Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | HMG-CoA reductase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0264 | 1 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0165 | 0.4702 | 0.5 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0264 | 1 | 1 |
Echinococcus granulosus | serotonin transporter | 0.0264 | 1 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0078 | 0 | 0.5 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0078 | 0 | 0.5 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.0165 | 0.4702 | 0.5 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0165 | 0.4702 | 0.5 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0264 | 1 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0078 | 0 | 0.5 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0165 | 0.4702 | 0.5 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0264 | 1 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0165 | 0.4702 | 0.5 |
Loa Loa (eye worm) | serotonin transporter b | 0.0264 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0264 | 1 | 1 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0264 | 1 | 0.5 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0264 | 1 | 1 |
Echinococcus multilocularis | serotonin transporter | 0.0264 | 1 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0078 | 0 | 0.5 |
Onchocerca volvulus | 0.0264 | 1 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0264 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.234 uM | In vitro inhibitory activity against HMG-CoA reductase by employing a crude liver homogenate derived from rats fed a chow diet containing 5% cholestyramine | ChEMBL. | 2296027 |
IC50 (binding) | = 0.234 uM | In vitro inhibitory activity against HMG-CoA reductase by employing a crude liver homogenate derived from rats fed a chow diet containing 5% cholestyramine | ChEMBL. | 2296027 |
Relative potency (binding) | = 19.6 | Relative CSI (cholesterol synthesis inhibition) potency was determined using IC50 values relative to compactin potency | ChEMBL. | 2296027 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.