Detailed information for compound 2187538

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 585.337 | Formula: C34H44BN3O5
  • H donors: 3 H acceptors: 2 LogP: 6.72 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 2
  • SMILES: CC(C[C@@H](B1OC2[C@](O1)(C)[C@H]1C[C@@H](C2)C1(C)C)NC(=O)[C@H](Cc1c[nH]c2c1cccc2)NC(=O)OCc1ccccc1)C
  • InChi: InChI=1S/C34H44BN3O5/c1-21(2)15-30(35-42-29-18-24-17-28(33(24,3)4)34(29,5)43-35)38-31(39)27(16-23-19-36-26-14-10-9-13-25(23)26)37-32(40)41-20-22-11-7-6-8-12-22/h6-14,19,21,24,27-30,36H,15-18,20H2,1-5H3,(H,37,40)(H,38,39)/t24-,27-,28-,29?,30-,34-/m0/s1
  • InChiKey: NNSQITORDKKUSC-AVXGFUSMSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens proteasome (prosome, macropain) subunit, beta type, 5 References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania braziliensis proteasome beta 5 subunit, putative Get druggable targets OG5_127100 All targets in OG5_127100
Brugia malayi Proteasome A-type and B-type family protein Get druggable targets OG5_127100 All targets in OG5_127100
Leishmania donovani proteasome subunit beta type-5, putative Get druggable targets OG5_127100 All targets in OG5_127100
Plasmodium yoelii proteosome PSMB5/8 protein Get druggable targets OG5_127100 All targets in OG5_127100
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. Get druggable targets OG5_127100 All targets in OG5_127100
Schistosoma japonicum ko:K02737 20S proteasome subunit beta 5, putative Get druggable targets OG5_127100 All targets in OG5_127100
Leishmania major proteasome beta 5 subunit, putative Get druggable targets OG5_127100 All targets in OG5_127100
Theileria parva proteasome subunit beta type 5, putative Get druggable targets OG5_127100 All targets in OG5_127100
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative Get druggable targets OG5_127100 All targets in OG5_127100
Candida albicans proteasome subunit Get druggable targets OG5_127100 All targets in OG5_127100
Plasmodium vivax proteasome subunit beta type-5, putative Get druggable targets OG5_127100 All targets in OG5_127100
Trypanosoma congolense proteasome subunit beta type-5, putative Get druggable targets OG5_127100 All targets in OG5_127100
Neospora caninum Family T1, proteasome beta subunit, threonine peptidase, related Get druggable targets OG5_127100 All targets in OG5_127100
Echinococcus multilocularis proteasome (prosome, macropain) Get druggable targets OG5_127100 All targets in OG5_127100
Candida albicans proteasome subunit Get druggable targets OG5_127100 All targets in OG5_127100
Trypanosoma cruzi proteasome subunit beta type-5, putative Get druggable targets OG5_127100 All targets in OG5_127100
Mycobacterium ulcerans proteasome PrcB Get druggable targets OG5_127100 All targets in OG5_127100
Plasmodium berghei proteasome subunit beta type-5, putative Get druggable targets OG5_127100 All targets in OG5_127100
Babesia bovis proteasome epsilon subunit, putative Get druggable targets OG5_127100 All targets in OG5_127100
Trypanosoma cruzi proteasome subunit beta type-5, putative Get druggable targets OG5_127100 All targets in OG5_127100
Loa Loa (eye worm) proteasome A-type and B-type family protein Get druggable targets OG5_127100 All targets in OG5_127100
Echinococcus granulosus proteasome prosome macropain Get druggable targets OG5_127100 All targets in OG5_127100
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_127100 All targets in OG5_127100
Leishmania mexicana proteasome beta 5 subunit, putative Get druggable targets OG5_127100 All targets in OG5_127100
Trypanosoma brucei gambiense proteasome beta 5 subunit, putative Get druggable targets OG5_127100 All targets in OG5_127100
Mycobacterium leprae proteasome (beta subunit) PrcB Get druggable targets OG5_127100 All targets in OG5_127100
Cryptosporidium parvum Pre2p/proteasome subunit beta type 5; NTN hydrolase fold Get druggable targets OG5_127100 All targets in OG5_127100
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase Get druggable targets OG5_127100 All targets in OG5_127100
Plasmodium falciparum proteasome subunit beta type-5 Get druggable targets OG5_127100 All targets in OG5_127100
Trypanosoma brucei proteasome subunit beta type-5, putative Get druggable targets OG5_127100 All targets in OG5_127100
Leishmania infantum proteasome beta 5 subunit, putative Get druggable targets OG5_127100 All targets in OG5_127100
Plasmodium knowlesi proteasome subunit beta type-5, putative Get druggable targets OG5_127100 All targets in OG5_127100
Toxoplasma gondii proteasome subunit beta type, putative Get druggable targets OG5_127100 All targets in OG5_127100
Giardia lamblia Proteasome subunit beta type 5 precursor Get druggable targets OG5_127100 All targets in OG5_127100
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) Get druggable targets OG5_127100 All targets in OG5_127100
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum proteasome subunit alpha type-5, putative proteasome (prosome, macropain) subunit, beta type, 5 160 aa 148 aa 23.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0043 0.1262 0.1262
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0039 0.1028 0.0991
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0051 0.0153
Echinococcus multilocularis FTZ F1 alpha 0.0039 0.1028 0.309
Loa Loa (eye worm) hypothetical protein 0.0018 0.0041 0.0041
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0039 0.1028 0.0991
Loa Loa (eye worm) hypothetical protein 0.0018 0.0041 0.0041
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.002 0.0146 0.044
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0039 0.1028 0.1028
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0039 0.1028 0.1028
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0271 0.0271
Toxoplasma gondii FATC domain-containing protein 0.0025 0.0384 0.1017
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0051 0.0051
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0384 0.0345
Schistosoma mansoni retinoic acid receptor RXR 0.0039 0.1028 0.1028
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0039 0.1028 0.0991
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.0384 0.1017
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0086 0.3327 1
Brugia malayi nuclear hormone receptor 0.0039 0.1028 0.0991
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0025 0.0384 0.0384
Loa Loa (eye worm) hypothetical protein 0.0018 0.0041 0.0041
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.002 0.0146 0.0146
Schistosoma mansoni zinc finger protein 0.002 0.0124 0.0124
Loa Loa (eye worm) hypothetical protein 0.0018 0.0041 0.0041
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0039 0.1028 0.0991
Schistosoma mansoni bromodomain containing protein 0.0064 0.2279 0.2279
Loa Loa (eye worm) hypothetical protein 0.002 0.0146 0.0146
Schistosoma mansoni hypothetical protein 0.0021 0.0177 0.0177
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0039 0.1028 0.0991
Echinococcus multilocularis GA binding protein alpha chain 0.0074 0.273 0.8205
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0039 0.1028 0.1028
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0039 0.1028 0.0991
Brugia malayi photoreceptor-specific nuclear receptor 0.0039 0.1028 0.0991
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0931 0.2798
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0039 0.1028 0.0991
Schistosoma mansoni nuclear receptor 0.0018 0.0041 0.0041
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0086 0.3327 0.5
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0039 0.1028 0.309
Brugia malayi ecdysteroid receptor 0.0039 0.1028 0.0991
Loa Loa (eye worm) hypothetical protein 0.0042 0.1168 0.1168
Leishmania major proteasome beta 5 subunit, putative 0.0086 0.3327 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0039 0.1028 0.1028
Brugia malayi nuclear receptor RXR 0.002 0.0146 0.0106
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.002 0.0146 0.044
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0086 0.3327 0.5
Loa Loa (eye worm) hypothetical protein 0.0039 0.1028 0.1028
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0039 0.1028 0.309
Echinococcus granulosus zinc finger protein 0.002 0.0124 0.0374
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0039 0.1028 0.0991
Schistosoma mansoni gabp alpha 0.0074 0.273 0.273
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0051 0.0153
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0039 0.1028 0.309
Brugia malayi hypothetical protein 0.002 0.0146 0.0106
Schistosoma mansoni nuclear receptor nhr-48 0.0018 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.002 0.0146 0.0146
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0074 0.273 0.273
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.0051 0.0153
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0051 0.001
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0039 0.1028 0.309
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.003 0.003
Schistosoma mansoni thyroid hormone receptor 0.0039 0.1028 0.1028
Loa Loa (eye worm) hypothetical protein 0.0018 0.0041 0.0041
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0086 0.3327 1
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0271 0.0814
Loa Loa (eye worm) hypothetical protein 0.0039 0.1051 0.1051
Loa Loa (eye worm) hypothetical protein 0.002 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0039 0.1028 0.1028
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0039 0.1028 0.309
Echinococcus granulosus thyroid hormone receptor alpha 0.0018 0.0041 0.0122
Brugia malayi PHD-finger family protein 0.0025 0.0387 0.0348
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0018 0.0041 0.0122
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0039 0.1028 1
Echinococcus granulosus nuclear receptor nhr 48 0.0018 0.0041 0.0122
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0086 0.3327 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0039 0.1028 0.0991
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0146 0.0106
Schistosoma mansoni nuclear receptor 0.0018 0.0041 0.0041
Onchocerca volvulus Bile acid receptor homolog 0.0039 0.1028 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0039 0.1028 0.1028
Loa Loa (eye worm) hypothetical protein 0.0018 0.0041 0.0041
Brugia malayi Proteasome A-type and B-type family protein 0.0086 0.3327 0.33
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0146 0.0106
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0039 0.1028 0.309
Plasmodium vivax proteasome subunit beta type-5, putative 0.0086 0.3327 0.5
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0053 0.0005
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0022 0.0212 0.0493
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0051 0.001
Echinococcus granulosus Nuclear hormone receptor HR96 0.0018 0.0041 0.0122
Entamoeba histolytica hypothetical protein 0.0025 0.0384 0.1017
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0039 0.1028 0.309
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0177 0.0177
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.0051 0.0153
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0051 0.0051
Brugia malayi Bromodomain containing protein 0.0076 0.2857 0.2828
Loa Loa (eye worm) hypothetical protein 0.0039 0.1028 0.1028
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0039 0.1028 0.309
Onchocerca volvulus Protein ultraspiracle homolog 0.0039 0.1028 1
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0086 0.3327 1
Schistosoma mansoni RAR-like nuclear receptor 0.0039 0.1028 0.1028
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0018 0.0041 0.0122
Loa Loa (eye worm) DR-78 0.0018 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0072 0.2646 0.2646
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0086 0.3327 0.3327
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0018 0.0041 0.0122
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0271 0.0814
Brugia malayi Nuclear hormone receptor-like 1 0.0039 0.1028 0.0991
Echinococcus multilocularis nuclear receptor nhr 48 0.0018 0.0041 0.0122
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0018 0.0041 0.0041
Brugia malayi Ets-domain containing protein 0.0074 0.273 0.27
Brugia malayi nuclear receptor NHR-88 0.0039 0.1028 0.0991
Loa Loa (eye worm) hypothetical protein 0.0022 0.0212 0.0212
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0018 0.0041 0.0122
Brugia malayi hypothetical protein 0.002 0.0146 0.0106
Onchocerca volvulus 0.0039 0.1028 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0039 0.1028 0.309
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0018 0.0041 0.0041
Echinococcus granulosus proteasome prosome macropain 0.0086 0.3327 1
Echinococcus multilocularis serine protein kinase ATM 0.0025 0.0384 0.1154
Brugia malayi Ets-domain containing protein 0.0074 0.273 0.27
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0025 0.0384 0.1017
Loa Loa (eye worm) hypothetical protein 0.0063 0.2212 0.2212
Echinococcus granulosus ecdysone induced protein 78C 0.0039 0.1028 0.309
Brugia malayi steroid hormone receptor 0.0039 0.1028 0.0991
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.0051 0.0051
Schistosoma mansoni nuclear hormone receptor 0.0039 0.1028 0.1028
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0039 0.1028 0.309
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0086 0.3327 0.3327
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0041 0.0122
Loa Loa (eye worm) hypothetical protein 0.002 0.0146 0.0146
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0039 0.1028 0.0991
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0039 0.1028 0.0991
Loa Loa (eye worm) hypothetical protein 0.0039 0.1028 0.1028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0384 0.1017
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0039 0.1028 0.1028
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0039 0.1028 0.1028
Loa Loa (eye worm) fli-1 protein 0.0224 1 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0039 0.1028 0.309
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0039 0.1028 0.309
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0041 0.0122
Loa Loa (eye worm) hypothetical protein 0.0039 0.1028 0.1028
Loa Loa (eye worm) nuclear hormone receptor 0.0018 0.0041 0.0041
Mycobacterium ulcerans proteasome PrcB 0.0086 0.3327 0.5
Echinococcus multilocularis proteasome (prosome, macropain) 0.0086 0.3327 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.1028 0.1028
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0051 0.0051
Plasmodium falciparum proteasome subunit beta type-5 0.0086 0.3327 0.5
Schistosoma mansoni thyroid hormone receptor 0.0039 0.1028 0.1028
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0039 0.1028 0.309
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.002 0.0146 0.0146
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0039 0.1028 0.0991
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0018 0.0041 0.0122
Loa Loa (eye worm) steroid hormone receptor 0.0039 0.1028 0.1028
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0086 0.3327 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0018 0.0041 0.0041
Echinococcus granulosus serine protein kinase ATM 0.0025 0.0384 0.1154
Loa Loa (eye worm) hypothetical protein 0.0018 0.0041 0.0041
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0039 0.1028 0.1028
Loa Loa (eye worm) hypothetical protein 0.0018 0.0041 0.0041
Loa Loa (eye worm) nuclear receptor NHR-67 0.0018 0.0041 0.0041
Echinococcus granulosus Nuclear hormone receptor HR96 0.0018 0.0041 0.0122
Loa Loa (eye worm) hypothetical protein 0.0018 0.0041 0.0041
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0931 0.2798
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0039 0.1028 0.1028
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0053 0.0005
Loa Loa (eye worm) hypothetical protein 0.0018 0.0041 0.0041
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0039 0.1028 0.1028
Schistosoma mansoni ets-related 0.0224 1 1
Brugia malayi Bromodomain containing protein 0.0039 0.1048 0.1011
Schistosoma mansoni steroid hormone receptor ad4bp 0.0039 0.1028 0.1028
Loa Loa (eye worm) hypothetical protein 0.0039 0.1028 0.1028
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0039 0.1028 0.1028
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0039 0.1028 0.309
Loa Loa (eye worm) hypothetical protein 0.0018 0.0041 0.0041
Echinococcus multilocularis zinc finger protein 0.002 0.0124 0.0374
Loa Loa (eye worm) hypothetical protein 0.0039 0.1028 0.1028
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0018 0.0041 0.0041
Brugia malayi Steroid receptor seven-up type 2 0.0039 0.1028 0.0991
Schistosoma mansoni zinc finger protein 0.0018 0.0041 0.0041
Echinococcus granulosus GA binding protein alpha chain 0.0074 0.273 0.8205
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0039 0.1028 0.0991
Echinococcus multilocularis thyroid hormone receptor alpha 0.0039 0.1028 0.309
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.2103 0.6321
Toxoplasma gondii proteasome subunit beta type, putative 0.0086 0.3327 1
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0041 0.0041
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0146 0.0146
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0086 0.3327 1
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0041 0.0041
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.2103 0.6321
Echinococcus granulosus FTZ F1 alpha 0.0039 0.1028 0.309
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0039 0.1028 0.1028
Schistosoma mansoni coup transcription factor 0.0039 0.1028 0.1028
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0039 0.1028 0.1028
Loa Loa (eye worm) hypothetical protein 0.0018 0.0041 0.0041

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1.61 Inhibition of chymotrypsin like activity of human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate preincubated for 10 mins followed by substrate addition measured after 1 hr by spectrofluorimetric analysis ChEMBL. 27117691
IC50 (binding) = 41.2 nM Inhibition of chymotrypsin like activity of human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate preincubated for 10 mins followed by substrate addition measured after 1 hr by spectrofluorimetric analysis ChEMBL. 27117691

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.