Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | thymidylate synthase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0195 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0195 | 1 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0195 | 1 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0093 | 0.4241 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0537 | 0.0537 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0195 | 1 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.0195 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0195 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0093 | 0.4241 | 0.378 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.074 | 0.074 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0031 | 0.074 | 0.074 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0031 | 0.074 | 0.074 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0031 | 0.074 | 0.074 |
Loa Loa (eye worm) | thymidylate synthase | 0.0195 | 1 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0195 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.074 | 0.074 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0195 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0195 | 1 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0195 | 1 | 1 |
Onchocerca volvulus | 0.0195 | 1 | 1 | |
Echinococcus granulosus | thymidylate synthase | 0.0195 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0093 | 0.4241 | 0.378 |
Mycobacterium ulcerans | thymidylate synthase | 0.0195 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4.4 nM | Inhibition of isolated thymidylate synthase partially purified from L1210 mouse leukemia cells | ChEMBL. | 10508430 |
IC50 (binding) | = 4.4 nM | Inhibition of isolated thymidylate synthase partially purified from L1210 mouse leukemia cells | ChEMBL. | 10508430 |
IC50 (functional) | = 0.19 uM | Growth inhibition of murine tumor L1210 cell line | ChEMBL. | 10508430 |
IC50 (functional) | = 0.19 uM | Growth inhibition of murine tumor L1210 cell line | ChEMBL. | 10508430 |
IC50 (functional) | = 0.32 uM | Tested for inhibition of cell growth in culture against murine tumor L1210:RD1694 cell lines | ChEMBL. | 10508430 |
IC50 (functional) | = 0.32 uM | Tested for inhibition of cell growth in culture against murine tumor L1210:RD1694 cell lines | ChEMBL. | 10508430 |
IC50 (functional) | = 4.4 uM | Inhibition of cell growth in culture against murine tumor L1210:1565 cell lines | ChEMBL. | 10508430 |
Relative resistance (functional) | = 1.7 | Relative resistance ratio of the compound evaluated for murine tumor L1210:RD1694 cells with 10% horse serum as supplement | ChEMBL. | 10508430 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 10508430 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.