Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | thymidylate synthase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0195 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0195 | 1 | 0.5 |
Mycobacterium ulcerans | thymidylate synthase | 0.0195 | 1 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.0195 | 1 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.0195 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0093 | 0 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.0195 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0195 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0195 | 1 | 0.5 |
Onchocerca volvulus | 0.0195 | 1 | 0.5 | |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0195 | 1 | 0.5 |
Schistosoma mansoni | lipoxygenase | 0.0137 | 0.433 | 0.4157 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0195 | 1 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0195 | 1 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0195 | 1 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0195 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Control (functional) | = 103 % | The compound was tested for inhibition of cell growth in culture against protection at 10*IC50 | ChEMBL. | 10508430 |
IC50 (binding) | = 1.6 nM | Inhibition of isolated thymidylate synthase partially purified from L1210 mouse leukemia cells | ChEMBL. | 10508430 |
IC50 (binding) | = 1.6 nM | Inhibition of isolated thymidylate synthase partially purified from L1210 mouse leukemia cells | ChEMBL. | 10508430 |
IC50 (functional) | = 0.23 uM | Growth inhibition of murine tumor L1210 cell line | ChEMBL. | 10508430 |
IC50 (functional) | = 0.23 uM | Growth inhibition of murine tumor L1210 cell line | ChEMBL. | 10508430 |
IC50 (functional) | = 0.93 uM | Tested for inhibition of cell growth in culture against murine tumor L1210:RD1694 cell lines | ChEMBL. | 10508430 |
IC50 (functional) | = 0.93 uM | Tested for inhibition of cell growth in culture against murine tumor L1210:RD1694 cell lines | ChEMBL. | 10508430 |
IC50 (functional) | = 10 uM | Inhibition of cell growth in culture against murine tumor L1210:1565 cell lines | ChEMBL. | 10508430 |
Relative resistance (functional) | = 4 | Relative resistance ratio of the compound evaluated for murine tumor L1210:RD1694 cells with 10% horse serum as supplement | ChEMBL. | 10508430 |
Relative resistance (functional) | = 43 | Relative resistance ratio evaluated for murine tumor L1210:1565 cells with 10% fetal calf serum as supplement | ChEMBL. | 10508430 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 10508430 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.