Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | peroxidasin | 0.0032 | 0.5 | 0.5 |
Brugia malayi | Peroxidasin | 0.0032 | 0.5 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0032 | 0.5 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0032 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0032 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0032 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.5 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.0032 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0032 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0032 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0032 | 0.5 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.0032 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0032 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0032 | 0.5 | 0.5 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0032 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0032 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0032 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0032 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0032 | 0.5 | 0.5 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0032 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0032 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0032 | 0.5 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.5 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0032 | 0.5 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.0032 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0032 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0032 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 6.55 uM | Inhibition concentration against cyclooxygenase-2(COX-2) in human whole blood | ChEMBL. | 15239665 |
IC50 (binding) | = 6.55 uM | Inhibition concentration against cyclooxygenase-2(COX-2) in human whole blood | ChEMBL. | 15239665 |
Inhibition (binding) | Ratio of inhibitory activity of the compound against cyclooxygenase- (COX-1) to that of cyclooxygenase- (COX-2); No data | ChEMBL. | 15239665 | |
Inhibition (binding) | uM | Inhibition concentration against cyclooxygenase-1(COX-1) in human whole blood; nt=Not tested | ChEMBL. | 15239665 |
ND (binding) | 0 | Ratio of inhibitory activity of the compound against cyclooxygenase- (COX-1) to that of cyclooxygenase- (COX-2); No data | ChEMBL. | 15239665 |
ND (functional) | 0 mg kg-1 | Effective dose of the compound in the yeast-induced pyresis model in rat; nt=Not tested | ChEMBL. | 15239665 |
ND (binding) | 0 uM | Inhibition concentration against cyclooxygenase-1(COX-1) in human whole blood; nt=Not tested | ChEMBL. | 15239665 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.