Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.0064 | 0.2235 | 0.2235 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0112 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0112 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0064 | 0.2235 | 0.2235 |
Echinococcus granulosus | tyrosine kinase | 0.0064 | 0.2235 | 0.2235 |
Schistosoma mansoni | nck2/grb4 | 0.0098 | 0.7765 | 0.7765 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0112 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.0064 | 0.2235 | 0.2235 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0112 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0062 | 0.2038 | 0.2038 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0112 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0064 | 0.2235 | 0.2235 |
Brugia malayi | SH2 domain containing protein | 0.0064 | 0.2235 | 0.2235 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0112 | 1 | 1 |
Echinococcus multilocularis | growth factor receptor bound protein 2 | 0.0098 | 0.7765 | 0.7765 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0112 | 1 | 1 |
Loa Loa (eye worm) | SRC-1 | 0.0112 | 1 | 1 |
Echinococcus granulosus | NCK adaptor protein | 0.0098 | 0.7765 | 0.7765 |
Schistosoma mansoni | tyrosine kinase | 0.0112 | 1 | 1 |
Schistosoma mansoni | adapter molecule crk | 0.0098 | 0.7765 | 0.7765 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0112 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0064 | 0.2235 | 0.2235 |
Onchocerca volvulus | 0.0064 | 0.2235 | 1 | |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0064 | 0.2235 | 0.2235 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0064 | 0.2235 | 0.2235 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0112 | 1 | 1 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0112 | 1 | 1 |
Brugia malayi | Sex muscle abnormal protein 5 | 0.0098 | 0.7765 | 0.7765 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0098 | 0.7765 | 0.7765 |
Echinococcus multilocularis | tyrosine protein kinase Fps85D | 0.0064 | 0.2235 | 0.2235 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0064 | 0.2235 | 0.2235 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.0064 | 0.2235 | 0.2235 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase abl1 | 0.0098 | 0.7765 | 0.7765 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0098 | 0.7765 | 0.7765 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0064 | 0.2235 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0112 | 1 | 1 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0112 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.0064 | 0.2235 | 0.2235 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0064 | 0.2235 | 0.2235 |
Echinococcus granulosus | c src tyrosine kinase | 0.0112 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0112 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0112 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0112 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.7765 | 0.7765 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0064 | 0.2235 | 0.2235 |
Echinococcus multilocularis | tyrosine kinase | 0.0064 | 0.2235 | 0.2235 |
Echinococcus multilocularis | NCK adaptor protein | 0.0098 | 0.7765 | 0.7765 |
Onchocerca volvulus | 0.0064 | 0.2235 | 1 | |
Echinococcus granulosus | tyrosine protein kinase shark | 0.0064 | 0.2235 | 0.2235 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0064 | 0.2235 | 0.2235 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.0064 | 0.2235 | 0.2235 |
Loa Loa (eye worm) | TK protein kinase | 0.0064 | 0.2235 | 0.2235 |
Onchocerca volvulus | 0.0064 | 0.2235 | 1 | |
Brugia malayi | SRC-1 | 0.0112 | 1 | 1 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0112 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0064 | 0.2235 | 0.2235 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.2235 | 0.2235 |
Schistosoma mansoni | tyrosine kinase | 0.0112 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Fps85D | 0.0064 | 0.2235 | 0.2235 |
Schistosoma mansoni | tyrosine kinase | 0.0112 | 1 | 1 |
Onchocerca volvulus | 0.0064 | 0.2235 | 1 | |
Brugia malayi | Variant SH3 domain containing protein | 0.0098 | 0.7765 | 0.7765 |
Brugia malayi | Protein kinase domain containing protein | 0.0064 | 0.2235 | 0.2235 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0112 | 1 | 1 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.0064 | 0.2235 | 0.2235 |
Schistosoma mansoni | tyrosine kinase | 0.0064 | 0.2235 | 0.2235 |
Brugia malayi | SH2 domain containing protein | 0.0064 | 0.2235 | 0.2235 |
Onchocerca volvulus | 0.0064 | 0.2235 | 1 | |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0112 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Srms | 0.0064 | 0.2235 | 0.2235 |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.0064 | 0.2235 | 0.2235 |
Onchocerca volvulus | 0.0064 | 0.2235 | 1 | |
Schistosoma mansoni | tyrosine kinase | 0.0064 | 0.2235 | 0.2235 |
Brugia malayi | Protein kinase domain containing protein | 0.0064 | 0.2235 | 0.2235 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0112 | 1 | 1 |
Echinococcus granulosus | growth factor receptor bound protein 2 | 0.0098 | 0.7765 | 0.7765 |
Loa Loa (eye worm) | sex muscle abnormal protein 5 | 0.0098 | 0.7765 | 0.7765 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0064 | 0.2235 | 0.2235 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0112 | 1 | 1 |
Loa Loa (eye worm) | variant SH3 domain-containing protein | 0.0098 | 0.7765 | 0.7765 |
Brugia malayi | hypothetical protein | 0.0064 | 0.2235 | 0.2235 |
Brugia malayi | Protein kinase domain containing protein | 0.0064 | 0.2235 | 0.2235 |
Brugia malayi | Variant SH3 domain containing protein | 0.0098 | 0.7765 | 0.7765 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0064 | 0.2235 | 0.2235 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0112 | 1 | 1 |
Brugia malayi | protein-tyrosine kinase | 0.0064 | 0.2235 | 0.2235 |
Echinococcus granulosus | tyrosine protein kinase ABL1 | 0.0064 | 0.2235 | 0.2235 |
Schistosoma mansoni | tyrosine kinase | 0.0112 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0112 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0064 | 0.2235 | 0.2235 |
Echinococcus granulosus | tyrosine kinase | 0.0064 | 0.2235 | 0.2235 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 5.85 | Inhibitory activity against human IL-1 beta converting enzyme from monocytic THP-1 cell line, activity expressed as the logarithm of the second order rate constant for inactivation | ChEMBL. | 9986707 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.