Detailed information for compound 2189901

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 2025.89 | Formula: C79H131N31O24S4
  • H donors: 29 H acceptors: 25 LogP: -13.42 Rotable bonds: 40
    Rule of 5 violations (Lipinski): 3
  • SMILES: NCCCC[C@@H]1NC(=O)[C@H]2CSSC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](CSSC[C@H](C(=O)N[C@H](C(=O)N2)CC(=O)N)N)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]2N(C(=O)[C@@H](NC1=O)C)CCC2)CCC(=O)O)[C@H](O)C)C)CC(C)C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N)Cc1cnc[nH]1)CCC(=O)N)CCC(=O)N
  • InChi: InChI=1S/C79H131N31O24S4/c1-35(2)26-49-70(127)107-51-31-136-135-30-41(81)63(120)105-50(28-57(84)114)71(128)108-53(73(130)99-42(12-7-8-22-80)64(121)96-38(5)77(134)110-25-11-15-54(110)75(132)102-47(18-21-58(115)116)69(126)109-59(39(6)111)76(133)95-37(4)62(119)104-49)33-138-137-32-52(106-66(123)44(14-10-24-92-79(88)89)98-65(122)43(13-9-23-91-78(86)87)97-61(118)36(3)94-72(51)129)74(131)101-45(16-19-55(82)112)67(124)100-46(17-20-56(83)113)68(125)103-48(60(85)117)27-40-29-90-34-93-40/h29,34-39,41-54,59,111H,7-28,30-33,80-81H2,1-6H3,(H2,82,112)(H2,83,113)(H2,84,114)(H2,85,117)(H,90,93)(H,94,129)(H,95,133)(H,96,121)(H,97,118)(H,98,122)(H,99,130)(H,100,124)(H,101,131)(H,102,132)(H,103,125)(H,104,119)(H,105,120)(H,106,123)(H,107,127)(H,108,128)(H,109,126)(H,115,116)(H4,86,87,91)(H4,88,89,92)/t36-,37-,38-,39+,41+,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54-,59-/m0/s1
  • InChiKey: YVIIHEKJCKCXOB-DUXFPFHYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0065 0.0234 0.0552
Echinococcus multilocularis lysine specific demethylase 6a 0.0009 0.0001 0.0001
Trichomonas vaginalis CMGC family protein kinase 0.0045 0.0151 0.1965
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0035 0.0111 0.1328
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0015 0.0027 0.1103
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.0155 0.2036
Onchocerca volvulus 0.0037 0.0118 0.2033
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0083 0.0306 0.1653
Plasmodium falciparum glutathione reductase 0.0043 0.0144 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0118 0.0279
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0057 0.0201 0.8597
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 21 0.0037 0.0118 0.0632
Schistosoma mansoni intermediate filament proteins 0.0075 0.0273 0.0644
Echinococcus granulosus histone acetyltransferase KAT2B 0.0153 0.0595 0.141
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0045 0.0151 0.644
Echinococcus granulosus lamin 0.0075 0.0273 0.0647
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0072 0.0261 0.0618
Schistosoma mansoni hypothetical protein 0.0072 0.0261 0.0616
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0299 0.1201 0.2848
Loa Loa (eye worm) hypothetical protein 0.0456 0.1849 0.4384
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0015 0.0027 0.1103
Echinococcus granulosus potassium channel subfamily K 8 0.0037 0.0118 0.0279
Brugia malayi latrophilin 2 splice variant baaae 0.0155 0.0604 0.3263
Toxoplasma gondii ABC1 family protein 0.0065 0.0234 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0033 0.01 0.4242
Echinococcus multilocularis beta LACTamase domain containing family member 0.0065 0.0234 0.0234
Schistosoma mansoni hypothetical protein 0.0155 0.0604 0.143
Schistosoma mansoni twik family of potassium channels-related 0.0037 0.0118 0.0277
Giardia lamblia Histone acetyltransferase GCN5 0.0042 0.0139 0.9078
Echinococcus granulosus Two pore potassium channel protein sup 9 0.0037 0.0118 0.0279
Schistosoma mansoni survival motor neuron protein 0.0045 0.0152 0.0359
Echinococcus granulosus smad 0.0009 0.0001 0.0002
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 19. C. elegans unc-58 ortholog 0.0037 0.0118 0.0632
Plasmodium vivax hypothetical protein, conserved 0.0065 0.0234 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0108 0.0256
Mycobacterium tuberculosis Probable oxidoreductase 0.011 0.042 0.2374
Onchocerca volvulus 0.0075 0.0273 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0015 0.0027 0.1792
Echinococcus granulosus importin subunit beta 1 0.0028 0.0081 0.0191
Schistosoma mansoni hypothetical protein 0.0045 0.0152 0.0359
Echinococcus granulosus peregrin 0.0031 0.0094 0.0223
Echinococcus granulosus small conductance calcium activated potassium 0.103 0.4217 1
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 30. 0.0037 0.0118 0.0632
Mycobacterium tuberculosis Probable lipase LipE 0.0065 0.0234 0.1248
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0033 0.01 0.1156
Loa Loa (eye worm) hypothetical protein 0.0037 0.0118 0.0279
Echinococcus multilocularis ubiquitin specific protease 41 0.0033 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0226 0.09 0.2133
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0011 0.0009 0.0518
Loa Loa (eye worm) hypothetical protein 0.0037 0.0118 0.0279
Loa Loa (eye worm) hypothetical protein 0.0037 0.0118 0.0279
Loa Loa (eye worm) hypothetical protein 0.0065 0.0234 0.0554
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0001 0.0002
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0045 0.0152 0.0819
Echinococcus multilocularis TWiK family of potassium channels protein 7 0.0037 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0037 0.0118 0.0279
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.004 0.013 0.0308
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0015 0.0027 0.0064
Mycobacterium ulcerans hypothetical protein 0.0065 0.0234 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0003
Echinococcus multilocularis survival motor neuron protein 1 0.0223 0.0885 0.0885
Brugia malayi Twik (KCNK-like) family of potasium channels, alpha subunit 40 0.0037 0.0118 0.0632
Echinococcus multilocularis twik family of potassium channels 0.0037 0.0118 0.0118
Echinococcus multilocularis muscleblind protein 0.0456 0.1849 0.1849
Echinococcus multilocularis jumonji domain containing protein 0.0038 0.0123 0.0123
Leishmania major trypanothione reductase 0.0043 0.0144 0.6155
Mycobacterium ulcerans transmembrane cation transporter 0.0037 0.0118 0.4392
Brugia malayi jmjC domain containing protein 0.0009 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0037 0.0118 0.0279
Brugia malayi AF-10 protein 0.0009 0.0002 0.0005
Brugia malayi jmjC domain containing protein 0.0009 0.0001 0.0002
Brugia malayi Inositol-1 0.0035 0.0111 0.0594
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 24 0.0037 0.0118 0.0632
Onchocerca volvulus 0.0037 0.0118 0.2033
Loa Loa (eye worm) hypothetical protein 0.0037 0.0118 0.0279
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0033 0.01 0.0535
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0033 0.01 0.4242
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0033 0.01 0.0237
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0011 0.001 0.0051
Brugia malayi cytoplasmic intermediate filament protein 0.004 0.013 0.0697
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0009 0.0319
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0027 0.0078 0.0183
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0173 0.0677 0.3659
Loa Loa (eye worm) transcription factor SMAD2 0.0129 0.0496 0.1176
Leishmania major ion transport protein-like protein 0.0037 0.0118 0.5011
Loa Loa (eye worm) hypothetical protein 0.0072 0.0261 0.0618
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0072 0.0261 0.0261
Loa Loa (eye worm) hypothetical protein 0.0065 0.0234 0.0554
Mycobacterium tuberculosis Conserved protein 0.0065 0.0234 0.1248
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0009 0.0002 0.002
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0083 0.0306 0.0724
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0033 0.01 0.0235
Echinococcus granulosus ubiquitin specific protease 41 0.0033 0.01 0.0237
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0035 0.0111 0.471
Loa Loa (eye worm) hypothetical protein 0.0075 0.0273 0.0647
Echinococcus multilocularis PHD finger protein rhinoceros 0.0027 0.0078 0.0078
Trypanosoma cruzi trypanothione reductase, putative 0.0015 0.0027 0.1103
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0035 0.0111 0.471
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0099 0.0374 0.2098
Echinococcus multilocularis small conductance calcium activated potassium 0.103 0.4217 0.4217
Echinococcus multilocularis potassium channel subfamily K 8 0.0037 0.0118 0.0118
Mycobacterium tuberculosis Possible transmembrane cation transporter 0.0037 0.0118 0.0548
Giardia lamblia PHD finger protein 15 0.0027 0.0078 0.4131
Trypanosoma cruzi calcium-activated potassium channel, putative 0.0037 0.0118 0.5011
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0001 0.0001
Trichomonas vaginalis CMGC family protein kinase 0.0045 0.0151 0.1965
Loa Loa (eye worm) hypothetical protein 0.0035 0.0108 0.0256
Loa Loa (eye worm) hypothetical protein 0.0037 0.0118 0.0279
Echinococcus granulosus twik family of potassium channels 0.0037 0.0118 0.0279
Loa Loa (eye worm) hypothetical protein 0.0381 0.1537 0.3645
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0081 0.3411
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0027 0.1103
Loa Loa (eye worm) hypothetical protein 0.0342 0.1376 0.3263
Echinococcus multilocularis smad 0.0009 0.0001 0.0001
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.011 0.042 0.2374
Loa Loa (eye worm) hypothetical protein 0.0037 0.0118 0.0279
Echinococcus granulosus snurportin 1 0.0299 0.1201 0.2848
Loa Loa (eye worm) hypothetical protein 0.0065 0.0234 0.0554
Echinococcus multilocularis twik family of potassium channels 0.0037 0.0118 0.0118
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0027 0.1103
Trypanosoma cruzi ion transport protein, putative 0.0037 0.0118 0.5011
Schistosoma mansoni twik family of potassium channels-related 0.0037 0.0118 0.0277
Echinococcus granulosus potassium channel subfamily K 8 0.0037 0.0118 0.0279
Echinococcus multilocularis inositol monophosphatase 1 0.0035 0.0111 0.0111
Mycobacterium tuberculosis Probable esterase LipL 0.0065 0.0234 0.1248
Mycobacterium leprae conserved hypothetical protein 0.0065 0.0234 0.4256
Echinococcus multilocularis snurportin 1 0.0299 0.1201 0.1201
Echinococcus granulosus thioredoxin glutathione reductase 0.0043 0.0144 0.0342
Echinococcus multilocularis JmjC domain containing protein 4 0.0009 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0009 0.0002 0.0002
Echinococcus multilocularis phd:f box containing protein 0.0009 0.0001 0.0001
Mycobacterium ulcerans aldehyde dehydrogenase 0.0057 0.0201 0.8423
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0028 0.0081 0.0191
Loa Loa (eye worm) hypothetical protein 0.0037 0.0118 0.0279
Loa Loa (eye worm) S-phase kinase-associated protein 1A 0.0037 0.0118 0.0279
Brugia malayi intermediate filament protein 0.0075 0.0273 0.1471
Echinococcus granulosus survival motor neuron protein 1 0.0223 0.0885 0.2097
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0015 0.0027 0.1103
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0059 0.2468
Mycobacterium tuberculosis Probable dehydrogenase 0.0099 0.0374 0.2098
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0035 0.0111 0.4055
Loa Loa (eye worm) hypothetical protein 0.0037 0.0118 0.0279
Loa Loa (eye worm) hypothetical protein 0.0223 0.0885 0.2097
Echinococcus multilocularis lysine specific demethylase 5A 0.0033 0.0102 0.0102
Mycobacterium ulcerans aldehyde dehydrogenase 0.0057 0.0201 0.8423
Trypanosoma brucei trypanothione reductase 0.0043 0.0144 0.6155
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0015 0.0027 0.1103
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0081 0.3411
Schistosoma mansoni hypothetical protein 0.0072 0.0261 0.0616
Loa Loa (eye worm) hypothetical protein 0.0037 0.0118 0.0279
Mycobacterium ulcerans esterase/lipase LipP 0.0065 0.0234 1
Plasmodium falciparum potassium channel 0.0037 0.0118 0.8141
Brugia malayi glutathione reductase 0.0043 0.0144 0.0776
Brugia malayi PHD-finger family protein 0.0011 0.0008 0.004
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.005 0.2094
Schistosoma mansoni hypothetical protein 0.103 0.4217 1
Loa Loa (eye worm) uncoordinated protein 58 0.0037 0.0118 0.0279
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0015 0.0027 0.1103
Schistosoma mansoni calcium-activated potassium channel 0.0723 0.2949 0.6991
Trypanosoma brucei hypothetical protein, conserved 0.0065 0.0234 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0078 0.0185
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.009 0.0336 0.0797
Trichomonas vaginalis inositol monophosphatase, putative 0.0035 0.0111 0.1328
Plasmodium vivax potassium channel, putative 0.0037 0.0118 0.5011
Loa Loa (eye worm) hypothetical protein 0.0065 0.0234 0.0554
Loa Loa (eye worm) PHD-finger family protein 0.0027 0.0078 0.0185
Brugia malayi acetyltransferase, GNAT family protein 0.0157 0.0613 0.3311
Entamoeba histolytica hypothetical protein 0.0023 0.0059 0.0969
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0001 0.0002
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0226 0.09 0.2133
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0045 0.0151 0.644
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0083 0.0306 0.0724
Schistosoma mansoni ran 0.0021 0.005 0.0116
Loa Loa (eye worm) hypothetical protein 0.027 0.108 0.2562
Loa Loa (eye worm) hypothetical protein 0.0065 0.0234 0.0554
Loa Loa (eye worm) hypothetical protein 0.0037 0.0118 0.0279
Trypanosoma cruzi ion transport protein, putative 0.0037 0.0118 0.5011
Schistosoma mansoni jumonji domain containing protein 0.0071 0.026 0.0614
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0033 0.01 0.01
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0009 0.0002 0.002
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0109 0.0255
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0083 0.0306 0.0724
Leishmania major GTP-binding protein, putative 0.0021 0.005 0.2094
Schistosoma mansoni phosphatidylserine receptor 0.0009 0.0001 0.0001
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 17 0.0037 0.0118 0.0632
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0118 0.5011
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0109 0.0255
Schistosoma mansoni calcium-activated potassium channel 0.103 0.4217 1
Schistosoma mansoni lamin 0.0075 0.0273 0.0644
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.005 0.2094
Loa Loa (eye worm) TWK-28 protein 0.0037 0.0118 0.0279
Echinococcus granulosus lysine specific demethylase 6a 0.0009 0.0001 0.0003
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0027 0.1103
Schistosoma mansoni cpg binding protein 0.0029 0.0085 0.0199
Loa Loa (eye worm) hypothetical protein 0.0037 0.0118 0.0279
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.0109 0.0257
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.005 0.1857
Schistosoma mansoni protein phosphatase 2C 0.0009 0.0001 0.0001
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0065 0.0234 0.0554
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0416 0.1682 1
Echinococcus multilocularis jumonji domain containing 1A 0.0009 0.0001 0.0001
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0083 0.0306 0.0306
Mycobacterium tuberculosis Conserved protein 0.0065 0.0234 0.1248
Brugia malayi jmjC domain containing protein 0.009 0.0336 0.1814
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.0155 0.6632
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.005 0.2094
Echinococcus granulosus inositol monophosphatase 1 0.0035 0.0111 0.0263
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0079 0.0186
Brugia malayi jmjC domain containing protein 0.0009 0.0001 0.0002
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.0155 0.6632
Brugia malayi jmjC domain containing protein 0.0009 0.0001 0.0002
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0033 0.01 0.4242
Mycobacterium ulcerans aldehyde dehydrogenase 0.0057 0.0201 0.8423
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 32 0.0037 0.0118 0.0632
Schistosoma mansoni jumonji domain containing protein 0.0009 0.0001 0.0001
Loa Loa (eye worm) intermediate filament protein 0.0075 0.0273 0.0647
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 13 0.0037 0.0118 0.0632
Brugia malayi Calcitonin receptor-like protein seb-1 0.0226 0.09 0.4863
Echinococcus multilocularis lamin 0.0075 0.0273 0.0273
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0037 0.0118 0.1439
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0037 0.0118 0.5011
Echinococcus multilocularis muscleblind protein 1 0.0456 0.1849 0.1849
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0109 0.0257
Onchocerca volvulus 0.0075 0.0273 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0118 0.0279
Loa Loa (eye worm) beta-lactamase 0.0065 0.0234 0.0554
Schistosoma mansoni twik family of potassium channels-related 0.0037 0.0118 0.0277
Loa Loa (eye worm) hypothetical protein 0.0073 0.0267 0.0633
Brugia malayi beta-lactamase family protein 0.0065 0.0234 0.1259
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0045 0.0151 0.644
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.005 0.3402
Schistosoma mansoni lamin 0.0075 0.0273 0.0644
Loa Loa (eye worm) MH2 domain-containing protein 0.0129 0.0496 0.1176
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0065 0.0234 0.0552
Leishmania major hypothetical protein, conserved 0.0037 0.0118 0.5011
Schistosoma mansoni cellular tumor antigen P53 0.0043 0.0142 0.0334
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0035 0.0111 0.1328
Onchocerca volvulus 0.0037 0.0118 0.2033
Loa Loa (eye worm) large conductance calcium-activated potassium channel alpha subunit ai 0.0037 0.0118 0.0279
Loa Loa (eye worm) jmjC domain-containing protein 0.0057 0.0199 0.0472
Trypanosoma brucei protein kinase, putative 0.0045 0.0151 0.644
Echinococcus granulosus mitogen activated protein kinase 0.0045 0.0151 0.0358
Echinococcus granulosus TWiK family of potassium channels protein 7 0.0037 0.0118 0.0279
Echinococcus granulosus intermediate filament protein 0.0075 0.0273 0.0647
Schistosoma mansoni serine/threonine protein kinase 0.0045 0.0151 0.0356
Echinococcus multilocularis potassium channel subfamily K 0.0037 0.0118 0.0118
Trichomonas vaginalis D-aminoacylase, putative 0.0065 0.0234 0.3276
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0118 0.5011
Mycobacterium leprae Probable lipase LipE 0.0065 0.0234 0.4256
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 38. C. elegans sup-9 ortholog 0.0037 0.0118 0.0632
Mycobacterium ulcerans beta-lactamase 0.0065 0.0234 1
Brugia malayi CXXC zinc finger family protein 0.0028 0.0079 0.042
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0015 0.0027 0.0141
Onchocerca volvulus 0.0037 0.0118 0.2033
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0027 0.1103
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0011 0.001 0.0051
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0045 0.0151 0.644
Echinococcus granulosus Smad4 0.0009 0.0001 0.0002
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0045 0.0151 0.0358
Echinococcus multilocularis tumor protein p63 0.0293 0.1173 0.1173
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0015 0.0027 0.0027
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0035 0.0111 0.471
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.005 0.2094
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0045 0.0151 0.644
Loa Loa (eye worm) hypothetical protein 0.0037 0.0118 0.0279
Leishmania major potassium channel subunit-like protein 0.0037 0.0118 0.5011
Loa Loa (eye worm) thioredoxin reductase 0.0043 0.0144 0.0342
Entamoeba histolytica calcium-gated potassium channel protein, putative 0.0037 0.0118 0.7568
Brugia malayi Latrophilin receptor protein 2 0.0072 0.0261 0.1405
Loa Loa (eye worm) hypothetical protein 0.0037 0.0118 0.0279
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0075 0.0273 0.0647
Onchocerca volvulus 0.0065 0.0234 0.7987
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0015 0.0027 0.1792
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0095 0.0414
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.01 0.1156
Echinococcus multilocularis mitogen activated protein kinase 0.0045 0.0151 0.0151
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0072 0.0261 0.0261
Toxoplasma gondii thioredoxin reductase 0.0043 0.0144 0.6155
Loa Loa (eye worm) Smad1 0.0009 0.0001 0.0002
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.005 0.0119
Brugia malayi Importin beta-1 subunit 0.0028 0.0081 0.0431
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0015 0.0027 0.1103
Echinococcus granulosus JmjC domain containing protein 4 0.0009 0.0001 0.0003
Echinococcus granulosus tumor protein p63 0.0293 0.1173 0.2782
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0035 0.0111 1
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0033 0.01 0.4242
Leishmania major calcium/potassium channel (CAKC), putative 0.0037 0.0118 0.5011
Giardia lamblia Kinase, CMGC MAPK 0.0045 0.0151 1
Echinococcus granulosus mitogen activated protein kinase 3 0.0045 0.0151 0.0358
Entamoeba histolytica acetyltransferase, GNAT family 0.0042 0.0139 1
Plasmodium vivax importin-beta 2, putative 0.0028 0.0081 0.3411
Mycobacterium tuberculosis Probable hydrolase 0.0065 0.0234 0.1248
Trypanosoma cruzi hypothetical protein, conserved 0.0065 0.0234 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0045 0.0151 0.644
Echinococcus multilocularis peregrin 0.0031 0.0094 0.0094
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.011 0.042 1
Echinococcus granulosus jumonji domain containing protein 0.0038 0.0123 0.0291
Toxoplasma gondii aldehyde dehydrogenase 0.0057 0.0201 0.8597
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0043 0.0144 0.0709
Giardia lamblia Hypothetical protein 0.0037 0.0118 0.7322
Loa Loa (eye worm) TWK-7 protein 0.0037 0.0118 0.0279
Leishmania major hypothetical protein, conserved 0.0065 0.0234 1
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.001 0.0008 0.0008
Trichomonas vaginalis D-aminoacylase, putative 0.0065 0.0234 0.3276
Onchocerca volvulus 0.0065 0.0234 0.7987
Loa Loa (eye worm) hypothetical protein 0.0037 0.0118 0.0279
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0009 0.0002 0.002
Trichomonas vaginalis penicillin-binding protein, putative 0.0065 0.0234 0.3276
Loa Loa (eye worm) hypothetical protein 0.0037 0.0118 0.0279
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 35 0.0037 0.0118 0.0632
Plasmodium vivax thioredoxin reductase, putative 0.0043 0.0144 0.6155
Loa Loa (eye worm) hypothetical protein 0.0011 0.0008 0.002
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0036 0.0113 0.0113
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0003
Loa Loa (eye worm) jmjC domain-containing protein 0.0009 0.0001 0.0003
Brugia malayi hypothetical protein 0.0037 0.0118 0.0632
Trichomonas vaginalis D-aminoacylase, putative 0.0065 0.0234 0.3276
Schistosoma mansoni ran 0.0021 0.005 0.0116
Echinococcus multilocularis potassium channel subfamily K 8 0.0037 0.0118 0.0118
Brugia malayi MH2 domain containing protein 0.0129 0.0496 0.2679
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0072 0.0261 0.1405
Schistosoma mansoni twik family of potassium channels-related 0.0037 0.0118 0.0277
Loa Loa (eye worm) hypothetical protein 0.0037 0.0118 0.0279
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0035 0.0111 0.471
Echinococcus granulosus potassium channel subfamily K 0.0037 0.0118 0.0279
Schistosoma mansoni importin beta-1 0.0028 0.0081 0.0189
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0072 0.0261 0.0618
Plasmodium vivax hypothetical protein, conserved 0.0027 0.0078 0.3308
Schistosoma mansoni hypothetical protein 0.0072 0.0261 0.0616
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0015 0.0027 0.0062
Toxoplasma gondii PHD-finger domain-containing protein 0.0009 0.0002 0.002
Toxoplasma gondii NADPH-glutathione reductase 0.0015 0.0027 0.1103
Loa Loa (eye worm) hypothetical protein 0.0037 0.0118 0.0279
Plasmodium vivax glutathione reductase, putative 0.0043 0.0144 0.6155
Loa Loa (eye worm) hypothetical protein 0.103 0.4217 1
Trichomonas vaginalis conserved hypothetical protein 0.0168 0.0658 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0083 0.0306 0.0726
Loa Loa (eye worm) hypothetical protein 0.0037 0.0118 0.0279
Loa Loa (eye worm) acetyltransferase 0.0157 0.0613 0.1453
Loa Loa (eye worm) hypothetical protein 0.0037 0.0118 0.0279
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0099 0.0374 0.8592
Loa Loa (eye worm) potassium voltage-gated channel subfamily Q member 5 0.0037 0.0118 0.0279
Brugia malayi hypothetical protein 0.0037 0.0118 0.0632
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0083 0.0306 0.0306
Brugia malayi Muscleblind-like protein 0.0456 0.1849 1
Trypanosoma brucei calcium-activated potassium channel, putative 0.0037 0.0118 0.5011
Echinococcus granulosus PHD finger protein rhinoceros 0.0027 0.0078 0.0185
Echinococcus multilocularis Smad4 0.0009 0.0001 0.0001
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0058 0.0206 0.0486
Loa Loa (eye worm) jmjC domain-containing protein 0.0009 0.0001 0.0003
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0027 0.1103
Treponema pallidum NADH oxidase 0.0015 0.0027 0.5
Plasmodium falciparum glutathione reductase 0.0015 0.0027 0.1792
Onchocerca volvulus 0.0028 0.0079 0.0018
Plasmodium falciparum potassium channel 0.0037 0.0118 0.8141
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0015 0.0027 0.1103
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0033 0.01 0.5572
Loa Loa (eye worm) latrophilin receptor protein 2 0.0072 0.0261 0.0618
Loa Loa (eye worm) glutathione reductase 0.0043 0.0144 0.0342
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0045 0.0151 0.644
Trypanosoma cruzi trypanothione reductase, putative 0.0043 0.0144 0.6155
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 28 0.0037 0.0118 0.0632
Echinococcus granulosus phd:f box containing protein 0.0009 0.0001 0.0003
Brugia malayi Intermediate filament tail domain containing protein 0.0075 0.0273 0.1471
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0037 0.0118 0.1439
Echinococcus multilocularis mitogen activated protein kinase 3 0.0045 0.0151 0.0151
Echinococcus granulosus muscleblind protein 0.0456 0.1849 0.4384
Loa Loa (eye worm) hypothetical protein 0.0036 0.0113 0.0269
Plasmodium vivax potassium channel, putative 0.0037 0.0118 0.5011
Schistosoma mansoni hypothetical protein 0.0072 0.0261 0.0616
Onchocerca volvulus 0.0037 0.0118 0.2033
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0081 0.3411
Schistosoma mansoni hypothetical protein 0.0037 0.0118 0.0277
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.001 0.0008 0.0019
Trypanosoma cruzi hypothetical protein, conserved 0.0065 0.0234 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0065 0.0234 0.3276
Loa Loa (eye worm) hypothetical protein 0.0065 0.0234 0.0554
Schistosoma mansoni inositol monophosphatase 0.0035 0.0111 0.026
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0099 0.0374 0.2098
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.009 0.0336 0.0336
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0045 0.0151 0.644
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.0155 0.6632
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0083 0.0306 0.0726
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0009 0.0001 0.0001
Mycobacterium tuberculosis Conserved protein 0.0065 0.0234 0.1248
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0059 0.0503
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0001 0.0002
Schistosoma mansoni aldehyde dehydrogenase 0.0057 0.0201 0.0474
Echinococcus granulosus jumonji domain containing 1A 0.0009 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0037 0.0118 0.0279
Echinococcus multilocularis lamin dm0 0.0075 0.0273 0.0273
Brugia malayi beta-lactamase 0.0065 0.0234 0.1259
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.005 0.0265
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0083 0.0306 0.0726
Brugia malayi F/Y-rich N-terminus family protein 0.0017 0.0037 0.0193
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0226 0.09 0.4863
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0037 0.0118 0.1439
Loa Loa (eye worm) hypothetical protein 0.0037 0.0118 0.0279
Plasmodium falciparum thioredoxin reductase 0.0015 0.0027 0.1792
Echinococcus multilocularis cpg binding protein 0.0029 0.0085 0.0085
Schistosoma mansoni aldehyde dehydrogenase 0.0057 0.0201 0.0474
Loa Loa (eye worm) hypothetical protein 0.0037 0.0118 0.0279
Mycobacterium tuberculosis Probable reductase 0.0099 0.0374 0.2098
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0015 0.0027 0.1103
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 7 0.0037 0.0118 0.0632
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.011 0.042 0.2374
Onchocerca volvulus 0.0065 0.0234 0.7987
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.005 0.0119
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0065 0.0234 0.1248
Echinococcus multilocularis Two pore potassium channel protein sup 9 0.0037 0.0118 0.0118
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0035 0.0111 0.6789
Brugia malayi RNA, U transporter 1 0.008 0.0294 0.1586
Plasmodium falciparum histone acetyltransferase GCN5 0.0042 0.0139 0.9664
Onchocerca volvulus 0.0037 0.0118 0.2033
Schistosoma mansoni phd/f-box containing protein 0.0009 0.0001 0.0001
Leishmania major importin beta-1 subunit, putative 0.0023 0.0059 0.2468
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0033 0.01 0.01
Schistosoma mansoni calcium-activated potassium channel 0.0037 0.0118 0.0277
Loa Loa (eye worm) inositol-1 0.0035 0.0111 0.0263
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0037 0.0118 0.1439
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.005 0.005
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39A 0.0037 0.0118 0.0632
Brugia malayi jmjC domain containing protein 0.0035 0.0109 0.0582
Mycobacterium tuberculosis Probable lipase LipD 0.0065 0.0234 0.1248
Loa Loa (eye worm) hypothetical protein 0.0456 0.1849 0.4384
Plasmodium falciparum importin beta, putative 0.0028 0.0081 0.5542
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0057 0.0201 0.0201
Loa Loa (eye worm) hypothetical protein 0.0037 0.0118 0.0279
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.003 0.0069
Echinococcus multilocularis thioredoxin glutathione reductase 0.0043 0.0144 0.0144
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0015 0.0027 0.1103
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0065 0.0234 0.1248
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0001 0.0001
Plasmodium falciparum thioredoxin reductase 0.0043 0.0144 1
Trichomonas vaginalis esterase, putative 0.0065 0.0234 0.3276
Schistosoma mansoni hypothetical protein 0.0299 0.1201 0.2846
Onchocerca volvulus 0.0037 0.0118 0.2033
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 5 0.0037 0.0118 0.0632
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0036 0.0113 0.0269
Loa Loa (eye worm) hypothetical protein 0.0155 0.0604 0.1432
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39B 0.0037 0.0118 0.0632
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0033 0.01 0.5881
Onchocerca volvulus 0.0045 0.0152 0.3815
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0057 0.0201 0.0477
Toxoplasma gondii ion channel protein 0.0037 0.0118 0.5011
Loa Loa (eye worm) hypothetical protein 0.0037 0.0118 0.0279
Echinococcus granulosus calcium activated potassium channel variant 0.0037 0.0118 0.0279
Toxoplasma gondii ion channel protein 0.0037 0.0118 0.5011
Trichomonas vaginalis CMGC family protein kinase 0.0045 0.0151 0.1965
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0065 0.0234 0.1259
Loa Loa (eye worm) hypothetical protein 0.0037 0.0118 0.0279
Schistosoma mansoni cpg binding protein 0.0028 0.0079 0.0184
Brugia malayi MAP kinase sur-1 0.0045 0.0151 0.0811
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0015 0.0027 0.1103
Loa Loa (eye worm) hypothetical protein 0.0047 0.0159 0.0378
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.0155 0.2036
Brugia malayi PHD-finger family protein 0.0027 0.0078 0.0418
Loa Loa (eye worm) hypothetical protein 0.0173 0.0677 0.1605
Schistosoma mansoni twik family of potassium channels-related 0.0037 0.0118 0.0277
Loa Loa (eye worm) hypothetical protein 0.0037 0.0118 0.0279
Trypanosoma brucei calcium/potassium channel (CAKC), putative 0.0037 0.0118 0.5011
Onchocerca volvulus 0.0043 0.0142 0.3265
Toxoplasma gondii PHD-finger domain-containing protein 0.0027 0.0078 0.3308
Echinococcus multilocularis GPCR, family 2 0.0072 0.0261 0.0261
Toxoplasma gondii PHD-finger domain-containing protein 0.0027 0.0078 0.3308
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0033 0.01 0.0237
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0033 0.01 0.1156
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 12 0.0037 0.0118 0.0632
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0035 0.0111 0.471
Loa Loa (eye worm) hypothetical protein 0.0033 0.01 0.0237
Brugia malayi hypothetical protein 0.0223 0.0885 0.4782
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.0155 0.0368
Trichomonas vaginalis ran, putative 0.0021 0.005 0.0365
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0057 0.0201 0.1051
Schistosoma mansoni calcium-activated potassium channel 0.0037 0.0118 0.0277
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0081 0.0081
Mycobacterium ulcerans lipase LipD 0.0065 0.0234 1
Plasmodium falciparum phd finger protein, putative 0.0027 0.0078 0.5374
Schistosoma mansoni twik family of potassium channels-related 0.0037 0.0118 0.0277
Brugia malayi Thioredoxin reductase 0.0043 0.0144 0.0776
Echinococcus granulosus GPCR family 2 0.0072 0.0261 0.0618
Echinococcus granulosus beta LACTamase domain containing family member 0.0065 0.0234 0.0554
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0157 0.0613 0.1451
Mycobacterium ulcerans ion transport protein 0.0037 0.0118 0.4392
Brugia malayi beta-lactamase family protein 0.0065 0.0234 0.1259
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0065 0.0234 1
Onchocerca volvulus 0.0037 0.0118 0.2033
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0015 0.0027 0.1103
Brugia malayi Bromodomain containing protein 0.0031 0.0094 0.0504
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0065 0.0234 0.1248
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0157 0.0613 0.0613
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0099 0.0374 0.2098
Echinococcus multilocularis musashi 0.0075 0.0273 0.0273
Schistosoma mansoni twik family of potassium channels-related 0.0037 0.0118 0.0277
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0015 0.0027 0.1103
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0099 0.0374 0.2098
Echinococcus multilocularis calcium activated potassium channel variant 0.0037 0.0118 0.0118
Echinococcus granulosus lamin dm0 0.0075 0.0273 0.0647
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0015 0.0027 0.5
Echinococcus granulosus twik family of potassium channels 0.0037 0.0118 0.0279
Loa Loa (eye worm) hypothetical protein 0.0037 0.0118 0.0279
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 45 0.0037 0.0118 0.0632
Trypanosoma cruzi calcium-activated potassium channel, putative 0.0037 0.0118 0.5011
Schistosoma mansoni cpg binding protein 0.0029 0.0085 0.0199
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0033 0.01 0.0235
Schistosoma mansoni twik family of potassium channels-related 0.0037 0.0118 0.0277
Schistosoma mansoni inositol monophosphatase 0.0035 0.0111 0.026
Loa Loa (eye worm) jmjC domain-containing protein 0.0009 0.0001 0.0003
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0059 0.0503
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0037 0.0118 0.5011
Loa Loa (eye worm) hypothetical protein 0.0037 0.0118 0.0279
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.005 0.2094
Echinococcus granulosus cpg binding protein 0.0029 0.0085 0.0202
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0027 0.1103
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0037 0.0118 0.1439
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0196 0.8389
Loa Loa (eye worm) hypothetical protein 0.0043 0.0142 0.0336
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0059 0.0503
Leishmania major hypothetical protein, conserved 0.0037 0.0118 0.5011
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0015 0.0027 0.1103
Trichomonas vaginalis CMGC family protein kinase 0.0045 0.0151 0.1965
Loa Loa (eye worm) hypothetical protein 0.0037 0.0118 0.0279
Schistosoma mansoni hypothetical protein 0.0027 0.0078 0.0183

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1.6 10'-11M Displacement of [125I]apamin from rat cerebral cortex small conductance calcium-activated potassium channel ChEMBL. 26988801

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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