Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | HMG-CoA reductase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Animal haem peroxidase family protein | 0.0167 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 1 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0078 | 0.2866 | 1 |
Echinococcus multilocularis | protein dispatched 1 | 0.0068 | 0.2109 | 0.2109 |
Brugia malayi | CHE-14 protein | 0.0068 | 0.2109 | 0.2109 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.9857 | 0.9857 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.2109 | 0.2109 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 1 | 1 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.0165 | 0.9857 | 0.9857 |
Brugia malayi | Animal haem peroxidase family protein | 0.0167 | 1 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0165 | 0.9857 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 1 | 1 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.0165 | 0.9857 | 0.5 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0165 | 0.9857 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0167 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0167 | 1 | 1 |
Brugia malayi | Peroxidasin | 0.0167 | 1 | 1 |
Schistosoma mansoni | patched 1 | 0.0068 | 0.2109 | 0.2109 |
Onchocerca volvulus | Peroxidase homolog | 0.0167 | 1 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0078 | 0.2866 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0167 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0167 | 1 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0167 | 1 | 1 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0068 | 0.2109 | 0.2109 |
Toxoplasma gondii | EGF family domain-containing protein | 0.0042 | 0 | 0.5 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.0165 | 0.9857 | 0.9857 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 1 | 1 |
Onchocerca volvulus | 0.0167 | 1 | 1 | |
Schistosoma mansoni | peroxidasin | 0.0167 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 1 | 1 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0068 | 0.2109 | 0.2109 |
Onchocerca volvulus | Peroxidasin homolog | 0.0167 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0167 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0167 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 1 | 1 |
Onchocerca volvulus | 0.0167 | 1 | 1 | |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0068 | 0.2109 | 0.2109 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0167 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 1 | 1 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0068 | 0.2109 | 0.2109 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0078 | 0.2866 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 1 | 1 |
Brugia malayi | Hydroxymethylglutaryl-coenzyme A reductase family protein | 0.0165 | 0.9857 | 0.9857 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0165 | 0.9857 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.0167 | 1 | 1 |
Onchocerca volvulus | 0.0167 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 1 | 1 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0068 | 0.2109 | 0.2109 |
Echinococcus multilocularis | protein patched | 0.0068 | 0.2109 | 0.2109 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0167 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 1 | 1 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.0165 | 0.9857 | 0.9857 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0167 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0167 | 1 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0167 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0167 | 1 | 1 |
Echinococcus granulosus | peroxidasin | 0.0167 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 1 | 1 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0068 | 0.2109 | 0.2109 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0068 | 0.2109 | 0.2109 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0078 | 0.2866 | 1 |
Brugia malayi | Blistered cuticle protein 3 | 0.0167 | 1 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0165 | 0.9857 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 10 uM | In vitro inhibitory activity against HMG-CoA reductase by employing a crude liver homogenate derived from rats fed a chow diet containing 5% cholestyramine | ChEMBL. | 2296027 |
IC50 (binding) | = 10 uM | In vitro inhibitory activity against HMG-CoA reductase by employing a crude liver homogenate derived from rats fed a chow diet containing 5% cholestyramine | ChEMBL. | 2296027 |
Relative potency (binding) | = 0.32 | Relative CSI (cholesterol synthesis inhibition) potency was determined using IC50 values relative to compactin potency | ChEMBL. | 2296027 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.