Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Plasmodium berghei | bifunctional dihydrofolate reductase-thymidylate synthase, putative | Starlite/ChEMBL | References |
Escherichia coli | Dihydrofolate reductase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.0165 | 0.531 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.013 | 0.3589 | 0.6569 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0065 | 0.0427 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.0165 | 0.531 | 0.517 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0065 | 0.0427 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0262 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0132 | 0.3711 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0132 | 0.3711 | 0.0709 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0132 | 0.3711 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0132 | 0.3711 | 0.6813 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0065 | 0.0427 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.0132 | 0.3711 | 1 |
Brugia malayi | hypothetical protein | 0.0062 | 0.0291 | 0.0548 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.0165 | 0.531 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0065 | 0.0427 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0132 | 0.3711 | 0.6987 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0262 | 1 | 1 |
Brugia malayi | dihydrofolate reductase family protein | 0.0132 | 0.3711 | 0.6987 |
Onchocerca volvulus | 0.013 | 0.3589 | 0.5 | |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0132 | 0.3711 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.0165 | 0.531 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0262 | 1 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0165 | 0.531 | 0.517 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0262 | 1 | 1 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.0065 | 0.0427 | 0.0805 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0065 | 0.0427 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0065 | 0.0427 | 1 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0065 | 0.0427 | 1 |
Brugia malayi | thymidylate synthase | 0.013 | 0.3589 | 0.6757 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.0165 | 0.531 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.013 | 0.3589 | 0.9671 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.0165 | 0.531 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0165 | 0.531 | 0.517 |
Schistosoma mansoni | dihydrofolate reductase | 0.0132 | 0.3711 | 0.0709 |
Echinococcus multilocularis | thymidylate synthase | 0.013 | 0.3589 | 0.9628 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0165 | 0.531 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0262 | 1 | 1 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0165 | 0.531 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.013 | 0.3589 | 0.9628 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0065 | 0.0427 | 0.014 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0132 | 0.3711 | 0.0709 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
clogP | = 0.996 | Calculated partition coefficient (clogP) | ChEMBL. | 8941396 |
I50 (binding) | = 0.0000003 M | Inhibitory activity against Dihydrofolate reductase enzyme purified from E. coli | ChEMBL. | 6991692 |
I50 (binding) | = 0.00000048 M | Inhibitory activity against Dihydrofolate reductase enzyme purified from P. berghei. | ChEMBL. | 6991692 |
I50 (binding) | = 30 M | Inhibition against dihydrofolate reductase enzyme of Escherichia coli | ChEMBL. | 6991695 |
I50 (binding) | = 48 M | Compound was tested for its inhibition against dihydrofolate reductase enzyme of Plasmodium berghei | ChEMBL. | 6991695 |
IC50 (binding) | = 6.52 | Compound was tested for inhibition of E. coli Dihydrofolate reductase. | ChEMBL. | 8941396 |
IC50 (binding) | = 0.0000003 M | Inhibition against dihydrofolate reductase enzyme of Escherichia coli | ChEMBL. | 6991695 |
IC50 (binding) | = 0.0000003 M | Inhibitory activity against Dihydrofolate reductase enzyme purified from E. coli | ChEMBL. | 6991692 |
IC50 (binding) | = 0.00000048 M | Compound was tested for its inhibition against dihydrofolate reductase enzyme of Plasmodium berghei | ChEMBL. | 6991695 |
IC50 (binding) | = 0.00000048 M | Inhibitory activity against Dihydrofolate reductase enzyme purified from P. berghei. | ChEMBL. | 6991692 |
Log (binding) | = 6.52 1/IC50 | Compound was tested for inhibition of E. coli Dihydrofolate reductase. | ChEMBL. | 8941396 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.