Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | proteasome (prosome, macropain) subunit, beta type, 5 | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | proteasome subunit alpha type-5, putative | proteasome (prosome, macropain) subunit, beta type, 5 | 160 aa | 148 aa | 23.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.54 | 0.6376 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0033 | 0.2196 | 0.2593 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 1 | 1 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0086 | 0.8148 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.007 | 0.6388 | 0.6388 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0089 | 0.8468 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0089 | 0.8468 | 1 |
Echinococcus granulosus | proteasome prosome macropain | 0.0086 | 0.8148 | 0.9622 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0033 | 0.2196 | 0.2196 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0103 | 1 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0089 | 0.8468 | 0.8468 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.2196 | 0.2593 |
Brugia malayi | RNA binding protein | 0.0061 | 0.54 | 0.54 |
Loa Loa (eye worm) | RNA binding protein | 0.0061 | 0.54 | 0.54 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0033 | 0.2196 | 0.2196 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0089 | 0.8468 | 0.8468 |
Mycobacterium ulcerans | proteasome PrcB | 0.0086 | 0.8148 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0061 | 0.54 | 0.6376 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0086 | 0.8148 | 0.8148 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.54 | 0.6376 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0089 | 0.8468 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.54 | 0.6376 |
Loa Loa (eye worm) | TAR-binding protein | 0.0061 | 0.54 | 0.54 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0086 | 0.8148 | 0.9622 |
Schistosoma mansoni | hypothetical protein | 0.007 | 0.6388 | 0.7543 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0089 | 0.8468 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0033 | 0.2196 | 0.2593 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0033 | 0.2196 | 0.2593 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.2196 | 0.2593 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0086 | 0.8148 | 0.5 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0086 | 0.8148 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.54 | 0.6376 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0089 | 0.8468 | 1 |
Brugia malayi | Proteasome A-type and B-type family protein | 0.0086 | 0.8148 | 0.8148 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0086 | 0.8148 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0061 | 0.54 | 0.6376 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0086 | 0.8148 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.2196 | 0.2593 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0061 | 0.54 | 0.54 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0089 | 0.8468 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0033 | 0.2196 | 0.2593 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0086 | 0.8148 | 0.5 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0033 | 0.2196 | 0.2593 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.54 | 0.6376 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.2196 | 0.2593 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0086 | 0.8148 | 0.5 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0086 | 0.8148 | 0.5 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0086 | 0.8148 | 0.9622 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0086 | 0.8148 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.6388 | 0.6388 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0086 | 0.8148 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0103 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.2196 | 0.2196 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0086 | 0.8148 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0089 | 0.8468 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0033 | 0.2196 | 0.2593 |
Brugia malayi | TAR-binding protein | 0.0061 | 0.54 | 0.54 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0033 | 0.2196 | 0.2196 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0086 | 0.8148 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0061 | 0.54 | 0.54 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.44 | Inhibition of chymotrypsin like activity of human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate preincubated for 10 mins followed by substrate addition measured after 1 hr by spectrofluorimetric analysis | ChEMBL. | 27117691 |
IC50 (binding) | = 2.73 nM | Inhibition of chymotrypsin like activity of human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate preincubated for 10 mins followed by substrate addition measured after 1 hr by spectrofluorimetric analysis | ChEMBL. | 27117691 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.