Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | poly (ADP-ribose) polymerase family, member 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0235 | 0.0846 |
Echinococcus multilocularis | serotonin receptor | 0.0153 | 0.2371 | 0.2287 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0082 | 0.0961 | 0.3456 |
Schistosoma mansoni | P2X receptor subunit | 0.0066 | 0.0627 | 0.2256 |
Echinococcus granulosus | WGR domain containing protein | 0.0054 | 0.039 | 0.0159 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.2371 | 1 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0066 | 0.0627 | 0.0524 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0318 | 0.1341 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0535 | 1 | 1 |
Schistosoma mansoni | P2X receptor subunit | 0.0066 | 0.0627 | 0.2256 |
Schistosoma mansoni | jumonji domain containing protein | 0.0059 | 0.0499 | 0.1794 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0066 | 0.0627 | 0.0401 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0182 | 0.2955 | 0.5 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0182 | 0.2955 | 0.5 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0059 | 0.0499 | 0.1794 |
Schistosoma mansoni | P2X receptor subunit | 0.0066 | 0.0627 | 0.2256 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0059 | 0.0499 | 0.0394 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.0235 | 0.0992 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0095 | 0.1218 | 0.4381 |
Brugia malayi | jmjC domain containing protein | 0.0059 | 0.0499 | 0.1794 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0235 | 0.0846 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0235 | 0.0128 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0059 | 0.0499 | 0.1794 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0182 | 0.2955 | 0.5 |
Trypanosoma brucei | poly(adp-ribose) polymerase | 0.0095 | 0.1218 | 0.5 |
Brugia malayi | jmjC domain containing protein | 0.0059 | 0.0499 | 0.1794 |
Trypanosoma cruzi | poly(ADP-ribose) polymerase, putative | 0.0095 | 0.1218 | 0.5 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0059 | 0.0499 | 0.0394 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.0235 | 0.0846 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0235 | 0.0128 |
Trypanosoma cruzi | poly(ADP-ribose) polymerase, putative | 0.0095 | 0.1218 | 0.5 |
Echinococcus multilocularis | poly (adp ribose) polymerase 2 | 0.0095 | 0.1218 | 0.1121 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0182 | 0.2955 | 0.5 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0066 | 0.0627 | 0.0524 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0153 | 0.2371 | 0.2187 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0174 | 0.278 | 1 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0066 | 0.0627 | 0.0524 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0066 | 0.0627 | 0.0401 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0182 | 0.2955 | 1 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0182 | 0.2955 | 0.5 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0066 | 0.0627 | 0.0401 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0235 | 0.0846 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.0318 | 0.1144 |
Entamoeba histolytica | poly(ADP-ribose) polymerase, putative | 0.0174 | 0.278 | 0.5 |
Echinococcus multilocularis | serotonin receptor | 0.0153 | 0.2371 | 0.2287 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.1952 | 0.8234 |
Schistosoma mansoni | P2X receptor subunit | 0.0066 | 0.0627 | 0.2256 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0059 | 0.0499 | 0.027 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0182 | 0.2955 | 0.5 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0059 | 0.0499 | 0.027 |
Echinococcus granulosus | poly (ADP ribose) polymerase | 0.0054 | 0.039 | 0.0159 |
Echinococcus multilocularis | poly (ADP ribose) polymerase 1 | 0.0174 | 0.278 | 0.2701 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0182 | 0.2955 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.0318 | 0.1341 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.2371 | 1 |
Trichomonas vaginalis | hypothetical protein | 0.0182 | 0.2955 | 0.5 |
Brugia malayi | WGR domain containing protein | 0.0095 | 0.1218 | 0.4381 |
Echinococcus granulosus | poly ADP ribose polymerase 1 | 0.0174 | 0.278 | 0.2606 |
Echinococcus granulosus | poly adp ribose polymerase 2 | 0.0095 | 0.1218 | 0.1006 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.0318 | 0.1144 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.1218 | 0.5137 |
Loa Loa (eye worm) | poly(ADP-ribose) polymerase | 0.0068 | 0.0679 | 0.2865 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0153 | 0.2371 | 0.8528 |
Brugia malayi | WGR domain containing protein | 0.0174 | 0.278 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0059 | 0.0499 | 0.2103 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.34 uM | Inhibition of the DNA repair Poly (ADP-ribose) polymerase 1, in permeabilised L1210 murine leukemia cells | ChEMBL. | 9857092 |
IC50 (binding) | = 1.34 uM | poly(ADP-ribose)polymerase(PARP) inhibition | ChEMBL. | 11689065 |
IC50 (binding) | = 1.34 uM | Inhibition of the DNA repair Poly (ADP-ribose) polymerase 1, in permeabilised L1210 murine leukemia cells | ChEMBL. | 9857092 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.