding) | = 0.27 uM | Inhibition of the DNA repair Poly (ADP-ribose) polymerase 1, in permeabilised L1210 murine leukemia cells | ChEMBL. | 9857092 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.