Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0059 | 0.2112 | 1 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.0174 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.0174 | 1 | 0.5 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.0174 | 1 | 0.5 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.0174 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0068 | 0.2747 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0068 | 0.2747 | 0.5 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0174 | 1 | 0.5 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.0174 | 1 | 0.5 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0068 | 0.2747 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0068 | 0.2747 | 0.2747 |
Brugia malayi | Cytochrome P450 family protein | 0.0059 | 0.2112 | 0.2112 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0068 | 0.2747 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0174 | 1 | 1 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0068 | 0.2747 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.0174 | 1 | 1 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0068 | 0.2747 | 0.5 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0174 | 1 | 1 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.0174 | 1 | 1 |
Leishmania major | dihydroorotate dehydrogenase | 0.0174 | 1 | 1 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0068 | 0.2747 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0068 | 0.2747 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0174 | 1 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0068 | 0.2747 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0068 | 0.2747 | 0.5 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0068 | 0.2747 | 0.5 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.0174 | 1 | 1 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.0174 | 1 | 0.5 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.0068 | 0.2747 | 0.2747 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 11 nM | Inhibition of Iks current in isolated guinea pig myocytes during a 1s voltage clamp step from -50 to +50 mV. | ChEMBL. | 9397166 |
Inhibition (functional) | = 25 % | Inhibition of Ikr current in isolated guinea pig myocytes during a 0.5 s voltage clamp step from -50 to -10 mV at 100 nM | ChEMBL. | 9397166 |
Inhibition (functional) | = 25 % | Inhibition of Ikr current in isolated guinea pig myocytes during a 0.5 s voltage clamp step from -50 to -10 mV at 100 nM | ChEMBL. | 9397166 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.