Detailed information for compound 21903

Basic information

Technical information
  • TDR Targets ID: 21903
  • Name: 5-benzylpyrimidine-2,4-diamine
  • MW: 200.24 | Formula: C11H12N4
  • H donors: 2 H acceptors: 2 LogP: 1.43 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1ncc(c(n1)N)Cc1ccccc1
  • InChi: 1S/C11H12N4/c12-10-9(7-14-11(13)15-10)6-8-4-2-1-3-5-8/h1-5,7H,6H2,(H4,12,13,14,15)
  • InChiKey: XHPZVBGIPQQTQW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-(phenylmethyl)pyrimidine-2,4-diamine
  • (2-amino-5-benzyl-pyrimidin-4-yl)amine
  • 2,4-diamino-5-benzylpyrimidine
  • [2-amino-5-(benzyl)pyrimidin-4-yl]amine
  • 7319-45-1
  • AIDS195912
  • 2,4-Pyrimidinediamine, 5-(phenylmethyl)-
  • 5-Benzyl-pyrimidine-2,4-diamine
  • AIDS-195912

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Candida albicans dihydrofolate reductase Starlite/ChEMBL References
Gallus gallus Dihydrofolate reductase Starlite/ChEMBL References
Escherichia coli Dihydrofolate reductase Starlite/ChEMBL References
Salmonella enterica subsp. enterica serovar Typhi Dihydrofolate reductase Starlite/ChEMBL References
Leishmania major dihydrofolate reductase-thymidylate synthase Curated by TDR Targets References
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase Curated by TDR Targets References
Lactobacillus casei Dihydrofolate reductase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans Thymidylate synthase capable of functional substitution for S. cerevisiae CDC21 (YOR074C) Get druggable targets OG5_127385 All targets in OG5_127385
Neospora caninum Bifunctional dihydrofolate reductase-thymidylate synthase, related Get druggable targets OG5_127385 All targets in OG5_127385
Echinococcus multilocularis dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Leishmania braziliensis dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Plasmodium berghei bifunctional dihydrofolate reductase-thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Loa Loa (eye worm) dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) Get druggable targets OG5_128410 All targets in OG5_128410
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Candida albicans Thymidylate synthase capable of functional substitution for S. cerevisiae CDC21 (YOR074C) Get druggable targets OG5_127385 All targets in OG5_127385
Leishmania mexicana dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Cryptosporidium hominis chain A, crystal structure of Dhfr Get druggable targets OG5_127385 All targets in OG5_127385
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) Get druggable targets OG5_127385 All targets in OG5_127385
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Mycobacterium ulcerans dihydrofolate reductase DfrA Get druggable targets OG5_128410 All targets in OG5_128410
Brugia malayi thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Echinococcus granulosus dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Brugia malayi Dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Trypanosoma brucei gambiense dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Candida albicans dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Chlamydia trachomatis dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Plasmodium knowlesi bifunctional dihydrofolate reductase-thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Loa Loa (eye worm) thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Schistosoma mansoni dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Echinococcus granulosus thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Echinococcus multilocularis thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Babesia bovis dihydrofolate reductase/thymidilate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127385 All targets in OG5_127385
Leishmania infantum dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Candida albicans hypothetical protein Get druggable targets OG5_128410 All targets in OG5_128410
Brugia malayi dihydrofolate reductase family protein Get druggable targets OG5_128410 All targets in OG5_128410
Schistosoma japonicum ko:K00560 thymidylate synthase [EC2.1.1.45], putative Get druggable targets OG5_127385 All targets in OG5_127385
Theileria parva dihydrofolate reductase-thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Cryptosporidium parvum dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Plasmodium yoelii thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Candida albicans dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Leishmania donovani dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Schistosoma japonicum ko:K00287 dihydrofolate reductase [EC1.5.1.3], putative Get druggable targets OG5_128410 All targets in OG5_128410
Onchocerca volvulus Get druggable targets OG5_127385 All targets in OG5_127385
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) Get druggable targets OG5_128410 All targets in OG5_128410
Leishmania major dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) Get druggable targets OG5_127385 All targets in OG5_127385
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Mycobacterium ulcerans thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Chlamydia trachomatis dihydrofolate reductase Dihydrofolate reductase   157 aa 133 aa 24.8 %
Candida albicans dihydrofolate reductase Dihydrofolate reductase   157 aa 149 aa 29.5 %
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   159 aa 130 aa 30.8 %
Onchocerca volvulus Putative dihydrofolate reductase Dihydrofolate reductase   163 aa 173 aa 27.2 %
Trypanosoma cruzi ATP- dependent RNA helicase, putative Dihydrofolate reductase   157 aa 140 aa 22.9 %
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   189 aa 201 aa 29.4 %
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) Dihydrofolate reductase   157 aa 158 aa 29.1 %
Leishmania major dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   189 aa 172 aa 34.3 %
Plasmodium falciparum dihydrofolate synthase/folylpolyglutamate synthase Dihydrofolate reductase   157 aa 127 aa 19.7 %
Plasmodium yoelii hypothetical protein Dihydrofolate reductase   157 aa 132 aa 24.2 %
Leishmania major serine carboxypeptidase (CBP1), putative,serine peptidase, Clan SC, Family S10 Dihydrofolate reductase   157 aa 159 aa 21.4 %
Mycobacterium ulcerans dihydrofolate reductase DfrA Dihydrofolate reductase   157 aa 159 aa 28.3 %
Leishmania donovani serine carboxypeptidase (CBP1), putative Dihydrofolate reductase   157 aa 159 aa 23.3 %
Babesia bovis dihydrofolate reductase/thymidilate synthase Dihydrofolate reductase   189 aa 189 aa 31.7 %
Leishmania donovani dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   189 aa 172 aa 34.3 %
Cryptosporidium hominis GDP-mannose pyrophosphorylase (4N40) Dihydrofolate reductase   157 aa 139 aa 28.1 %
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   189 aa 185 aa 35.7 %
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   189 aa 154 aa 33.8 %
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) Dihydrofolate reductase   157 aa 160 aa 29.4 %
Leishmania infantum serine carboxypeptidase (CBP1), putative,serine peptidase, Clan SC, Family S10 Dihydrofolate reductase   157 aa 159 aa 23.3 %
Dictyostelium discoideum dihydrofolate reductase Dihydrofolate reductase   157 aa 146 aa 27.4 %
Cryptosporidium parvum mannose-1-phosphate guanylyltransferase Dihydrofolate reductase   157 aa 139 aa 27.3 %
Leishmania infantum dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   189 aa 172 aa 34.3 %
Plasmodium berghei bifunctional dihydrofolate reductase-thymidylate synthase, putative Dihydrofolate reductase   189 aa 212 aa 29.2 %
Theileria parva dihydrofolate reductase-thymidylate synthase, putative Dihydrofolate reductase   189 aa 194 aa 31.4 %
Echinococcus multilocularis EF hand calcium binding domain containing protein Dihydrofolate reductase   189 aa 155 aa 22.6 %
Leishmania mexicana dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   189 aa 172 aa 33.1 %
Neospora caninum Bifunctional dihydrofolate reductase-thymidylate synthase, related Dihydrofolate reductase   189 aa 180 aa 34.4 %
Schistosoma mansoni dihydrofolate reductase Dihydrofolate reductase   157 aa 147 aa 28.6 %
Plasmodium knowlesi bifunctional dihydrofolate reductase-thymidylate synthase, putative Dihydrofolate reductase   189 aa 209 aa 28.7 %
Onchocerca volvulus Germline survival defective-1 homolog Dihydrofolate reductase   159 aa 166 aa 26.5 %
Leishmania braziliensis dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   189 aa 172 aa 33.7 %
Candida albicans dihydrofolate reductase Dihydrofolate reductase   157 aa 149 aa 29.5 %
Trypanosoma brucei gambiense dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   159 aa 130 aa 30.8 %
Candida albicans hypothetical protein Dihydrofolate reductase   157 aa 149 aa 29.5 %
Plasmodium yoelii thymidylate synthase, putative Dihydrofolate reductase   163 aa 139 aa 21.6 %
Cryptosporidium hominis chain A, crystal structure of Dhfr Dihydrofolate reductase   159 aa 173 aa 31.8 %
Cryptosporidium parvum dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   159 aa 173 aa 30.6 %
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative Dihydrofolate reductase   189 aa 209 aa 28.2 %
Plasmodium vivax hypothetical protein, conserved Dihydrofolate reductase   157 aa 127 aa 26.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis mitogen activated protein kinase 14 0.0126 0.0524 0.0899
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0762 0.3466 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0031 0.0088
Schistosoma mansoni dihydrofolate reductase 0.1015 0.4638 0.71
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0079 0.0109
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0045 0.0149 0.0429
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0017 0.0041
Giardia lamblia DINP protein human, muc B family 0.0019 0.0031 0.0832
Brugia malayi Lipocalin / cytosolic fatty-acid binding protein family protein 0.0136 0.057 0.0605
Schistosoma mansoni intermediate filament proteins 0.0027 0.0066 0.0089
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0287 0.1267 0.1363
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.003 0.0052
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0036 0.0107 0.0299
Brugia malayi Dihydrofolate reductase 0.1015 0.4638 0.4983
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0017 0.005
Schistosoma mansoni nuclear receptor 0.0135 0.0567 0.0857
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.003 0.0034
Loa Loa (eye worm) thymidylate synthase 0.026 0.1142 0.1228
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0096 0.0927
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0031 0.0088
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0033 0.0056
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0023 0.0067
Brugia malayi Nuclear hormone receptor-like 1 0.0287 0.1267 0.1355
Brugia malayi nuclear receptor RXR 0.0135 0.0567 0.0602
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0222 0.0639
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.003 0.0291
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0018 0.0023 0.0067
Brugia malayi hypothetical protein 0.0101 0.0409 0.0431
Leishmania major trypanothione reductase 0.0047 0.016 0.046
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.0179 0.0515
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0014 0.0022
Schistosoma mansoni hypothetical protein 0.0018 0.0023 0.0023
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0045 0.0149 0.0421
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0017 0.003
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0287 0.1267 0.1931
Schistosoma mansoni hypothetical protein 0.0036 0.0108 0.0153
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0222 0.0619
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.003 0.0034
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.003 0.0032
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0018 0.0023 0.0013
Brugia malayi Cytochrome P450 family protein 0.0056 0.0199 0.0206
Onchocerca volvulus 0.0055 0.0197 0.0197
Brugia malayi PXA domain containing protein 0.0019 0.003 0.0024
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0034 0.004
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0031 0.008
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0127 0.0183
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0287 0.1267 0.1355
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0135 0.0567 0.0868
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0107 0.0439 0.0912
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0028 1
Brugia malayi PAS domain containing protein 0.0048 0.0166 0.017
Echinococcus multilocularis Ankyrin 0.0014 0.0009 0.0015
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0058 0.0158
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.003 0.0291
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0033 0.0056
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0015 0.0011 0.0005
Brugia malayi Pre-SET motif family protein 0.0207 0.0901 0.0961
Schistosoma mansoni ap endonuclease 0.0019 0.0028 0.0031
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0018 0.0023 0.0013
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0038 0.0116 0.0124
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.0011 0.0012
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.016 0.0172
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.0179 0.0515
Schistosoma mansoni hypothetical protein 0.0336 0.1497 0.2283
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0045 0.0149 0.0152
Loa Loa (eye worm) agrin synaptic family protein 0.0038 0.0116 0.0124
Onchocerca volvulus 0.002 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0287 0.1267 0.1363
Brugia malayi Doublecortin family protein 0.002 0.0033 0.0026
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0287 0.1267 0.1931
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0045 0.0149 0.0228
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0033 0.0044
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0018 0.0023 0.0013
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0045 0.0149 0.0429
Brugia malayi Cytochrome P450 family protein 0.0026 0.0064 0.006
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0179 0.0515
Echinococcus granulosus RUN 0.002 0.0033 0.005
Echinococcus multilocularis survival motor neuron protein 1 0.0236 0.1031 0.1769
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0017 0.001
Echinococcus granulosus fatty acid binding protein FABP2 0.0136 0.057 0.0873
Onchocerca volvulus 0.0135 0.0567 0.0567
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0015 0.0011 0.0017
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0064 0.0184
Toxoplasma gondii protease inhibitor PI2 0.0038 0.0116 0.0313
Echinococcus granulosus nuclear factor of activated T cells 5 0.0073 0.0281 0.043
Loa Loa (eye worm) hypothetical protein 0.0019 0.003 0.0032
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0287 0.1267 0.1355
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0031 0.0029
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0126 0.0524 0.1512
Leishmania major cytochrome p450-like protein 0.0018 0.0023 0.0067
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0028 0.0022
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0017 0.005
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0036 0.0107 0.0308
Schistosoma mansoni hypothetical protein 0.0016 0.0014 0.001
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0031 0.008
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.002 0.0034 0.0028
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0045 0.0149 0.0255
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0017 0.005
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0034 0.004
Loa Loa (eye worm) cytochrome P450 0.0018 0.0023 0.0025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0106 0.103
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0018 0.0023 0.0067
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0108 0.0184
Echinococcus granulosus Ankyrin 0.0014 0.0009 0.0013
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0107 0.0439 0.0912
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0179 0.1729
Brugia malayi hypothetical protein 0.0019 0.003 0.0024
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0034 0.004
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0762 0.3466 1
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0018 0.0023 0.0013
Brugia malayi hypothetical protein 0.0163 0.0694 0.0738
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0018 0.0023 0.0013
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0135 0.0567 0.0973
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0014 0.0004 0.0012
Brugia malayi Uncoordinated protein 44 0.0014 0.0008 0.0000000186
Echinococcus multilocularis ecdysone induced protein 78C 0.0287 0.1267 0.2174
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0101 0.0973
Trypanosoma brucei protein kinase, putative 0.0051 0.0179 0.0507
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0108 0.0153
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0028 0.0024
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.003 0.0052
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0038 0.0116 0.0313
Loa Loa (eye worm) CYP4Cod1 0.0026 0.0064 0.0068
Schistosoma mansoni loxhd1 0.002 0.0033 0.0038
Loa Loa (eye worm) hypothetical protein 0.0032 0.0089 0.0096
Brugia malayi Pre-SET motif family protein 0.003 0.0079 0.0077
Loa Loa (eye worm) hypothetical protein 0.0017 0.002 0.0022
Brugia malayi nuclear hormone receptor 0.2024 0.93 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0287 0.1267 0.1363
Echinococcus multilocularis mitogen activated protein kinase 11 0.0126 0.0524 0.0899
Leishmania major hypothetical protein, conserved 0.0025 0.0058 0.0167
Loa Loa (eye worm) hypothetical protein 0.0287 0.1267 0.1363
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0287 0.1267 0.1931
Loa Loa (eye worm) hypothetical protein 0.0038 0.0116 0.0124
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0028 0.0024
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0019 0.0028 0.0071
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0762 0.3466 1
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0038 0.0116 0.0313
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0045 0.0149 0.0429
Schistosoma mansoni regulator of G protein signaling 0.0019 0.003 0.0034
Loa Loa (eye worm) hypothetical protein 0.0287 0.1267 0.1363
Schistosoma mansoni hypothetical protein 0.0125 0.0522 0.0788
Brugia malayi thymidylate synthase 0.026 0.1142 0.122
Leishmania major DNA polymerase eta, putative 0.0019 0.0031 0.0088
Schistosoma mansoni hypothetical protein 0.0154 0.0655 0.0992
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.003 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.0123 0.0513 0.4963
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.003 0.0046
Loa Loa (eye worm) hypothetical protein 0.0236 0.1031 0.1109
Mycobacterium leprae putative cytochrome p450 0.0018 0.0023 0.005
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0287 0.1267 0.1355
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0014 0.0007
Loa Loa (eye worm) hypothetical protein 0.0055 0.0197 0.0211
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0018 0.0023 0.0013
Plasmodium vivax SET domain protein, putative 0.003 0.0079 0.0205
Schistosoma mansoni hypothetical protein 0.002 0.0033 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0287 0.1267 0.1355
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0055 0.0197 0.0211
Onchocerca volvulus 0.0027 0.0066 0.0066
Echinococcus granulosus beta-adrenergic receptor kinase 0.002 0.0034 0.0053
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0151 0.0642 0.0972
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.0008 0.000000026502
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0135 0.0567 0.0857
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0031 0.008
Brugia malayi Steroid receptor seven-up type 2 0.0287 0.1267 0.1355
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0287 0.1267 0.1355
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0038 0.0116 0.0116
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0031 0.008
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0038 0.0116 0.0116
Echinococcus granulosus GPCR family 2 0.0016 0.0014 0.0022
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0014 0.0004 0.0012
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0015 0.0011 0.0023
Entamoeba histolytica hypothetical protein 0.0036 0.0108 0.657
Chlamydia trachomatis dihydrofolate reductase 0.1015 0.4638 1
Schistosoma mansoni regulator of G protein signaling 0.0019 0.003 0.0034
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0028 0.0691
Brugia malayi intermediate filament protein 0.0027 0.0066 0.0062
Echinococcus multilocularis mitogen activated protein kinase 14 0.0126 0.0524 0.0899
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.0179 0.0507
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0018 0.0023 0.0013
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0018 0.0023 0.0013
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0074 0.0114
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0017 0.0167
Trypanosoma cruzi MFS transporter, putative 0.0055 0.0197 0.0567
Loa Loa (eye worm) nuclear receptor NHR-67 0.0135 0.0567 0.061
Mycobacterium tuberculosis Probable oxidoreductase 0.0119 0.0494 0.1032
Schistosoma mansoni hypothetical protein 0.0034 0.0099 0.0139
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0028 0.0058
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.003 0.0052
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0055 0.0197 0.0337
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0287 0.1267 0.1941
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0287 0.1267 0.1355
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0287 0.1267 0.2174
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0151 0.0642 0.1101
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0018 0.0023 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0106 0.103
Echinococcus multilocularis nuclear receptor nhr 48 0.0135 0.0567 0.0973
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0055 0.0197 0.0301
Schistosoma mansoni DNA polymerase eta 0.0019 0.0031 0.0035
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0287 0.1267 0.1931
Echinococcus granulosus dna polymerase kappa 0.0019 0.0031 0.0047
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0108 0.0165
Toxoplasma gondii thioredoxin reductase 0.0047 0.016 0.044
Loa Loa (eye worm) RecQ helicase 0.0021 0.004 0.0043
Loa Loa (eye worm) hypothetical protein 0.0135 0.0567 0.061
Loa Loa (eye worm) hypothetical protein 0.1888 0.8675 0.9328
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0053 0.0517
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0015 0.0011 0.0019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0054 0.0518
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0135 0.0567 0.0602
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0058 0.0118
Schistosoma mansoni nuclear hormone receptor 0.0135 0.0567 0.0857
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.004 0.0035
Echinococcus granulosus hypothetical protein 0.0695 0.3154 0.4831
Echinococcus granulosus netrin receptor unc 5 0.0014 0.0008 0.0012
Echinococcus granulosus lamin dm0 0.0027 0.0066 0.0101
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0018 0.0023 0.0013
Echinococcus multilocularis dihydrofolate reductase 0.1015 0.4638 0.7956
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0017 0.0041
Echinococcus granulosus Nuclear hormone receptor HR96 0.0135 0.0567 0.0868
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0287 0.1267 0.1363
Brugia malayi Nuclear hormone receptor E75 0.0135 0.0567 0.0602
Echinococcus granulosus dihydrofolate reductase 0.1015 0.4638 0.7103
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0017 0.0041
Loa Loa (eye worm) hypothetical protein 0.0287 0.1267 0.1363
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.1273 0.5829 1
Leishmania major protein kinase, putative 0.0014 0.0004 0.0012
Loa Loa (eye worm) hypothetical protein 0.0287 0.1267 0.1363
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0011 0.0108
Brugia malayi Protein kinase domain containing protein 0.0015 0.0012 0.0005
Echinococcus granulosus nuclear receptor nhr 48 0.0135 0.0567 0.0868
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0031 0.0297
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0011 0.0108
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0015 0.0011 0.0023
Onchocerca volvulus Protein ultraspiracle homolog 0.0287 0.1267 0.1267
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0018 0.0023 0.0013
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0079 0.0109
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0028 1
Loa Loa (eye worm) hypothetical protein 0.0135 0.0567 0.061
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0065 0.0634
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0014 0.0025
Schistosoma mansoni thyroid hormone receptor 0.0412 0.1847 0.282
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0058 0.0144
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0079 0.0208
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0002 0.0003
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0207 0.0901 0.0968
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.003 0.0046
Onchocerca volvulus 0.026 0.1142 0.1142
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0011 0.0108
Schistosoma mansoni regulator of G protein signaling 0.0019 0.003 0.0034
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.0179 0.0515
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.009 0.0356 0.0533
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0028 0.0275
Giardia lamblia GTOR 0.0045 0.0149 0.8151
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0179 0.0262
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0018 0.0023 0.0013
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0171 0.0176
Schistosoma mansoni hypothetical protein 0.0016 0.0014 0.001
Loa Loa (eye worm) hypothetical protein 0.0135 0.0567 0.061
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0179 0.0515
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0222 0.0442
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0018 0.0023 0.0013
Brugia malayi hypoxia-induced factor 1 0.015 0.0635 0.0675
Onchocerca volvulus 0.0036 0.0108 0.0108
Plasmodium falciparum glutathione reductase 0.0047 0.016 0.0413
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.003 0.0024
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0073 0.0281 0.0482
Onchocerca volvulus 0.0236 0.1034 0.1034
Echinococcus granulosus mitogen activated protein kinase 11 0.0126 0.0524 0.0803
Loa Loa (eye worm) nuclear receptor nhr-7B 0.2024 0.93 1
Schistosoma mansoni survival motor neuron protein 0.0048 0.0164 0.0239
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0017 0.005
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0222 0.038
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0031 0.008
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0119 0.0494 0.1032
Brugia malayi sodium-independent organic anion transporter family protein 0.0055 0.0197 0.0203
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0054 0.0518
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0058 0.0167
Echinococcus multilocularis conserved hypothetical protein 0.0687 0.3121 0.5354
Echinococcus granulosus Solute carrier organic anion transporter family 0.0055 0.0197 0.0301
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0037 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.0135 0.0567 0.061
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0014 0.0007
Brugia malayi hypothetical protein 0.0236 0.1031 0.1101
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0031 0.0035
Leishmania major protein kinase, putative 0.0018 0.0027 0.0077
Echinococcus multilocularis expressed protein 0.0372 0.1661 0.285
Trypanosoma brucei cytochrome P450, putative 0.0026 0.0064 0.0175
Brugia malayi hypothetical protein 0.0135 0.0567 0.0602
Brugia malayi PXA domain containing protein 0.0019 0.003 0.0024
Mycobacterium ulcerans thymidylate synthase 0.026 0.1142 0.2434
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0066 0.0062
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0031 0.008
Brugia malayi Nuclear hormone receptor-like 1 0.0151 0.0642 0.0682
Trypanosoma cruzi target of rapamycin kinase 3 0.0036 0.0107 0.0308
Echinococcus granulosus ecdysone induced protein 78C 0.0287 0.1267 0.1941
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0038 0.0116 0.0313
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0018 0.0023 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0149 0.144
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0002 0.0003
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0018 0.0023 0.0013
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0018 0.0023 0.0013
Echinococcus multilocularis microtubule associated protein 2 0.0688 0.3121 0.5354
Brugia malayi hypothetical protein 0.0123 0.0513 0.0543
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0028 0.0073
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0126 0.0524 0.1504
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0064 0.0184
Onchocerca volvulus Putative organic anion transporter 0.0055 0.0197 0.0197
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0287 0.1267 0.2174
Echinococcus granulosus survival motor neuron protein 1 0.0236 0.1031 0.1579
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0014 0.0004 0.0012
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.016 0.0244
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0287 0.1267 0.1931
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.003 0.0046
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0031 0.008
Brugia malayi nuclear hormone receptor family member nhr-6 0.0135 0.0567 0.0602
Brugia malayi P38 map kinase family protein 2 0.0126 0.0524 0.0555
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0037 0.0112 0.0171
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.003 0.0052
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.003 0.0034
Brugia malayi ecdysteroid receptor 0.0287 0.1267 0.1355
Toxoplasma gondii exonuclease III APE 0.0019 0.0028 0.0061
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0135 0.0567 0.0868
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0008 0.0009
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.003 0.0032
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.003 0.0046
Onchocerca volvulus 0.0055 0.0197 0.0197
Loa Loa (eye worm) hypothetical protein 0.003 0.0079 0.0085
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.1015 0.4638 1
Echinococcus multilocularis mitogen activated protein kinase 11 0.0126 0.0524 0.0899
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.003 0.0291
Brugia malayi tailless protein 0.0135 0.0567 0.0602
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0055 0.0197 0.0337
Loa Loa (eye worm) hypothetical protein 0.0287 0.1267 0.1363
Schistosoma mansoni zinc finger protein 0.0135 0.0567 0.0857
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0053 0.0517
Onchocerca volvulus 0.0038 0.0116 0.0116
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0031 0.0297
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.003 0.0046
Loa Loa (eye worm) hypothetical protein 0.0151 0.0642 0.069
Brugia malayi dihydrofolate reductase family protein 0.1015 0.4638 0.4983
Schistosoma mansoni RAR-like nuclear receptor 0.0287 0.1267 0.1931
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0064 0.0622
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0126 0.0524 0.1512
Schistosoma mansoni coup transcription factor 0.0287 0.1267 0.1931
Entamoeba histolytica hypothetical protein 0.0036 0.0108 0.657
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0065 0.0634
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0055 0.0196 0.03
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0287 0.1267 0.1941
Schistosoma mansoni axis inhibition protein axin 0.0019 0.003 0.0034
Brugia malayi SPARC precursor 0.0038 0.0116 0.0116
Brugia malayi cytochrome P450 0.0018 0.0023 0.0016
Onchocerca volvulus 0.0055 0.0197 0.0197
Echinococcus multilocularis RUN 0.002 0.0033 0.0056
Loa Loa (eye worm) glutathione reductase 0.0047 0.016 0.0172
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0287 0.1267 0.1355
Echinococcus granulosus axis inhibition protein axin 0.0019 0.003 0.0046
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.002 0.0034 0.0037
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0014 0.0016
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0119 0.0494 0.1065
Loa Loa (eye worm) hypothetical protein 0.0034 0.0099 0.0106
Echinococcus multilocularis FTZ F1 alpha 0.0287 0.1267 0.2174
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.0179 0.0515
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.004 0.0106
Onchocerca volvulus 0.0287 0.1267 0.1267
Brugia malayi conserved hypotetical protein 0.0135 0.0567 0.0602
Brugia malayi nuclear receptor NHR-67 0.0135 0.0567 0.0602
Mycobacterium leprae Conserved hypothetical protein 0.0018 0.0023 0.005
Schistosoma mansoni organic anion transporter 0.0055 0.0197 0.0289
Loa Loa (eye worm) hypothetical protein 0.0287 0.1267 0.1363
Schistosoma mansoni hypothetical protein 0.0016 0.0014 0.001
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0287 0.1267 0.1941
Echinococcus multilocularis agrin 0.0038 0.0116 0.0199
Echinococcus granulosus death domain containing protein 0.0014 0.0008 0.0012
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0287 0.1267 0.2174
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0287 0.1267 0.1941
Schistosoma mansoni lipoxygenase 0.0055 0.0196 0.0288
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0099 0.0098
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0096 0.0927
Echinococcus granulosus axis inhibition protein axin 0.0019 0.003 0.0046
Onchocerca volvulus 0.0101 0.0408 0.0408
Schistosoma mansoni nuclear hormone receptor 0.0287 0.1267 0.1931
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.0179 0.0306
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0125 0.0522 0.0799
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0015 0.0011 0.0032
Brugia malayi Nuclear hormone receptor-like 1 0.0151 0.0642 0.0682
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.003 0.0291
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0031 0.0047
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.016 0.046
Echinococcus multilocularis expressed protein 0.0038 0.0116 0.0199
Schistosoma mansoni single-minded 0.0048 0.0166 0.0242
Entamoeba histolytica hypothetical protein 0.0036 0.0108 0.657
Loa Loa (eye worm) hypothetical protein 0.0027 0.0066 0.0071
Loa Loa (eye worm) hypothetical protein 0.0055 0.0197 0.0211
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0028 0.0049
Brugia malayi hypothetical protein 0.002 0.0033 0.0026
Brugia malayi Death domain containing protein 0.0014 0.0008 0.0000000186
Loa Loa (eye worm) hypothetical protein 0.002 0.0033 0.0035
Echinococcus granulosus retinoic acid receptor rxr beta a 0.1424 0.6529 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.003 0.0032
Schistosoma mansoni nuclear receptor nhr-48 0.0135 0.0567 0.0857
Onchocerca volvulus 0.0135 0.0567 0.0567
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0287 0.1267 0.1355
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0037 0.0112 0.012
Mycobacterium tuberculosis Hypothetical protein 0.0123 0.0513 0.1072
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.0179 0.0306
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.003 0.0024
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0018 0.0023 0.0013
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0055 0.0196 0.0336
Brugia malayi nuclear hormone receptor 0.0287 0.1267 0.1355
Loa Loa (eye worm) hypothetical protein 0.0151 0.0642 0.069
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0014 0.0004 0.0012
Echinococcus multilocularis dna polymerase eta 0.0019 0.0031 0.0053
Echinococcus granulosus bloom syndrome protein 0.0021 0.004 0.0061
Toxoplasma gondii cytochrome p450 superfamily protein 0.0018 0.0023 0.0046
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0031 0.008
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.003 0.0024
Echinococcus granulosus dna polymerase eta 0.0019 0.0031 0.0047
Loa Loa (eye worm) hypothetical protein 0.0055 0.0197 0.0211
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0031 0.008
Onchocerca volvulus 0.0055 0.0197 0.0197
Schistosoma mansoni axis inhibition protein axin 0.0019 0.003 0.0034
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0038 0.0116 0.0116
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0287 0.1267 0.2174
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0018 0.0023 0.0013
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0018 0.0023 0.0013
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0031 0.0188
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0014 0.0022
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.0179 0.0495
Echinococcus granulosus microtubule associated protein 2 0.0688 0.3121 0.478
Brugia malayi Nuclear hormone receptor E75 0.0135 0.0567 0.0602
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0079 0.0121
Onchocerca volvulus 0.0041 0.0132 0.0132
Schistosoma mansoni regulator of G protein signaling 0.0019 0.003 0.0034
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.026 0.1142 0.2434
Loa Loa (eye worm) hypothetical protein 0.0019 0.003 0.0032
Brugia malayi orphan nuclear receptor NR2E1 0.0135 0.0567 0.0602
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0031 0.0053
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0123 0.0513 0.1479
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0031 0.0029
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0018 0.0023 0.0013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0287 0.1267 0.1363
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0041 0.0132 0.019
Loa Loa (eye worm) phosphatidylinositol 3 0.0045 0.0149 0.016
Schistosoma mansoni organic anion transporter 0.0055 0.0197 0.0289
Loa Loa (eye worm) hypothetical protein 0.0135 0.0567 0.061
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0064 0.0622
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0009
Brugia malayi nuclear receptor NHR-88 0.0135 0.0567 0.0602
Loa Loa (eye worm) hypothetical protein 0.0135 0.0567 0.061
Loa Loa (eye worm) hypothetical protein 0.0019 0.003 0.0032
Schistosoma mansoni thyroid hormone receptor 0.0412 0.1847 0.282
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.003 0.0052
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0031 0.0088
Schistosoma mansoni nuclear hormone receptor 0.0135 0.0567 0.0857
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0018 0.0023 0.0013
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0018 0.0023 0.0013
Onchocerca volvulus 0.0048 0.0164 0.0164
Schistosoma mansoni hypothetical protein 0.0016 0.0014 0.001
Leishmania major DNA polymerase kappa, putative 0.0019 0.0031 0.0088
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.003 0.0052
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0031 0.0029
Brugia malayi sodium-independent organic anion transporter family protein 0.0055 0.0197 0.0203
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0028 0.0082
Loa Loa (eye worm) hypothetical protein 0.0287 0.1267 0.1363
Mycobacterium tuberculosis Probable reductase 0.0107 0.0439 0.0912
Trichomonas vaginalis set domain proteins, putative 0.0236 0.1033 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0101 0.0973
Loa Loa (eye worm) hypothetical protein 0.0151 0.0642 0.069
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.0011 0.0003
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0011 0.0032
Loa Loa (eye worm) hypothetical protein 0.0101 0.0408 0.0439
Loa Loa (eye worm) hypothetical protein 0.005 0.0171 0.0184
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0018 0.0023 0.0013
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0179 0.1729
Trypanosoma brucei unspecified product 0.0019 0.0031 0.008
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0287 0.1267 0.2174
Onchocerca volvulus 0.0101 0.0408 0.0408
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0045 0.0149 1
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0127 0.0183
Brugia malayi M-phase phosphoprotein, mpp8 0.0101 0.0408 0.0431
Echinococcus multilocularis follistatin 0.0038 0.0116 0.0199
Schistosoma mansoni aryl hydrocarbon receptor 0.0048 0.0166 0.0242
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0031 0.008
Leishmania major phosphatidylinositol 3-kinase, putative 0.0015 0.0011 0.0032
Loa Loa (eye worm) RGS-3 protein 0.0019 0.003 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.003 0.0291
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0151 0.0642 0.0983
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0076 0.0737
Brugia malayi hypothetical protein 0.0151 0.0642 0.0682
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0149 0.144
Brugia malayi secreted modular calcium-binding protein 1 0.0038 0.0116 0.0116
Schistosoma mansoni microtubule-associated protein tau 0.0688 0.3121 0.4774
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0033 0.0056
Loa Loa (eye worm) hypothetical protein 0.0101 0.0409 0.044
Schistosoma mansoni nuclear receptor 0.0135 0.0567 0.0857
Onchocerca volvulus Putative organic anion transporter 0.0055 0.0197 0.0197
Toxoplasma gondii transporter, major facilitator family protein 0.0055 0.0197 0.0547
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.016 0.0438
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0126 0.0524 0.0564
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.0008 0.0014
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.026 0.1142 0.2462
Echinococcus granulosus lamin 0.0027 0.0066 0.0101
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0058 0.0118
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0028 0.0082
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0031 0.0033
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0179 0.1729
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0018 0.0023 0.0013
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.1015 0.4638 1
Loa Loa (eye worm) hypothetical protein 0.0151 0.0642 0.069
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0096 0.0927
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0018 0.0023 0.0013
Plasmodium vivax glutathione reductase, putative 0.0047 0.016 0.0438
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0026 0.0064 0.01
Schistosoma mansoni cytochrome P450 0.0018 0.0023 0.0023
Echinococcus multilocularis geminin 0.0336 0.1497 0.2568
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0017 0.0026
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.003 0.0024
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.0179 0.0274
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0038 0.0116 0.0313
Leishmania major cytochrome p450-like protein 0.0026 0.0064 0.0184
Brugia malayi photoreceptor-specific nuclear receptor 0.0287 0.1267 0.1355
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0119 0.0494 0.1032
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0031 0.008
Loa Loa (eye worm) hypothetical protein 0.0135 0.0567 0.061
Loa Loa (eye worm) hypothetical protein 0.0019 0.0031 0.0033
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0018 0.0023 0.0013
Echinococcus multilocularis fatty acid binding protein FABP2 0.0136 0.057 0.0978
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0126 0.0524 0.1512
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.004 0.0388
Entamoeba histolytica hypothetical protein 0.0036 0.0108 0.657
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0016
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0017 0.005
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.009 0.0356 0.0533
Brugia malayi MAP kinase sur-1 0.0051 0.0179 0.0184
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0031 0.0088
Loa Loa (eye worm) hypothetical protein 0.0038 0.0116 0.0124
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0011 0.0032
Trypanosoma brucei trypanothione reductase 0.0047 0.016 0.0452
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0287 0.1267 0.1931
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.003 0.0291
Loa Loa (eye worm) hypoxia-induced factor 1 0.015 0.0635 0.0683
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0222 0.0442
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0079 0.0136
Loa Loa (eye worm) hypothetical protein 0.0038 0.0116 0.0124
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0031 0.0088
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0096 0.0927
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0018 0.0023 0.0013
Schistosoma mansoni polycystin 1-related 0.002 0.0033 0.0038
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0058 0.0146
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0028 0.0032
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0287 0.1267 0.1355
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0081 0.0781
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0287 0.1267 0.2174
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0107 0.0439 0.0946
Loa Loa (eye worm) hypothetical protein 0.0038 0.0116 0.0124
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0287 0.1267 0.1363
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0287 0.1267 0.1355
Mycobacterium tuberculosis Probable dehydrogenase 0.0107 0.0439 0.0912
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0222 0.0327
Loa Loa (eye worm) hypothetical protein 0.0055 0.0197 0.0211
Loa Loa (eye worm) hypothetical protein 0.0055 0.0197 0.0211
Loa Loa (eye worm) hypothetical protein 0.0019 0.003 0.0032
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0287 0.1267 0.1363
Loa Loa (eye worm) nuclear hormone receptor 0.0135 0.0567 0.061
Loa Loa (eye worm) hypothetical protein 0.0135 0.0567 0.061
Brugia malayi Thioredoxin reductase 0.0047 0.016 0.0163
Entamoeba histolytica hypothetical protein 0.0019 0.003 0.0139
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0287 0.1267 0.1363
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0045 0.0149 0.0216
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0031 0.0024
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.1015 0.4638 1
Schistosoma mansoni hypothetical protein 0.0048 0.0164 0.0239
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0011 0.0108
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0064 0.0068
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0033 0.007
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0017 0.005
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0135 0.0567 0.0567
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.0179 0.0192
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0096 0.0927
Schistosoma mansoni fatty acid binding protein 0.0136 0.057 0.0862
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0014 0.0008 0.0009
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.026 0.1142 0.1739
Echinococcus granulosus Ankyrin repeat domain containing protein 0.009 0.0356 0.0545
Schistosoma mansoni hypothetical protein 0.0336 0.1497 0.2283
Brugia malayi nuclear receptor RXR 0.0151 0.0642 0.0682
Echinococcus granulosus expressed protein 0.0372 0.1661 0.2545
Brugia malayi hypothetical protein 0.0055 0.0197 0.0203
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0045 0.0149 0.0421
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.016 0.0308
Schistosoma mansoni steroid hormone receptor ad4bp 0.0287 0.1267 0.1931
Brugia malayi prostaglandin transporter 0.0055 0.0197 0.0203
Brugia malayi hypothetical protein 0.0151 0.0642 0.0682
Loa Loa (eye worm) hypothetical protein 0.0163 0.0694 0.0746
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0031 0.008
Echinococcus multilocularis 0.0018 0.0023 0.004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0149 0.144
Giardia lamblia Kinase, CMGC MAPK 0.0051 0.0179 1
Brugia malayi steroid hormone receptor 0.0429 0.1927 0.2065
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0017 0.0028
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0135 0.0567 0.0973
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0135 0.0567 0.0973
Loa Loa (eye worm) DR-78 0.0135 0.0567 0.061
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0066 0.0071
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0018 0.0023 0.0013
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0066 0.0071
Loa Loa (eye worm) hypothetical protein 0.0151 0.0642 0.069
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0287 0.1267 0.1355
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0017 0.005
Echinococcus granulosus Nuclear hormone receptor HR96 0.0135 0.0567 0.0868
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0119 0.1147
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0106 0.103
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0017 0.0041
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0107 0.0439 0.0912
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0011 0.0108
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0096 0.0255
Loa Loa (eye worm) steroid hormone receptor 0.0429 0.1927 0.2072
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.003 0.0291
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0028 0.0082
Loa Loa (eye worm) hypothetical protein 0.0135 0.0567 0.061
Mycobacterium ulcerans putative regulatory protein 0.0036 0.0108 0.0196
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0171 0.0184
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0164 0.0168
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0031 0.0053
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0017 0.0014
Echinococcus granulosus mitogen activated protein kinase 14 0.0126 0.0524 0.0803
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0107 0.0439 0.0912
Echinococcus granulosus fatty acid binding protein FABP2 0.0136 0.057 0.0873
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0017 0.005
Plasmodium falciparum thioredoxin reductase 0.0047 0.016 0.0413
Echinococcus granulosus thymidylate synthase 0.026 0.1142 0.1749
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0287 0.1267 0.1941
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0079 0.0136
Loa Loa (eye worm) hypothetical protein 0.0055 0.0197 0.0211
Entamoeba histolytica hypothetical protein 0.0019 0.003 0.0139
Echinococcus multilocularis lamin 0.0027 0.0066 0.0113
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0017 0.005
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0135 0.0567 0.0857
Brugia malayi sodium-independent organic anion transporter family protein 0.0055 0.0197 0.0203
Loa Loa (eye worm) hypothetical protein 0.0014 0.0008 0.0009
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0151 0.0642 0.0972
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0028 0.0032
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0017 0.005
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.003 0.0034
Echinococcus multilocularis bloom syndrome protein 0.0021 0.004 0.0069
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0018 0.0023 0.0013
Entamoeba histolytica hypothetical protein 0.0019 0.003 0.0139
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0018 0.0023 0.0013
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0762 0.3466 1
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0135 0.0567 0.0973
Echinococcus multilocularis transfer RNA-Lys 0.0036 0.0108 0.0185
Loa Loa (eye worm) hypothetical protein 0.0026 0.0064 0.0069
Echinococcus multilocularis musashi 0.0027 0.0066 0.0113
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0106 0.103
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.003 0.0052
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.0017 0.0037
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0125 0.0522 0.0895
Onchocerca volvulus 0.0055 0.0197 0.0197
Echinococcus multilocularis netrin receptor unc 5 0.0014 0.0008 0.0014
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0151 0.0642 0.069
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0065 0.0634
Echinococcus multilocularis thymidylate synthase 0.026 0.1142 0.1959
Schistosoma mansoni lamin 0.0027 0.0066 0.0089
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0054 0.0518
Schistosoma mansoni follistatin 0.0038 0.0116 0.0165
Echinococcus multilocularis GPCR, family 2 0.0016 0.0014 0.0025
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0222 0.0442
Onchocerca volvulus Netrin receptor homolog 0.0014 0.0008 0.0008
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0031 0.008
Loa Loa (eye worm) hypothetical protein 0.0019 0.003 0.0032
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0762 0.3466 1
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0018 0.0023 0.0013
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.002 0.0034 0.0037
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0171 0.0176
Brugia malayi nuclear hormone receptor family member odr-7 0.0135 0.0567 0.0602
Echinococcus multilocularis lamin dm0 0.0027 0.0066 0.0113
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0017 0.0026
Onchocerca volvulus 0.0027 0.0066 0.0066
Loa Loa (eye worm) cytochrome P450 family protein 0.0056 0.0199 0.0214
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0014 0.0025
Brugia malayi hypothetical protein 0.0135 0.0567 0.0602
Brugia malayi hypothetical protein 0.002 0.0033 0.0026
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0179 0.1729
Schistosoma mansoni lamin 0.0027 0.0066 0.0089
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0014 0.0009 0.0001
Loa Loa (eye worm) hypothetical protein 0.002 0.0033 0.0035
Schistosoma mansoni regulator of G protein signaling 0.0019 0.003 0.0034
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0018 0.0023 0.0013
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0017 0.0028
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0023 0.0067
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.0179 0.0274
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0287 0.1267 0.1355
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0033 0.005
Schistosoma mansoni lipoxygenase 0.002 0.0033 0.0038
Loa Loa (eye worm) hypothetical protein 0.0135 0.0567 0.061
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0018 0.0023 0.0013
Onchocerca volvulus Putative organic anion transporter 0.0055 0.0197 0.0197
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0045 0.0149 0.0429
Echinococcus granulosus single minded 2 0.0039 0.0123 0.0189
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.003 0.0052
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0017 0.005
Onchocerca volvulus Bile acid receptor homolog 0.0287 0.1267 0.1267
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0018 0.0023 0.0013
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0045 0.0149 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0031 0.0029
Brugia malayi hypothetical protein 0.0016 0.0017 0.0009
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0222 0.0327
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0018 0.0023 0.0013
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.004 0.0388
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0106 0.103
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0096 0.0927
Brugia malayi nuclear receptor NHR-88 0.0287 0.1267 0.1355
Loa Loa (eye worm) dihydrofolate reductase 0.1015 0.4638 0.4987
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0018 0.0023 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0287 0.1267 0.1355
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.003 0.0052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0054 0.0518
Echinococcus multilocularis beta adrenergic receptor kinase 0.002 0.0034 0.0059
Loa Loa (eye worm) hypothetical protein 0.0025 0.0058 0.0062
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0037 0.0112 0.0192
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.003 0.0024
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0762 0.3466 1
Brugia malayi hypothetical protein 0.0025 0.0058 0.0054
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.016 0.0274
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.009 0.0356 0.061
Echinococcus granulosus agrin 0.0038 0.0116 0.0177
Schistosoma mansoni fatty acid binding protein 0.0136 0.057 0.0862
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0018 0.0023 0.0013
Schistosoma mansoni ap endonuclease 0.0019 0.0028 0.0031
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.0008 0.0012
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0028 0.0031
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0135 0.0567 0.0567
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0031 0.0024
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0017 0.0026
Brugia malayi hypothetical protein 0.0036 0.0108 0.0107
Loa Loa (eye worm) hypothetical protein 0.0135 0.0567 0.061
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0031 0.008
Brugia malayi hypothetical protein 0.0019 0.003 0.0024
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0033 0.005
Brugia malayi ecdysone receptor 0.0135 0.0567 0.0602
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0017 0.0167
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0031 0.0035
Loa Loa (eye worm) doublecortin family protein 0.002 0.0033 0.0035
Echinococcus multilocularis fatty acid binding protein FABP2 0.0136 0.057 0.0978
Loa Loa (eye worm) hypothetical protein 0.0055 0.0197 0.0211
Echinococcus granulosus cytochrome P450 2K1 0.0018 0.0023 0.0036
Echinococcus granulosus follistatin 0.0038 0.0116 0.0177
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0058 0.0167
Loa Loa (eye worm) hypothetical protein 0.0135 0.0567 0.061
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0018 0.0023 0.0058
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0019 0.0017
Brugia malayi Cytochrome P450 family protein 0.0026 0.0064 0.006
Echinococcus granulosus intermediate filament protein 0.0027 0.0066 0.0101
Loa Loa (eye worm) hypothetical protein 0.0135 0.0567 0.061
Schistosoma mansoni agrin 0.0038 0.0116 0.0165
Echinococcus granulosus FTZ F1 alpha 0.0287 0.1267 0.1941
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0222 0.0339
Loa Loa (eye worm) lipocalin/cytosolic fatty-acid binding protein family protein 0.0136 0.057 0.0613
Echinococcus granulosus geminin 0.0336 0.1497 0.2292
Brugia malayi glutathione reductase 0.0047 0.016 0.0163
Onchocerca volvulus 0.002 0.0033 0.0033
Leishmania major cytochrome p450-like protein 0.0018 0.0023 0.0067
Echinococcus granulosus thyroid hormone receptor alpha 0.0278 0.1227 0.1879
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0096 0.0927
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0053 0.0517
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0079 0.0109
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0222 0.0442
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0017 0.005
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0031 0.0088
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0033 0.005
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0028 0.0043
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0018 0.0023 0.0013
Schistosoma mansoni rab6-interacting 0.002 0.0033 0.0038
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0038 0.0116 0.0116
Schistosoma mansoni retinoic acid receptor RXR 0.1424 0.6529 1
Brugia malayi bHLH-PAS transcription factor 0.0036 0.0108 0.0107
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0017 0.005
Echinococcus multilocularis thyroid hormone receptor alpha 0.0412 0.1847 0.3169
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0018 0.0023 0.0013
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0064 0.0068
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0287 0.1267 0.1941
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0018 0.0023 0.0013
Brugia malayi hypothetical protein 0.0055 0.0197 0.0203
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0028 0.0275
Brugia malayi Cytochrome P450 family protein 0.0018 0.0023 0.0016
Schistosoma mansoni rab6-interacting 0.002 0.0033 0.0038

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) = 6.18 Inhibitory activity against dihydrofolate reductase ChEMBL. 11495588
Activity (binding) = 6.18 Activity against dihydrofolate reductase of Escherichia coli strain MB 1428 ChEMBL. 1507206
Activity (binding) = 4.68 % Binding affinity for dihydrofolate reductase from Lactobacillus casei ChEMBL. 9379435
Activity (binding) = 4.68 % Binding affinity for dihydrofolate reductase from Lactobacillus casei ChEMBL. 9379435
clogP = 1.591 Calculated partition coefficient (clogP) ChEMBL. 8941396
I50 (binding) = 0.16 uM l-1 Inhibitory activity of the compound against cell free dihydrofolate redutase (DHFR) from Escherichia coli ChEMBL. 14695838
I50 (binding) = 14.77 uM l-1 Inhibitory activity of the compound against cell free dihydrofolate redutase (DHFR) from Mycobacterium lufu ChEMBL. 14695838
I50 (binding) = 90.45 uM l-1 Inhibitory activity against cell free dihydrofolate reductase (DHFR) from Candida albicans ChEMBL. 14695838
I50 (binding) = 115.3 uM l-1 Inhibitory activity of the compound against cell free dihydrofolate reductase (DHFR) from rat ChEMBL. 14695838
IC50 (binding) = 5.47 Inhibition of Escherichia coli dihydrofolate reductase ChEMBL. 319234
IC50 (binding) = 5.71 Compound was tested for inhibition of E. coli Dihydrofolate reductase. ChEMBL. 8941396
IC50 (binding) = 0.16 uM l-1 Inhibitory activity of the compound against cell free dihydrofolate redutase (DHFR) from Escherichia coli ChEMBL. 14695838
IC50 (binding) = 14.77 uM l-1 Inhibitory activity of the compound against cell free dihydrofolate redutase (DHFR) from Mycobacterium lufu ChEMBL. 14695838
IC50 (binding) = 90.45 uM l-1 Inhibitory activity against cell free dihydrofolate reductase (DHFR) from Candida albicans ChEMBL. 14695838
IC50 (binding) = 115.3 uM l-1 Inhibitory activity of the compound against cell free dihydrofolate reductase (DHFR) from rat ChEMBL. 14695838
Ki (binding) = -5.2 Inhibition of Dihydrofolate reductase from Lactobacillus casei ChEMBL. 9784101
Ki (binding) = -4.71 Inhibition of chicken liver Dihydrofolate reductase (dihydrofolate reductase) ChEMBL. 9784101
Ki (binding) = 4.71 Compound was evaluated for inhibitory activity against chicken dihydrofolate reductase ChEMBL. 1899453
Ki (binding) = 4.71 Inhibitory activity against chicken liver dihydrofolate reductase ChEMBL. 2502631
Ki (binding) = 5.2 Inhibitory activity against Lactobacillus casei dihydrofolate reductase ChEMBL. 2502631
Ki (binding) = 6.18 Inhibitory activity against E. coli dihydrofolate reductase ChEMBL. 1899453
Ki (binding) = 6.18 Inhibition constant against binding of E. coli dihydrofolate reductase ChEMBL. 3290487
Log (binding) = 5.71 1/IC50 Compound was tested for inhibition of E. coli Dihydrofolate reductase. ChEMBL. 8941396
Log (binding) = 4.71 1/Ki Compound was evaluated for inhibitory activity against chicken dihydrofolate reductase ChEMBL. 1899453
Log (binding) = 6.18 1/Ki Inhibitory activity against E. coli dihydrofolate reductase ChEMBL. 1899453
Log 1/C (functional) = 2.92 Inhibition of growth of methotrexate-resistant (MB1428) strain of Escherichia coli cells. ChEMBL. 3934385
Log 1/C (binding) = 3.82 The concentration of the compound required to inhibit dihydrofolate reductase in rat liver ChEMBL. 6737433
Log 1/C (functional) = 4.28 Inhibition of growth of methotrexate-sensitive (MB1417) strain of Escherichia coli cells. ChEMBL. 3934385
Log 1/C (binding) = 4.71 Inhibition of chicken liver dihydrofolate reductase ChEMBL. 3701780
Log 1/C (binding) = 5.19 Inhibition of bovine liver dehydrofolate reductase. ChEMBL. 7005446
Log 1/C (binding) = 5.19 Inhibition of bovine liver dihydrofolate reductase. ChEMBL. 6345782
Log 1/C (binding) = 5.19 Inhibition of bovine liver Dihydrofolate reductase. ChEMBL. 7277386
Log 1/C (functional) = 2.92 Inhibition of growth of methotrexate-resistant (MB1428) strain of Escherichia coli cells. ChEMBL. 3934385
Log 1/C (binding) = 3.82 The concentration of the compound required to inhibit dihydrofolate reductase in rat liver ChEMBL. 6737433
Log 1/C (functional) = 3.88 Inhibitory activity against murine tumor cells (L5178Y/R) ChEMBL. 7086836
Log 1/C (functional) = 4.28 Inhibition of growth of methotrexate-sensitive (MB1417) strain of Escherichia coli cells. ChEMBL. 3934385
Log 1/C (binding) = 4.71 Inhibition of chicken liver dihydrofolate reductase ChEMBL. 3701780
Log 1/C (binding) = 5.19 Inhibition of bovine liver dihydrofolate reductase. ChEMBL. 6345782
Log 1/C (binding) = 5.19 Inhibition of bovine liver Dihydrofolate reductase. ChEMBL. 7277386
Log 1/C (binding) = 5.19 Inhibition of bovine liver dehydrofolate reductase. ChEMBL. 7005446
Log 1/C (functional) = 5.24 Inhibitory activity against murine tumor cells (L5178Y/S) ChEMBL. 7086836
Log 1/C (binding) = 6.18 Inhibition of dihydrofolate reductase (DHFR) from E. coli. ChEMBL. 3882967
Log 1/C (binding) = 6.18 In vitro inhibition of E. Coli dihydrofolate reductase. ChEMBL. 7005446
Log 1/Ki (binding) = 4.71 Inhibitory activity against chicken liver dihydrofolate reductase ChEMBL. 2502631
Log 1/Ki (binding) = 5.2 Inhibitory activity against Lactobacillus casei dihydrofolate reductase ChEMBL. 2502631
Log 1/Ki app (binding) = 4.71 Inhibitory activity against chicken dihydrofolate reductase at pH 7.2. ChEMBL. 7069722
Log 1/Ki app (binding) = 5.2 Inhibitory activity against dihydrofolate reductase (DHFR) from Lactobacillus casei (expressed as log 1/Kiapp) ChEMBL. 6809941
Log 1/Ki app (binding) = 5.67 Inhibitory activity against bovine liver dihydrofolate reductase at pH 7.2. ChEMBL. 7069722
Log 1/Ki app (binding) = 5.67 Inhibition of dihydrofolate reductase from bovine liver ChEMBL. 7017146
Log 1/Ki app (binding) = 4.71 Inhibitory activity against chicken dihydrofolate reductase at pH 7.2. ChEMBL. 7069722
Log 1/Ki app (binding) = 5.2 Inhibitory activity against dihydrofolate reductase (DHFR) from Lactobacillus casei (expressed as log 1/Kiapp) ChEMBL. 6809941
Log 1/Ki app (binding) = 5.67 Inhibition of dihydrofolate reductase from bovine liver ChEMBL. 7017146
Log 1/Ki app (binding) = 5.67 Inhibitory activity against bovine liver dihydrofolate reductase at pH 7.2. ChEMBL. 7069722
Log 1/Ki app (binding) = 6.18 Compound is evaluated for the inhibition of dihydrofolate reductase from Escherichia coli ChEMBL. 7017146
Log 1/Ki app (binding) = 6.18 Apparent inhibitory (log 1/Ki) activity against Escherichia coli dihydrofolate reductase ChEMBL. 3276891
Log 1/Ki app (binding) = 6.18 Inhibitory activity against dihydrofolate reductase (DHFR) from Escherichia coli (expressed as log 1/Kiapp) ChEMBL. 6809941
Log Ki (binding) = 4.71 Inhibition of chicken liver Dihydrofolate reductase (dihydrofolate reductase) ChEMBL. 9784101
Log Ki (binding) = 5.2 Inhibition of Dihydrofolate reductase from Lactobacillus casei ChEMBL. 9784101
Log Ki (binding) = 6.18 Inhibition constant against binding of E. coli dihydrofolate reductase ChEMBL. 3290487
log(1/I50) (binding) = 4.8 Inhibition of rat liver dihydrofolate reductase ChEMBL. 319234
log(1/I50) (binding) = 5.19 Inhibition of bovine liver dihydrofolate reductase using dihydrofolic acid as substrate ChEMBL. 458817
logD (ADMET) = -1.03 Partition coefficient (logD) (aqueous phase 0.1 N HCl) ChEMBL. 3701780
logD = -1.03 Compound was evaluated for the partition coefficients probably at the pH >> 7.2 at the aqueous phase 0.1 N HCl ChEMBL. 7005446
logD (ADMET) = -1.03 Partition coefficient (logD) (aqueous phase 0.1 N HCl) ChEMBL. 2502631
logD (ADMET) = 1.54 Partition coefficient(log P) of the compound was measured in aqueous phase(methanol-water, pH 8.4) ChEMBL. 3701780
logD (ADMET) = 1.54 Partition coefficient (logD) (0.01 N NaOH) ChEMBL. 2502631
logD (ADMET) = 1.58 Partition coefficient (logD) (0.1 N NAOH) ChEMBL. 3701780
logD = 1.58 Compound was evaluated for the partition coefficients probably at the pH >> 7.2 at the aqueous phase 0.1 N NaOH ChEMBL. 7005446
logD (ADMET) = 1.58 Partition coefficient (logD) (0.01 N NaOH) ChEMBL. 2502631
Selectivity index (binding) = 0.49 Selectivity measured as log[1/Ki(L.caseiDHFR)]-log[1/Ki(chicken liver DHFR)] ChEMBL. 9784101
SI (functional) = 5.2 Compound was evaluated for selectivity index against L. casei DHFR . ChEMBL. 1899453

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Targets
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania major 25954  
Annotator: aaronjr@u.washington.edu Comment: Drug: 77113-60-1; Drug: 78025-72-6; Drug: 80407-61-0; Drug: 98612-09-0. chemical inhibition with DHFR inhibitors leads to slow growth of Leishmania sp. in cell assay; References: 3185614
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) amastigote (BTO:0000062) inferred from bioassay (ECO:0000094) Leishmania major 25954  
Annotator: aaronjr@u.washington.edu Comment: Drug: 77113-60-1; Drug: 78025-72-6; Drug: 80407-61-0; Drug: 98612-09-0. chemical inhibition with DHFR inhibitors leads to slow growth of Leishmania sp. in cell assay; References: 3185614
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from specific protein inhibition (ECO:0000020) Leishmania major 25954  
Annotator: aaronjr@u.washington.edu Comment: Drug: 77113-60-1; Drug: 78025-72-6; Drug: 80407-61-0; Drug: 98612-09-0. chemical inhibition with DHFR inhibitors leads to reduced enzyme activity in vitro; References: 3185614

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

22 literature references were collected for this gene.

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