Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | hydroxyacid oxidase (glycolate oxidase) 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Candida albicans | cytochrome b2 precursor | Get druggable targets OG5_126945 | All targets in OG5_126945 |
Mycobacterium leprae | POSSIBLE L-LACTATE DEHYDROGENASE (CYTOCHROME) LLDD2 | Get druggable targets OG5_126945 | All targets in OG5_126945 |
Candida albicans | cytochrome b2 precursor | Get druggable targets OG5_126945 | All targets in OG5_126945 |
Treponema pallidum | hypothetical protein | Get druggable targets OG5_126945 | All targets in OG5_126945 |
Mycobacterium ulcerans | L-lactate dehydrogenase (cytochrome) LldD2 | Get druggable targets OG5_126945 | All targets in OG5_126945 |
Mycobacterium tuberculosis | Possible L-lactate dehydrogenase (cytochrome) LldD2 | Get druggable targets OG5_126945 | All targets in OG5_126945 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium ulcerans | L-lactate dehydrogenase (cytochrome) LldD1 | hydroxyacid oxidase (glycolate oxidase) 1 | 370 aa | 353 aa | 38.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | endoprotease bli-4 | 0.0143 | 0.2324 | 1 |
Loa Loa (eye worm) | aspartic protease BmAsp-2 | 0.0064 | 0.0218 | 0.094 |
Toxoplasma gondii | aspartyl protease ASP1 | 0.0064 | 0.0218 | 0.5 |
Echinococcus multilocularis | 0.0115 | 0.1584 | 1 | |
Plasmodium vivax | aspartyl proteinase, putative | 0.0064 | 0.0218 | 0.5 |
Leishmania major | isopentenyl-diphosphate delta-isomerase, putative,isomerase, putative | 0.0075 | 0.0499 | 0.5 |
Mycobacterium leprae | POSSIBLE L-LACTATE DEHYDROGENASE (CYTOCHROME) LLDD2 | 0.0209 | 0.4077 | 0.5 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0157 | 0.269 | 0.2568 |
Plasmodium vivax | plasmepsin IV, putative | 0.0064 | 0.0218 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.2324 | 1 |
Echinococcus granulosus | proprotein convertase subtilisin:kexin type 5 | 0.0087 | 0.0824 | 0.2877 |
Echinococcus granulosus | neuroendocrine convertase 2 | 0.009 | 0.0903 | 0.3252 |
Trypanosoma brucei | isopentenyl-diphosphate delta-isomerase (type II) | 0.0075 | 0.0499 | 0.5 |
Plasmodium falciparum | plasmepsin IV | 0.0064 | 0.0218 | 0.5 |
Plasmodium falciparum | plasmepsin II | 0.0064 | 0.0218 | 0.5 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0087 | 0.0824 | 1 |
Entamoeba histolytica | isopentenyl-diphosphate delta-isomerase, putative | 0.0075 | 0.0499 | 0.5 |
Echinococcus multilocularis | neuroendocrine convertase 2 | 0.009 | 0.0903 | 0.5012 |
Mycobacterium tuberculosis | Possible L-lactate dehydrogenase (cytochrome) LldD2 | 0.0209 | 0.4077 | 0.5 |
Echinococcus granulosus | furin | 0.0143 | 0.2324 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0218 | 0.094 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0157 | 0.269 | 0.2568 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0064 | 0.0218 | 0.0056 |
Plasmodium falciparum | plasmepsin I | 0.0064 | 0.0218 | 0.5 |
Mycobacterium ulcerans | L-lactate dehydrogenase (cytochrome) LldD2 | 0.0209 | 0.4077 | 1 |
Toxoplasma gondii | aspartyl proteinase (eimepsin), putative | 0.0064 | 0.0218 | 0.5 |
Plasmodium falciparum | plasmepsin VI | 0.0064 | 0.0218 | 0.5 |
Echinococcus multilocularis | proprotein convertase subtilisin:kexin type 5 | 0.0087 | 0.0824 | 0.4434 |
Brugia malayi | endoprotease bli-4 precursor | 0.0143 | 0.2324 | 1 |
Treponema pallidum | hypothetical protein | 0.0209 | 0.4077 | 0.5 |
Brugia malayi | celfurPC protein | 0.0115 | 0.1584 | 0.4795 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0087 | 0.0824 | 1 |
Schistosoma mansoni | subfamily S8B unassigned peptidase (S08 family) | 0.0143 | 0.2324 | 0.2196 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
I50 (binding) | = 0.000000063 M | In vitro inhibition of porcine Glycolate oxidase | ChEMBL. | 6348285 |
IC50 (binding) | = 0.000000063 M | In vitro inhibition of porcine Glycolate oxidase | ChEMBL. | 6348285 |
pKa | = 3.6 | Acidic dissociation constant (pKa) determined in 50% aqueous ethanol | ChEMBL. | 6348285 |
pKa | = 8.35000000000003 | Acidic dissociation constant (pKa) determined in 50% aqueous ethanol | ChEMBL. | 6348285 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.